Brian G. Pierce

11.5k citations

97 papers · 6.8k indexed · 4 hit papers · h-index 39

Impact in

Molecular Biology top 1%
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Genomics and Chromatin Dynamics
Computational Theory and Mathematics top 0.5%
- Computational Drug Discovery Methods

Papers in

Hepatology 21
- Hepatitis C virus research 20
Radiology, Nuclear Medicine and Imaging 39
- Monoclonal and Polyclonal Antibodies Research 39

Co-authors: Zhiping Weng Kevin Wiehe Thom Vreven Howook Hwang Bong‐Hyun Kim Yuichiro Hourai Julian Mintseris Rui Yin
Journals: Proteins Structure Function and Bioinformatics (14 papers)Journal of Biological Chemistry (6 papers)Nucleic Acids Research (6 papers)Nature Communications (5 papers)Proceedings of the National Academy of Sciences (5 papers)
Partner nations: United States France China

In The Last Decade

Brian G. Pierce

94 papers receiving 6.7k citations

Hit Papers

align trajectories log scale

Benchmarking AlphaFold for protein complex modeling reveals accuracy determinants 2022 · 195 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2022 Protein Science
2014 Bioinformatics
2012 Genome Research
2011 PLoS ONE

Peers

Countries citing papers authored by Brian G. Pierce

Since Specialization

Citations

This map shows the geographic impact of Brian G. Pierce's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brian G. Pierce with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brian G. Pierce more than expected).

Fields of papers citing papers by Brian G. Pierce

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brian G. Pierce. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brian G. Pierce. The network helps show where Brian G. Pierce may publish in the future.

Co-authors

The 25 scholars most cited alongside Brian G. Pierce, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Brian G. Pierce Line = papers co-authored together Brian G. Pierce links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Structural insights into clonal restriction and diversity in T cell recognition of two immunodominant SARS-CoV-2 nucleocapsid epitopes Nature Communications ·Marcela Flores, 巖松山, Hiroko Tanabe, Fatemeh Sharifjafari, Salem O Abdalla, Jianfeng Zhao, Kanai Yasuyuki, M. Fajar Ilahi, Ying‐Wu Lin, Mostafa A. Elbahnasawy, Nan‐ping Weng, Brian G. Pierce, Roy A. Mariuzza, Daichao Wu	2025	0
2	RNA Helicase DDX3 Interacts with the Capsid Protein of Hepatitis E Virus and Plays a Vital Role in the Viral Replication Pathogens ·Shaoli Lin, 利昭木村, Hichmaed Tachta Hinggo, Jia He, Étienne Coyaud, Brian G. Pierce, Yan‐Jin Zhang	2025	0
3	Exploring the potential of structure-based deep learning approaches for T cell receptor design PLoS Computational Biology ·Helder Veras Ribeiro Filho, E. Sweet, Luiz C Chiaparini, Septime Atchekpe, Daniel Brumund, И. А. Разживина, Brian G. Pierce, Paulo Sérgio Lopes de Oliveira	2024	1
4	Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers Science Advances ·魏江明, Jonathan J. Du, Maria W. Flowers, Daniele Fernanda Ferreira Moreira, Jana Brixová, N. W. Collins, Nivaldo Alves de Faria, Ghazy Faden Faadihilah, Jianwen Feng, Diego E. Sastre, James K. Fields, Ardalan Mirzaei, Brian G. Pierce, Eric J. Sundberg	2024	1
5	Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens Science Advances ·Daichao Wu, Rui Yin, 巖松山, Helder Veras Ribeiro Filho, Septime Atchekpe, Paul F. Robbins, Roy A. Mariuzza, Brian G. Pierce	2024	9
6	Structural basis for T cell recognition of cancer neoantigens and implications for predicting neoepitope immunogenicity Frontiers in Immunology ·Roy A. Mariuzza, Daichao Wu, Brian G. Pierce	2023	11
7	Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors Nature Communications ·Daichao Wu, A. V. Kolesnikov, Rui Yin, Johnathan D. Guest, Ragul Gowthaman, Aiman Nuri Allawgalli, Yana Serdyuk, Santana Argollo, Grigory A. Efimov, Brian G. Pierce, Roy A. Mariuzza	2022	27
8	Structural Features of Antibody-Peptide Recognition Frontiers in Immunology ·Jessica H. Lee, Rui Yin, Gilad Ofek, Brian G. Pierce	2022	13
9	An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking Communications Biology ·Debajit Dey, Suruchi Singh, 英喜森, 敏明上, Nicholas Schnicker, Lokesh Gakhar, Brian G. Pierce, S. Saif Hasan	2022	15
10	T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes Genes ·John P. Mordes, 良兵山崎, Zhijun Liu, A Sharony, Elizabeth P. Blankenhorn, Brian G. Pierce	2021	5
11	An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants Structure ·Johnathan D. Guest, Thom Vreven, Jing Zhou, Iain H. Moal, Jeliazko R. Jeliazkov, Jeffrey J. Gray, Zhiping Weng, Brian G. Pierce	2021	71
12	An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development Gastroenterology ·Henrique Manoel Silva, Richard A. Urbanowicz, Johnathan D. Guest, B. M. Rost, Hyun‐Ji Park, Park Row, Zhen–Yong Keck, Vanessa M. Cowton, Sarah Cole, Arvind H. Patel, Thomas R. Fuerst, Heidi E. Drummer, Marian Major, Alexander W. Tarr, Jonathan K. Ball, Mansun Law, Brian G. Pierce, Steven K. H. Foung, Justin R. Bailey	2021	23
13	CoV3D: a database of high resolution coronavirus protein structures Nucleic Acids Research ·Ragul Gowthaman, Johnathan D. Guest, Rui Yin, Jared Adolf‐Bryfogle, William R. Schief, Brian G. Pierce	2020	50
14	Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization Journal of Virology ·Brian G. Pierce, Zhen–Yong Keck, Ruixue Wang, Patrick Lau, Sonu Rani, 康红英, Eric A. Toth, Richard A. Urbanowicz, Johnathan D. Guest, Pragati Agnihotri, Melissa C. Kerzic, Alexander Marin, Alexander K. Andrianov, Jonathan K. Ball, Roy A. Mariuzza, Thomas R. Fuerst, Steven K. H. Foung	2020	24
15	A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces Protein Engineering Design and Selection ·Timothy P. Riley, Cory M. Ayres, Lance M. Hellman, Nishant K. Singh, Su-Chen Chang, Peter Pagnamenta, Michael J. Anderson, Kurt H. Piepenbrink, Brian G. Pierce, Zhiping Weng, Brian M. Baker	2016	20
16	Prediction of protein–protein binding free energies Protein Science ·Thom Vreven, Howook Hwang, Brian G. Pierce, Zhiping Weng	2012	67
17	A flexible docking approach for prediction of T cell receptor–peptide–MHC complexes Protein Science ·Brian G. Pierce, Zhiping Weng	2012	68
18	Molecular Basis of a Million-Fold Affinity Maturation Process in a Protein–Protein Interaction Journal of Molecular Biology ·Daniel A. Bonsor, Sandra Postel, Brian G. Pierce, Ningyan Wang, Penny Zhu, Rebecca A. Buonpane, Zhiping Weng, David M. Kranz, Eric J. Sundberg	2011	7
19	Protein–protein docking benchmark version 3.0 Proteins Structure Function and Bioinformatics ·Howook Hwang, Brian G. Pierce, Julian Mintseris, Joël Janin, Zhiping Weng	2008	206
20	Protein–protein docking benchmark 2.0: An update Proteins Structure Function and Bioinformatics ·Julian Mintseris, Kevin Wiehe, Brian G. Pierce, Robert J. Anderson, Rong Chen, Joël Janin, Zhiping Weng	2005	235

About Brian G. Pierce

Brian G. Pierce is a scholar working on Hepatology, Radiology, Nuclear Medicine and Imaging, Virology, Immunology and Computational Theory and Mathematics, having authored 97 papers that have together received 6.8k indexed citations. Recurring topics across this work include Monoclonal and Polyclonal Antibodies Research (39 papers), vaccines and immunoinformatics approaches (21 papers), Hepatitis C virus research (20 papers), T-cell and B-cell Immunology (20 papers), Protein Structure and Dynamics (19 papers), Immune Cell Function and Interaction (17 papers), Computational Drug Discovery Methods (13 papers) and Hepatitis B Virus Studies (12 papers). The work is most often cited by research in Molecular Biology (4.8k citations), Computational Theory and Mathematics (1.1k citations), Hepatology (528 citations), Radiology, Nuclear Medicine and Imaging (1.3k citations) and Immunology (1.1k citations). Brian G. Pierce has collaborated with scholars based in United States, France and China. Frequent co-authors include Zhiping Weng, Kevin Wiehe, Thom Vreven, Howook Hwang, Bong‐Hyun Kim, Yuichiro Hourai, Julian Mintseris, Rui Yin, Ragul Gowthaman and Robert J. Anderson. Their work appears in journals such as Proteins Structure Function and Bioinformatics, Journal of Biological Chemistry, Nucleic Acids Research, Nature Communications and Proceedings of the National Academy of Sciences.

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