Boris Ν. Kholodenko

16.2k total citations · 2 hit papers
217 papers, 11.5k citations indexed

About

Boris Ν. Kholodenko is a scholar working on Molecular Biology, Cell Biology and Computational Theory and Mathematics. According to data from OpenAlex, Boris Ν. Kholodenko has authored 217 papers receiving a total of 11.5k indexed citations (citations by other indexed papers that have themselves been cited), including 188 papers in Molecular Biology, 42 papers in Cell Biology and 23 papers in Computational Theory and Mathematics. Recurrent topics in Boris Ν. Kholodenko's work include Gene Regulatory Network Analysis (74 papers), Microbial Metabolic Engineering and Bioproduction (40 papers) and Bioinformatics and Genomic Networks (35 papers). Boris Ν. Kholodenko is often cited by papers focused on Gene Regulatory Network Analysis (74 papers), Microbial Metabolic Engineering and Bioproduction (40 papers) and Bioinformatics and Genomic Networks (35 papers). Boris Ν. Kholodenko collaborates with scholars based in United States, Ireland and Russia. Boris Ν. Kholodenko's co-authors include Jan B. Hoek, Walter Kölch, Hans V. Westerhoff, Anatoly Kiyatkin, Edita Aksamitiene, Lan K. Nguyen, Guy C. Brown, John F. Hancock, Marc R. Birtwistle and Oleg V. Demin and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Boris Ν. Kholodenko

213 papers receiving 11.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Cell-signalling dynamics in time and space

2006 992 citations Boris Ν. Kholodenko profile →
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

2004 511 citations Jan B. Hoek, Boris Ν. Kholodenko et al. profile →

Peers

Boris Ν. Kholodenko

ONCOL

CTM

BIOPH

John J. Tyson United States

Nikolay V. Dokholyan United States

James E. Ferrell United States

James Inglese United States

Jan B. Hoek United States

Brenda Andrews Canada

Béla Novák United Kingdom

Ravi Iyengar United States

Brian Kuhlman United States

Henning Hermjakob United Kingdom

John J. Tyson United States

Boris Ν. Kholodenko

10.0k ×1.1

2.6k ×1.5

914 ×0.9

ONCOL

728 ×0.8

CTM

710 ×0.9

BIOPH

Citations per year, relative to Boris Ν. Kholodenko Boris Ν. Kholodenko (= 1×) peers John J. Tyson

Countries citing papers authored by Boris Ν. Kholodenko

Since Specialization

Citations

This map shows the geographic impact of Boris Ν. Kholodenko's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Boris Ν. Kholodenko with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Boris Ν. Kholodenko more than expected).

Fields of papers citing papers by Boris Ν. Kholodenko

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Boris Ν. Kholodenko. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Boris Ν. Kholodenko. The network helps show where Boris Ν. Kholodenko may publish in the future.

Co-authorship network of co-authors of Boris Ν. Kholodenko

This figure shows the co-authorship network connecting the top 25 collaborators of Boris Ν. Kholodenko. A scholar is included among the top collaborators of Boris Ν. Kholodenko based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Boris Ν. Kholodenko. Boris Ν. Kholodenko is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Rukhlenko, Oleksii S., et al.. (2025). cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling. Science Advances. 11(1). eado9970–eado9970. 7 indexed citations

Rukhlenko, Oleksii S., et al.. (2024). Cell State Transition Models Stratify Breast Cancer Cell Phenotypes and Reveal New Therapeutic Targets. Cancers. 16(13). 2354–2354. 3 indexed citations

Rauch, Nora, Leonidas G. Alexopoulos, Jens Rauch, et al.. (2023). A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression. Biomolecules. 13(8). 1212–1212. 5 indexed citations

Rukhlenko, Oleksii S., et al.. (2019). Mapping connections in signaling networks with ambiguous modularity. npj Systems Biology and Applications. 5(1). 8 indexed citations

Weitsman, Gregory, Paul R. Barber, Lan K. Nguyen, et al.. (2016). HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status. Oncotarget. 7(32). 51012–51026. 25 indexed citations

Varusai, Thawfeek, Walter Kölch, Boris Ν. Kholodenko, & Lan K. Nguyen. (2015). Protein–protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose–responses. Molecular BioSystems. 11(10). 2750–2762. 26 indexed citations

Degasperi, Andrea, Marc R. Birtwistle, Natalia Volinsky, et al.. (2014). Evaluating Strategies to Normalise Biological Replicates of Western Blot Data. PLoS ONE. 9(1). e87293–e87293. 165 indexed citations

Nikonova, Elena, M. A. Tsyganov, Walter Kölch, Dirk Fey, & Boris Ν. Kholodenko. (2013). Control of the G-protein cascade dynamics by GDP dissociation inhibitors. Molecular BioSystems. 9(10). 2454–2462. 13 indexed citations

Vandamme, Didier, et al.. (2013). Systems medicine: helping us understand the complexity of disease. QJM. 106(10). 891–895. 26 indexed citations

10.

Tsyganov, M. A., Walter Kölch, & Boris Ν. Kholodenko. (2012). The topology design principles that determine the spatiotemporal dynamics of G-protein cascades. Molecular BioSystems. 8(3). 730–743. 29 indexed citations

11.

Birtwistle, Marc R., Alex von Kriegsheim, Maciej Dobrzyński, Boris Ν. Kholodenko, & Walter Kölch. (2012). Mammalian protein expression noise: scaling principles and the implications for knockdown experiments. Molecular BioSystems. 8(11). 3068–3076. 8 indexed citations

12.

Baljuls, Angela, Boris Ν. Kholodenko, & Walter Kölch. (2012). It takes two to tango – signalling by dimeric Raf kinases. Molecular BioSystems. 9(4). 551–558. 36 indexed citations

13.

Blüthgen, Nils, Frank J. Bruggeman, Stefan Legewie, et al.. (2006). Effects of sequestration on signal transduction cascades. FEBS Journal. 273(5). 895–906. 126 indexed citations

14.

Kholodenko, Boris Ν. & Hans V. Westerhoff. (2004). Metabolic engineering in the post genomic era. 46 indexed citations

15.

Kholodenko, Boris Ν., Jan B. Hoek, & Hans V. Westerhoff. (2000). Why cytoplasmic signalling proteins should be recruited to cell membranes. Trends in Cell Biology. 10(5). 173–178. 185 indexed citations

16.

Brown, Guy C. & Boris Ν. Kholodenko. (1999). Spatial gradients of cellular phospho‐proteins. FEBS Letters. 457(3). 452–454. 156 indexed citations

17.

Kholodenko, Boris Ν., Jan B. Hoek, Hans V. Westerhoff, & Guy C. Brown. (1997). Quantification of information transfer via cellular signal transduction pathways. FEBS Letters. 414(2). 430–434. 132 indexed citations

18.

Westerhoff, Hans V., et al.. (1996). Biothermokinetics of the living cell. Open Repository and Bibliography (University of Liège). 32 indexed citations

19.

Kholodenko, Boris Ν.. (1995). The macroworld versus the microworld of biochemical regulation and control. Trends in Biochemical Sciences. 20(2). 52–54. 45 indexed citations

20.

Kholodenko, Boris Ν.. (1988). How do external parameters control fluxes and concentrations of metabolites? An additional relationship in the theory of metabolic control. FEBS Letters. 232(2). 383–386. 33 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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