Arash Grakoui

16.0k total citations · 13 hit papers
101 papers, 12.1k citations indexed

About

Arash Grakoui is a scholar working on Hepatology, Immunology and Epidemiology. According to data from OpenAlex, Arash Grakoui has authored 101 papers receiving a total of 12.1k indexed citations (citations by other indexed papers that have themselves been cited), including 58 papers in Hepatology, 44 papers in Immunology and 34 papers in Epidemiology. Recurrent topics in Arash Grakoui's work include Hepatitis C virus research (47 papers), Immune Cell Function and Interaction (34 papers) and T-cell and B-cell Immunology (24 papers). Arash Grakoui is often cited by papers focused on Hepatitis C virus research (47 papers), Immune Cell Function and Interaction (34 papers) and T-cell and B-cell Immunology (24 papers). Arash Grakoui collaborates with scholars based in United States, Canada and France. Arash Grakoui's co-authors include Charles M. Rice, Paul M. Allen, Cenk Sumen, Mark M. Davis, Andréy S. Shaw, Michael L. Dustin, Shannon K. Bromley, S M Feinstone, Czeslaw Wychowski and Christopher M. Walker and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Arash Grakoui

99 papers receiving 11.8k citations

Hit Papers

The Immunological Synapse... 1989 2026 2001 2013 1999 1993 2003 2003 1993 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
    1999 2.5k citations Arash Grakoui, Shannon K. Bromley et al. Science profile →
  2. Expression and identification of hepatitis C virus polyprotein cleavage products
    1993 757 citations Arash Grakoui, Charles M. Rice et al. Journal of Virology profile →
  3. HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
    2003 645 citations Arash Grakoui, Naglaa H. Shoukry et al. Science profile →
  4. Memory CD8 + T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection
    2003 487 citations Naglaa H. Shoukry, Arash Grakoui et al. profile →
  5. Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites
    1993 483 citations Arash Grakoui, Charles M. Rice et al. Journal of Virology profile →
  6. Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics
    2006 460 citations Arash Grakoui, Charles M. Rice et al. profile →
  7. Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders
    2020 339 citations Arash Grakoui et al. profile →
  8. A second hepatitis C virus-encoded proteinase.
    1993 321 citations Arash Grakoui, Charles M. Rice et al. Proceedings of the National Academy of Sciences profile →
  9. Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
    1990 292 citations Arash Grakoui, Charles M. Rice et al. Proceedings of the National Academy of Sciences profile →
  10. HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.
    1995 273 citations Margaret James Koziel, Darryll D. Dudley et al. Journal of Clinical Investigation profile →
  11. Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes
    1993 264 citations Arash Grakoui, Charles M. Rice et al. Journal of Virology profile →
  12. Transcription of infectious yellow fever RNA from full-length cDNA templates produced by in vitro ligation.
    1989 249 citations Charles M. Rice, Arash Grakoui et al. profile →
  13. Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites
    1991 211 citations Arash Grakoui, Charles M. Rice et al. Journal of Virology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Arash Grakoui United States 44 5.3k 4.4k 4.1k 2.7k 1.5k 101 12.1k
Darius Moradpour Switzerland 61 10.4k 2.0× 7.4k 1.7× 3.0k 0.7× 3.6k 1.3× 2.4k 1.6× 273 15.4k
Thomas F. Baumert France 65 8.4k 1.6× 7.9k 1.8× 1.8k 0.4× 3.2k 1.2× 1.3k 0.9× 273 13.9k
Brett D. Lindenbach United States 40 4.9k 0.9× 4.7k 1.1× 1.3k 0.3× 2.7k 1.0× 2.5k 1.7× 71 10.5k
Stefan Wieland United States 49 7.3k 1.4× 7.8k 1.8× 2.8k 0.7× 2.6k 1.0× 1.4k 0.9× 90 12.0k
Alfredo Nicosia Italy 48 3.2k 0.6× 3.2k 0.7× 1.4k 0.3× 3.0k 1.1× 856 0.6× 141 8.4k
Nobuyuki Kato Japan 55 7.2k 1.3× 6.0k 1.4× 1.5k 0.4× 2.9k 1.1× 1.3k 0.9× 223 11.3k
Michinori Kohara Japan 56 5.2k 1.0× 4.9k 1.1× 1.5k 0.4× 3.9k 1.5× 2.1k 1.4× 263 11.3k
Robert E. Lanford United States 56 5.6k 1.0× 5.3k 1.2× 1.6k 0.4× 4.1k 1.5× 1.6k 1.1× 170 11.8k
François–Loïc Cosset France 73 7.6k 1.4× 7.8k 1.7× 2.2k 0.5× 6.8k 2.5× 2.3k 1.5× 285 18.5k
Kunitada Shimotohno Japan 74 10.4k 2.0× 8.5k 1.9× 4.7k 1.1× 7.8k 2.9× 1.9k 1.3× 355 21.8k

Countries citing papers authored by Arash Grakoui

Since Specialization
Citations

This map shows the geographic impact of Arash Grakoui's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Arash Grakoui with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Arash Grakoui more than expected).

Fields of papers citing papers by Arash Grakoui

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Arash Grakoui. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Arash Grakoui. The network helps show where Arash Grakoui may publish in the future.

Co-authorship network of co-authors of Arash Grakoui

This figure shows the co-authorship network connecting the top 25 collaborators of Arash Grakoui. A scholar is included among the top collaborators of Arash Grakoui based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Arash Grakoui. Arash Grakoui is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Trivedi, Sheetal, Piyush Dravid, Peter D. Burbelo, et al.. (2025). Design and nonviral delivery of live attenuated vaccine to prevent chronic hepatitis C virus-like infection. Nature Communications. 16(1). 7629–7629. 1 indexed citations
2.
Kumari, Anuradha, Sheetal Trivedi, Yongtao Wang, et al.. (2025). iHALT unlocks liver functionality as a surrogate secondary lymphoid organ. Nature. 649(8098). 991–1002.
3.
Kumari, Anuradha, Alireza Saeidi, Elizabeth J. Elrod, et al.. (2024). Hyperfunctional T cell responses unchecked by regulatory T cells are unable to resolve hepaciviral infection without humoral contribution. Journal of Hepatology. 82(4). 604–614. 2 indexed citations
4.
Fay, Meredith E., Ashley Bennett, Kimberly Pachura, et al.. (2024). BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images. American Journal of Physiology-Gastrointestinal and Liver Physiology. 327(1). G1–G15. 2 indexed citations
5.
Vanderheiden, Abigail, Elizabeth J. Elrod, Katharine Floyd, et al.. (2024). CD4 + and CD8 + T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment. Science Advances. 10(34). eadp2636–eadp2636. 9 indexed citations
6.
Chen, Yunfeng, et al.. (2023). Memory in repetitive protein–protein interaction series. APL Bioengineering. 7(1). 1 indexed citations
7.
Zhang, Wanrui, Elizabeth J. Elrod, Nicole F. Bernard, et al.. (2016). Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus–Specific Memory B Cells. The Journal of Immunology. 197(12). 4848–4858. 24 indexed citations
8.
Grakoui, Arash & Ian Nicholas Crispe. (2016). Presentation of hepatocellular antigens. Cellular and Molecular Immunology. 13(3). 293–300. 34 indexed citations
9.
Grakoui, Arash, Shannon K. Bromley, Cenk Sumen, et al.. (2015). Pillars Article: The Immunological Synapse: A Molecular Machine Controlling T Cell Activation. Science. 1999. 285: 221–227. The Journal of Immunology. 194(9). 4066–4072. 7 indexed citations
10.
Sehgal, Mohit, Marija Zeremski, Andrew H. Talal, et al.. (2015). IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment. Journal of Interferon & Cytokine Research. 35(9). 698–709. 13 indexed citations
11.
Fuller, Michael J., Benoît Callendret, Baogong Zhu, et al.. (2013). Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1). Proceedings of the National Academy of Sciences. 110(37). 15001–15006. 140 indexed citations
12.
Yost, Samantha A., et al.. (2012). Structural and functional insights into alphavirus polyprotein processing and pathogenesis. Proceedings of the National Academy of Sciences. 109(41). 16534–16539. 127 indexed citations
13.
Chinnadurai, Raghavan, Victoria M. Velazquez, & Arash Grakoui. (2011). Hepatic Transplant and HCV: A New Playground for an Old Virus. American Journal of Transplantation. 12(2). 298–305. 17 indexed citations
14.
Radziewicz, Henry, Chris Ibegbu, Huiming Hon, et al.. (2010). Transient CD86 Expression on Hepatitis C Virus-Specific CD8+ T Cells in Acute Infection Is Linked to Sufficient IL-2 Signaling. The Journal of Immunology. 184(5). 2410–2422. 16 indexed citations
15.
Berger, Kristi L., Jacob D. Cooper, Nicholas S. Heaton, et al.. (2009). Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. Proceedings of the National Academy of Sciences. 106(18). 7577–7582. 284 indexed citations
16.
McMullan, Laura K., Arash Grakoui, Matthew J. Evans, et al.. (2007). Evidence for a functional RNA element in the hepatitis C virus core gene. Proceedings of the National Academy of Sciences. 104(8). 2879–2884. 95 indexed citations
17.
Radziewicz, Henry, Chris Ibegbu, Marina L. Fernandez, et al.. (2006). Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression. Journal of Virology. 81(6). 2545–2553. 387 indexed citations
18.
Grakoui, Arash, Naglaa H. Shoukry, David J. Woollard, et al.. (2003). HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help. Science. 302(5645). 659–662. 645 indexed citations breakdown →
19.
Kersh, Gilbert J., Michael J. Miley, Christopher A. Nelson, et al.. (2001). Structural and Functional Consequences of Altering a Peptide MHC Anchor Residue. The Journal of Immunology. 166(5). 3345–3354. 93 indexed citations
20.
Koziel, Margaret James, Darryll D. Dudley, Nezam H. Afdhal, et al.. (1995). HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.. Journal of Clinical Investigation. 96(5). 2311–2321. 273 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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