Gertrude B. Elion

17.3k total citations · 17 hit papers
176 papers, 13.0k citations indexed

About

Gertrude B. Elion is a scholar working on Molecular Biology, Epidemiology and Immunology. According to data from OpenAlex, Gertrude B. Elion has authored 176 papers receiving a total of 13.0k indexed citations (citations by other indexed papers that have themselves been cited), including 84 papers in Molecular Biology, 53 papers in Epidemiology and 30 papers in Immunology. Recurrent topics in Gertrude B. Elion's work include Biochemical and Molecular Research (46 papers), Herpesvirus Infections and Treatments (30 papers) and Cytomegalovirus and herpesvirus research (24 papers). Gertrude B. Elion is often cited by papers focused on Biochemical and Molecular Research (46 papers), Herpesvirus Infections and Treatments (30 papers) and Cytomegalovirus and herpesvirus research (24 papers). Gertrude B. Elion collaborates with scholars based in United States, United Kingdom and Norway. Gertrude B. Elion's co-authors include George H. Hitchings, P de Miranda, James A. Fyfe, Lilia M. Beauchamp, Thomas A. Krenitsky, Phillip A. Furman, Howard J. Schaeffer, P A Furman, Paul M. Keller and Samuel Singer and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Gertrude B. Elion

173 papers receiving 11.6k citations

Hit Papers

Selectivity of action of an antiherpetic agent, 9-(2-hydr... 1952 2026 1976 2001 1977 1978 1989 1978 1954 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine
    1977 1.3k citations Gertrude B. Elion et al. profile →
  2. 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group
    1978 935 citations Gertrude B. Elion et al. profile →
  3. The Purine Path to Chemotherapy
    1989 547 citations Gertrude B. Elion profile →
  4. Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
    1978 476 citations Richard L. Miller, Gertrude B. Elion et al. Journal of Biological Chemistry profile →
  5. ANTAGONISTS OF NUCLEIC ACID DERIVATIVES
    1954 364 citations Gertrude B. Elion, George H. Hitchings et al. Journal of Biological Chemistry profile →
  6. On the Mechanism of Inactivation of Xanthine Oxidase by Allopurinol and Other Pyrazolo[3,4-d]pyrimidines
    1970 337 citations Vincent Massey, Gertrude B. Elion et al. Journal of Biological Chemistry profile →
  7. A comparison of the specificities of xanthine oxidase and aldehyde oxidase
    1972 287 citations Thomas A. Krenitsky, Gertrude B. Elion et al. profile →
  8. Metabolic studies of allopurinol, an inhibitor of xanthine oxidase
    1966 281 citations Gertrude B. Elion, George H. Hitchings et al. Biochemical Pharmacology profile →
  9. Mechanism of action and selectivity of acyclovir
    1982 279 citations Gertrude B. Elion The American Journal of Medicine profile →
  10. Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate
    1979 274 citations Janet L. Rideout, Gertrude B. Elion et al. profile →
  11. Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase
    1963 250 citations Gertrude B. Elion, Samuel Bieber et al. Biochemical Pharmacology profile →
  12. Studies on Condensed Pyrimidine Systems. IX. The Synthesis of Some 6-Substituted Purines
    1952 217 citations Gertrude B. Elion, George H. Hitchings et al. Journal of the American Chemical Society profile →
  13. Human Hypoxanthine Phosphoribosyltransferase
    1969 200 citations Thomas A. Krenitsky, Gertrude B. Elion et al. Journal of Biological Chemistry profile →
  14. Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity.
    1976 192 citations Thomas A. Krenitsky, George W. Koszalka et al. Journal of Biological Chemistry profile →
  15. ANTAGONISTS OF NUCLEIC ACID DERIVATIVES
    1952 185 citations George H. Hitchings, Elvira A. Falco et al. Journal of Biological Chemistry profile →
  16. Effect of Acycloguanosine Treatment on Acute and Latent Herpes Simplex Infections in Mice
    1979 153 citations Gertrude B. Elion et al. profile →
  17. 6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals.
    1953 122 citations Gertrude B. Elion, George H. Hitchings et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Gertrude B. Elion United States 55 5.4k 5.0k 2.0k 1.7k 1.5k 176 13.0k
George H. Hitchings United States 42 3.1k 0.6× 1.2k 0.2× 918 0.4× 553 0.3× 748 0.5× 144 6.7k
Kurt J. Isselbacher United States 79 7.9k 1.4× 2.8k 0.6× 558 0.3× 3.4k 1.9× 321 0.2× 324 20.2k
Charles E. Myers United States 72 6.3k 1.2× 957 0.2× 1.2k 0.6× 4.8k 2.8× 678 0.4× 196 16.4k
Thomas A. Krenitsky United States 40 3.3k 0.6× 1.5k 0.3× 1.3k 0.6× 622 0.4× 466 0.3× 96 5.0k
Ting‐Chao Chou United States 60 14.1k 2.6× 2.4k 0.5× 2.9k 1.4× 8.1k 4.6× 839 0.5× 350 29.3k
Joseph R. Bertino United States 75 10.2k 1.9× 1.3k 0.3× 1.0k 0.5× 8.6k 4.9× 2.9k 1.9× 471 23.2k
Hiroshi Maeda Japan 58 4.1k 0.8× 1.1k 0.2× 540 0.3× 1.1k 0.6× 358 0.2× 229 11.1k
Anthony W. Segal United Kingdom 73 7.1k 1.3× 2.2k 0.4× 1.3k 0.6× 920 0.5× 593 0.4× 292 19.9k
Hiroaki Mitsuya United States 74 7.8k 1.4× 4.8k 1.0× 14.1k 6.9× 2.1k 1.2× 525 0.3× 522 25.5k
Gabriel Lopez‐Berestein United States 78 13.2k 2.4× 1.9k 0.4× 1.3k 0.7× 3.8k 2.2× 550 0.4× 349 21.1k

Countries citing papers authored by Gertrude B. Elion

Since Specialization
Citations

This map shows the geographic impact of Gertrude B. Elion's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gertrude B. Elion with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gertrude B. Elion more than expected).

Fields of papers citing papers by Gertrude B. Elion

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gertrude B. Elion. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gertrude B. Elion. The network helps show where Gertrude B. Elion may publish in the future.

Co-authorship network of co-authors of Gertrude B. Elion

This figure shows the co-authorship network connecting the top 25 collaborators of Gertrude B. Elion. A scholar is included among the top collaborators of Gertrude B. Elion based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Gertrude B. Elion. Gertrude B. Elion is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Kurtzberg, Joanne, T J Ernst, Michael J. Keating, et al.. (2005). Phase I Study of 506U78 Administered on a Consecutive 5-Day Schedule in Children and Adults With Refractory Hematologic Malignancies. Journal of Clinical Oncology. 23(15). 3396–3403. 129 indexed citations
2.
Friedman, Henry S., Robert C. Castellino, Gertrude B. Elion, et al.. (2000). Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts. Cancer Chemotherapy and Pharmacology. 45(4). 345–349. 30 indexed citations
3.
Rich, Jeremy N., Gertrude B. Elion, Daniel Wellner, et al.. (1995). The effect ofl-amino acid oxidase on activity of melphalan against an intracranial xenograft. Cancer Chemotherapy and Pharmacology. 36(5). 379–384. 3 indexed citations
4.
Harkness, R. A., Gertrude B. Elion, & Nepomuk Zöllner. (1991). Chemotherapy, ATP depletion, and gout. Plenum Press eBooks. 1 indexed citations
5.
Elion, Gertrude B., et al.. (1991). Positive therapeutic interaction between thiopurines and alkylating drugs in human glioma xenografts. Cancer Chemotherapy and Pharmacology. 27(4). 278–284. 6 indexed citations
6.
Elion, Gertrude B.. (1989). The purine path to chemotherapy. In Vitro Cellular & Developmental Biology - Plant. 25(4). 321–330. 35 indexed citations
7.
Skapek, Stephen X., O. Michael Colvin, Owen W. Griffith, et al.. (1988). Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts. Biochemical Pharmacology. 37(22). 4313–4317. 18 indexed citations
8.
Rideout, Janet L., Thomas A. Krenitsky, Esther Y. Chao, et al.. (1983). Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 3. Synthesis and activity of some nucleosides of 4-[(arylalkenyl)thio]pyrazolo[3,4-d]pyrimidines. Journal of Medicinal Chemistry. 26(10). 1489–1494. 9 indexed citations
9.
Biron, Karen K. & Gertrude B. Elion. (1982). Effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro. The American Journal of Medicine. 73(1). 54–57. 19 indexed citations
10.
Nelson, Donald J., Christopher J.L. Buggé, Gertrude B. Elion, Randolph L. Berens, & J. Joseph Marr. (1979). Metabolism of pyrazolo(3,4-d)pyrimidines in Leishmania braziliensis and Leishmania donovani. Allopurinol, oxipurinol, and 4-aminopyrazolo(3,4-d)pyrimidine.. Journal of Biological Chemistry. 254(10). 3959–3964. 71 indexed citations
11.
Miller, Richard L., Wayne H. Miller, George W. Koszalka, et al.. (1979). Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity. Journal of Biological Chemistry. 254(7). 2346–2352. 157 indexed citations
12.
Zimmerman, Thomas P., L.‐C. Chu, Christopher J.L. Buggé, et al.. (1974). Formation of 5′-nucleotides of 6-methylmercaptopurine ribonucleoside in human tissues in vitro. Biochemical Pharmacology. 23(19). 2737–2749. 21 indexed citations
13.
Massey, Vincent, Dale E. Edmondson, G Palmer, L M Beacham, & Gertrude B. Elion. (1972). The separation of functional and non-functional xanthine oxidase by affinity chromatography. Biochemical Journal. 127(2). 10P–11P. 2 indexed citations
14.
Miller, Richard L., et al.. (1972). Guanine phosphoribosyltransferase from Escherichia coli. Specificity and properties. Biochemistry. 11(25). 4723–4731. 55 indexed citations
15.
Elion, Gertrude B.. (1972). Mechanisms of Action of Drugs Affecting Immune Responses. Proceedings of the Royal Society of Medicine. 65(3). 257–260. 45 indexed citations
16.
Elion, Gertrude B., et al.. (1964). Deamination Studies on Pyrimidine and Condensed Pyrimidine Systems1,2. The Journal of Organic Chemistry. 29(9). 2674–2677. 22 indexed citations
17.
Bieber, Samuel, L.S. Dietrich, Gertrude B. Elion, George H. Hitchings, & Daniel Martín. (1961). The Incorporation of 6-Mercaptopurine-S35 into the Nucleic Acids of Sensitive and Nonsensitive Transplantable Mouse Tumors. Cancer Research. 21(2). 228–231. 28 indexed citations
18.
Elion, Gertrude B., et al.. (1956). Studies on Condensed Pyrimidine Systems. XIII. Some Amino-substituted Derivatives of Guanine and 6-Thioguanine. Journal of the American Chemical Society. 78(1). 217–220. 41 indexed citations
19.
Hitchings, George H., Elvira A. Falco, Henry Vanderwerff, Peter B. Russell, & Gertrude B. Elion. (1952). ANTAGONISTS OF NUCLEIC ACID DERIVATIVES. Journal of Biological Chemistry. 199(1). 43–56. 185 indexed citations breakdown →
20.
Elion, Gertrude B. & George H. Hitchings. (1951). ANTAGONISTS OF NUCLEIC ACID DERIVATIVES. Journal of Biological Chemistry. 188(2). 611–621. 13 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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