Ann E. Eakin

3.0k citations

50 papers · 2.2k indexed · h-index 25

Impact in

Molecular Medicine top 1%
- Antibiotic Resistance in Bacteria
Applied Microbiology and Biotechnology top 2%

Papers in

Molecular Medicine 8
- Antibiotic Resistance in Bacteria 8
Infectious Diseases 27
- HIV/AIDS drug development and treatment 21

Co-authors: Sydney P. Craig Charles S. Craik James H. McKerrow Pamela J. Focia Juan C. Engel Alea A. Mills G Harth Robert J. Fletterick
Journals: Antimicrobial Agents and Chemotherapy (7 papers)Biochemistry (5 papers)Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (3 papers)Journal of Biological Chemistry (3 papers)Journal of Medicinal Chemistry (2 papers)
Partner nations: United States Puerto Rico United Kingdom

In The Last Decade

Ann E. Eakin

50 papers receiving 2.2k citations

Peers

Countries citing papers authored by Ann E. Eakin

Since Specialization

Citations

This map shows the geographic impact of Ann E. Eakin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ann E. Eakin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ann E. Eakin more than expected).

Fields of papers citing papers by Ann E. Eakin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ann E. Eakin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ann E. Eakin. The network helps show where Ann E. Eakin may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Ann E. Eakin, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ann E. Eakin Line = papers co-authored together Ann E. Eakin links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans Antimicrobial Agents and Chemotherapy ·Jürgen B. Bulitta, William Hope, Ann E. Eakin, Tína Guina, Vincent H. Tam, Arnold Louie, George L. Drusano, Jennifer L. Hoover	2019	139
2	In Vivo Activity of Amodiaquine against Ebola Virus Infection Scientific Reports ·Lisa Evans DeWald, Joshua C. Johnson, Rodriguez Jh, Gholam-Resa Kuros, Elena Postnikova, Anna N. Honko, Krisztina Janosko, Louis Huzella, William E. Dowling, Ann E. Eakin, Blaire L. Osborn, Janet Gahagen, Liang Tang, Carol E. Green, Jon C. Mirsalis, Michael R. Holbrook, Peter B. Jahrling, Julie Dyall, Lisa E. Hensley	2019	13
3	Novel DNA gyrase inhibitors: Microbiological characterisation of pyrrolamides International Journal of Antimicrobial Agents ·Maria Uria-Nickelsen, Zhanxiang Chen, Heather D. Kamp, Ann E. Eakin, Brian Sherer, Esthefany Yuletsy Niño Riaño	2012	15
4	Novel Bacterial NAD ⁺ -Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo Antimicrobial Agents and Chemotherapy ·Scott D. Mills, Ann E. Eakin, Ed T. Buurman, Joseph Newman, Ning Gao, Hoan K. Huynh, Kenneth D. Johnson, Sushmita D. Lahiri, Adam B. Shapiro, Grant K. Walkup, Wei Yang, S. Stokes	2010	63
5	Saturation mutagenesis, complement selection, and steady-state kinetic studies illuminate the roles of invariant residues in active site loop I of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ·Frances Yayra Sefenu, Francisco J. Medrano, Ann E. Eakin, Sydney P. Craig	2004	6
6	Interactions at the Dimer Interface Influence the Relative Efficiencies for Purine Nucleotide Synthesis and Pyrophosphorolysis in a Phosphoribosyltransferase Journal of Molecular Biology ·Elina Paul, Francisco J. Medrano, Liu Li-Ling, Pamela J. Focia, Ann E. Eakin, Sydney P. Craig	2003	28
7	Functional roles for amino acids in active site loop II of a hypoxanthine phosphoribosyltransferase Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ·Francisco J. Medrano, Liu Li-Ling, Ann E. Eakin, Sydney P. Craig	2003	11
8	Implications of selective type II IMP dehydrogenase (IMPDH) inhibition by the 6-ethoxycarbonyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones on tumor cell death22Abbreviations: IMPDH, IMP dehydrogenase; MPA, mycophenolic acid; 6-MP, 6-mercaptopurine; and VP-16, etoposide. Biochemical Pharmacology ·Betsy Barnes, Ann E. Eakin, Robert A. Izydore, V.P. Zhdanov	2001	8
9	Induction of Tmolt4 Leukemia Cell Death by 3,3-Disubstituted-6,6-pentamethylene-1,5-diazabicyclo[3.1.0]hexane-2,4-diones: Specificity for Type II Inosine 5′-Monophosphate Dehydrogenase Journal of Pharmacology and Experimental Therapeutics ·Betsy Barnes, Robert A. Izydore, Ann E. Eakin, Iris H. Hall	2001	1
10	Structure-based inhibitor design Vitamins and hormones ·Sydney P. Craig, Ann E. Eakin	2000	9
11	Purine Phosphoribosyltransferases Journal of Biological Chemistry ·Sydney P. Craig, Ann E. Eakin	2000	83
12	Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi Chemistry & Biology ·Douglas Freymann, Liu Li-Ling, Juan C. Engel, Jun Feng, Pamela J. Focia, Ann E. Eakin, Sydney P. Craig	2000	52
13	Determinants of Phencyclidine Potency on the Nicotinic Acetylcholine Receptors from Muscle and Electric Organ Cellular and Molecular Neurobiology ·Vesna A. Eterović, Ruiliang Lu, Ann E. Eakin, Abimael D. Rodrı́guez, P.A. Ferchmin	1999	11
14	Ternary complex structure of human hgprtase, prpp, mg²⁺, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding Protein Science ·Ganesaratnam K. Balendiran, طيبة عبدالمحسن العصفور, Yiming Xu, Ellie Mainou, Kim Thu Vu, Pamela J. Focia, Ann E. Eakin, James C. Sacchettini, Sydney P. Craig	1999	61
15	Limited proteolysis of a trypanosomal hypoxanthine phosphoribosyltransferase yields crystals that diffract X-rays to near atomic resolution Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ·René Nieves-Alicea, Pamela J. Focia, Sydney P. Craig, Ann E. Eakin	1998	7
16	Bacterial complementation as a means to test enzyme-ligand interactions Applied Microbiology and Biotechnology ·Elina Paul, Sydney P. Craig, Ann E. Eakin	1998	8
17	Purine salvage enzymes of parasites as targets for structure-based inhibitor design Parasitology Today ·Sydney P. Craig, Ann E. Eakin	1997	33
18	The Crystal Structure of Cruzain: A Therapeutic Target for Chagas' Disease Journal of Molecular Biology ·Mary E. McGrath, Ann E. Eakin, Juan C. Engel, James H. McKerrow, Charles S. Craik, Robert J. Fletterick	1995	212
19	Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene. Journal of Clinical Investigation ·Sharon L. Reed, Jacques Bouvier, Emanuela Pervito, Juan C. Engel, M A Brown, Ken Hirata, Xuchu Que, Ann E. Eakin, Per Hagblom, Frances D. Gillin	1993	72
20	Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites Molecular and Biochemical Parasitology ·Ann E. Eakin, Jacques Bouvier, Judy A. Sakanari, Charles S. Craik, J.H. McKerrow	1990	77

About Ann E. Eakin

Ann E. Eakin is a scholar working on Molecular Medicine, Infectious Diseases, Epidemiology, Applied Microbiology and Biotechnology and Molecular Biology, having authored 50 papers that have together received 2.2k indexed citations. Recurring topics across this work include Biochemical and Molecular Research (29 papers), HIV/AIDS drug development and treatment (21 papers), Trypanosoma species research and implications (19 papers), Antibiotic Resistance in Bacteria (8 papers), Cancer therapeutics and mechanisms (6 papers), Antibiotics Pharmacokinetics and Efficacy (5 papers), Cytomegalovirus and herpesvirus research (5 papers) and Pneumonia and Respiratory Infections (4 papers). The work is most often cited by research in Molecular Medicine (375 citations), Applied Microbiology and Biotechnology (69 citations), Infectious Diseases (550 citations), Parasitology (192 citations) and Toxicology (99 citations). Ann E. Eakin has collaborated with scholars based in United States, Puerto Rico and United Kingdom. Frequent co-authors include Sydney P. Craig, Charles S. Craik, James H. McKerrow, Pamela J. Focia, Juan C. Engel, Alea A. Mills, G Harth, Robert J. Fletterick, J.H. McKerrow and Judy A. Sakanari. Their work appears in journals such as Antimicrobial Agents and Chemotherapy, Biochemistry, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Journal of Biological Chemistry and Journal of Medicinal Chemistry.

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