Alfred P. Spada

2.5k citations

44 papers · 1.8k indexed · h-index 22

Co-authors: Asher Zilberstein Martin P. Maguire Henry W. Pauls William R. Ewing Michael R. Myers J.P. Guilloteau Michael R. Becker Alexander Levitzki
Topics: Blood Coagulation and Thrombosis Mechanisms (13 papers)Atrial Fibrillation Management and Outcomes (5 papers)Liver Disease Diagnosis and Treatment (5 papers)
Cited by: Organic Chemistry Hepatology Hematology
Journals: Journal of Biological Chemistry Circulation Hepatology
Partner nations: United States Switzerland United Kingdom

In The Last Decade

Alfred P. Spada

44 papers receiving 1.7k citations

Peers

Countries citing papers authored by Alfred P. Spada

Since Specialization

Citations

This map shows the geographic impact of Alfred P. Spada's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred P. Spada with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred P. Spada more than expected).

Fields of papers citing papers by Alfred P. Spada

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred P. Spada. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred P. Spada. The network helps show where Alfred P. Spada may publish in the future.

Co-authorship network of co-authors of Alfred P. Spada

This figure shows the co-authorship network connecting the top 25 collaborators of Alfred P. Spada. A scholar is included among the top collaborators of Alfred P. Spada based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alfred P. Spada. Alfred P. Spada is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo 2018 ·Clinical Gastroenterology and Hepatology ·Catherine Frenette,Giuseppe Morelli,Mitchell L. Shiffman,R. Todd Frederick,Raymond A. Rubin,Michael B. Fallon,(unknown),Matt Cave,Saira Khaderi,Omar Massoud,Nikolaos Pyrsopoulos,James Park,James M. Robinson,Mason Yamashita,Alfred P. Spada,Jean L. Chan,David Hagerty	75
2	A Placebo-Controlled, Multicenter, Double-Blind, Phase 2 Randomized Trial of the Pan-Caspase Inhibitor Emricasan in Patients with Acutely Decompensated Cirrhosis 2017 ·Journal of Clinical and Experimental Hepatology ·Gautam Mehta,(unknown),Gary Burgess,Mark Morris,Gavin Wright,Stuart McPherson,Catherine Frenette,Matthew C. Cave,David Hagerty,Alfred P. Spada,Rajiv Jalan	27
3	Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo 2017 ·Toxicological Sciences ·Anna K. Kopec,Alfred P. Spada,Patricia C. Contreras,Nigel Mackman,James P. Luyendyk	7
4	Carcinogenicity assessment of the pan-caspase inhibitor, emricasan, in Tg.rasH2 mice 2015 ·Regulatory Toxicology and Pharmacology ·Reem H. Elbekai,(unknown),P. Contreras,Alfred P. Spada	8
5	Stent-induced Restenosis in the Swine Coronary Artery Is Inhibited by a Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor, TKI963 2003 ·Journal of Cardiovascular Pharmacology ·Glenda E. Bilder,Dilip Amin,Lisa Morgan,Matthew J. McVey,Saul Needle,Helen Galczenski,Robert J. Leadley,Wei He,Michael R. Myers,Alfred P. Spada,(unknown),(unknown),Mark H. Perrone	8
6	Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor 2003 ·Bioorganic & Medicinal Chemistry Letters ·He Wang,(unknown),Barbara Hanney,Alfred P. Spada,Glenda E. Bilder,(unknown),Dilip Amin,Saul Needle,Ken Page,Zaid Jayyosi,(unknown)	136
7	Optimization of the β-Aminoester class of factor Xa inhibitors. part 1: P4 and side-Chain modifications for improved In vitro potency 2002 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Scott I. Klein,Kevin R. Guertin,(unknown),Allison L. Zulli,Henry W. Pauls,Alfred P. Spada,Daniel L. Cheney,Karen Brown,Dennis Colussi,Valeria Chu,Robert J. Leadley,Christopher T. Dunwiddie	14
8	Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity 2002 ·Bioorganic & Medicinal Chemistry Letters ·Kevin R. Guertin,(unknown),Scott I. Klein,Allison L. Zulli,(unknown),Yong Gong,Alfred P. Spada,Daniel L. Cheney,(unknown),J.P. Guilloteau,Karen Brown,Dennis Colussi,Valeria Chu,Christopher L. Heran,(unknown),Ross Bentley,Christopher T. Dunwiddie,Robert J. Leadley,Henry W. Pauls	45
9	Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors 2002 ·Bioorganic & Medicinal Chemistry Letters ·Wei He,Barbara Hanney,Michael R. Myers,Stephen M. Condon,Michael R. Becker,Alfred P. Spada,Christopher J. Burns,Karen Brown,Dennis Colussi,Valeria Chu	6
10	Amido-(propyl and allyl)-hydroxybenzamidines: development of achiral inhibitors of factor Xa 2000 ·Bioorganic & Medicinal Chemistry Letters ·Yong Gong,Henry W. Pauls,Alfred P. Spada,(unknown),Guyan Liang,Valeria Chu,Dennis Colussi,Karen Brown,Jingbo Gao	9
11	Nonbenzamidine compounds as selective factor xa inhibitors 2000 ·Bioorganic & Medicinal Chemistry Letters ·Wei He,Barbara Hanney,Michael R. Myers,Alfred P. Spada,Karen Brown,Dennis Colussi,Valeria Chu	10
12	In Vitro Characterization of a Novel Factor Xa Inhibitor, RPR 130737 2000 ·Thrombosis Research ·Valeria Chu,Karen Brown,Dennis Colussi,(unknown),Dan Green,Henry W. Pauls,Alfred P. Spada,Mark H. Perrone,Robert J. Leadley,Christopher T. Dunwiddie	16
13	Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors 1999 ·Bioorganic & Medicinal Chemistry Letters ·Michael R. Becker,William R. Ewing,(unknown),Henry W. Pauls,Cuong Q. Ly,(unknown),Helen J. Mason,Yong Mi Choi-Sledeski,Alfred P. Spada,Valeria Chu,Karen Brown,Dennis Colussi,Robert J. Leadley,Ross Bentley,(unknown),Charles Kasiewski,(unknown)	19
14	Pharmacodynamic Activity and Antithrombotic Efficacy of RPR120844, a Novel Inhibitor of Coagulation Factor Xa 1999 ·Journal of Cardiovascular Pharmacology ·Robert J. Leadley,(unknown),Ross Bentley,Jeffrey S. Bostwick,Charles Kasiewski,Christopher L. Heran,Valeria Chu,Karen Brown,(unknown),William R. Ewing,Henry W. Pauls,Alfred P. Spada,Mark H. Perrone,Christopher T. Dunwiddie	15
15	A New Series of PDGF Receptor Tyrosine Kinase Inhibitors: 3-Substituted Quinoline Derivatives 1994 ·Journal of Medicinal Chemistry ·Martin P. Maguire,(unknown),(unknown),Alfred P. Spada,Asher Zilberstein	396
16	Singlet oxygen in synthesis. Oxazoles as carbonyl 1,1-dipole synthons. 1992 ·Tetrahedron Letters ·Harry H. Wasserman,Robert Desimone,Wen‐Bin Ho,Keith E. McCarthy,(unknown),Alfred P. Spada	10
17	Inhibition kinetics and selectivity of the tyrosine kinase inhibitor erbstatin and a pyridone-based analogue 1992 ·Biochemical Pharmacology ·(unknown),(unknown),Martin P. Maguire,Alfred P. Spada,Asher Zilberstein	10
18	Teatro, Mauá, SP. 1991 ·PubMed ·Toshiyuki Yoneda,R. Lyall,(unknown),(unknown),Alfred P. Spada,Alexander Levitzki,Asher Zilberstein,Gregory R. Mundy	97
19	Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by Lavendustin-A and its analogue. 1991 ·Journal of Biological Chemistry ·Chia‐Yi Hsu,(unknown),Alfred P. Spada,Rodney A. Bednar,Alexander Levitzki,Asher Zilberstein	71
20	Photo-ring contraction reactions of 4-hydroxypyrylium cations 1979 ·Tetrahedron Letters ·James W. Pavlik,Alfred P. Spada	3

About Alfred P. Spada

Alfred P. Spada is a scholar working on Hematology, Hepatology and Internal Medicine, having authored 44 papers that have together received 1.8k indexed citations. Recurring topics across this work include Blood Coagulation and Thrombosis Mechanisms (13 papers), Atrial Fibrillation Management and Outcomes (5 papers) and Liver Disease Diagnosis and Treatment (5 papers). The work is most often cited by research in Organic Chemistry (789 citations), Hepatology (195 citations) and Hematology (229 citations). Alfred P. Spada has collaborated with scholars based in United States, Switzerland and United Kingdom. Frequent co-authors include Asher Zilberstein, Martin P. Maguire, Henry W. Pauls, William R. Ewing, Michael R. Myers, J.P. Guilloteau, Michael R. Becker, Alexander Levitzki, Yong Mi Choi-Sledeski and S. Maignan. Their work appears in journals such as Journal of Biological Chemistry, Circulation and Hepatology.

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