Alfred E. Chang

27.4k total citations · 6 hit papers
295 papers, 20.9k citations indexed

About

Alfred E. Chang is a scholar working on Oncology, Immunology and Surgery. According to data from OpenAlex, Alfred E. Chang has authored 295 papers receiving a total of 20.9k indexed citations (citations by other indexed papers that have themselves been cited), including 184 papers in Oncology, 160 papers in Immunology and 37 papers in Surgery. Recurrent topics in Alfred E. Chang's work include Immunotherapy and Immune Responses (140 papers), CAR-T cell therapy research (81 papers) and Immune Cell Function and Interaction (64 papers). Alfred E. Chang is often cited by papers focused on Immunotherapy and Immune Responses (140 papers), CAR-T cell therapy research (81 papers) and Immune Cell Function and Interaction (64 papers). Alfred E. Chang collaborates with scholars based in United States, China and Japan. Alfred E. Chang's co-authors include Steven A. Rosenberg, Claudia A. Seipp, Colleen Simpson, Michael T. Lotze, Susan F. Leitman, Linda Muul, Michael S. Sabel, Seth M. Steinberg, Donald E. White and John T. Vetto and has published in prestigious journals such as New England Journal of Medicine, Proceedings of the National Academy of Sciences and Journal of Clinical Investigation.

In The Last Decade

Alfred E. Chang

290 papers receiving 20.2k citations

Hit Papers

A Progress Report on the Treatment of 157 Patients with A... 1985 2026 1998 2012 1987 1985 1998 1993 2009 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone
    1987 2.2k citations Alfred E. Chang et al. profile →
  2. Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer
    1985 2.0k citations Alfred E. Chang et al. profile →
  3. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity.
    1998 1.1k citations Alfred E. Chang et al. profile →
  4. Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.
    1993 692 citations Alfred E. Chang et al. profile →
  5. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
    2009 623 citations Ilona Kryczek, Linhua Vatan et al. profile →
  6. A Prospective Randomized Trial of Regional Versus Systemic Continuous 5-Fluorodeoxyuridine Chemotherapy in the Treatment of Colorectal Liver Metastases
    1987 440 citations Alfred E. Chang et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Alfred E. Chang United States 67 11.3k 9.7k 4.2k 3.4k 2.5k 295 20.9k
Lothar Kanz Germany 83 6.6k 0.6× 6.3k 0.7× 5.8k 1.4× 2.8k 0.8× 3.4k 1.4× 579 22.1k
Arnon Nagler Israel 88 12.5k 1.1× 12.6k 1.3× 7.8k 1.8× 2.0k 0.6× 2.4k 0.9× 1.1k 39.3k
John B.A.G. Haanen Netherlands 72 13.9k 1.2× 10.8k 1.1× 6.8k 1.6× 4.6k 1.4× 1.3k 0.5× 429 23.8k
Ignacio Melero Spain 88 15.8k 1.4× 16.8k 1.7× 6.6k 1.6× 3.0k 0.9× 1.1k 0.4× 396 28.2k
Jack W. Singer United States 85 7.3k 0.6× 5.4k 0.6× 5.4k 1.3× 2.0k 0.6× 1.3k 0.5× 472 26.0k
James L. Gulley United States 71 11.7k 1.0× 8.3k 0.9× 4.2k 1.0× 5.7k 1.7× 1.9k 0.8× 568 18.4k
Anne Berger France 37 11.3k 1.0× 7.5k 0.8× 3.5k 0.8× 3.5k 1.0× 3.2k 1.3× 148 17.7k
Matthew F. Krummel United States 65 11.2k 1.0× 17.8k 1.8× 6.4k 1.5× 2.9k 0.9× 2.1k 0.8× 162 27.4k
Gerhard Ehninger Germany 78 6.5k 0.6× 4.3k 0.4× 6.1k 1.5× 1.8k 0.5× 2.1k 0.8× 678 25.0k
Glenn Heller United States 82 7.0k 0.6× 4.0k 0.4× 4.6k 1.1× 6.6k 1.9× 1.6k 0.6× 301 20.5k

Countries citing papers authored by Alfred E. Chang

Since Specialization
Citations

This map shows the geographic impact of Alfred E. Chang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred E. Chang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred E. Chang more than expected).

Fields of papers citing papers by Alfred E. Chang

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred E. Chang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred E. Chang. The network helps show where Alfred E. Chang may publish in the future.

Co-authorship network of co-authors of Alfred E. Chang

This figure shows the co-authorship network connecting the top 25 collaborators of Alfred E. Chang. A scholar is included among the top collaborators of Alfred E. Chang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alfred E. Chang. Alfred E. Chang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Fang, Zheng, Shan Zhang, Alfred E. Chang, et al.. (2025). Breaking Immunosuppression to Enhance Cancer Stem Cell-Targeted Immunotherapy. International Journal of Biological Sciences. 21(4). 1819–1836. 2 indexed citations
2.
Qin, You, et al.. (2022). Emerging concepts regarding pro- and anti tumor properties of B cells in tumor immunity. Frontiers in Immunology. 13. 881427–881427. 20 indexed citations
3.
Sinco, Brandy, Alfred E. Chang, Michael S. Sabel, et al.. (2022). Prophylactic mastectomy and occult malignancy: Surgical and imaging considerations. Journal of Surgical Oncology. 127(1). 18–27. 5 indexed citations
4.
Xia, Leiming, Lu Wen, You Qin, et al.. (2021). HER2-targeted antibody-drug conjugate induces host immunity against cancer stem cells. Cell chemical biology. 28(5). 610–624.e5. 10 indexed citations
5.
Oba, Takaaki, Kenichi Makino, Ryutaro Kajihara, et al.. (2021). In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models. Journal for ImmunoTherapy of Cancer. 9(5). e002432–e002432. 30 indexed citations
6.
Yamauchi, Takayoshi, Toshifumi Hoki, Takaaki Oba, et al.. (2020). CX3CR1–CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment. JCI Insight. 5(8). 55 indexed citations
7.
Ruan, Shasha, Ming Lin, Lawrence G. Lum, et al.. (2019). Integrin β4–Targeted Cancer Immunotherapies Inhibit Tumor Growth and Decrease Metastasis. Cancer Research. 80(4). 771–783. 60 indexed citations
8.
Saito, Hidehito, Keisuke Okita, Alfred E. Chang, & Fumito Ito. (2016). Adoptive Transfer of CD8 + T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory. Cancer Research. 76(12). 3473–3483. 28 indexed citations
9.
Jin, Meiyan, Luke F. Peterson, Denzil Bernard, et al.. (2016). Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma. Clinical Cancer Research. 22(21). 5383–5393. 35 indexed citations
10.
Lü, Lin, Ke Pan, Haixia Zheng, et al.. (2013). IL-17A Promotes Immune Cell Recruitment in Human Esophageal Cancers and the Infiltrating Dendritic Cells Represent a Positive Prognostic Marker for Patient Survival. Journal of Immunotherapy. 36(8). 451–458. 77 indexed citations
11.
Ning, Ning, Qin Pan, Fang Zheng, et al.. (2012). Cancer Stem Cell Vaccination Confers Significant Antitumor Immunity. Cancer Research. 72(7). 1853–1864. 177 indexed citations
12.
Xia, Jian‐Chuan, Ke Pan, Wei Wang, et al.. (2011). Intratumoral Expression of IL-17 and Its Prognostic Role in Gastric Adenocarcinoma Patients. International Journal of Biological Sciences. 7(1). 53–60. 90 indexed citations
13.
Kryczek, Ilona, Rebecca Liu, Guobin Wang, et al.. (2009). FOXP3 Defines Regulatory T Cells in Human Tumor and Autoimmune Disease. Cancer Research. 69(9). 3995–4000. 151 indexed citations
14.
Li, Shaozhi, et al.. (2008). Genetically engineered T cells expressing a HER2-specific chimeric receptor mediate antigen-specific tumor regression. Cancer Gene Therapy. 15(6). 382–392. 23 indexed citations
15.
Li, Qiao, Mu Li, & Alfred E. Chang. (2008). Ligation of CD24 on T cells and B cells modulates the cytokine production profile of activated tumor-draining lymph node cells. Cancer Research. 68. 4627–4627. 1 indexed citations
16.
Arora, Alisha, Lori Lowe, Lyndon Su, et al.. (2005). Wide excision without radiation for desmoplastic melanoma. Cancer. 104(7). 1462–1467. 36 indexed citations
17.
Coughlin, Christina, Kevin E. Salhany, Maria Wysocka, et al.. (1998). Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.. Journal of Clinical Investigation. 101(6). 1441–1452. 356 indexed citations
18.
Geiger, James D., Paul D. Wagner, Mark J. Cameron, Suyu Shu, & Alfred E. Chang. (1993). Generation of T-Cells Reactive to the Poorly Immunogenic B16-BL6 Melanoma with Efficacy in the Treatment of Spontaneous Metastases. Journal of Immunotherapy. 13(3). 153–165. 44 indexed citations
19.
Strome, Scott E., John C. Krauss, Alfred E. Chang, & Suyu Shu. (1993). Strategies of Lymphocyte Activation for the Adoptive Immunotherapy of Metastatic Cancer: A Review. Journal of Hematotherapy. 2(1). 63–73. 4 indexed citations
20.
Chang, Alfred E., Nathaniel A. Young, Robert L. Reddick, et al.. (1978). Small bowel obstruction as a complication of disseminated varicella-zoster infection.. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich). 83(4). 371–4. 24 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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