Adriaan P. IJzerman

28.1k citations

470 papers · 21.3k indexed · 5 hit papers · h-index 66

Physiology top 0.01%
- Adenosine and Purinergic Signaling 228
Cellular and Molecular Neuroscience top 0.1%
- Neuropeptides and Animal Physiology 96
- Neuroscience and Neuropharmacology Research 32
Molecular Biology top 0.1%
- Receptor Mechanisms and Signaling 247
- Pharmacological Receptor Mechanisms and Effects 96
- Chemical Synthesis and Analysis 30
Computational Theory and Mathematics top 0.1%
- Computational Drug Discovery Methods 41
Endocrine and Autonomic Systems top 0.5%
Organic Chemistry
- Synthesis and Biological Evaluation 68

Co-authors: Kenneth A. Jacobson Joel Linden Bertil B. Fredholm Laura H. Heitman Karl‐Norbert Klotz Raymond C. Stevens Gerard J. P. van Westen Christa E. Müller
Cited by: Physiology Cellular and Molecular Neuroscience Molecular Biology
Journals: Nature (1 paper)Science (2 papers)Chemical Reviews (2 papers)
Partner nations: Netherlands United States United Kingdom

In The Last Decade

Adriaan P. IJzerman

466 papers receiving 20.7k citations

Hit Papers

5 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2016 Biochemical and Biophysical Research Communications
2012 Science
2011 Pharmacological Reviews
2008 Science
2001 Pharmacological Reviews

Peers

Countries citing papers authored by Adriaan P. IJzerman

Since Specialization

Citations

This map shows the geographic impact of Adriaan P. IJzerman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Adriaan P. IJzerman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Adriaan P. IJzerman more than expected).

Fields of papers citing papers by Adriaan P. IJzerman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Adriaan P. IJzerman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Adriaan P. IJzerman. The network helps show where Adriaan P. IJzerman may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Adriaan P. IJzerman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Adriaan P. IJzerman Line = papers co-authored together Adriaan P. IJzerman links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Computational Characterization of Membrane Proteins as Anticancer Targets: Current Challenges and Opportunities International Journal of Molecular Sciences ·Marina Gorostiola González,P. Rakers,Willem Jespers,Adriaan P. IJzerman,Laura H. Heitman,Gerard J. P. van Westen	2024	1
2	N-Acyl-N-Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A_2B Receptor as Case Study ACS Chemical Biology ·Bert L. H. Beerkens,Vasiliki Andrianopoulou,Xuesong Wang,Rongfang Liu,Gerard J. P. van Westen,Willem Jespers,Adriaan P. IJzerman,Laura H. Heitman,Daan van der Es	2024	3
3	Label-free detection of prostaglandin transporter (SLCO2A1) function and inhibition: insights by wound healing and TRACT assays Frontiers in Pharmacology ·Tamara A. M. Mocking,Wieke M. van Oostveen,Jacobus P. D. van Veldhoven,Hugo Minnee,Cynthia M. Fehres,Charles E. Whitehurst,Adriaan P. IJzerman,Laura H. Heitman	2024	1
4	Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors Purinergic Signalling ·Anna Vlachodimou,Jara Bouma,Michel De Cleyn,Didier Berthelot,Stefan Pype,Jean-Paul Bosmans,Herman van Vlijmen,Berthold Wroblowski,Laura H. Heitman,Adriaan P. IJzerman	2023	3
5	DrugEx v3: scaffold-constrained drug design with graph transformer-based reinforcement learning Journal of Cheminformatics ·Xuhan Liu,Kai Ye,Herman van Vlijmen,Adriaan P. IJzerman,Gerard J. P. van Westen	2023	45
6	Advances and Challenges in Computational Target Prediction Journal of Chemical Information and Modeling ·Dominique Sydow,Lindsey Burggraaff,Angelika Szengel,Herman van Vlijmen,Adriaan P. IJzerman,Gerard J. P. van Westen,Andrea Volkamer	2019	77
7	A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor Purinergic Signalling ·Mónica Bouzo-Lorenzo,Leigh A. Stoddart,Lizi Xia,Adriaan P. IJzerman,Laura H. Heitman,Stephen J. Briddon,Stephen J. Hill	2019	33
8	Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization Journal of Medicinal Chemistry ·Maarten L. J. Doornbos,Xuesong Wang,Sophie C. Vermond,Luc Peeters,Laura Pérez‐Benito,Andrés A. Trabanco,Hilde Lavreysen,José M. Cid,Laura H. Heitman,Gary Tresadern,Adriaan P. IJzerman	2018	21
9	Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB₂ Receptor Expression and Ligand Engagement in Human Cells Journal of the American Chemical Society ·Marjolein Soethoudt,Sara Christina Stolze,Matthias V. Westphal,Luuk van Stralen,Andrea Martella,Eva J. van Rooden,Wolfgang Guba,Zoltán V. Varga,Hui Deng,Sander I. van Kasteren,Uwe Grether,Adriaan P. IJzerman,Pál Pacher,Erick M. Carreira,Herman S. Overkleeft,Andreea Ioan‐Facsinay,Laura H. Heitman,Mario van der Stelt	2018	71
10	Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 Journal of Medicinal Chemistry ·Maarten L. J. Doornbos,José M. Cid,Jordi Haubrich,Alexandro Nunes,Jasper W. van de Sande,Sophie C. Vermond,Thea Mulder‐Krieger,Andrés A. Trabanco,A. Ahnaou,Wilhelmus Drinkenburg,Hilde Lavreysen,Laura H. Heitman,Adriaan P. IJzerman,Gary Tresadern	2017	35
11	A new hERG allosteric modulator rescues genetic and drug‐induced long‐ QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells EMBO Molecular Medicine ·Luca Sala,Zhiyi Yu,Dorien Ward‐van Oostwaard,Jacobus PD van Veldhoven,Alessandra Moretti,Karl‐Ludwig Laugwitz,Christine L. Mummery,Adriaan P. IJzerman,Milena Bellin	2016	68
12	Structural Basis for Allosteric Regulation of GPCRs by Sodium Ionsbreakdown → Science ·Wei Liu,Eugene Chun,Aaron A. Thompson,Pavel Chubukov,Fei Xu,Vsevolod Katritch,Gye Won Han,C. Roth,Laura H. Heitman,Adriaan P. IJzerman,Vadim Cherezov,Raymond C. Stevens	2012	777
13	Adenosine A _2B Receptor Agonism Inhibits Neointimal Lesion Development After Arterial Injury in Apolipoprotein E–Deficient Mice Arteriosclerosis Thrombosis and Vascular Biology ·Ilze Bot,Henk de Vries,Suzanne J.A. Korporaal,Amanda C. Foks,Martine Bot,Jacobus van Veldhoven,Mariëtte N. D. ter Borg,Peter J. van Santbrink,Theo J.C. van Berkel,Johan Kuiper,Adriaan P. IJzerman	2012	22
14	Biological and Pharmacological Roles of HCA Receptors Advances in pharmacology ·Clara C. Blad,Kashan Ahmed,Adriaan P. IJzerman,Stefan Offermanns	2011	57
15	International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Updatebreakdown → Pharmacological Reviews ·Bertil B. Fredholm,Adriaan P. IJzerman,Kenneth A. Jacobson,Joel Linden,Christa E. Müller	2011	1079
16	The 2.6 Angstrom Crystal Structure of a Human A _2A Adenosine Receptor Bound to an Antagonistbreakdown → Science ·Veli‐Pekka Jaakola,Mark T. Griffith,Michael A. Hanson,Vadim Cherezov,Ellen Y. T. Chien,J. Robert Lane,Adriaan P. IJzerman,Raymond C. Stevens	2008	1475
17	Selectivity of action of 8‐alkylamino analogues of N⁶‐cyclopentyladenosine in vivo: haemodynamic versus anti‐lipolytic responses in rats British Journal of Pharmacology ·E.A. van Schaick,H.E. Tukker,H. C. P. F. ROELEN,Adriaan P. IJzerman,Meindert Danhof	1998	35
18	Nucleoside transport inhibition and platelet aggregation in human blood: R75231 and its enantiomers, draflazine and R88016 European Journal of Pharmacology Molecular Pharmacology ·Margot W. Beukers,Cornel J. M. Kerkhof,Adriaan P. IJzerman,W. Soudijn	1994	16
19	Radioligand Binding Studies on the Nucleoside Transport Protein Advances in experimental medicine and biology ·Adriaan P. IJzerman,Armand H. Voorschuur,Marieke Kruidering,Ileana Pirovano,Herman Van Belle,Cor Janssen	1991	0
20	Limiting Solubilities and lonization Constants of Sparingly Soluble Compounds: Determination from Aqueous Potentiometric Titration Data Only Pharmaceutical Research ·Adriaan P. IJzerman	1988	6

About Adriaan P. IJzerman

Adriaan P. IJzerman is a scholar working on Physiology, Cellular and Molecular Neuroscience and Molecular Biology, having authored 470 papers that have together received 21.3k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (247 papers), Adenosine and Purinergic Signaling (228 papers), Pharmacological Receptor Mechanisms and Effects (96 papers), Neuropeptides and Animal Physiology (96 papers), Synthesis and Biological Evaluation (68 papers), Computational Drug Discovery Methods (41 papers), Neuroscience and Neuropharmacology Research (32 papers) and Chemical Synthesis and Analysis (30 papers). The work is most often cited by research in Physiology (7.8k citations), Cellular and Molecular Neuroscience (5.7k citations) and Molecular Biology (13.9k citations). Adriaan P. IJzerman has collaborated with scholars based in Netherlands, United States and United Kingdom. Frequent co-authors include Kenneth A. Jacobson, Joel Linden, Bertil B. Fredholm, Laura H. Heitman, Karl‐Norbert Klotz, Raymond C. Stevens, Gerard J. P. van Westen, Christa E. Müller, Vadim Cherezov and J. Robert Lane. Their work appears in journals such as Nature, Science and Chemical Reviews.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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