Standout Papers

Epigenetic regulation of gene expression: how the genome integr... 1992 2026 2003 2014 4.5k
  1. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals (2003)
    Rudolf Jaenisch, Adrian Bird Nature Genetics
  2. A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells (2006)
    B Bernstein, Tarjei S. Mikkelsen et al. Cell
  3. Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells (2005)
    Laurie A. Boyer, Tong Ihn Lee et al. Cell
  4. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals (2009)
    Mitchell Guttman, Ido Amit et al. Nature
  5. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality (1992)
    En Li, Timothy H. Bestor et al. Cell
  6. Histone H3K27ac separates active from poised enhancers and predicts developmental state (2010)
    Menno P. Creyghton, Albert W. Cheng et al. Proceedings of the National Academy of Sciences
  7. One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering (2013)
    Haoyi Wang, Hui Yang et al. Cell
  8. Polycomb complexes repress developmental regulators in murine embryonic stem cells (2006)
    Laurie A. Boyer, Kathrin Plath et al. Nature
  9. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state (2007)
    Marius Wernig, Alexander Meissner et al. Nature
  10. Genome-scale DNA methylation maps of pluripotent and differentiated cells (2008)
    Alexander Meissner, Tarjei S. Mikkelsen et al. Nature
  11. HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation (2003)
    Thorsten Cramer, Yuji Yamanishi et al. Cell
  12. Role for DNA methylation in genomic imprinting (1993)
    Rudolf Jaenisch et al. Nature
  13. WT-1 is required for early kidney development (1993)
    Jordan A. Kreidberg, Hannu Sariola et al. Cell
  14. Role for DNA methylation in genomic imprinting (1994)
    Caroline Beard, Rudolf Jaenisch et al. Trends in Genetics
  15. A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells (2007)
    Matthew G. Guenther, Stuart S. Levine et al. Cell
  16. MyoD or Myf-5 is required for the formation of skeletal muscle (1993)
    Michael A. Rudnicki, R. H. Stead et al. Cell
  17. Simplified mammalian DNA isolation procedure (1991)
    Peter W. Laird, Michael A. Rudnicki et al. Nucleic Acids Research
  18. Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters (2008)
    Andrea Ventura, Amanda Young et al. Cell
  19. HDAC2 negatively regulates memory formation and synaptic plasticity (2009)
    Ji‐Song Guan, Stephen J. Haggarty et al. Nature
  20. Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution (2007)
    Nimet Maherali, Rupa Sridharan et al. Cell stem cell
  21. One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering (2013)
    Hui Yang, Haoyi Wang et al. Cell
  22. Induction of Tumors in Mice by Genomic Hypomethylation (2003)
    François Gaudet, John Hodgson et al. Science
  23. Dissecting direct reprogramming through integrative genomic analysis (2008)
    Tarjei S. Mikkelsen, Jacob H. Hanna et al. Nature
  24. Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells (2008)
    Alexander Marson, Stuart S. Levine et al. Cell
  25. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009)
    Frank Soldner, Dirk Hockemeyer et al. Cell
  26. Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming (2008)
    Rudolf Jaenisch, Richard A. Young Cell
  27. Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin (2007)
    Jacob H. Hanna, Marius Wernig et al. Science
  28. Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice (2001)
    Richard Z. Chen, Schahram Akbarian et al. Nature Genetics
  29. A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival (2001)
    Peggy P. Lee, David Fitzpatrick et al. Immunity
  30. Chromosomal Instability and Tumors Promoted by DNA Hypomethylation (2003)
    Amir Eden, François Gaudet et al. Science
  31. YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells (2007)
    Fernando D. Camargo, Sumita Gokhale et al. Current Biology
  32. Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2 (2003)
    Wen Chen, Qiang Chang et al. Science
  33. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages (1992)
    Peter Mombaerts, Alan R. Clarke et al. Nature
  34. Mice lacking brain-derived neurotrophic factor develop with sensory deficits (1994)
    Patrik Ernfors, Kuo‐Fen Lee et al. Nature
  35. Genetic engineering of human pluripotent cells using TALE nucleases (2011)
    Dirk Hockemeyer, Haoyi Wang et al. Nature Biotechnology
  36. β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells (1990)
    Maarten Zijlstra, Mark Bix et al. Nature
  37. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease (2008)
    Marius Wernig, Jan Pruszak et al. Proceedings of the National Academy of Sciences
  38. Editing DNA Methylation in the Mammalian Genome (2016)
    X. Shawn Liu, Hao Wu et al. Cell
  39. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system (1992)
    Kuo‐Fen Lee, En Li et al. Cell
  40. Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development (1992)
    Michael A. Rudnicki, Thomas Braun et al. Cell
  41. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases (2009)
    Dirk Hockemeyer, Frank Soldner et al. Nature Biotechnology
  42. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal (2007)
    Yangming Wang, Collin Melton et al. Nature Genetics
  43. Direct cell reprogramming is a stochastic process amenable to acceleration (2009)
    Jacob H. Hanna, Krishanu Saha et al. Nature
  44. Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a (2000)
    Bernard Ramsahoye, Detlev Biniszkiewicz et al. Proceedings of the National Academy of Sciences
  45. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents (1994)
    Patrik Ernfors, Kuo-Fen Lee et al. Cell
  46. Activation of proto-oncogenes by disruption of chromosome neighborhoods (2016)
    Denes Hnisz, Abraham S. Weintraub et al. Science
  47. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells (1996)
    Hong Lei, S. Paul Oh et al. Development
  48. Ectopic Expression of Oct-4 Blocks Progenitor-Cell Differentiation and Causes Dysplasia in Epithelial Tissues (2005)
    Konrad Hochedlinger, Yasuhiro Yamada et al. Cell
  49. YY1 Is a Structural Regulator of Enhancer-Promoter Loops (2017)
    Abraham S. Weintraub, Charles H. Li et al. Cell
  50. Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs (2010)
    Jacob H. Hanna, Albert W. Cheng et al. Proceedings of the National Academy of Sciences
  51. Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity (2001)
    Maribel Rios, Guoping Fan et al. Molecular Endocrinology
  52. Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase (2012)
    Yosef Buganim, Dina A. Faddah et al. Cell
  53. Sequential Expression of Pluripotency Markers during Direct Reprogramming of Mouse Somatic Cells (2008)
    Tobias Brambrink, Ruth K. Foreman et al. Cell stem cell
  54. Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency (2008)
    Jacob H. Hanna, Styliani Markoulaki et al. Cell
  55. Xist-deficient mice are defective in dosage compensation but not spermatogenesis. (1997)
    York Marahrens, Barbara Panning et al. Genes & Development
  56. Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death (1992)
    Thomas Braun, Michael A. Rudnicki et al. Cell
  57. Suppression of intestinal neoplasia by DNA hypomethylation (1995)
    Peter W. Laird, Laurie Jackson‐Grusby et al. Cell
  58. Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system (2013)
    Albert W. Cheng, Haoyi Wang et al. Cell Research
  59. Chromosomal silencing and localization are mediated by different domains of Xist RNA (2002)
    Anton Wutz, Theodore P. Rasmussen et al. Nature Genetics
  60. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis (1996)
    Jordan A. Kreidberg, Michael J. Donovan et al. Development
  61. Epigenetic Instability in ES Cells and Cloned Mice (2001)
    David Humpherys, Kevin Eggan et al. Science
  62. Nuclear Cloning and Epigenetic Reprogramming of the Genome (2001)
    William M. Rideout, Kevin Eggan et al. Science
  63. Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations (2011)
    Frank Soldner, Josée Laganière et al. Cell
  64. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation (2001)
    Laurie Jackson‐Grusby, Caroline Beard et al. Nature Genetics
  65. Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells (2007)
    Alexander Meissner, Marius Wernig et al. Nature Biotechnology
  66. Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues (2010)
    Jacob H. Hanna, Krishanu Saha et al. Cell
  67. Efficient derivation of microglia-like cells from human pluripotent stem cells (2016)
    Julien Muffat, Yun Li et al. Nature Medicine
  68. Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression (2016)
    Frank Soldner, Yonatan Stelzer et al. Nature
  69. Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming (2019)
    Geoffrey Schiebinger, Jian Shu et al. Cell
  70. Generating genetically modified mice using CRISPR/Cas-mediated genome engineering (2014)
    Hui Yang, Haoyi Wang et al. Nature Protocols
  71. Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene (2018)
    X. Shawn Liu, Hao Wu et al. Cell
  72. Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. (1991)
    Maryna C. Eichelberger, W Allan et al. The Journal of Experimental Medicine

Immediate Impact

82 by Nobel laureates 101 from Science/Nature 234 standout
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Citing Papers

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44 intermediate papers

Works of Rudolf Jaenisch being referenced

Editing DNA Methylation in the Mammalian Genome
2016 Standout
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
2003 Standout
and 24 more

Author Peers

Author Last Decade Papers Cites
Rudolf Jaenisch 105873 32767 10368 13861 585 134.8k
Pierre Chambon 80127 45125 15675 7676 697 115.9k
Tom Maniatis 120104 34810 24042 12262 278 188.4k
Eric N. Olson 107676 15298 6715 23802 753 133.2k
Michael G. Rosenfeld 54392 22282 6877 9330 388 78.4k
Christopher K. Glass 60633 17811 19001 12036 372 94.9k
Hans Clevers 96581 23870 14772 18194 721 156.0k
Tony Hunter 77156 9410 11765 8538 502 103.0k
George D. Yancopoulos 54500 5959 15739 11822 425 101.4k
Michael E. Greenberg 57907 9759 6851 8159 249 87.5k
Neal G. Copeland 42413 12148 13543 5110 622 72.4k

All Works

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