Standout Papers

Seven-transmembrane receptors 1980 2026 1995 2010 2.1k
  1. Seven-transmembrane receptors (2002)
    Kristen L. Pierce, Richard T. Premont et al. Nature Reviews Molecular Cell Biology
  2. Transduction of Receptor Signals by ß-Arrestins (2005)
    Robert J. Lefkowitz, Sudha K. Shenoy Science
  3. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. (1980)
    A. De Léan, Jeffrey M. Stadel et al. Journal of Biological Chemistry
  4. β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes (1999)
    Louis M. Luttrell, Stephen S. G. Ferguson et al. Science
  5. β-Arrestins and Cell Signaling (2007)
    Scott M. DeWire, Seungkirl Ahn et al. Annual Review of Physiology
  6. G PROTEIN–COUPLED RECEPTOR KINASES (1998)
    Julie A. Pitcher, Neil J. Freedman et al. Annual Review of Biochemistry
  7. Turning off the signal: desensitization of β‐adrenergic receptor function (1990)
    William P. Hausdorff, Marc G. Caron et al. The FASEB Journal
  8. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. (1993)
    Philippe Samama, Susanna Cotecchia et al. Journal of Biological Chemistry
  9. Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A (1997)
    Yehia Daaka, Louis M. Luttrell et al. Nature
  10. International Union of Pharmacology nomenclature of adrenoceptors. (1994)
    Dan Bylund, J. Paul Hieble et al. Pharmacological Reviews
  11. Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin (1986)
    Richard A. F. Dixon, Brian K. Kobilka et al. Nature
  12. β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function (1990)
    Martin J. Lohse, Jeffrey Benovic et al. Science
  13. G Protein-coupled Receptors (1998)
    Robert J. Lefkowitz Journal of Biological Chemistry
  14. The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals (2002)
    Louis M. Luttrell, Robert J. Lefkowitz Journal of Cell Science
  15. Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2 (1999)
    Laura Bohn, Robert J. Lefkowitz et al. Science
  16. An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior (2005)
    Jean‐Martin Beaulieu, Tatyana D. Sotnikova et al. Cell
  17. μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence (2000)
    Laura Bohn, Raul R. Gainetdinov et al. Nature
  18. Seven-transmembrane-spanning receptors and heart function (2002)
    Howard A. Rockman, Walter J. Koch et al. Nature
  19. β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3 (2000)
    Patricia McDonald, William E. Miller et al. Science
  20. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins (1993)
    Robert J. Lefkowitz, Susanna Cotecchia et al. Trends in Pharmacological Sciences
  21. Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin (2001)
    Sudha K. Shenoy, Patricia McDonald et al. Science
  22. Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor (1987)
    Brian K. Kobilka, Hiroaki Matsui et al. Science
  23. Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds (2001)
    Louis M. Luttrell, William E. Miller et al. Proceedings of the National Academy of Sciences
  24. DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS (2004)
    Raul R. Gainetdinov, Richard T. Premont et al. Annual Review of Neuroscience
  25. Teaching old receptors new tricks: biasing seven-transmembrane receptors (2010)
    Sudarshan Rajagopal, Keshava Rajagopal et al. Nature Reviews Drug Discovery
  26. International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. (1995)
    J. Paul Hieble, Dan Bylund et al. Pharmacological Reviews
  27. Chimeric α 2 -,β 2 -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity (1988)
    Brian K. Kobilka, Tong Sun Kobilka et al. Science
  28. Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model (1985)
    David R. Sibley, Robert J. Lefkowitz Nature
  29. Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor (1995)
    Walter J. Koch, Howard A. Rockman et al. Science
  30. β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor (2005)
    Sudha K. Shenoy, Matthew T. Drake et al. Journal of Biological Chemistry
  31. Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor (1994)
    Carmelo A. Milano, Lee F. Allen et al. Science
  32. Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors (1992)
    Julie A. Pitcher, James Inglese et al. Science
  33. Regulation of tyrosine kinase cascades by G-protein-coupled receptors (1999)
    Louis M. Luttrell, Yehia Daaka et al. Current Opinion in Cell Biology
  34. Regulation of transmembrane signaling by receptor phosphorylation (1987)
    David R. Sibley, Jeffrey Benovic et al. Cell
  35. β-arrestin-mediated receptor trafficking and signal transduction (2011)
    Sudha K. Shenoy, Robert J. Lefkowitz Trends in Pharmacological Sciences
  36. Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. (1982)
    A. De Léan, Arthur A. Hancock et al. Molecular Pharmacology
  37. cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. (1987)
    Brian K. Kobilka, Richard A. F. Dixon et al. Proceedings of the National Academy of Sciences
  38. Beta-adrenergic receptors: biochemical mechanisms of physiological regulation (1984)
    Gary L. Stiles, Marc G. Caron et al. Physiological Reviews
  39. Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2 (2003)
    Huijun Wei, Seungkirl Ahn et al. Proceedings of the National Academy of Sciences
  40. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. (1986)
    Jeffrey Benovic, R. H. Strasser et al. Proceedings of the National Academy of Sciences
  41. GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling (2006)
    Éric Reiter, Robert J. Lefkowitz Trends in Endocrinology and Metabolism
  42. Palmitoylation of the human β2-adrenergic receptor (1989)
    Brian F. O’Dowd, Mark Hnatowich et al. Journal of Biological Chemistry
  43. A family of receptors coupled to guanine nucleotide regulatory proteins (1987)
    Henrik Dohlman, Marc G. Caron et al. Biochemistry
  44. Biased signalling: from simple switches to allosteric microprocessors (2018)
    Jeffrey S. Smith, Robert J. Lefkowitz et al. Nature Reviews Drug Discovery
  45. Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. (1988)
    Susanna Cotecchia, Debra A. Schwinn et al. Proceedings of the National Academy of Sciences
  46. Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway (1995)
    Brian E. Hawes, Deirdre K. Luttrell et al. Nature
  47. Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin (2011)
    Kunhong Xiao, Seungkirl Ahn et al. Science Signaling
  48. Cloning of the cDNA for the human beta 1-adrenergic receptor. (1987)
    Thomas Frielle, Sheila Collins et al. Proceedings of the National Academy of Sciences
  49. The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange (1998)
    Randy A. Hall, Richard T. Premont et al. Nature
  50. Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. (1992)
    Michael A. Kjelsberg, Susanna Cotecchia et al. Journal of Biological Chemistry
  51. The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor (1988)
    A. Fargin, John R. Raymond et al. Nature
  52. Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases (1996)
    Louis M. Luttrell, Brian E. Hawes et al. Journal of Biological Chemistry
  53. β-Arrestin-biased ligands at seven-transmembrane receptors (2007)
    Jonathan D. Violin, Robert J. Lefkowitz Trends in Pharmacological Sciences
  54. Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase (1998)
    Yehia Daaka, Louis M. Luttrell et al. Journal of Biological Chemistry
  55. A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling (2007)
    James W. Wisler, Scott M. DeWire et al. Proceedings of the National Academy of Sciences
  56. Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. (1977)
    L T Williams, Ralph Snyderman et al. Proceedings of the National Academy of Sciences
  57. Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. (1992)
    Håvard Attramadal, J.L. Arriza et al. Journal of Biological Chemistry
  58. β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7 (2009)
    Sudarshan Rajagopal, Ji‐Hee Kim et al. Proceedings of the National Academy of Sciences
  59. Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation (1987)
    Takaaki Yoshimasa, David R. Sibley et al. Nature
  60. Protein kinases that phosphorylate activated G protein‐coupled receptors (1995)
    Richard T. Premont, James Inglese et al. The FASEB Journal
  61. A Quantitative Analysis of Beta-Adrenergic Receptor Interactions: Resolution of High and Low Affinity States of the Receptor by Computer Modeling of Ligand Binding Data (1980)
    Richard S. Kent, André De Léan et al. Molecular Pharmacology
  62. Thyroid hormone regulation of beta-adrenergic receptor number. (1977)
    L T Williams, Robert J. Lefkowitz et al. Journal of Biological Chemistry
  63. Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor (2004)
    Seungkirl Ahn, Sudha K. Shenoy et al. Journal of Biological Chemistry
  64. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins (1987)
    Brian K. Kobilka, Thomas Frielle et al. Nature
  65. Therapeutic potential of β-arrestin- and G protein-biased agonists (2010)
    Erin J. Whalen, Sudarshan Rajagopal et al. Trends in Molecular Medicine
  66. Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor (1997)
    Louis M. Luttrell, Gregory J. Della Rocca et al. Journal of Biological Chemistry
  67. The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. (1993)
    Walter J. Koch, James Inglese et al. Journal of Biological Chemistry
  68. Binding of G protein beta gamma-subunits to pleckstrin homology domains. (1994)
    Kazushige Touhara, James Inglese et al. Journal of Biological Chemistry
  69. Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors (1997)
    Gregory J. Della Rocca, Tim van Biesen et al. Journal of Biological Chemistry
  70. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling (2016)
    A. Thomsen, Bianca Plouffe et al. Cell
  71. Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation (1995)
    Brian E. Hawes, Tim van Biesen et al. Journal of Biological Chemistry
  72. Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice (1998)
    Howard A. Rockman, Kenneth R. Chien et al. Proceedings of the National Academy of Sciences
  73. Activation of the cloned muscarinic potassium channel by G protein βγ subunits (1994)
    Eitan Reuveny, Paul A. Slesinger et al. Nature
  74. Structure and mechanism of the G protein-coupled receptor kinases. (1993)
    James Inglese, Neil J. Freedman et al. Journal of Biological Chemistry
  75. Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins (2002)
    Stephen J. Perry, George S. Baillie et al. Science
  76. ADENYLATE CYCLASE-COUPLED BETA-ADRENERGIC RECEPTORS: Structure and Mechanisms of Activation and Desensitization (1983)
    Robert J. Lefkowitz, Jeffrey M. Stadel et al. Annual Review of Biochemistry
  77. G protein—coupled receptor kinases (1993)
    Robert J. Lefkowitz Cell
  78. β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family (1989)
    Jeffrey Benovic, Antonio DeBlasi et al. Science
  79. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. (1994)
    Walter J. Koch, Brian E. Hawes et al. Journal of Biological Chemistry
  80. Mitogenic Signaling via G Protein-Coupled Receptors (1996)
    Tim van Biesen, Louis M. Luttrell et al. Endocrine Reviews
  81. Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization (1988)
    Michel Bouvier, William P. Hausdorff et al. Nature
  82. Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors (2001)
    Kristen L. Pierce, Robert J. Lefkowitz Nature reviews. Neuroscience
  83. Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation (2006)
    Diane Gesty‐Palmer, Minyong Chen et al. Journal of Biological Chemistry
  84. Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. (1988)
    John W. Regan, Tong Sun Kobilka et al. Proceedings of the National Academy of Sciences
  85. Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins. (1988)
    Robert J. Lefkowitz, M G Caron Journal of Biological Chemistry
  86. Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor (1995)
    Richard A. Bond, Paul Leff et al. Nature
  87. Molecular Basis for Interactions of G Protein βγ Subunits with Effectors (1998)
    Nikolai P. Skiba, Hyunsu Bae et al. Science
  88. Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes (2001)
    Weizhong Zhu, Minghao Zheng et al. Proceedings of the National Academy of Sciences
  89. β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection (2007)
    Takahisa Noma, Anthony Lemaire et al. Journal of Clinical Investigation
  90. Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization (1989)
    William P. Hausdorff, Michel Bouvier et al. Journal of Biological Chemistry
  91. Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling (2011)
    Arun K. Shukla, Kunhong Xiao et al. Trends in Biochemical Sciences
  92. Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway (1996)
    Brian E. Hawes, Louis M. Luttrell et al. Journal of Biological Chemistry
  93. Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling. (1988)
    Brian F. O’Dowd, Mark Hnatowich et al. Journal of Biological Chemistry
  94. Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. (1990)
    Martin J. Lohse, J.L. Benovic et al. Journal of Biological Chemistry
  95. A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. (1994)
    Lawrence S Barak, Mario Tiberi et al. Journal of Biological Chemistry
  96. Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. (1994)
    Carmelo A. Milano, Paul C. Dolber et al. Proceedings of the National Academy of Sciences
  97. Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release. (1978)
    Marc G. Caron, Jean‐Martin Beaulieu et al. Journal of Biological Chemistry
  98. Quantifying Ligand Bias at Seven-Transmembrane Receptors (2011)
    Sudarshan Rajagopal, Seungkirl Ahn et al. Molecular Pharmacology
  99. Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. (1975)
    Chhabirani Mukherjee, Robert J. Lefkowitz et al. Proceedings of the National Academy of Sciences
  100. Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. (1985)
    L.M. Fredrik Leeb-Lundberg, Susanna Cotecchia et al. Proceedings of the National Academy of Sciences
  101. Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems. (1992)
    Martin J. Lohse, J Pitcher et al. Journal of Biological Chemistry
  102. Mechanisms of Membrane-Receptor Regulation (1984)
    Franklin H. Epstein, Robert J. Lefkowitz et al. New England Journal of Medicine
  103. Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. (1985)
    Jeffrey Benovic, Linda J. Pike et al. Journal of Biological Chemistry
  104. Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides. (1976)
    Robert J. Lefkowitz, Debra Mullikin et al. Journal of Biological Chemistry
  105. Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor (1989)
    Michel Bouvier, Sheila Collins et al. Journal of Biological Chemistry
  106. ACTH Receptors in the Adrenal: Specific Binding of ACTH- 125 I and Its Relation to Adenyl Cyclase (1970)
    Robert J. Lefkowitz, Jesse Roth et al. Proceedings of the National Academy of Sciences
  107. Multiple ligand-specific conformations of the β2-adrenergic receptor (2011)
    Alem W. Kahsai, Kunhong Xiao et al. Nature Chemical Biology

Immediate Impact

52 by Nobel laureates 87 from Science/Nature 110 standout
Sub-graph 1 of 15

Citing Papers

Molecular signatures of G-protein-coupled receptors
2013 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
81 intermediate papers

Works of Robert J. Lefkowitz being referenced

Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin
2011 Standout
Regulation of tyrosine kinase cascades by G-protein-coupled receptors
1999 Standout
and 122 more

Author Peers

Author Last Decade Papers Cites
Robert J. Lefkowitz 95248 52044 6537 13294 711 117.7k
Solomon H. Snyder 73879 57757 1350 29487 976 140.4k
Marc G. Caron 54404 45350 3144 7666 592 79.2k
Kenji Kangawa 25871 21376 2053 24184 989 82.8k
George D. Yancopoulos 54500 18351 508 11945 425 101.4k
Paul Greengard 69535 51642 488 19363 956 111.1k
Ronald M. Evans 95165 18602 683 19767 619 146.4k
Brian K. Kobilka 50369 29474 2836 4303 356 60.2k
Roger Y. Tsien 70492 28180 393 8028 315 110.3k
Nahum Sonenberg 75137 5366 1588 4807 664 94.7k
Michael J. Berridge 41817 19000 465 7633 196 64.9k

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