Standout Papers

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Cl... 1997 2026 2006 2016 942
  1. Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes (1999)
    R. Scott Obach Drug Metabolism and Disposition
  2. The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. (1997)
    R. Scott Obach, James G. Baxter et al. PubMed
  3. Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds (2008)
    R. Scott Obach, Franco Lombardo et al. Drug Metabolism and Disposition
  4. Managing the challenge of chemically reactive metabolites in drug development (2011)
    B. Kevin Park, Alan R. Boobis et al. Nature Reviews Drug Discovery

Immediate Impact

8 by Nobel laureates 21 from Science/Nature 69 standout
Sub-graph 1 of 22

Citing Papers

Skeletal Editing Approach to Bridge-Functionalized Bicyclo[1.1.1]pentanes from Azabicyclo[2.1.1]hexanes
2023 Standout
Late-stage Functionalization for Improving Drug-like Molecular Properties
2023 Standout
18 intermediate papers

Works of R. Scott Obach being referenced

Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure–Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H 1 Receptor Inverse Agonist
2020
Biosynthesis of Fluorinated Analogs of Drugs Using Human Cytochrome P450 Enzymes Followed by Deoxyfluorination and Quantitative Nuclear Magnetic Resonance Spectroscopy to Improve Metabolic Stability
2016
and 26 more

Author Peers

Author Last Decade Papers Cites
R. Scott Obach 7921 4462 3829 213 14.3k
Thomas A. Baillie 4340 4682 2455 209 11.9k
James R. Halpert 8431 3569 3701 240 11.2k
Tsutomu Shimada 10849 6580 4965 313 19.9k
Steven Wrighton 10999 3795 6670 172 16.9k
John O. Miners 10008 4538 5582 282 16.4k
Allan E. Rettie 8509 2961 3262 213 12.6k
Olavi Pelkonen 6217 3822 2681 286 12.8k
Malcolm Rowland 5477 2806 4656 292 15.7k
Tsuyoshi Yokoi 7087 6130 4709 368 15.9k
Paul R. Ortiz de Montellano 4310 9019 1731 325 16.8k

All Works

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Rankless by CCL
2026