Standout Papers

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub>... 1998 2026 2007 2016 4.5k
  1. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation (2001)
    Panu Jaakkola, David R. Mole et al. Science
  2. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis (1999)
    Patrick H. Maxwell, Michael S. Wiesener et al. Nature
  3. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation (2001)
    Andrew Epstein, Jonathan Gleadle et al. Cell
  4. Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway (2008)
    William G. Kaelin, Peter J. Ratcliffe Molecular Cell
  5. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (1998)
    Peter Carmeliet, Yuval Dor et al. Nature
  6. Regulation of angiogenesis by hypoxia: role of the HIF system (2003)
    Christopher W. Pugh, Peter J. Ratcliffe Nature Medicine
  7. Oxygen sensing by HIF hydroxylases (2004)
    Christopher J. Schofield, Peter J. Ratcliffe Nature Reviews Molecular Cell Biology
  8. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. (2000)
    Charles C. Wykoff, Nigel Beasley et al. PubMed
  9. The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages (2000)
    Helen Turley, Kevin C. Gatter et al. American Journal Of Pathology
  10. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth (1997)
    Patrick H. Maxwell, Gabi U. Dachs et al. Proceedings of the National Academy of Sciences
  11. Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein (2000)
    Matthew E. Cockman, Norma Masson et al. Journal of Biological Chemistry
  12. Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor (2004)
    Ya‐Min Tian, Raju R. Raval et al. Journal of Biological Chemistry
  13. Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation (2001)
    Norma Masson, Carsten Willam et al. The EMBO Journal
  14. Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma (2005)
    Raju R. Raval, Maxine Tran et al. Molecular and Cellular Biology
  15. The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases (2011)
    Rasheduzzaman Chowdhury, Kar Kheng Yeoh et al. EMBO Reports
  16. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability (2005)
    Jennifer S. Isaacs, Yun Jin Jung et al. Cancer Cell
  17. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. (2001)
    Heidi Sowter, Peter J. Ratcliffe et al. PubMed
  18. Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL (2002)
    Wai‐Ching Hon, Michael Wilson et al. Nature
  19. Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family (2002)
    Kirsty S. Hewitson, Luke A. McNeill et al. Journal of Biological Chemistry
  20. Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs (2002)
    Michael S. Wiesener, Jan Steffen Jürgensen et al. The FASEB Journal
  21. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq (2011)
    Johannes Schödel, Spyros Oikonomopoulos et al. Blood
  22. Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α (1998)
    Michael S. Wiesener, Helen Turley et al. Blood
  23. Expression of Hypoxia-Inducible Factor-1α and -2α in Hypoxic and Ischemic Rat Kidneys (2002)
    Christian Rosenberger, Stefano J. Mandriota et al. Journal of the American Society of Nephrology
  24. Hypoxic Regulation of Lactate Dehydrogenase A (1995)
    John D. Firth, Benjamin L. Ebert et al. Journal of Biological Chemistry
  25. Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences (1995)
    Benjamin L. Ebert, John D. Firth et al. Journal of Biological Chemistry
  26. Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts (2009)
    David R. Mole, Christine Blancher et al. Journal of Biological Chemistry
  27. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer. (1994)
    J. D. Firth, Benjamin L. Ebert et al. Proceedings of the National Academy of Sciences
  28. Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit (1997)
    Christopher W. Pugh, John F. O’Rourke et al. Journal of Biological Chemistry
  29. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. (2001)
    Adrian L. Harris, S.E. Davidson et al. PubMed
  30. HIF activation identifies early lesions in VHL kidneys (2002)
    Stefano J. Mandriota, Kevin Turner et al. Cancer Cell
  31. Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition (2006)
    Gareth Elvidge, Peter J. Ratcliffe et al. Journal of Biological Chemistry
  32. Prognostic Significance of a Novel Hypoxia-Regulated Marker, Carbonic Anhydrase IX, in Invasive Breast Carcinoma (2001)
    Stephen Chia, Charles C. Wykoff et al. Journal of Clinical Oncology
  33. Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism. (1993)
    P H Maxwell, Christopher W. Pugh et al. Proceedings of the National Academy of Sciences
  34. Identification of the renal erythropoietin-producing cells using transgenic mice (1993)
    Patrick H. Maxwell, Mark Osmond et al. Kidney International
  35. Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer (2015)
    Johannes Schödel, Steffen Grampp et al. European Urology
  36. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival (2014)
    Hani Choudhry, Ashwag Albukhari et al. Oncogene
  37. Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways (2014)
    Norma Masson, Peter J. Ratcliffe Cancer & Metabolism
  38. Mechanisms of hypoxia signalling: new implications for nephrology (2019)
    Johannes Schödel, Peter J. Ratcliffe Nature Reviews Nephrology
  39. Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants (2019)
    Norma Masson, Thomas P. Keeley et al. Science

Immediate Impact

308 by Nobel laureates 69 from Science/Nature 503 standout
Sub-graph 1 of 13

Citing Papers

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2018 Standout
1 intermediate paper

Works of Peter J. Ratcliffe being referenced

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways
2014 Standout

Author Peers

Author Last Decade Papers Cites
Peter J. Ratcliffe 35213 33040 8972 361 55.8k
M. Celeste Simon 20715 25915 4122 259 46.7k
Patrick H. Maxwell 21346 19893 5156 208 34.1k
William G. Kaelin 22252 35237 5899 244 49.6k
Manel Esteller 20419 56762 9131 651 73.1k
Chi V. Dang 23758 38321 2975 299 52.1k
Pier Paolo Pandolfi 22576 61139 5704 449 79.2k
Christopher W. Pugh 21532 19067 5142 142 32.0k
Scott W. Lowe 16688 49438 4162 324 68.3k
Matthew G. Vander Heiden 25534 36431 1848 218 53.1k
Curtis C. Harris 24469 40543 4515 571 65.7k

All Works

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