Standout Papers

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain ... 1993 2026 2004 2015 1.8k
  1. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs (1994)
    Alfred H. Schinkel, Jasper Smit et al. Cell
  2. Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease (1993)
    Jasper Smit, Alfred H. Schinkel et al. Cell
  3. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. (1996)
    Alfred H. Schinkel, Els Wagenaar et al. Journal of Clinical Investigation
  4. Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. (1995)
    Alfred H. Schinkel, Els Wagenaar et al. Journal of Clinical Investigation
  5. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins (1997)
    Alfred H. Schinkel, Ulrich Mayer et al. Proceedings of the National Academy of Sciences
  6. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. (1998)
    Raymond Evers, Marcel Kool et al. Journal of Clinical Investigation

Immediate Impact

21 by Nobel laureates 10 from Science/Nature 91 standout
Sub-graph 1 of 15

Citing Papers

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
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2017 StandoutScience
5 intermediate papers

Works of Liesbeth van Deemter being referenced

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.
1996 Standout
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
1994 Standout
and 5 more

Author Peers

Author Last Decade Papers Cites
Liesbeth van Deemter 7095 3663 2560 24 9.1k
Carla A.A.M. Mol 6076 3338 1731 16 7.7k
I Pastan 8341 2633 4679 47 10.8k
Marcel de Haas 4185 1738 2055 36 6.0k
R G Deeley 5300 1738 3563 60 8.2k
Martin A. van der Valk 4086 1798 2083 46 6.1k
Els Wagenaar 10040 5013 4283 97 13.9k
Jasper Smit 3597 1612 1179 19 4.5k
Norbert Kartner 3211 580 3931 49 7.6k
Ursula A. Germann 2914 931 2331 49 4.8k
Peter R. Wielinga 2256 1015 960 37 4.0k

All Works

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