Standout Papers

Targeting RAS signalling pathways in cancer therapy... 1984 2026 1998 2012 2.4k
  1. Targeting RAS signalling pathways in cancer therapy (2003)
    Julian Downward Nature reviews. Cancer
  2. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells (1984)
    A Ullrich, Lisa M. Coussens et al. Nature
  3. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences (1984)
    Julian Downward, Yosef Yarden et al. Nature
  4. Phosphatidylinositol-3-OH kinase direct target of Ras (1994)
    Pablo Rodriguez‐Viciana, Patricia H. Warne et al. Nature
  5. Mechanisms and consequences of activation of protein kinase B/Akt (1998)
    Julian Downward Current Opinion in Cell Biology
  6. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB (1997)
    Andrea Kauffmann-Zeh, Pablo Rodriguez‐Viciana et al. Nature
  7. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor (1993)
    László Buday, Julian Downward Cell
  8. Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras (1997)
    Pablo Rodriguez‐Viciana, Patricia H. Warne et al. Cell
  9. Stimulation of p21ras upon T-cell activation (1990)
    Julian Downward, Jonathan D. Graves et al. Nature
  10. Akt Phosphorylates the Yes-Associated Protein, YAP, to Induce Interaction with 14-3-3 and Attenuation of p73-Mediated Apoptosis (2003)
    Subham Basu, Nicholas F. Totty et al. Molecular Cell
  11. PI 3-kinase, Akt and cell survival (2004)
    Julian Downward Seminars in Cell and Developmental Biology
  12. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro (1993)
    Patricia H. Warne, Julian Downward et al. Nature
  13. Autophosphorylation sites on the epidermal growth factor receptor (1984)
    Julian Downward, Peter J. Parker et al. Nature
  14. Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis (2002)
    Elżbieta Janda, Kerstin Lehmann et al. The Journal of Cell Biology
  15. RAS Interaction with PI3K: More Than Just Another Effector Pathway (2011)
    Esther Castellano, Julian Downward Genes & Cancer
  16. Expression cloning and characterization of the TGF-β type III receptor (1991)
    Xiao‐Fan Wang, Herbert Y. Lin et al. Cell
  17. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients (1992)
    Tanya Basu, David H. Gutmann et al. Nature
  18. Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA (2017)
    Matthew A. Coelho, Sophie de Carné Trécesson et al. Immunity
  19. Guidelines for the use of cell lines in biomedical research (2014)
    Amanda Capes‐Davis, John M. Davis et al. British Journal of Cancer
  20. Exploiting the therapeutic implications of KRAS inhibition on tumor immunity (2024)
    Míriam Molina‐Arcas, Julian Downward Cancer Cell

Immediate Impact

33 by Nobel laureates 133 from Science/Nature 192 standout
Sub-graph 1 of 12

Citing Papers

The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
77 intermediate papers

Works of Julian Downward being referenced

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
1984 StandoutNature
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
1984 StandoutNature
and 36 more

Author Peers

Author Last Decade Papers Cites
Julian Downward 29860 11325 5875 289 41.2k
Mariano Barbacid 30539 14700 6107 262 51.4k
Gérard I. Evan 29571 11800 4210 244 42.5k
Nathanael S. Gray 29806 10733 3927 471 41.2k
Channing J. Der 35801 12591 10541 403 47.7k
Frank McCormick 42325 14260 9298 376 56.7k
Lena Claesson‐Welsh 22006 6841 4782 253 31.8k
William C. Hahn 26136 11079 3439 289 40.1k
Kevan M. Shokat 23898 6774 5375 301 33.5k
Pier Giuseppe Pelicci 31361 9522 3342 526 45.1k
Meenhard Herlyn 26134 16922 6633 539 42.2k

All Works

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