Standout Papers

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor... 1999 2026 2008 2017 5.4k
  1. Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor (1999)
    Anne Brunet, Azad Bonni et al. Cell
  2. Molecular mechanisms of mTOR-mediated translational control (2009)
    Xiaoju Max, John Blenis Nature Reviews Molecular Cell Biology
  3. ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions (2004)
    Philippe P. Roux, John Blenis Microbiology and Molecular Biology Reviews
  4. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation (2011)
    Michelle C. Mendoza, Ekrem Emrah Er et al. Trends in Biochemical Sciences
  5. Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway (2002)
    Brendan D. Manning, Andrew R. Tee et al. Molecular Cell
  6. Signal transduction via the MAP kinases: proceed at your own RSK. (1993)
    John Blenis Proceedings of the National Academy of Sciences
  7. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases (1992)
    Calvin J. Kuo, John Blenis et al. Cell
  8. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression (2004)
    Diane C. Fingar, John Blenis Oncogene
  9. Nuclear localization and regulation of erk- and rsk-encoded protein kinases. (1992)
    Rey‐Huei Chen, John Blenis et al. Molecular and Cellular Biology
  10. mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events (2005)
    Marina K. Holz, Bryan A. Ballif et al. Cell
  11. Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb (2003)
    Andrew R. Tee, Brendan D. Manning et al. Current Biology
  12. Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation (1994)
    Bentley Cheatham, Chris J. Vlahos et al. Molecular and Cellular Biology
  13. Rapamycin: One Drug, Many Effects (2014)
    Jing Li, Sang Gyun Kim et al. Cell Metabolism
  14. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E (2002)
    Diane C. Fingar, Sofie R. Salama et al. Genes & Development
  15. ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK (1992)
    Kenneth W. Wood, Thomas M. Roberts et al. Cell
  16. Molecular interpretation of ERK signal duration by immediate early gene products (2002)
    Leon O. Murphy, Sallie W. Smith et al. Nature Cell Biology
  17. mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E (2003)
    Diane C. Fingar, Celeste Richardson et al. Molecular and Cellular Biology
  18. FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2 (2000)
    Martin R. Sprick, Markus Weigand et al. Immunity
  19. Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling (2011)
    Yonghao Yu, George Poulogiannis et al. Science
  20. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase (1994)
    Jongkyeong Chung, Katherine P. Lemon et al. Nature
  21. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling (2002)
    Andrew R. Tee, Diane C. Fingar et al. Proceedings of the National Academy of Sciences
  22. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation (2008)
    Andrew Y. Choo, Sang-Oh Yoon et al. Proceedings of the National Academy of Sciences
  23. Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos (2003)
    Sudhanshu Agrawal, Anshu Agrawal et al. The Journal of Immunology
  24. The RSK family of kinases: emerging roles in cellular signalling (2008)
    Rana Anjum, John Blenis Nature Reviews Molecular Cell Biology
  25. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase (2004)
    Philippe P. Roux, Bryan A. Ballif et al. Proceedings of the National Academy of Sciences
  26. MAPK signal specificity: the right place at the right time (2006)
    Leon O. Murphy, John Blenis Trends in Biochemical Sciences
  27. RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation (2007)
    Philippe P. Roux, David Shahbazian et al. Journal of Biological Chemistry
  28. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. (1994)
    Bentley Cheatham, Chris J. Vlahos et al. Molecular and Cellular Biology
  29. STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation (1997)
    Jongkyeong Chung, Eriko Uchida et al. Molecular and Cellular Biology
  30. Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes (1995)
    Xiaokui Zhang, John Blenis et al. Science
  31. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase (1992)
    Calvin J. Kuo, Jongkyeong Chung et al. Nature

Immediate Impact

13 by Nobel laureates 99 from Science/Nature 232 standout
Sub-graph 1 of 13

Citing Papers

Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Facing up to the global challenges of ageing
2018 StandoutNature
4 intermediate papers

Works of John Blenis being referenced

TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease
2017
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
2011 Standout
and 5 more

Author Peers

Author Last Decade Papers Cites
John Blenis 38903 8109 5551 6419 221 51.3k
Hediye Erdjument‐Bromage 52815 7276 5909 6857 283 67.2k
Guy S. Salvesen 36881 8899 8145 9492 293 54.0k
Gérard I. Evan 29571 11800 5517 5650 244 42.5k
James R. Woodgett 35405 5807 4419 4820 293 47.2k
Dario R. Alessi 50134 7625 5602 4899 308 64.7k
Xiaodong Wang 48200 7966 7429 11272 305 62.6k
Paul Tempst 61550 8205 7571 8945 320 79.9k
Erwin F. Wagner 33303 14036 7924 7459 356 49.9k
Brian A. Hemmings 32877 5076 3379 3745 312 42.0k
Junying Yuan 35952 5046 4795 10246 251 51.9k

All Works

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2026