Standout Papers

TGF-β SIGNAL TRANSDUCTION 1990 2026 2002 2014 6.5k
  1. TGF-β SIGNAL TRANSDUCTION (1998)
    Joan Massagué Annual Review of Biochemistry
  2. Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus (2003)
    Yigong Shi, Joan Massagué Cell
  3. Cancer Metastasis: Building a Framework (2006)
    Gaorav P. Gupta, Joan Massagué Cell
  4. TGFβ in Cancer (2008)
    Joan Massagué Cell
  5. The Transforming Growth Factor-beta Family (1990)
    Joan Massagué PubMed
  6. TGFβ signalling in context (2012)
    Joan Massagué Nature Reviews Molecular Cell Biology
  7. Genes that mediate breast cancer metastasis to lung (2005)
    Andy J. Minn, Gaorav P. Gupta et al. Nature
  8. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. (1986)
    Ronald A. Ignotz, Joan Massagué Journal of Biological Chemistry
  9. Metastasis: from dissemination to organ-specific colonization (2009)
    Don X. Nguyen, Paula D. Bos et al. Nature reviews. Cancer
  10. TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders (2000)
    Joan Massagué, Stacy W. Blain et al. Cell
  11. A multigenic program mediating breast cancer metastasis to bone (2003)
    Yibin Kang, Peter M. Siegel et al. Cancer Cell
  12. Mechanism of activation of the TGF-β receptor (1994)
    Jeffrey L. Wrana, Liliana Attisano et al. Nature
  13. Smad transcription factors (2005)
    Joan Massagué, Joan Seoane et al. Genes & Development
  14. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals (1994)
    Kornélia Polyák, Hediye Erdjument‐Bromage et al. Cell
  15. NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system (2000)
    Joan Massagué The EMBO Journal
  16. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. (1994)
    Kornélia Polyák, Jun‐ya Kato et al. Genes & Development
  17. How cells read TGF-β signals (2000)
    Joan Massagué Nature Reviews Molecular Cell Biology
  18. Transforming Growth Factor-β Signaling in Immunity and Cancer (2019)
    Eduard Batlle, Joan Massagué Immunity
  19. Controlling TGF-beta signaling. (2000)
    Joan Massagué, Ye-Guang Chen PubMed
  20. Endogenous human microRNAs that suppress breast cancer metastasis (2008)
    Sohail F. Tavazoie, Claudio R. Alarcón et al. Nature
  21. Metastatic colonization by circulating tumour cells (2016)
    Joan Massagué, Anna C. Obenauf Nature
  22. Controlling TGF-β signaling (2000)
    Joan Massagué, Ye‐Guang Chen Genes & Development
  23. TGFβ signals through a heteromeric protein kinase receptor complex (1992)
    Jeffrey L. Wrana, Liliana Attisano et al. Cell
  24. Genes that mediate breast cancer metastasis to the brain (2009)
    Paula D. Bos, Xiang H.-F. Zhang et al. Nature
  25. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer (2003)
    Peter M. Siegel, Joan Massagué Nature reviews. Cancer
  26. Epithelial-Mesenchymal Transitions (2004)
    Yibin Kang, Joan Massagué Cell
  27. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex (1995)
    Philip D. Jeffrey, Alicia A. Russo et al. Nature
  28. Tumor Self-Seeding by Circulating Cancer Cells (2009)
    Mi Young Kim, Thórdur Óskarsson et al. Cell
  29. TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance (2005)
    Dori A. Thomas, Joan Massagué Cancer Cell
  30. G1 cell-cycle control and cancer (2004)
    Joan Massagué Nature
  31. A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012)
    Swarnali Acharyya, Thórdur Óskarsson et al. Cell
  32. A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras (1999)
    Marcus Kretzschmar, Jacqueline Doody et al. Genes & Development
  33. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. (1995)
    Inga Reynisdóttir, Kornélia Polyák et al. Genes & Development
  34. Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation (2004)
    Joan Seoane, Lijian Shen et al. Cell
  35. Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation (2012)
    Alexandre Calon, Elisa Espinet et al. Cancer Cell
  36. lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin (1994)
    Jamison L. Nourse, Eduardo Firpo et al. Nature
  37. Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways (1996)
    Giorgio Lagna, Akiko Hata et al. Nature
  38. Molecular Basis of Metastasis (2008)
    Anne C. Chiang, Joan Massagué New England Journal of Medicine
  39. TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development (1999)
    Juan Juan Yin, Katri S. Selander et al. Journal of Clinical Investigation
  40. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. (1995)
    Mong‐Hong Lee, Inga Reynisdóttir et al. Genes & Development
  41. TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4 (2008)
    David Padua, Xiang H.-F. Zhang et al. Cell
  42. Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex (1996)
    Alicia A. Russo, Philip D. Jeffrey et al. Nature
  43. TGFβ Signaling: Receptors, Transducers, and Mad Proteins (1996)
    Joan Massagué Cell
  44. Betaglycan presents ligand to the TGFβ signaling receptor (1993)
    Fernando López‐Casillas, Jeffrey L. Wrana et al. Cell
  45. Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation (1990)
    Marikki Laiho, James A. DeCaprio et al. Cell
  46. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. (1992)
    Sela Cheifetz, Teresa Bellón et al. Journal of Biological Chemistry
  47. Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer (2016)
    Qing Chen, Adrienne Boire et al. Nature
  48. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway (1999)
    Luis Ulloa, Jacqueline Doody et al. Nature
  49. Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation (1994)
    Jun‐ya Kato, Masaaki Matsuoka et al. Cell
  50. Roles of TGFβ in metastasis (2008)
    David Padua, Joan Massagué Cell Research
  51. Targeting metastatic cancer (2021)
    Karuna Ganesh, Joan Massagué Nature Medicine
  52. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs (2011)
    Thórdur Óskarsson, Swarnali Acharyya et al. Nature Medicine
  53. Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta. (1987)
    Ronald A. Ignotz, Takeshi Endo et al. Journal of Biological Chemistry
  54. Genetic determinants of cancer metastasis (2007)
    Don X. Nguyen, Joan Massagué Nature Reviews Genetics
  55. The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors (1987)
    Sela Cheifetz, James A. Weatherbee et al. Cell
  56. The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor. (1982)
    Joan Massagué, Michael Czech Journal of Biological Chemistry
  57. The logic of TGFβ signaling (2006)
    Joan Massagué, Roger R. Gomis FEBS Letters
  58. Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways (2009)
    Claudio R. Alarcón, Qiaoran Xi et al. Cell
  59. Crystal Structure of a Smad MH1 Domain Bound to DNA (1998)
    Yigong Shi, Yanfei Wang et al. Cell
  60. GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. (1995)
    Rotraud Wieser, Jeffrey L. Wrana et al. The EMBO Journal
  61. Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β (1989)
    Jyrki Heino, Ronald A. Ignotz et al. Journal of Biological Chemistry
  62. The TGF-β family of growth and differentiation factors (1987)
    Joan Massagué Cell
  63. Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis (2014)
    Manuel Valiente, Anna C. Obenauf et al. Cell
  64. A human Mad protein acting as a BMP-regulated transcriptional activator (1996)
    Fang Liu, Akiko Hata et al. Nature
  65. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor (1998)
    Akiko Hata, Giorgio Lagna et al. Genes & Development
  66. Contextual determinants of TGFβ action in development, immunity and cancer (2018)
    Charles J. David, Joan Massagué Nature Reviews Molecular Cell Biology
  67. Silencing of TGF-β signalling by the pseudoreceptor BAMBI (1999)
    Daria Onichtchouk, Ye-Guang Chen et al. Nature
  68. MEMBRANE-ANCHORED GROWTH FACTORS (1993)
    Joan Massagué, Atanasio Pandiella Annual Review of Biochemistry
  69. Receptors for the TGF-β family (1992)
    Joan Massagué Cell
  70. Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage (2002)
    Joan Seoane, H. Carl Le et al. Nature
  71. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis (2007)
    Gaorav P. Gupta, Don X. Nguyen et al. Nature
  72. Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system (1991)
    Fernando López‐Casillas, Sela Cheifetz et al. Cell
  73. Metastatic Stem Cells: Sources, Niches, and Vital Pathways (2014)
    Thórdur Óskarsson, Eduard Batlle et al. Cell stem cell
  74. Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals (2009)
    Xiang H.-F. Zhang, Qiongqing Wang et al. Cancer Cell
  75. Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors (2005)
    Andy J. Minn, Yibin Kang et al. Journal of Clinical Investigation
  76. Type beta transforming growth factor is an inhibitor of myogenic differentiation. (1986)
    Joan Massagué, Sela Cheifetz et al. Proceedings of the National Academy of Sciences
  77. Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs (2011)
    Qing Chen, Xiang H.-F. Zhang et al. Cancer Cell
  78. TGF-β Tumor Suppression through a Lethal EMT (2016)
    Charles J. David, Yun-Han Huang et al. Cell
  79. Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells. (1983)
    Joan Massagué Journal of Biological Chemistry
  80. VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors (2011)
    Xin Lü, Euphemia W. Mu et al. Cancer Cell
  81. Therapy-induced tumour secretomes promote resistance and tumour progression (2015)
    Anna C. Obenauf, Yilong Zou et al. Nature

Immediate Impact

19 by Nobel laureates 77 from Science/Nature 209 standout
Sub-graph 1 of 17

Citing Papers

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
A view on drug resistance in cancer
2019 StandoutNature
115 intermediate papers

Works of Joan Massagué being referenced

Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis
2017
Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
2016 StandoutNature
and 80 more

Author Peers

Author Last Decade Papers Cites
Joan Massagué 94714 46583 22328 356 135.6k
Douglas Hanahan 78402 43041 35907 224 134.4k
Judah Folkman 62209 24238 29198 391 103.7k
Lewis C. Cantley 103801 27070 29279 702 148.2k
Zena Werb 45042 34757 33138 411 108.4k
Napoleone Ferrara 60705 20350 23583 257 97.7k
Kari Alitalo 56192 44972 12285 713 93.0k
Robert A. Weinberg 133196 93880 55373 377 219.6k
Raghu Kalluri 48220 20553 24773 315 80.9k
Hans Clevers 96581 52291 18194 721 156.0k
Peter Carmeliet 52350 14817 27080 720 98.1k

All Works

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