Standout Papers

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the live... 2002 2026 2010 2018 3.6k
  1. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver (2002)
    Jay D. Horton, Joseph L. Goldstein et al. Journal of Clinical Investigation
  2. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver (2002)
    Jay D. Horton, Joseph L. Goldstein et al. Journal of Clinical Investigation
  3. Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity (2004)
    Jeffrey D. Browning, Lidia S. Szczepaniak et al. Hepatology
  4. Human Fatty Liver Disease: Old Questions and New Insights (2011)
    Jonathan C. Cohen, Jay D. Horton et al. Science
  5. Molecular mediators of hepatic steatosis and liver injury (2004)
    Jeffrey D. Browning, Jay D. Horton Journal of Clinical Investigation
  6. Molecular mediators of hepatic steatosis and liver injury (2004)
    Jeffrey D. Browning, Jay D. Horton Journal of Clinical Investigation
  7. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes (2003)
    Jay D. Horton, Nila Shah et al. Proceedings of the National Academy of Sciences
  8. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. (1997)
    Hitoshi Shimano, Jay D. Horton et al. Journal of Clinical Investigation
  9. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. (1996)
    Hitoshi Shimano, Jay D. Horton et al. Journal of Clinical Investigation
  10. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. (1997)
    Iichiro Shimomura, Hitoshi Shimano et al. Journal of Clinical Investigation
  11. Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation (2007)
    Dawei Zhang, Thomas A. Lagace et al. Journal of Biological Chemistry
  12. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes (1999)
    Iichiro Shimomura, Yuriy K. Bashmakov et al. Proceedings of the National Academy of Sciences
  13. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis (2004)
    Katsumi Iizuka, Richard K. Bruick et al. Proceedings of the National Academy of Sciences
  14. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. (1998)
    Jay D. Horton, Iichiro Shimomura et al. Journal of Clinical Investigation
  15. Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus (1999)
    Iichiro Shimomura, Yuriy K. Bashmakov et al. Journal of Biological Chemistry
  16. A Highly Durable RNAi Therapeutic Inhibitor of PCSK9 (2016)
    Kevin Fitzgerald, Anna Borodovsky et al. New England Journal of Medicine
  17. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9 (2005)
    Shirya Rashid, David E. Curtis et al. Proceedings of the National Academy of Sciences
  18. Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c (2002)
    Guosheng Liang, Jian Yang et al. Journal of Biological Chemistry
  19. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice (1998)
    Jay D. Horton, Yuriy K. Bashmakov et al. Proceedings of the National Academy of Sciences
  20. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol (2002)
    Liqing Yu, Jia Li-Hawkins et al. Journal of Clinical Investigation
  21. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice (2006)
    Thomas A. Lagace, David E. Curtis et al. Journal of Clinical Investigation
  22. Acetate Dependence of Tumors (2014)
    Sarah A. Comerford, Zhi‐Guang Huang et al. Cell
  23. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol (2002)
    Liqing Yu, Jia Li-Hawkins et al. Journal of Clinical Investigation
  24. Molecular Characterization of Loss-of-Function Mutations in PCSK9 and Identification of a Compound Heterozygote (2006)
    Zhenze Zhao, Thomas A. Lagace et al. The American Journal of Human Genetics
  25. Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial (2013)
    Kevin Fitzgerald, Maria Frank-Kamenetsky et al. The Lancet

Immediate Impact

77 by Nobel laureates 33 from Science/Nature 168 standout
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113 intermediate papers

Works of Jay D. Horton being referenced

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
and 44 more

Author Peers

Author Last Decade Papers Cites
Jay D. Horton 16376 15716 5229 11646 121 37.0k
Helen H. Hobbs 20944 12744 2930 12382 191 43.7k
Jonathan C. Cohen 13850 9592 2473 11409 180 33.9k
Peter Tontonoz 13131 27078 4415 7701 227 44.3k
Ira Tabas 10701 19656 2544 10488 275 45.1k
Alan R. Tall 24302 16612 3048 5752 359 44.5k
Steven A. Kliewer 10888 32561 3505 7605 166 55.4k
Jean‐Charles Fruchart 10128 15619 2540 4911 380 31.3k
Timothy M. Willson 10605 30944 4446 6869 225 53.2k
Jan L. Breslow 11853 9575 1782 4086 266 29.5k
Hitoshi Shimano 8638 10855 3267 4532 375 23.4k

All Works

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