Standout Papers

Signal integration in the endoplasmic reticulum unfolded protein r... 1999 2026 2008 2017 5.1k
  1. Signal integration in the endoplasmic reticulum unfolded protein response (2007)
    David Ron, Peter Walter Nature Reviews Molecular Cell Biology
  2. The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation (2011)
    Peter Walter, David Ron Science
  3. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase (1999)
    Heather P. Harding, Yuhong Zhang et al. Nature
  4. An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress (2003)
    Heather P. Harding, Yuhong Zhang et al. Molecular Cell
  5. Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells (2000)
    Heather P. Harding, Isabel Novoa et al. Molecular Cell
  6. Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1 (2000)
    Fumihiko Urano, Xiao-Zhong Wang et al. Science
  7. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA (2002)
    Marcella A. Calfon, Huiqing Zeng et al. Nature
  8. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response (2000)
    Anne Bertolotti, Yuhong Zhang et al. Nature Cell Biology
  9. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress (2011)
    Ira Tabas, David Ron Nature Cell Biology
  10. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum (1998)
    Hélène Zinszner, Masahiko Kuroda et al. Genes & Development
  11. Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response (2000)
    Heather P. Harding, Yuhong Zhang et al. Molecular Cell
  12. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum (2004)
    Stefan J. Marciniak, Chi Young Yun et al. Genes & Development
  13. A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress (2005)
    Michael Boyce, Kevin F. Bryant et al. Science
  14. Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α (2001)
    Isabel Novoa, Huiqing Zeng et al. The Journal of Cell Biology
  15. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. (1992)
    David Ron, Joel F. Habener Genes & Development
  16. Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival (2001)
    Heather P. Harding, Huiqing Zeng et al. Molecular Cell
  17. GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase (2005)
    David H. Munn, Madhav Sharma et al. Immunity
  18. Transcriptional and Translational Control in the Mammalian Unfolded Protein Response (2002)
    Heather P. Harding, Marcella A. Calfon et al. Annual Review of Cell and Developmental Biology
  19. Endoplasmic Reticulum Stress Signaling in Disease (2006)
    Stefan J. Marciniak, David Ron Physiological Reviews
  20. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol (2004)
    Yihong Ye, Yoko Shibata et al. Nature
  21. Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase (1996)
    David Ron et al. Science
  22. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response (2004)
    Phoebe D. Lu, Heather P. Harding et al. The Journal of Cell Biology
  23. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma (1993)
    Anne Crozat, Pierre Åman et al. Nature
  24. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages (2003)
    Bo Feng, Pin Mei Yao et al. Nature Cell Biology
  25. Translational control in the endoplasmic reticulum stress response (2002)
    David Ron Journal of Clinical Investigation
  26. Translational control in the endoplasmic reticulum stress response (2002)
    David Ron Journal of Clinical Investigation
  27. Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153) (1996)
    Xiao-Zhong Wang, Joseph W. Brewer et al. Molecular and Cellular Biology
  28. Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes (2008)
    Benbo Song, Donalyn Scheuner et al. Journal of Clinical Investigation
  29. ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth (2005)
    Meixia Bi, Christine Naczki et al. The EMBO Journal
  30. Linking of Autophagy to Ubiquitin-Proteasome System Is Important for the Regulation of Endoplasmic Reticulum Stress and Cell Viability (2007)
    Wen-Xing Ding, Hong-Min Ni et al. American Journal Of Pathology
  31. The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation (2010)
    Jiangbin Ye, Lori S. Hart et al. The EMBO Journal
  32. Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2 (2004)
    Jing Deng, Phoebe D. Lu et al. Molecular and Cellular Biology
  33. Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains (2013)
    Romain Volmer, Kattria van der Ploeg et al. Proceedings of the National Academy of Sciences
  34. Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis (2009)
    Gang Li, Marco Mongillo et al. The Journal of Cell Biology
  35. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule (2012)
    Benedict C. S. Cross, Peter J. Bond et al. Proceedings of the National Academy of Sciences
  36. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. (1994)
    Qian Zhan, K. A. Lord et al. Molecular and Cellular Biology
  37. Pharmacological targeting of endoplasmic reticulum stress in disease (2021)
    Stefan J. Marciniak, Joseph E. Chambers et al. Nature Reviews Drug Discovery

Immediate Impact

10 by Nobel laureates 77 from Science/Nature 170 standout
Sub-graph 1 of 20

Citing Papers

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
The integrated stress response: From mechanism to disease
2020 StandoutScience
115 intermediate papers

Works of David Ron being referenced

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B
2018 Science
Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
2011 Science
and 101 more

Author Peers

Author Last Decade Papers Cites
David Ron 44731 39939 22019 264 73.4k
Randal J. Kaufman 38504 41512 21170 467 80.8k
Kun‐Liang Guan 31416 57090 14056 418 87.4k
Noboru Mizushima 19876 42390 66427 269 92.8k
Heather P. Harding 25369 22068 12490 122 40.3k
Beth Levine 13173 38023 54664 187 82.6k
Peter Walter 24366 33673 10625 300 49.3k
Daniel J. Klionsky 21118 41849 50603 513 80.1k
Keiji Tanaka 11397 37364 19640 427 54.1k
Tamotsu Yoshimori 13934 24133 37620 245 55.0k
Alfred L. Goldberg 17188 49013 10117 365 66.4k

All Works

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