Standout Papers

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1... 2009 2026 2014 2020 4.3k
  1. Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1 (2009)
    Mamta Tahiliani, Kian Peng Koh et al. Science
  2. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage (2016)
    Alexis C. Komor, Michael S. Packer et al. Nature
  3. Search-and-replace genome editing without double-strand breaks or donor DNA (2019)
    Andrew V. Anzalone, Peyton B. Randolph et al. Nature
  4. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage (2017)
    Nicole M. Gaudelli, Alexis C. Komor et al. Nature
  5. Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors (2020)
    Andrew V. Anzalone, Luke W. Koblan et al. Nature Biotechnology
  6. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo (2014)
    John A. Zuris, David B. Thompson et al. Nature Biotechnology
  7. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity (2013)
    Vikram Pattanayak, Steven Lin et al. Nature Biotechnology
  8. Evolved Cas9 variants with broad PAM compatibility and high DNA specificity (2018)
    Johnny H. Hu, Shannon M. Miller et al. Nature
  9. Sequence-Controlled Polymers (2013)
    Jean‐François Lutz, Makoto Ouchi et al. Science
  10. Base editing: precision chemistry on the genome and transcriptome of living cells (2018)
    Holly A. Rees, David R. Liu Nature Reviews Genetics
  11. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes (2016)
    Alexis C. Komor, Ahmed H. Badran et al. Cell
  12. Methods for the directed evolution of proteins (2015)
    Michael S. Packer, David R. Liu Nature Reviews Genetics
  13. Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction (2018)
    Luke W. Koblan, Jordan L. Doman et al. Nature Biotechnology
  14. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification (2014)
    John P. Guilinger, David B. Thompson et al. Nature Biotechnology
  15. A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog (2009)
    Justin K. Ichida, Joel Blanchard et al. Cell stem cell
  16. Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity (2020)
    Michelle F. Richter, Kevin T. Zhao et al. Nature Biotechnology
  17. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions (2017)
    Alexis C. Komor, Jonathan M. Levy et al. Nature Biotechnology
  18. Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein (2016)
    Chi W. Pak, Alex S. Holehouse et al. Molecular Cell
  19. The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing (2010)
    Yun Huang, William A. Pastor et al. PLoS ONE
  20. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity (2017)
    Alexis C. Komor, Kevin T. Zhao et al. Science Advances
  21. Prime genome editing in rice and wheat (2020)
    Qiupeng Lin, Yuan Zong et al. Nature Biotechnology
  22. Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles (2016)
    Ming Wang, John A. Zuris et al. Proceedings of the National Academy of Sciences
  23. A system for the continuous directed evolution of biomolecules (2011)
    Kevin M. Esvelt, David R. Liu et al. Nature
  24. A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing (2020)
    Beverly Mok, Marcos H. de Moraes et al. Nature
  25. DNA‐Templated Organic Synthesis: Nature's Strategy for Controlling Chemical Reactivity Applied to Synthetic Molecules (2004)
    Xiaoyu Li, David R. Liu Angewandte Chemie International Edition
  26. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes (2021)
    Peter J. Chen, Jeffrey A. Hussmann et al. Cell
  27. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents (2017)
    Xue Gao, Yong Tao et al. Nature
  28. Predictable and precise template-free CRISPR editing of pathogenic variants (2018)
    Max W. Shen, Mandana Arbab et al. Nature
  29. Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins (2022)
    Samagya Banskota, Aditya Raguram et al. Cell
  30. Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses (2020)
    Jonathan M. Levy, Wei-Hsi Yeh et al. Nature Biomedical Engineering
  31. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery (2017)
    Holly A. Rees, Alexis C. Komor et al. Nature Communications
  32. Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors (2020)
    Jordan L. Doman, Aditya Raguram et al. Nature Biotechnology
  33. Prime editing for precise and highly versatile genome manipulation (2022)
    Peter J. Chen, David R. Liu Nature Reviews Genetics
  34. Therapeutic in vivo delivery of gene editing agents (2022)
    Aditya Raguram, Samagya Banskota et al. Cell
  35. Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase (2020)
    Christopher Wilson, Peter J. Chen et al. Nature Biotechnology
  36. Massively parallel assessment of human variants with base editor screens (2021)
    Ruth E. Hanna, Mudra Hegde et al. Cell
  37. Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity (2022)
    Monica E. Neugebauer, Alvin Hsu et al. Nature Biotechnology
  38. Phage-assisted evolution and protein engineering yield compact, efficient prime editors (2023)
    Jordan L. Doman, Smriti Pandey et al. Cell
  39. CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA (2022)
    Beverly Mok, Anna V. Kotrys et al. Nature Biotechnology
  40. DNA capture by a CRISPR-Cas9–guided adenine base editor (2020)
    Audronė Lapinaitė, Gavin J. Knott et al. Science
  41. Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors (2022)
    Jessie R. Davis, Xiao Wang et al. Nature Biomedical Engineering
  42. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo (2024)
    Meirui An, Aditya Raguram et al. Nature Biotechnology
  43. Efficient prime editing in mouse brain, liver and heart with dual AAVs (2023)
    Jessie R. Davis, Samagya Banskota et al. Nature Biotechnology
  44. Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice (2023)
    Daniel Reichart, Gregory A. Newby et al. Nature Medicine
  45. Small-molecule discovery through DNA-encoded libraries (2023)
    David R. Liu et al. Nature Reviews Drug Discovery
  46. Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice (2023)
    Kelcee A. Everette, Gregory A. Newby et al. Nature Biomedical Engineering
  47. Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing (2024)
    Smriti Pandey, Xin D. Gao et al. Nature Biomedical Engineering
  48. Branched chemically modified poly(A) tails enhance the translation capacity of mRNA (2024)
    Hongyu Chen, Abhishek Aditham et al. Nature Biotechnology

Immediate Impact

42 by Nobel laureates 98 from Science/Nature 205 standout
Sub-graph 1 of 9

Citing Papers

The road to fully programmable protein catalysis
2022 StandoutNatureNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
102 intermediate papers

Works of David R. Liu being referenced

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
2017 StandoutNature
Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
2016 Standout
and 40 more

Author Peers

Author Last Decade Papers Cites
David R. Liu 45346 10095 3506 4101 274 50.4k
Jonathan S. Weissman 66333 8084 521 3979 289 76.8k
Jennifer A. Doudna 69285 12026 323 7603 355 75.9k
Wendell A. Lim 23512 3965 480 2207 158 30.0k
Phillip A. Sharp 75784 17227 494 5702 428 91.6k
Osamu Nureki 19105 2923 444 1905 362 23.3k
Feng Zhang 74434 14566 216 7552 177 82.9k
Dinshaw J. Patel 44668 3411 2134 5481 555 50.8k
Robert Tjian 55642 13805 621 5474 336 69.0k
Yi Zhang 52178 9200 414 3526 413 59.2k
Hidde L. Ploegh 29898 4445 2561 1120 604 61.2k

All Works

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2026