Standout Papers

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -R... 1999 2026 2008 2017 4.5k
  1. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation (2001)
    Panu Jaakkola, David R. Mole et al. Science
  2. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis (1999)
    Patrick H. Maxwell, Michael S. Wiesener et al. Nature
  3. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation (2001)
    Andrew Epstein, Jonathan Gleadle et al. Cell
  4. Regulation of angiogenesis by hypoxia: role of the HIF system (2003)
    Christopher W. Pugh, Peter J. Ratcliffe Nature Medicine
  5. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. (2000)
    Charles C. Wykoff, Nigel Beasley et al. PubMed
  6. The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages (2000)
    Helen Turley, Kevin C. Gatter et al. American Journal Of Pathology
  7. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth (1997)
    Patrick H. Maxwell, Gabi U. Dachs et al. Proceedings of the National Academy of Sciences
  8. Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein (2000)
    Matthew E. Cockman, Norma Masson et al. Journal of Biological Chemistry
  9. Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor (2004)
    Ya‐Min Tian, Raju R. Raval et al. Journal of Biological Chemistry
  10. Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation (2001)
    Norma Masson, Carsten Willam et al. The EMBO Journal
  11. Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma (2005)
    Raju R. Raval, Maxine Tran et al. Molecular and Cellular Biology
  12. Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL (2002)
    Wai‐Ching Hon, Michael Wilson et al. Nature
  13. Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family (2002)
    Kirsty S. Hewitson, Luke A. McNeill et al. Journal of Biological Chemistry
  14. Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs (2002)
    Michael S. Wiesener, Jan Steffen Jürgensen et al. The FASEB Journal
  15. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq (2011)
    Johannes Schödel, Spyros Oikonomopoulos et al. Blood
  16. Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α (1998)
    Michael S. Wiesener, Helen Turley et al. Blood
  17. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer. (1994)
    J. D. Firth, Benjamin L. Ebert et al. Proceedings of the National Academy of Sciences
  18. Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit (1997)
    Christopher W. Pugh, John F. O’Rourke et al. Journal of Biological Chemistry
  19. Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism. (1993)
    P H Maxwell, Christopher W. Pugh et al. Proceedings of the National Academy of Sciences
  20. Identification of the renal erythropoietin-producing cells using transgenic mice (1993)
    Patrick H. Maxwell, Mark Osmond et al. Kidney International

Immediate Impact

241 by Nobel laureates 56 from Science/Nature 352 standout
Sub-graph 1 of 11

Citing Papers

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
2017 StandoutNature
10 intermediate papers

Works of Christopher W. Pugh being referenced

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
and 17 more

Author Peers

Author Last Decade Papers Cites
Christopher W. Pugh 21532 19067 5142 142 32.0k
Patrick H. Maxwell 21346 19893 5156 208 34.1k
Bing‐Hua Jiang 15985 19202 2972 306 31.1k
M. Celeste Simon 20715 25915 4122 259 46.7k
John M. Asara 11141 23820 2166 287 35.5k
Jacques Pouysségur 12099 28749 2687 368 41.5k
Chi V. Dang 23758 38321 2975 299 52.1k
Matthew G. Vander Heiden 25534 36431 1848 218 53.1k
William G. Kaelin 22252 35237 5899 244 49.6k
Amato J. Giaccia 17174 22859 2567 346 39.7k
Eamonn R. Maher 11620 19136 7556 415 31.7k

All Works

Loading papers...

Rankless by CCL
2026