Standout Papers

p53, the Cellular Gatekeeper for Growth and Division 1990 2026 2002 2014 6.3k
  1. p53, the Cellular Gatekeeper for Growth and Division (1997)
    Arnold J. Levine Cell
  2. Surfing the p53 network (2000)
    Bert Vogelstein, David P. Lane et al. Nature
  3. Stochastic Gene Expression in a Single Cell (2002)
    Michael B. Elowitz, Arnold J. Levine et al. Science
  4. The p53 tumour suppressor gene (1991)
    Arnold J. Levine, Jamil Momand et al. Nature
  5. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 (1990)
    Martin Scheffner, Bruce A. Werness et al. Cell
  6. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation (1992)
    Jamil Momand, Gerard P. Zambetti et al. Cell
  7. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays (1999)
    Uri Alon, Naama Barkai et al. Proceedings of the National Academy of Sciences
  8. Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53 (1990)
    Bruce A. Werness, Arnold J. Levine et al. Science
  9. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor (2003)
    Zhenyu Yue, Xin Jin et al. Proceedings of the National Academy of Sciences
  10. The p53 pathway: positive and negative feedback loops (2005)
    Sandra Harris, Arnold J. Levine Oncogene
  11. The p53-mdm-2 autoregulatory feedback loop. (1993)
    Jun Wu, J. Henri Bayle et al. Genes & Development
  12. Transcriptional control of human p53-regulated genes (2008)
    Todd Riley, Eduardo D. Sontag et al. Nature Reviews Molecular Cell Biology
  13. The first 30 years of p53: growing ever more complex (2009)
    Arnold J. Levine, Moshe Oren Nature reviews. Cancer
  14. Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells (1979)
    Daniel I. H. Linzer, Arnold J. Levine Cell
  15. A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans (2004)
    Gareth L. Bond, Wenwei Hu et al. Cell
  16. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. (1988)
    Cathy A. Finlay, Philip W. Hinds et al. Molecular and Cellular Biology
  17. The coordinate regulation of the p53 and mTOR pathways in cells (2005)
    Zhaohui Feng, Haiyan Zhang et al. Proceedings of the National Academy of Sciences
  18. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis (2006)
    Megan Cully, Han You et al. Nature reviews. Cancer
  19. The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes (2010)
    Arnold J. Levine, Anna M. Puzio‐Kuter Science
  20. Dynamics of the p53-Mdm2 feedback loop in individual cells (2004)
    Galit Lahav, Nitzan Rosenfeld et al. Nature Genetics
  21. Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells (1982)
    Peter Sarnow, Jim Williams et al. Cell
  22. Gain of function mutations in p53 (1993)
    Dirk P. Dittmer, Gerard P. Zambetti et al. Nature Genetics
  23. Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway (2012)
    William A. Freed-Pastor, Hideaki Mizuno et al. Cell
  24. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function (2010)
    Wenwei Hu, Cen Zhang et al. Proceedings of the National Academy of Sciences
  25. Mapping of the p53 and mdm-2 interaction domains. (1993)
    Jiandong Chen, Vincent Maréchal et al. Molecular and Cellular Biology
  26. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. (1994)
    Jiayuh Lin, Brian Elenbaas et al. Genes & Development
  27. The Regulation of Exosome Secretion: a Novel Function of the p53 Protein (2006)
    Xin Yu, Sandra Harris et al. Cancer Research
  28. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays (2000)
    Renbin Zhao, Kurt Gish et al. Genes & Development
  29. The P53 pathway: what questions remain to be explored? (2006)
    Arnold J. Levine, Wenwei Hu et al. Cell Death and Differentiation
  30. The genetics of the p53 pathway, apoptosis and cancer therapy (2008)
    Alexei Vázquez, Elisabeth E. Bond et al. Nature Reviews Drug Discovery
  31. Interaction between the retinoblastoma protein and the oncoprotein MDM2 (1995)
    Jiandong Chen, Arnold J. Levine et al. Nature
  32. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation (1989)
    Philip W. Hinds, Cathy A. Finlay et al. Journal of Virology
  33. p53: 800 million years of evolution and 40 years of discovery (2020)
    Arnold J. Levine Nature reviews. Cancer
  34. A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy (2017)
    Marta Łuksza, Nadeem Riaz et al. Nature
  35. Why are there hotspot mutations in the TP53 gene in human cancers? (2017)
    Evan H. Baugh, Hua Zhu Ke et al. Cell Death and Differentiation

Immediate Impact

32 by Nobel laureates 146 from Science/Nature 271 standout
Sub-graph 1 of 15

Citing Papers

Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
22 intermediate papers

Works of Arnold J. Levine being referenced

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
2010 Standout
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1992 Standout
and 38 more

Author Peers

Author Last Decade Papers Cites
Arnold J. Levine 59816 45342 11469 15872 437 88.9k
Tyler Jacks 58358 33760 5999 26145 336 86.1k
David P. Lane 37043 31996 4881 8635 606 57.0k
Scott W. Lowe 49438 22670 4162 16688 324 68.3k
Douglas Hanahan 78402 43041 13213 35907 224 134.4k
Stephen J. Elledge 75009 27392 9992 13658 360 91.4k
Joan Massagué 94714 46583 9178 22328 356 135.6k
Kenneth W. Kinzler 78978 48789 14694 37023 377 130.0k
John C. Reed 72596 21174 6028 12113 788 106.2k
Hans Clevers 96581 52291 23870 18194 721 156.0k
John D. Minna 41701 26002 6051 13132 784 72.6k

All Works

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