Yoshimitsu Akiyama

7.9k total citations · 1 hit paper
97 papers, 5.8k citations indexed

About

Yoshimitsu Akiyama is a scholar working on Molecular Biology, Pathology and Forensic Medicine and Oncology. According to data from OpenAlex, Yoshimitsu Akiyama has authored 97 papers receiving a total of 5.8k indexed citations (citations by other indexed papers that have themselves been cited), including 63 papers in Molecular Biology, 39 papers in Pathology and Forensic Medicine and 34 papers in Oncology. Recurrent topics in Yoshimitsu Akiyama's work include Genetic factors in colorectal cancer (35 papers), Epigenetics and DNA Methylation (25 papers) and Cancer-related gene regulation (23 papers). Yoshimitsu Akiyama is often cited by papers focused on Genetic factors in colorectal cancer (35 papers), Epigenetics and DNA Methylation (25 papers) and Cancer-related gene regulation (23 papers). Yoshimitsu Akiyama collaborates with scholars based in Japan, United States and China. Yoshimitsu Akiyama's co-authors include Yasuhito Yuasa, Yutaka Hashimoto, Shu Shimada, Stephen B. Baylin, Takeshi Otsubo, James G. Herman, Manon van Engeland, Hiromu Suzuki, Kam-Wing Jair and Kazuyoshi Yanagihara and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Nature Genetics and Gastroenterology.

In The Last Decade

Yoshimitsu Akiyama

97 papers receiving 5.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

2004 858 citations Yoshimitsu Akiyama, Manon van Engeland et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Yoshimitsu Akiyama Japan	42	4.2k	1.6k	1.4k	1.2k	801	97	5.8k
Ralf Bützow Finland	53	3.0k 0.7×	1.6k 1.0×	1.8k 1.3×	1.3k 1.1×	505 0.6×	188	7.4k
Roland P. Kuiper Netherlands	35	2.6k 0.6×	1.1k 0.7×	1.1k 0.8×	1.1k 0.9×	275 0.3×	123	5.4k
Wolfgang Dietmaier Germany	41	2.5k 0.6×	1.4k 0.9×	2.3k 1.6×	1.9k 1.6×	1.4k 1.7×	135	6.2k
Raffaele Baffa United States	43	4.5k 1.1×	1.7k 1.0×	1.3k 0.9×	669 0.6×	1.1k 1.4×	98	6.6k
Svetlana Pack United States	47	3.1k 0.7×	1.1k 0.7×	1.5k 1.1×	690 0.6×	933 1.2×	130	6.5k
Juan C. Cigudosa Spain	43	3.4k 0.8×	1.2k 0.8×	1.5k 1.1×	1.2k 1.0×	224 0.3×	149	6.0k
Alex Duval France	40	2.0k 0.5×	1.6k 1.0×	2.4k 1.7×	3.0k 2.5×	724 0.9×	101	5.0k
Martina Olivero Italy	33	3.0k 0.7×	813 0.5×	1.5k 1.0×	572 0.5×	958 1.2×	80	5.6k
Michael T. Barrett United States	34	1.9k 0.5×	1.1k 0.7×	1.4k 1.0×	608 0.5×	965 1.2×	99	4.2k
Michel Longy France	35	2.4k 0.6×	864 0.5×	1.3k 0.9×	1.0k 0.8×	256 0.3×	93	4.0k

Countries citing papers authored by Yoshimitsu Akiyama

Since Specialization

Citations

This map shows the geographic impact of Yoshimitsu Akiyama's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Yoshimitsu Akiyama with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Yoshimitsu Akiyama more than expected).

Fields of papers citing papers by Yoshimitsu Akiyama

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Yoshimitsu Akiyama. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Yoshimitsu Akiyama. The network helps show where Yoshimitsu Akiyama may publish in the future.

Co-authorship network of co-authors of Yoshimitsu Akiyama

This figure shows the co-authorship network connecting the top 25 collaborators of Yoshimitsu Akiyama. A scholar is included among the top collaborators of Yoshimitsu Akiyama based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Yoshimitsu Akiyama. Yoshimitsu Akiyama is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Akiyama, Yoshimitsu, Tomohiko Taniai, Keisuke Okuno, et al.. (2024). Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer. Oncogene. 44(11). 724–738. 13 indexed citations

Ono, Hiroaki, Yoshiya Ishikawa, Shuichi Watanabe, et al.. (2023). RRM1 is mediated by histone acetylation through gemcitabine resistance and contributes to invasiveness and ECM remodeling in pancreatic cancer. International Journal of Oncology. 62(4). 11 indexed citations

Asakawa, M, Michiko Itoh, Takayoshi Suganami, et al.. (2019). Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis. Scientific Reports. 9(1). 19601–19601. 19 indexed citations

Mizuno, Yuki, Shu Shimada, Yoshimitsu Akiyama, et al.. (2018). DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma. Scientific Reports. 8(1). 106–106. 18 indexed citations

Watanabe, Shuichi, Shu Shimada, Yoshimitsu Akiyama, et al.. (2018). Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality. International Journal of Cancer. 145(1). 192–205. 48 indexed citations

Shimada, Shu, Yoshimitsu Akiyama, Kaoru Mogushi, et al.. (2017). Acquired Resistance with Epigenetic Alterations Under Long-Term Antiangiogenic Therapy for Hepatocellular Carcinoma. Molecular Cancer Therapeutics. 16(6). 1155–1165. 34 indexed citations

Lentjes, Marjolein H.F.M., Hanneke E.C. Niessen, Yoshimitsu Akiyama, et al.. (2016). The emerging role of GATA transcription factors in development and disease. Expert Reviews in Molecular Medicine. 18. e3–e3. 171 indexed citations

Tanaka, Shinji, Shu Shimada, Yoshimitsu Akiyama, et al.. (2016). Proteasome activity is required for the initiation of precancerous pancreatic lesions. Scientific Reports. 6(1). 27044–27044. 6 indexed citations

Seol, Hyang Sook, Yoshimitsu Akiyama, Shu Shimada, et al.. (2014). Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes. Cancer Letters. 353(2). 232–241. 53 indexed citations

10.

Otsubo, Takeshi, Yoshimitsu Akiyama, Yutaka Hashimoto, et al.. (2011). MicroRNA-126 Inhibits SOX2 Expression and Contributes to Gastric Carcinogenesis. PLoS ONE. 6(1). e16617–e16617. 141 indexed citations

11.

Otsubo, Takeshi, Yoshimitsu Akiyama, Kazuyoshi Yanagihara, & Yasuhito Yuasa. (2008). SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. British Journal of Cancer. 98(4). 824–831. 186 indexed citations

12.

Bai, Yun-Qing, Hiroshi Yamamoto, Yoshimitsu Akiyama, et al.. (2002). Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Letters. 176(1). 47–55. 181 indexed citations

13.

Nakajima, Tomoko, Yoshimitsu Akiyama, Junichi Shiraishi, et al.. (2001). Age-related hypermethylation of thehMLH1 promoter in gastric cancers. International Journal of Cancer. 94(2). 208–211. 63 indexed citations

14.

Akiyama, Yoshimitsu, et al.. (2000). Distinct Expression ofCDX2 andGATA4/5, Development-Related Genes, in Human Gastric Cancer Cell Lines. Molecular Carcinogenesis. 28(3). 184–188. 48 indexed citations

15.

Yanagisawa, Yuka, Yoshimitsu Akiyama, Satoru Iida, et al.. (2000). Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability. International Journal of Cancer. 85(1). 50–53. 5 indexed citations

16.

Yanagisawa, Yuka, Yoshimitsu Akiyama, Satoru Iida, et al.. (2000). Methylation of thehMLH1 promoter in familial gastric cancer with microsatellite instability. International Journal of Cancer. 85(1). 50–53. 29 indexed citations

17.

Akiyama, Yoshimitsu, Hiromi Nagasaki, Kenji Yagi, Tadashi Nomizu, & Yasuhito Yuasa. (2000). β-Catenin and adenomatous polyposis coli (APC) mutations in adenomas from hereditary non-polyposis colorectal cancer patients. Cancer Letters. 157(2). 185–191. 19 indexed citations

18.

Arai, Takehiro, et al.. (1998). Allelotype analysis of early colorectal cancers with lymph node metastasis. International Journal of Cancer. 79(4). 418–423. 23 indexed citations

19.

Akiyama, Yoshimitsu, Ritsuko Iwanaga, Tomoko Ishikawa, et al.. (1996). Mutations of the transforming growth factor-β type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability. Cancer. 78(12). 2478–2484. 47 indexed citations

20.

Lu, Shi‐Long, Yoshimitsu Akiyama, H. Nagasaki, Kiyoshi Saitoh, & Yasuhito Yuasa. (1995). Mutations of the Transforming Growth Factor-β Type II Receptor Gene and Genomic Instability in Hereditary Nonpolyposis Colorectal Cancer. Biochemical and Biophysical Research Communications. 216(2). 452–457. 87 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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