William R. Jacobs

53.7k total citations · 9 hit papers
457 papers, 39.7k citations indexed

About

William R. Jacobs is a scholar working on Infectious Diseases, Epidemiology and Molecular Biology. According to data from OpenAlex, William R. Jacobs has authored 457 papers receiving a total of 39.7k indexed citations (citations by other indexed papers that have themselves been cited), including 303 papers in Infectious Diseases, 288 papers in Epidemiology and 134 papers in Molecular Biology. Recurrent topics in William R. Jacobs's work include Tuberculosis Research and Epidemiology (291 papers), Mycobacterium research and diagnosis (241 papers) and Bacteriophages and microbial interactions (73 papers). William R. Jacobs is often cited by papers focused on Tuberculosis Research and Epidemiology (291 papers), Mycobacterium research and diagnosis (241 papers) and Bacteriophages and microbial interactions (73 papers). William R. Jacobs collaborates with scholars based in United States, United Kingdom and France. William R. Jacobs's co-authors include Catherine Vilchèze, James C. Sacchettini, Barry R. Bloom, Graham F. Hatfull, Scott B. Snapper, Michael S. Glickman, Bing Chen, Jeffery S. Cox, John Chan and Laurent Kremer and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

William R. Jacobs

449 papers receiving 38.8k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

New use of BCG for recombinant vaccines

1991 1.3k citations Graham F. Hatfull, William R. Jacobs et al. profile →
inhA , a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis

1994 1.1k citations William R. Jacobs et al. profile →
Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis

1990 1.1k citations William R. Jacobs et al. profile →
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

2000 1.0k citations James C. Sacchettini, William R. Jacobs et al. profile →
An Outbreak of Tuberculosis with Accelerated Progression among Persons Infected with the Human Immunodeficiency Virus

1992 762 citations William R. Jacobs et al. profile →
Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

1999 588 citations Bing Chen, William R. Jacobs et al. profile →
The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue

2003 579 citations Tsungda Hsu, Bing Chen et al. Proceedings of the National Academy of Sciences profile →
Modification of the NADH of the Isoniazid Target (InhA) from Mycobacterium tuberculosis

1998 564 citations William R. Jacobs, James C. Sacchettini et al. profile →
A Novel Mycolic Acid Cyclopropane Synthetase Is Required for Cording, Persistence, and Virulence of Mycobacterium tuberculosis

2000 507 citations Michael S. Glickman, William R. Jacobs et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
William R. Jacobs	24.5k	20.8k	15.3k	5.1k	4.7k	457	39.7k
Stewart T. Cole	18.7k 0.8×	15.6k 0.7×	10.9k 0.7×	3.2k 0.6×	2.2k 0.5×	358	29.7k
Clifton E. Barry	19.4k 0.8×	14.5k 0.7×	11.2k 0.7×	2.9k 0.6×	1.0k 0.2×	287	28.9k
Michaël Otto	19.7k 0.8×	4.7k 0.2×	23.2k 1.5×	3.5k 0.7×	2.0k 0.4×	382	39.6k
Gurdyal S. Besra	10.6k 0.4×	10.1k 0.5×	11.8k 0.8×	11.2k 2.2×	1.2k 0.2×	516	31.4k
Brigitte Gicquel	14.3k 0.6×	12.9k 0.6×	5.3k 0.3×	3.9k 0.8×	1.6k 0.3×	255	20.6k
Barry R. Bloom	13.9k 0.6×	13.4k 0.6×	7.0k 0.5×	14.1k 2.8×	1.7k 0.4×	333	33.8k
Vojo Deretić	6.0k 0.2×	16.3k 0.8×	15.0k 1.0×	6.6k 1.3×	1.2k 0.3×	241	33.0k
Eric J. Rubin	9.6k 0.4×	7.2k 0.3×	9.1k 0.6×	1.8k 0.4×	2.0k 0.4×	263	18.1k
Alexander Tomasz	13.6k 0.6×	10.1k 0.5×	11.5k 0.8×	2.0k 0.4×	2.1k 0.4×	382	29.6k
Victor Nizet	8.5k 0.3×	6.6k 0.3×	15.3k 1.0×	11.4k 2.2×	1.2k 0.2×	564	43.2k

Countries citing papers authored by William R. Jacobs

Since Specialization

Citations

This map shows the geographic impact of William R. Jacobs's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William R. Jacobs with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William R. Jacobs more than expected).

Fields of papers citing papers by William R. Jacobs

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William R. Jacobs. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William R. Jacobs. The network helps show where William R. Jacobs may publish in the future.

Co-authorship network of co-authors of William R. Jacobs

This figure shows the co-authorship network connecting the top 25 collaborators of William R. Jacobs. A scholar is included among the top collaborators of William R. Jacobs based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William R. Jacobs. William R. Jacobs is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Saranathan, Rajagopalan, et al.. (2025). Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2. Science Advances. 11(27). eadw5194–eadw5194.

Saranathan, Rajagopalan, Shichun Lun, Catherine Vilchèze, et al.. (2025). Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion. Proceedings of the National Academy of Sciences. 122(36). e2509997122–e2509997122. 1 indexed citations

Saranathan, Rajagopalan, et al.. (2024). The SapM phosphatase can arrest phagosome maturation in an ESX-1 independent manner in Mycobacterium tuberculosis and BCG. Infection and Immunity. 92(7). e0021724–e0021724. 4 indexed citations

Ng, Tony W., Wakako Furuyama, Ariel S. Wirchnianski, et al.. (2024). A viral vaccine design harnessing prior BCG immunization confers protection against Ebola virus. Frontiers in Immunology. 15. 1429909–1429909. 1 indexed citations

Vilchèze, Catherine, Jim Werngren, Arnold Bainomugisa, et al.. (2023). Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 68(1). e0109623–e0109623. 2 indexed citations

Jacobs, William R., et al.. (2023). The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions. Journal of Clinical Investigation. 133(19). 9 indexed citations

Wang, Lin, Amol C. Shetty, Megan R. Edwards, et al.. (2022). Multiple genetic paths including massive gene amplification allow Mycobacterium tuberculosis to overcome loss of ESX-3 secretion system substrates. Proceedings of the National Academy of Sciences. 119(8). 17 indexed citations

Aschner, Clare Burn, Benjamin Galen, Rohit K. Jangra, et al.. (2020). HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses. Science Immunology. 5(50). 14 indexed citations

Morrissey, Christopher A., et al.. (2020). Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates. eLife. 9. 27 indexed citations

10.

Vilchèze, Catherine, Travis Hartman, Brian Weinrick, et al.. (2017). Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences. 114(17). 4495–4500. 135 indexed citations

11.

Qaqish, Arwa, Dan Huang, Crystal Y. Chen, et al.. (2017). Adoptive Transfer of Phosphoantigen-Specific γδ T Cell Subset Attenuates Mycobacterium tuberculosis Infection in Nonhuman Primates. The Journal of Immunology. 198(12). 4753–4763. 59 indexed citations

12.

Jensen, Kara, Rafiq Nabi, Koen K. A. Van Rompay, et al.. (2016). Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques. Journal of Virology. 90(16). 7285–7302. 24 indexed citations

13.

Trujillo, Carolina, Karl Syson, Hendrik Koliwer‐Brandl, et al.. (2016). Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice. PLoS Pathogens. 12(12). e1006043–e1006043. 28 indexed citations

14.

Vilchèze, Catherine, et al.. (2012). Anthelmintic Avermectins Kill Mycobacterium tuberculosis, Including Multidrug-Resistant Clinical Strains. Antimicrobial Agents and Chemotherapy. 57(2). 1040–1046. 104 indexed citations

15.

Jain, Paras, David S. Thaler, Mamoudou Maïga, et al.. (2011). Reporter Phage and Breath Tests: Emerging Phenotypic Assays for Diagnosing Active Tuberculosis, Antibiotic Resistance, and Treatment Efficacy. The Journal of Infectious Diseases. 204(suppl_4). S1142–S1150. 24 indexed citations

16.

Kalscheuer, Rainer, Brian Weinrick, Veeraraghavan Usha, Gurdyal S. Besra, & William R. Jacobs. (2010). Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences. 107(50). 21761–21766. 151 indexed citations

17.

Venkataswamy, Manjunatha M., Andrés Baena, Michael F. Goldberg, et al.. (2009). Incorporation of NKT Cell-Activating Glycolipids Enhances Immunogenicity and Vaccine Efficacy of Mycobacterium bovis Bacillus Calmette-Guérin. The Journal of Immunology. 183(3). 1644–1656. 64 indexed citations

18.

Chen, Bing, Jessica L. Miller, Serdar A. Gurses, et al.. (2007). Mycobacterium tuberculosis nuoG Is a Virulence Gene That Inhibits Apoptosis of Infected Host Cells. PLoS Pathogens. 3(7). e110–e110. 256 indexed citations

19.

Kuo, Mack, Héctor R. Morbidoni, David Alland, et al.. (2003). Targeting Tuberculosis and Malaria through Inhibition of Enoyl Reductase. Journal of Biological Chemistry. 278(23). 20851–20859. 218 indexed citations

20.

Andrews, Frank M., et al.. (1992). Comparison of standard and radionuclide methods for measurement of glomerular filtration rate and effective renal blood flow in female horses. American Journal of Veterinary Research. 53(9). 1612–1616. 22 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact