William R. Jacobs

53.7k total citations · 9 hit papers
457 papers, 39.7k citations indexed

About

William R. Jacobs is a scholar working on Infectious Diseases, Epidemiology and Molecular Biology. According to data from OpenAlex, William R. Jacobs has authored 457 papers receiving a total of 39.7k indexed citations (citations by other indexed papers that have themselves been cited), including 303 papers in Infectious Diseases, 288 papers in Epidemiology and 134 papers in Molecular Biology. Recurrent topics in William R. Jacobs's work include Tuberculosis Research and Epidemiology (291 papers), Mycobacterium research and diagnosis (241 papers) and Bacteriophages and microbial interactions (73 papers). William R. Jacobs is often cited by papers focused on Tuberculosis Research and Epidemiology (291 papers), Mycobacterium research and diagnosis (241 papers) and Bacteriophages and microbial interactions (73 papers). William R. Jacobs collaborates with scholars based in United States, United Kingdom and France. William R. Jacobs's co-authors include Catherine Vilchèze, James C. Sacchettini, Barry R. Bloom, Graham F. Hatfull, Scott B. Snapper, Michael S. Glickman, Bing Chen, Jeffery S. Cox, John Chan and Laurent Kremer and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

William R. Jacobs

449 papers receiving 38.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

New use of BCG for recombinant vaccines

1991 1.3k citations Graham F. Hatfull, William R. Jacobs et al. profile →
inhA , a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis

1994 1.1k citations William R. Jacobs et al. profile →
Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis

1990 1.1k citations William R. Jacobs et al. Molecular Microbiology profile →
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

2000 1.0k citations James C. Sacchettini, William R. Jacobs et al. profile →
An Outbreak of Tuberculosis with Accelerated Progression among Persons Infected with the Human Immunodeficiency Virus

1992 762 citations William R. Jacobs et al. profile →
Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

1999 588 citations Bing Chen, William R. Jacobs et al. profile →
The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue

2003 579 citations Tsungda Hsu, Bing Chen et al. Proceedings of the National Academy of Sciences profile →
Modification of the NADH of the Isoniazid Target (InhA) from Mycobacterium tuberculosis

1998 564 citations William R. Jacobs, James C. Sacchettini et al. profile →
A Novel Mycolic Acid Cyclopropane Synthetase Is Required for Cording, Persistence, and Virulence of Mycobacterium tuberculosis

2000 507 citations Michael S. Glickman, William R. Jacobs et al. profile →

Peers

Countries citing papers authored by William R. Jacobs

Since Specialization

Citations

This map shows the geographic impact of William R. Jacobs's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William R. Jacobs with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William R. Jacobs more than expected).

Fields of papers citing papers by William R. Jacobs

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William R. Jacobs. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William R. Jacobs. The network helps show where William R. Jacobs may publish in the future.

Co-authorship network of co-authors of William R. Jacobs

This figure shows the co-authorship network connecting the top 25 collaborators of William R. Jacobs. A scholar is included among the top collaborators of William R. Jacobs based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William R. Jacobs. William R. Jacobs is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2 2025 ·Science Advances ·(unknown), (unknown), Rajagopalan Saranathan, (unknown), (unknown), Manish Gupta, Jessica Shen, William R. Jacobs, William R. Bishai	0
2	Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion 2025 ·Proceedings of the National Academy of Sciences ·(unknown), Rajagopalan Saranathan, (unknown), Shichun Lun, Catherine Vilchèze, (unknown), Manish Gupta, (unknown), William R. Bishai, William R. Jacobs	1
3	The SapM phosphatase can arrest phagosome maturation in an ESX-1 independent manner in Mycobacterium tuberculosis and BCG 2024 ·Infection and Immunity ·(unknown), Rajagopalan Saranathan, William R. Jacobs, Miriam Braunstein	4
4	A viral vaccine design harnessing prior BCG immunization confers protection against Ebola virus 2024 ·Frontiers in Immunology ·Tony W. Ng, Wakako Furuyama, Ariel S. Wirchnianski, (unknown), (unknown), Kartik Chandran, William R. Jacobs, Andrea Marzi, Steven A. Porcelli	1
5	Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis 2023 ·Antimicrobial Agents and Chemotherapy ·(unknown), Catherine Vilchèze, Jim Werngren, Arnold Bainomugisa, Mikael Mansjö, Ramona Groenheit, Paolo Miotto, Daniela María Cirillo, Christopher Coulter, Alain R. Baulard, Thomas Schön, William R. Jacobs, (unknown), Claudio U. Köser	2
6	The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions 2023 ·Journal of Clinical Investigation ·(unknown), William R. Jacobs, William R. Bishai	9
7	Multiple genetic paths including massive gene amplification allow Mycobacterium tuberculosis to overcome loss of ESX-3 secretion system substrates 2022 ·Proceedings of the National Academy of Sciences ·Lin Wang, (unknown), Amol C. Shetty, (unknown), Megan R. Edwards, Rajagopalan Saranathan, Brian Weinrick, Jiayong Xu, Bing Chen, Angèle Bénard, Gordon Dougan, Daisy W. Leung, Gaya K. Amarasinghe, John Chan, Christopher F. Basler, William R. Jacobs, JoAnn M. Tufariello	17
8	HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses 2020 ·Science Immunology ·Clare Burn Aschner, (unknown), Benjamin Galen, (unknown), Rohit K. Jangra, S. Garforth, Kartik Chandran, Steven C. Almo, William R. Jacobs, Carl F. Ware, Betsy C. Herold	14
9	Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis 2017 ·Proceedings of the National Academy of Sciences ·Catherine Vilchèze, Travis Hartman, Brian Weinrick, Paras Jain, Torin R. Weisbrod, Lawrence W. Leung, Joel S. Freundlich, William R. Jacobs	135
10	Adoptive Transfer of Phosphoantigen-Specific γδ T Cell Subset Attenuates Mycobacterium tuberculosis Infection in Nonhuman Primates 2017 ·The Journal of Immunology ·Arwa Qaqish, Dan Huang, Crystal Y. Chen, Zhuoran Zhang, Richard Wang, (unknown), (unknown), Lü Yang, Michelle H. Larsen, William R. Jacobs, (unknown), (unknown), Ling Shen, Zheng W. Chen	59
11	Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques 2016 ·Journal of Virology ·Kara Jensen, Rafiq Nabi, Koen K. A. Van Rompay, (unknown), Jeffrey D. Lifson, Michael Piatak, William R. Jacobs, Glenn J. Fennelly, Don R. Canfield, Katie R. Mollan, Michael G. Hudgens, Michelle H. Larsen, Angela M. Amedee, Pamela A. Kozlowski, Kristina De Paris	24
12	Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice 2016 ·PLoS Pathogens ·(unknown), (unknown), Carolina Trujillo, Karl Syson, Hendrik Koliwer‐Brandl, René Deenen, Karl Köhrer, Michael A. DeJesus, Travis Hartman, William R. Jacobs, Stephen Bornemann, Thomas R. Ioerger, Sabine Ehrt, Rainer Kalscheuer	28
13	Specialized Transduction Designed for Precise High-Throughput Unmarked Deletions in Mycobacterium tuberculosis 2014 ·mBio ·Paras Jain, Tsungda Hsu, Masayoshi Arai, Karolin Biermann, David S. Thaler, Andrew Nguyen, Pablo A. González, JoAnn M. Tufariello, Jordan Kriakov, Bing Chen, Michelle H. Larsen, William R. Jacobs	123
14	Anthelmintic Avermectins Kill Mycobacterium tuberculosis, Including Multidrug-Resistant Clinical Strains 2012 ·Antimicrobial Agents and Chemotherapy ·(unknown), Catherine Vilchèze, (unknown), William R. Jacobs, Santiago Ramón‐García, Charles J. Thompson	104
15	Reporter Phage and Breath Tests: Emerging Phenotypic Assays for Diagnosing Active Tuberculosis, Antibiotic Resistance, and Treatment Efficacy 2011 ·The Journal of Infectious Diseases ·Paras Jain, David S. Thaler, Mamoudou Maïga, Graham S. Timmins, William R. Bishai, Graham F. Hatfull, Michelle H. Larsen, William R. Jacobs	24
16	Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis 2010 ·Proceedings of the National Academy of Sciences ·Rainer Kalscheuer, Brian Weinrick, Veeraraghavan Usha, Gurdyal S. Besra, William R. Jacobs	151
17	Mycobacterium tuberculosis nuoG Is a Virulence Gene That Inhibits Apoptosis of Infected Host Cells 2007 ·PLoS Pathogens ·(unknown), Bing Chen, Jessica L. Miller, (unknown), Serdar A. Gurses, Tsungda Hsu, Michael S. Glickman, William R. Jacobs, Steven A. Porcelli, Volker Briken	256
18	The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol 2005 ·Molecular Microbiology ·Roberto Colangeli, (unknown), Sudharsan Sridharan, Jingchuan Sun, Mandira Varma‐Basil, Manzour Hernando Hazbón, Ryhor Harbacheuski, Nicholas J. Megjugorac, William R. Jacobs, Andreas Holzenburg, James C. Sacchettini, David Alland	140
19	Targeting Tuberculosis and Malaria through Inhibition of Enoyl Reductase 2003 ·Journal of Biological Chemistry ·Mack Kuo, Héctor R. Morbidoni, David Alland, Scott Sneddon, Brian B. Gourlie, (unknown), (unknown), Jill S. Gregory, (unknown), Christopher Yee, James M. Musser, Barry N. Kreiswirth, Hiroyuki Iwamoto, Remo Perozzo, William R. Jacobs, James C. Sacchettini, David A. Fidock	218
20	Comparison of standard and radionuclide methods for measurement of glomerular filtration rate and effective renal blood flow in female horses 1992 ·American Journal of Veterinary Research ·(unknown), Frank M. Andrews, Gregory B. Daniel, William R. Jacobs, (unknown)	22

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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