W. Jeffrey Howe

2.3k total citations
35 papers, 1.6k citations indexed

About

W. Jeffrey Howe is a scholar working on Infectious Diseases, Molecular Biology and Organic Chemistry. According to data from OpenAlex, W. Jeffrey Howe has authored 35 papers receiving a total of 1.6k indexed citations (citations by other indexed papers that have themselves been cited), including 14 papers in Infectious Diseases, 14 papers in Molecular Biology and 10 papers in Organic Chemistry. Recurrent topics in W. Jeffrey Howe's work include HIV/AIDS drug development and treatment (14 papers), Chemical Synthesis and Analysis (10 papers) and HIV Research and Treatment (8 papers). W. Jeffrey Howe is often cited by papers focused on HIV/AIDS drug development and treatment (14 papers), Chemical Synthesis and Analysis (10 papers) and HIV Research and Treatment (8 papers). W. Jeffrey Howe collaborates with scholars based in United States. W. Jeffrey Howe's co-authors include Joseph B. Moon, E. J. Corey, Robert L. Heinrikson, Paul K. Tomich, Ilene M. Reardon, Suvit Thaisrivongs, Keith David Watenpaugh, Kuo‐Chen Chou, Richard D. Cramer and Kong-Teck Chong and has published in prestigious journals such as Journal of the American Chemical Society, Journal of Biological Chemistry and Analytical Chemistry.

In The Last Decade

W. Jeffrey Howe

35 papers receiving 1.5k citations

Peers

Countries citing papers authored by W. Jeffrey Howe

Since Specialization

Citations

This map shows the geographic impact of W. Jeffrey Howe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by W. Jeffrey Howe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites W. Jeffrey Howe more than expected).

Fields of papers citing papers by W. Jeffrey Howe

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by W. Jeffrey Howe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by W. Jeffrey Howe. The network helps show where W. Jeffrey Howe may publish in the future.

Co-authorship network of co-authors of W. Jeffrey Howe

This figure shows the co-authorship network connecting the top 25 collaborators of W. Jeffrey Howe. A scholar is included among the top collaborators of W. Jeffrey Howe based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with W. Jeffrey Howe. W. Jeffrey Howe is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Prediction of the Tertiary Structure of the β-Secretase Zymogen 2002 ·Biochemical and Biophysical Research Communications ·Kuo‐Chen Chou, W. Jeffrey Howe	77
2	Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors 1996 ·Journal of Medicinal Chemistry ·Suvit Thaisrivongs, Donna L. Romero, Rubén Tommasi, Musiri N. Janakiraman, Joseph W. Strohbach, Steve R. Turner, Carolyn Biles, (unknown), Paul D. Johnson, Paul A. Aristoff, Paul K. Tomich, Janet C. Lynn, Miao-Miao Horng, Kong-Teck Chong, Roger R. Hinshaw, W. Jeffrey Howe, B.C. Finzel, Keith David Watenpaugh	65
3	Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors 1995 ·Journal of Medicinal Chemistry ·Karen R. Romines, Keith David Watenpaugh, Paul K. Tomich, W. Jeffrey Howe, Jeanette K. Morris, (unknown), A. M. Mulichak, B.C. Finzel, Janet C. Lynn	52
4	Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure 1995 ·Journal of Medicinal Chemistry ·(unknown), Keith David Watenpaugh, W. Jeffrey Howe, Paul K. Tomich, (unknown), Joel Morris, Musiri N. Janakiraman, Janet C. Lynn, Miao-Miao Horng	17
5	Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors 1995 ·Journal of Medicinal Chemistry ·Harvey I. Skulnick, Paul D. Johnson, W. Jeffrey Howe, Paul K. Tomich, (unknown), Keith David Watenpaugh, Musiri N. Janakiraman, Lester A. Dolak, (unknown)	42
6	CXC Chemokines Connective Tissue Activating Peptide-III and Neutrophil Activating Peptide-2 are Heparin/Heparan Sulfate-degrading Enzymes 1995 ·Journal of Biological Chemistry ·Arlene J. Hoogewerf, Joseph W. Leone, Ilene M. Reardon, W. Jeffrey Howe, Darwin Asa, Robert L. Heinrikson, Steven Ledbetter	87
7	Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors 1995 ·Journal of Medicinal Chemistry ·Suvit Thaisrivongs, Keith David Watenpaugh, W. Jeffrey Howe, Paul K. Tomich, Lester A. Dolak, Kong-Teck Chong, (unknown), Alfredo G. Tomasselli, Steve R. Turner	103
8	The HIV-1 Protease as Enzyme and Substrate: Mutagenesis of Autolysis Sites and Generation of a Stable Mutant with Retained Kinetic Properties 1994 ·Biochemistry ·Ana M. Mildner, (unknown), Joseph W. Leone, Carol A. Bannow, June M. Lull, Ilene M. Reardon, (unknown), W. Jeffrey Howe, (unknown)	113
9	Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors 1994 ·Journal of Medicinal Chemistry ·Suvit Thaisrivongs, Paul K. Tomich, Keith David Watenpaugh, Kong-Teck Chong, W. Jeffrey Howe, Chih-Ping Yang, Joseph W. Strohbach, (unknown), (unknown)	113
10	Human immunodeficiency virus type‐1 reverse transcriptase and ribonuclease h as substrates of the viral protease 1993 ·Protein Science ·Alfredo G. Tomasselli, (unknown), (unknown), Ilene M. Reardon, W. Jeffrey Howe, David Evans, Satish Kumar Sharma, Robert L. Heinrikson	31
11	Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere 1993 ·Journal of Medicinal Chemistry ·Suvit Thaisrivongs, (unknown), Joseph W. Strohbach, Ruth E. TenBrink, W. Gary Tarpley, (unknown), Robert L. Heinrikson, Alfredo G. Tomasselli, John O. Hui, W. Jeffrey Howe	23
12	Crystal structure of a complex of HIV‐1 protease with a dihydroxyethylene‐containing inhibitor: Comparisons with molecular modeling 1992 ·Protein Science ·Narmada Thanki, Jayasimha Rao, Stephen I. Foundling, Alexander Wlodawer, W. Jeffrey Howe, Joseph B. Moon, John O. Hui, Alfredo G. Tomasselli, Robert L. Heinrikson, Suvit Thaisrivongs	60
13	HIV protease (HIV PR) inhibitor structure‐activity‐selectivity, and active site molecular modeling of high affinity Leu [CH(OH)CH₂]Val modified viral and nonviral substrate analogs 1992 ·International journal of peptide & protein research ·Tomi K. Sawyer, Douglas J. Staples, Li Liu, Alfredo G. Tomasselli, John O. Hui, Kathy L. O'Connell, Heinrich J. Schostarez, Jackson B. Hester, Joseph B. Moon, W. Jeffrey Howe, (unknown), Dianne L. DeCamp, Charles S. Craik, Ben M. Dunn, (unknown), (unknown), Roger A. Poorman, Alexander Wlodawer, Mariusz Jaskólski, Robert L. Heinrikson	8
14	The complexities of AIDS : an assessment of the HIV protease as a therapeutic target 1991 ·A G Tomasselli, W. Jeffrey Howe, T K Sawyer, A. Wlodawer, Robert L. Heinrikson	79
15	Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity 1991 ·Journal of Medicinal Chemistry ·Suvit Thaisrivongs, A G Tomasselli, Joseph B. Moon, John O. Hui, (unknown), (unknown), Joseph W. Strohbach, W. Jeffrey Howe, W. Gary Tarpley, Robert L. Heinrikson	38
16	Calcium‐free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2 1991 ·Proteins Structure Function and Bioinformatics ·Alfredo G. Tomasselli, W. Jeffrey Howe, John O. Hui, Tomi K. Sawyer, Ilene M. Reardon, Dianne L. DeCamp, Charles S. Craik, Robert L. Heinrikson	34
17	Computer design of bioactive molecules: A method for receptor‐based de novo ligand design 1991 ·Proteins Structure Function and Bioinformatics ·Joseph B. Moon, W. Jeffrey Howe	147
18	A fast algorithm for generating smooth molecular dot surface representations 1989 ·Journal of Molecular Graphics ·Joseph B. Moon, W. Jeffrey Howe	14
19	General methods of synthetic analysis. Strategic bond disconnections for bridged polycyclic structures 1975 ·Journal of the American Chemical Society ·E. J. Corey, W. Jeffrey Howe, (unknown), David A. Pensak, George A. Petersson	84
20	Computer-assisted synthetic analysis. Facile man-machine communication of chemical structure by interactive computer graphics 1972 ·Journal of the American Chemical Society ·E. J. Corey, W. Todd Wipke, Richard D. Cramer, W. Jeffrey Howe	66

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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