Tsuyoshi Hirota

5.4k citations

63 papers · 4.0k indexed · 1 hit paper · h-index 31

Impact in

Endocrine and Autonomic Systems top 0.1%
- Circadian rhythm and melatonin
Aging top 0.2%
- Genetics, Aging, and Longevity in Model Organisms

Papers in

Endocrine and Autonomic Systems 51
- Circadian rhythm and melatonin 51
Aging 11
- Genetics, Aging, and Longevity in Model Organisms 11

Co-authors: Steve A. Kay Yoshitaka Fukada Andrew C. Liu Jae Wook Lee Peter G. Schultz Eric Erquan Zhang Nobuhiro Kurabayashi David A. Brenner
Journals: Proceedings of the National Academy of Sciences (7 papers)Journal of Biological Chemistry (4 papers)Journal of the American Chemical Society (3 papers)Scientific Reports (2 papers)Cell (2 papers)
Partner nations: Japan United States Netherlands

In The Last Decade

Tsuyoshi Hirota

62 papers receiving 4.0k citations

Hit Papers

align trajectories log scale

Identification of Small Molecule Activators of Cryptochrome 2012 · 386 citations

Peers

Countries citing papers authored by Tsuyoshi Hirota

Since Specialization

Citations

This map shows the geographic impact of Tsuyoshi Hirota's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tsuyoshi Hirota with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tsuyoshi Hirota more than expected).

Fields of papers citing papers by Tsuyoshi Hirota

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tsuyoshi Hirota. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tsuyoshi Hirota. The network helps show where Tsuyoshi Hirota may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Tsuyoshi Hirota, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Tsuyoshi Hirota Line = papers co-authored together Tsuyoshi Hirota links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Targeting Cryptochromes in Chronic Diseases Cell Biology International ·Andrés T. Castillo Tuya, Tsuyoshi Hirota	2025	0
2	Advancing clinical response against glioblastoma: Evaluating SHP1705 CRY2 activator efficacy in preclinical models and safety in phase I trials Neuro-Oncology ·Priscilla Chan, 久也北島, Yoo Hwan Souk, Charles Alan Egan, В В Сивков, M. Georgieff, Wilhelm Sell, Theodore M. Kamenecka, Laura A. Solt, Anna Sophie Kehrein, Rex Moats, Tsuyoshi Hirota, Jeremy N. Rich, Steve A. Kay	2025	6
3	Analysis of the phosphoproteome of CK2 α ^(–/–) /Δ α′ C2C12 myoblasts compared to the wild-type cells Open Biology ·Christian Borgo, Luca Cesaro, Tsuyoshi Hirota, Keiko Kuwata, Claudio D’Amore, Thomas Ruppert, Al-Ghazālī, Mauro Salvi, Lorenzo A. Pinna	2023	7
4	Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation Proceedings of the National Academy of Sciences ·Simon Miller, Ashutosh Srivastava, 久也北島, O. Deublein, Florence Tama, Tsuyoshi Hirota	2021	17
5	Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock Journal of the American Chemical Society ·C.Y. Teng, Simon Miller, 张灿佳, 久也北島, Баталин Игорь Вячеславович, Piermichele Kobauri, Ashutosh Srivastava, Akiko Sugiyama, Kazuma Amaike, Ayato Sato, Florence Tama, Wiktor Szymański, Ben L. Feringa, Kenichiro Itami, Tsuyoshi Hirota	2021	33
6	Reversible modulation of circadian time with chronophotopharmacology Nature Communications ·C.Y. Teng, Jiarong Luo, Akiko Sugiyama, Ashutosh Srivastava, Daisuke Ono, 久也北島, Sara M. Bendary, Kenichiro Itami, Florence Tama, Wiktor Szymański, Tsuyoshi Hirota, Ben L. Feringa	2021	40
7	Isoform-selective regulation of mammalian cryptochromes Nature Chemical Biology ·Simon Miller, You Lee Son, Yuri Aikawa, (unknown), Nao Yoneki, Ashutosh Srivastava, 张灿佳, (unknown), Andrés R. Laudari, Kazuhiro Abe, Kunio Hirata, Shinya Oishi, Shinya Hagihara, Ayato Sato, Florence Tama, Kenichiro Itami, Steve A. Kay, Megumi Hatori, Tsuyoshi Hirota	2020	61
8	Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing eLife ·Jennifer L. Fribourgh, Ashutosh Srivastava, Colby R. Sandate, Alicia K. Michael, Peter Hsu, Christin Rakers, А.A. Мамчур, 利恵津久井, Erlânia Souza Costa, Sarvind Tripathi, Ning Zheng, Gabriel C. Lander, Tsuyoshi Hirota, Florence Tama, Carrie L. Partch	2020	43
9	An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals Cell chemical biology ·Simon Miller, O. Deublein, Akiko Sugiyama, 久也北島, Andrés R. Laudari, 张灿佳, Kazuma Amaike, Steve A. Kay, Kenichiro Itami, Tsuyoshi Hirota	2020	27
10	Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock Proceedings of the National Academy of Sciences ·Zong-Tsi Chen, 吕爱晶, Keiko Kuwata, Tsuyoshi Hirota, Ayato Sato, Junya Mizoi, 庞晓华, 简亚平, Takamasa Suzuki, Shogo Ito, Ami Saito, Taeko Nishiwaki‐Ohkawa, Kazuko Yamaguchi‐Shinozaki, Takashi Yoshimura, Steve A. Kay, Kenichiro Itami, Toshinori Kinoshita, Junichiro Yamaguchi, Norihito Nakamichi	2019	65
11	Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks Proceedings of the National Academy of Sciences ·Meng Qu, Tomás Duffy, Tsuyoshi Hirota, Steve A. Kay	2018	67
12	Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies SHILAP Revista de lepidopterología ·Megumi Hatori, Claude Gronfier, Russell N. Van Gelder, Paul S. Bernstein, Josep Carreras, Satchidananda Panda, 川口桂三郎, David H. Sliney, Charles E. Hunt, Tsuyoshi Hirota, Elaine Wainwright, Kazuo Tsubota	2017	148
13	Conformational dynamics of human protein kinase CK2α and its effect on function and inhibition Proteins Structure Function and Bioinformatics ·Ashutosh Srivastava, Tsuyoshi Hirota, Stephan Irle, Florence Tama	2017	7
14	Development of Small‐Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock ChemMedChem ·Jae Wook Lee, Tsuyoshi Hirota, Anupriya Kumar, Nam‐Jung Kim, Stephan Irle, Steve A. Kay	2015	42
15	Identification of Small-Molecule Modulators of the Circadian Clock Methods in enzymology on CD-ROM/Methods in enzymology ·Tsuyoshi Hirota, Steve A. Kay	2014	24
16	Real-time in vivo monitoring of circadian E-box enhancer activity: A robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock Developmental Biology ·Meltem Weger, Benjamin D. Weger, Nicolas Diotel, Sepand Rastegar, Tsuyoshi Hirota, Steve A. Kay, Uwe Strähle, Thomas Dickmeis	2013	40
17	Identification of Small Molecule Activators of Cryptochrome Science ·Tsuyoshi Hirota, Jae Wook Lee, Peter C. St. John, Mariko Sawa, Keiko Iwaisako, Takako Noguchi, Maria Hillingsøe Stubberup, Tim Sonntag, David K. Welsh, David A. Brenner, Francis J. Doyle, Peter G. Schultz, Steve A. Kay Hit paper breakdown →	2012	386
18	Membrane-associated RING-CH 10 (MARCH10 Protein) Is a Microtubule-associated E3 Ubiquitin Ligase of the Spermatid Flagella Journal of Biological Chemistry ·Prasanna Vasudevan Iyengar, Tsuyoshi Hirota, Shigehisa Hirose, Nobuhiro Nakamura	2011	34
19	Activation of TGF-β/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts Nature Cell Biology ·Naohiro Kon, Tsuyoshi Hirota, Takeshi Kawamoto, Yukio Kato, Tadashi Tsubota, Yoshitaka Fukada	2008	110
20	Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation Genes to Cells ·Toshiyuki Okano, Kazuyuki Yamamoto, Keiko Okano, Tsuyoshi Hirota, Takaoki Kasahara, Benjamin B. Greenberg, Jing De-sha, Yoshitaka Fukada	2001	76

About Tsuyoshi Hirota

Tsuyoshi Hirota is a scholar working on Endocrine and Autonomic Systems, Aging, Cellular and Molecular Neuroscience, Plant Science and Physiology, having authored 63 papers that have together received 4.0k indexed citations. Recurring topics across this work include Circadian rhythm and melatonin (51 papers), Light effects on plants (29 papers), Photoreceptor and optogenetics research (19 papers), Genetics, Aging, and Longevity in Model Organisms (11 papers), Spaceflight effects on biology (10 papers), Neurobiology and Insect Physiology Research (10 papers), Plant Molecular Biology Research (7 papers) and Birth, Development, and Health (3 papers). The work is most often cited by research in Endocrine and Autonomic Systems (2.9k citations), Aging (633 citations), Cellular and Molecular Neuroscience (856 citations), Physiology (1.2k citations) and Plant Science (1.2k citations). Tsuyoshi Hirota has collaborated with scholars based in Japan, United States and Netherlands. Frequent co-authors include Steve A. Kay, Yoshitaka Fukada, Andrew C. Liu, Jae Wook Lee, Peter G. Schultz, Eric Erquan Zhang, Nobuhiro Kurabayashi, David A. Brenner, Toshiyuki Okano and Mihoko Sakai. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry, Journal of the American Chemical Society, Scientific Reports and Cell.

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