Thomas R. Lane

2.4k total citations · 1 hit paper
68 papers, 1.5k citations indexed

About

Thomas R. Lane is a scholar working on Computational Theory and Mathematics, Infectious Diseases and Molecular Biology. According to data from OpenAlex, Thomas R. Lane has authored 68 papers receiving a total of 1.5k indexed citations (citations by other indexed papers that have themselves been cited), including 26 papers in Computational Theory and Mathematics, 25 papers in Infectious Diseases and 16 papers in Molecular Biology. Recurrent topics in Thomas R. Lane's work include Computational Drug Discovery Methods (26 papers), Pharmacogenetics and Drug Metabolism (8 papers) and Viral Infections and Outbreaks Research (8 papers). Thomas R. Lane is often cited by papers focused on Computational Drug Discovery Methods (26 papers), Pharmacogenetics and Drug Metabolism (8 papers) and Viral Infections and Outbreaks Research (8 papers). Thomas R. Lane collaborates with scholars based in United States, Russia and Brazil. Thomas R. Lane's co-authors include Sean Ekins, Kimberley M. Zorn, Daniel P. Russo, Alex M. Clark, Ana C. Puhl, Daniel H. Foil, Peter B. Madrid, Anthony J. Hickey, Jennifer J. Klein and Eni Minerali and has published in prestigious journals such as Nature Materials, Environmental Science & Technology and Journal of Molecular Biology.

In The Last Decade

Thomas R. Lane

60 papers receiving 1.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Exploiting machine learning for end-to-end drug discovery and development

2019 352 citations Sean Ekins, Ana C. Puhl et al. Nature Materials profile →

Peers

Countries citing papers authored by Thomas R. Lane

Since Specialization

Citations

This map shows the geographic impact of Thomas R. Lane's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas R. Lane with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas R. Lane more than expected).

Fields of papers citing papers by Thomas R. Lane

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas R. Lane. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas R. Lane. The network helps show where Thomas R. Lane may publish in the future.

Co-authorship network of co-authors of Thomas R. Lane

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas R. Lane. A scholar is included among the top collaborators of Thomas R. Lane based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas R. Lane. Thomas R. Lane is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Experimental and computational approaches for evaluating molecule interactions with equilibrative nucleoside transporters 1 and 2 2025 ·Journal of Pharmacology and Experimental Therapeutics ·(unknown), (unknown), (unknown), (unknown), Renuka Raman, Thomas R. Lane, Stephen H. Wright, Sean Ekins, Nathan J. Cherrington	0
2	Computational Approaches for Predicting Drug Interactions with Human Organic Anion Transporter 4 (OAT4) 2025 ·Molecular Pharmaceutics ·(unknown), (unknown), (unknown), Thomas R. Lane, Fabio Urbina, Stephen H. Wright, Sean Ekins, Nathan J. Cherrington	2
3	Machine learning modeling of zebrafish toxicity endpoints after exposure to PROTACs 2025 ·Toxicological Sciences ·(unknown), (unknown), Thomas R. Lane, (unknown), (unknown), Renuka Raman, Lisa Truong, (unknown), Seth W. Kullman, Sean Ekins	0
4	Oral Pyronaridine Tetraphosphate Reduces Tissue Presence of Parasites in a Mouse Model of Chagas Disease 2024 ·ACS Omega ·Jair L. Siqueira-Neto, Thomas R. Lane, Jean Bernatchez, (unknown), Elany Barbosa da Silva, Miriam A. Giardini, Sean Ekins	1
5	The Goldilocks paradigm: comparing classical machine learning, large language models, and few-shot learning for drug discovery applications 2024 ·Communications Chemistry ·(unknown), (unknown), (unknown), (unknown), Ana C. Puhl, Thomas R. Lane, John Corbett, Fabio Urbina, Sean Ekins	13
6	In Vitro Characterization and Rescue of VX Metabolism in Human Liver Microsomes 2024 ·Drug Metabolism and Disposition ·Thomas R. Lane, (unknown), (unknown), Robert A. Moyer, Sean Ekins	3
7	Repurposing lapatinib as a triple antagonist of chemokine receptors 3, 4, and 5 2024 ·Molecular Pharmacology ·Thomas R. Lane, Ana C. Puhl, (unknown), Keith R. Pennypacker, Sean Ekins	1
8	Indole-core inhibitors of influenza a neuraminidase: iterative medicinal chemistry and molecular modeling 2024 ·European Journal of Medicinal Chemistry ·(unknown), Michaela Schmidtke, (unknown), Irina A. Leneva, (unknown), Maria G. Khrenova, Thomas R. Lane, Sean Ekins, Vadim Makarov	0
9	Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5 2023 ·Antiviral Research ·Thomas R. Lane, Jianing Fu, Barbara Sherry, E. Bart Tarbet, Brett L. Hurst, Olga Riabova, Elena Kazakova, (unknown), Penny Clarke, J. Smith Leser, (unknown), (unknown), Kenneth L. Tyler, Thomas Klose, (unknown), (unknown), (unknown), Richard Kühn, Vadim Makarov, Sean Ekins	5
10	Targeted Metabolomics of Organophosphate Pesticides and Chemical Warfare Nerve Agent Simulants Using High- and Low-Dose Exposure in Human Liver Microsomes 2023 ·Metabolites ·Garima Agarwal, (unknown), (unknown), Thomas R. Lane, Sean Ekins, Craig A. McElroy	2
11	Learning from COVID-19: How drug hunters can prepare for the next pandemic 2023 ·Drug Discovery Today ·Ana C. Puhl, Thomas R. Lane, Sean Ekins	3
12	Transporter Inhibition Profile for the Antivirals Tilorone, Quinacrine and Pyronaridine 2023 ·ACS Omega ·(unknown), Thomas R. Lane, Ana C. Puhl, (unknown), Stephen H. Wright, Nathan J. Cherrington, Sean Ekins	2
13	1-Sulfonyl-3-amino-1H-1,2,4-triazoles as Yellow Fever Virus Inhibitors: Synthesis and Structure–Activity Relationship 2023 ·ACS Omega ·Elena Kazakova, Thomas R. Lane, (unknown), Ana C. Puhl, Olga Riabova, Vadim Makarov, Sean Ekins	4
14	N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor 2023 ·Journal of Medicinal Chemistry ·Thomas R. Lane, Vadim Makarov, Julie A. Nelson, Rick B. Meeker, Giuseppina Sanna, Olga Riabova, Elena Kazakova, (unknown), (unknown), Fabio Urbina, (unknown), (unknown), Sean Ekins	6
15	Discovery of 5-Nitro-6-thiocyanatopyrimidines as Inhibitors of Cryptococcus neoformans and Cryptococcus gattii 2021 ·ACS Medicinal Chemistry Letters ·Maureen J. Donlin, Thomas R. Lane, Olga Riabova, (unknown), Evan Xu, Jeffrey Lin, Vadim Makarov, Sean Ekins	6
16	Multiple Computational Approaches for Predicting Drug Interactions with Human Equilibrative Nucleoside Transporter 1 2021 ·Drug Metabolism and Disposition ·(unknown), Thomas R. Lane, Kimberley M. Zorn, Sean Ekins, Stephen H. Wright, Nathan J. Cherrington	11
17	Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig 2020 ·Antiviral Research ·Thomas R. Lane, (unknown), Jason E. Comer, Alexander N. Freiberg, Huanying Zhou, Julie Dyall, Michael R. Holbrook, Manu Anantpadma, Robert A. Davey, Peter B. Madrid, Sean Ekins	17
18	Exploiting machine learning for end-to-end drug discovery and development breakdown → 2019 ·Nature Materials ·Sean Ekins, Ana C. Puhl, Kimberley M. Zorn, Thomas R. Lane, Daniel P. Russo, Jennifer J. Klein, Anthony J. Hickey, Alex M. Clark	352
19	Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches 2018 ·Molecular Pharmaceutics ·Pan‐Fen Wang, (unknown), Thomas R. Lane, Kimberley M. Zorn, Sean Ekins, Evan D. Kharasch	26
20	Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display 2015 ·Protein Engineering Design and Selection ·Gurkan Guntas, Steven M. Lewis, Kathleen M. Mulvaney, Erica W. Cloer, Ashutosh Tripathy, Thomas R. Lane, Michael B. Major, Brian Kuhlman	23

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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