Thomas G. O’Brien

6.1k citations

96 papers · 5.1k indexed · 4 hit papers · h-index 34

Co-authors: Leila Diamond G Rovera R. K. Boutwell R. C. Simsiman William M. Baird John J. Osborn J. J. Murray J. Donald Hill
Topics: Polyamine Metabolism and Applications (44 papers)Amino Acid Enzymes and Metabolism (33 papers)Epigenetics and DNA Methylation (13 papers)
Cited by: Biochemistry Emergency Medicine Molecular Biology
Journals: Nature Science New England Journal of Medicine
Partner nations: United States China Belgium

In The Last Decade

Thomas G. O’Brien

94 papers receiving 4.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Prolonged Extracorporeal Oxygenation for Acute Post-Traumatic Respiratory Failure (Shock-Lung Syndrome)

1972 713 citations Thomas G. O’Brien et al. profile →
Induction of Differentiation in Human Promyelocytic Leukemia Cells by Tumor Promoters

1979 540 citations Thomas G. O’Brien, Leila Diamond et al. profile →
Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents.

1975 442 citations Thomas G. O’Brien, R. C. Simsiman et al. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) profile →
Tumor Promoters and the Mechanism of Tumor Promotion

1980 363 citations Leila Diamond, Thomas G. O’Brien et al. profile →

Peers

Countries citing papers authored by Thomas G. O’Brien

Since Specialization

Citations

This map shows the geographic impact of Thomas G. O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas G. O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas G. O’Brien more than expected).

Fields of papers citing papers by Thomas G. O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas G. O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas G. O’Brien. The network helps show where Thomas G. O’Brien may publish in the future.

Co-authorship network of co-authors of Thomas G. O’Brien

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas G. O’Brien. A scholar is included among the top collaborators of Thomas G. O’Brien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas G. O’Brien. Thomas G. O’Brien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Phase I/II clinical trial of 2‐difluoromethyl‐ornithine (DFMO) and a novel polyamine transport inhibitor (MQT 1426) for feline oral squamous cell carcinoma^* 2011 ·Veterinary and Comparative Oncology ·Katherine A. Skorupski,Thomas G. O’Brien,(unknown),Carlos O. Rodriguez,Mark R. Burns	12
2	Ornithine Decarboxylase Polymorphism Modification of Response to Aspirin Treatment for Colorectal Adenoma Prevention 2006 ·JNCI Journal of the National Cancer Institute ·Elizabeth L. Barry,John A. Baron,(unknown),Maria V. Grau,Carol A. Burke,Robert S. Sandler,Dennis J. Ahnen,Robert W. Haile,Thomas G. O’Brien	31
3	Identification of an X-linked locus modifying mouse skin tumor susceptibility 2005 ·Molecular Carcinogenesis ·Kenneth George,(unknown),(unknown),Thomas G. O’Brien	10
4	Therapy of murine squamous cell carcinomas with 2-difluoromethylornithine. 2004 ·Journal of Carcinogenesis ·Yan Chen,(unknown),David W. Boorman,Andres J. Klein–Szanto,Thomas G. O’Brien	8
5	Genetic Control of Polyamine-Dependent Susceptibility to Skin Tumorigenesis 2002 ·Genomics ·Louis C. Megosh,(unknown),(unknown),Thomas G. O’Brien	14
6	A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis 2001 ·American Journal Of Pathology ·Nihal Ahmad,Anita C. Gilliam,Santosh K. Katiyar,Thomas G. O’Brien,Hasan Mukhtar	58
7	AP-1 Activity Affects the Levels of Induced Erythroid and Megakaryocytic Differentiation of K562 Cells 1998 ·Archives of Biochemistry and Biophysics ·Dan Rosson,Thomas G. O’Brien	13
8	Protein Kinase C-α Activity Modulates Transepithelial Permeability and Cell Junctions in the LLC-PK1 Epithelial Cell Line 1997 ·Journal of Biological Chemistry ·Dan Rosson,Thomas G. O’Brien,(unknown),Zoltán Szállási,Krisztina Bögi,Peter M. Blumberg,James M. Mullin	83
9	Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity 1996 ·Journal of Investigative Dermatology ·Alejandro Peralta Soler,(unknown),Louis C. Megosh,Thomas G. O’Brien	57
10	Expression and Modulation of Protein Kinase C Isoforms in Differentiation-Competent and Differentiation-Resistant Erythroleukemic Cells 1995 ·Biochemical and Biophysical Research Communications ·Dan Rosson,Thomas G. O’Brien	13
11	Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate 1992 ·Carcinogenesis ·Susan K. Gilmour,Fredika M. Robertson,Louis C. Megosh,Sean M. O’Connell,John C. Mitchell,Thomas G. O’Brien	22
12	Complex mitogenic requirements of Na⁺ ‐K⁺ ‐Cl⁻ ‐cotransport‐deficient BALB/c‐3T3 cells 1990 ·Journal of Cellular Physiology ·Miriam J. Smyth,Thomas G. O’Brien,Walker Wharton	5
13	Flow cytometric detection of ornithine decarboxylase activity in epidermal cell subpopulations 1990 ·Cytometry ·Fredika M. Robertson,Susan K. Gilmour,Andrew J. Beavis,Sean M. O’Connell,A H Conney,(unknown),Jeffrey D. Laskin,Oili A. Hietala,Thomas G. O’Brien	4
14	Regulation of ornithine decarboxylase gene expression in normal and transformed hamster embryo fibroblasts following stimulation by 12-O-tetradecanoylphorbol-13-acetate 1989 ·Carcinogenesis ·Susan K. Gilmour,Thomas G. O’Brien	7
15	A phorbol ester‐nonproliferative variant of Swiss 3T3 cells is deficient in Na⁺ K⁺ Cl⁻ cotransport activity 1988 ·Journal of Cellular Physiology ·Thomas G. O’Brien,(unknown),Kenneth George,Harvey R. Herschman	11
16	Spontaneous reversal of polarity of the voltage across LLC‐PK₁ renal epithelial cell sheets 1987 ·Journal of Cellular Physiology ·James M. Mullin,Thomas G. O’Brien	6
17	A cell culture bioassay to analyze metabolism of phorbol diester tumor promoters. 1978 ·Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) ·Thomas G. O’Brien,Leila Diamond	12
18	Ornithine decarboxylase induction and DNA synthesis in hamster embryo cell cultures treated with tumor-promoting phorbol diesters. 1977 ·Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) ·Thomas G. O’Brien,Leila Diamond	81
19	Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents.breakdown → 1975 ·Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) ·Thomas G. O’Brien,R. C. Simsiman,R. K. Boutwell	442
20	GAS-EXCHANGE DYNAMICS OF GLYCEROLIZED FROZEN BLOOD 1960 ·Journal of Thoracic and Cardiovascular Surgery ·Thomas G. O’Brien,Elton Watkins	19

About Thomas G. O’Brien

Thomas G. O’Brien is a scholar working on Biochemistry, Clinical Biochemistry and Molecular Biology, having authored 96 papers that have together received 5.1k indexed citations. Recurring topics across this work include Polyamine Metabolism and Applications (44 papers), Amino Acid Enzymes and Metabolism (33 papers) and Epigenetics and DNA Methylation (13 papers). The work is most often cited by research in Biochemistry (1.0k citations), Emergency Medicine (482 citations) and Molecular Biology (3.4k citations). Thomas G. O’Brien has collaborated with scholars based in United States, China and Belgium. Frequent co-authors include Leila Diamond, G Rovera, R. K. Boutwell, R. C. Simsiman, William M. Baird, John J. Osborn, J. J. Murray, J. Donald Hill, M.L. Bramson and Frank Gerbode. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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