Thomas G. O’Brien

6.1k total citations · 4 hit papers
96 papers, 5.1k citations indexed

About

Thomas G. O’Brien is a scholar working on Molecular Biology, Biochemistry and Oncology. According to data from OpenAlex, Thomas G. O’Brien has authored 96 papers receiving a total of 5.1k indexed citations (citations by other indexed papers that have themselves been cited), including 83 papers in Molecular Biology, 34 papers in Biochemistry and 13 papers in Oncology. Recurrent topics in Thomas G. O’Brien's work include Polyamine Metabolism and Applications (44 papers), Amino Acid Enzymes and Metabolism (33 papers) and Epigenetics and DNA Methylation (13 papers). Thomas G. O’Brien is often cited by papers focused on Polyamine Metabolism and Applications (44 papers), Amino Acid Enzymes and Metabolism (33 papers) and Epigenetics and DNA Methylation (13 papers). Thomas G. O’Brien collaborates with scholars based in United States, China and Belgium. Thomas G. O’Brien's co-authors include Leila Diamond, G Rovera, R. K. Boutwell, R. C. Simsiman, William M. Baird, John J. Osborn, J. J. Murray, J. Donald Hill, M.L. Bramson and Frank Gerbode and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Thomas G. O’Brien

94 papers receiving 4.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Prolonged Extracorporeal Oxygenation for Acute Post-Traumatic Respiratory Failure (Shock-Lung Syndrome)

1972 713 citations Thomas G. O’Brien et al. profile →
Induction of Differentiation in Human Promyelocytic Leukemia Cells by Tumor Promoters

1979 540 citations Thomas G. O’Brien, Leila Diamond et al. profile →
Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents.

1975 442 citations Thomas G. O’Brien, R. C. Simsiman et al. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) profile →
Tumor Promoters and the Mechanism of Tumor Promotion

1980 363 citations Leila Diamond, Thomas G. O’Brien et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Thomas G. O’Brien United States	34	3.4k	1.0k	681	606	539	96	5.1k
Lei Xiao China	45	4.5k 1.3×	342 0.3×	268 0.4×	699 1.2×	502 0.9×	148	7.2k
Jordi Muntané Spain	43	2.3k 0.7×	418 0.4×	95 0.1×	1.1k 1.8×	694 1.3×	167	5.9k
Russell M. Medford United States	32	2.7k 0.8×	409 0.4×	168 0.2×	967 1.6×	342 0.6×	47	6.3k
Claudio Marcello Caldarera Italy	31	1.8k 0.5×	449 0.4×	152 0.2×	418 0.7×	162 0.3×	112	3.1k
Joseph T. O’Flaherty United States	51	2.8k 0.8×	897 0.9×	71 0.1×	467 0.8×	416 0.8×	132	6.1k
Isabelle Leclercq Belgium	50	2.7k 0.8×	471 0.4×	199 0.3×	1.9k 3.1×	725 1.3×	161	9.6k
Wolfgang Siess Germany	49	3.1k 0.9×	802 0.8×	53 0.1×	1.2k 2.0×	351 0.7×	157	8.0k
Ye-Shih Ho United States	36	2.5k 0.7×	403 0.4×	78 0.1×	243 0.4×	366 0.7×	55	5.1k
Maurizio Parola Italy	54	3.1k 0.9×	441 0.4×	150 0.2×	1.5k 2.5×	993 1.8×	167	10.5k
Peter Brecher United States	44	2.8k 0.8×	602 0.6×	33 0.0×	941 1.6×	431 0.8×	113	5.4k

Countries citing papers authored by Thomas G. O’Brien

Since Specialization

Citations

This map shows the geographic impact of Thomas G. O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas G. O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas G. O’Brien more than expected).

Fields of papers citing papers by Thomas G. O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas G. O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas G. O’Brien. The network helps show where Thomas G. O’Brien may publish in the future.

Co-authorship network of co-authors of Thomas G. O’Brien

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas G. O’Brien. A scholar is included among the top collaborators of Thomas G. O’Brien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas G. O’Brien. Thomas G. O’Brien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Skorupski, Katherine A., et al.. (2011). Phase I/II clinical trial of 2‐difluoromethyl‐ornithine (DFMO) and a novel polyamine transport inhibitor (MQT 1426) for feline oral squamous cell carcinoma^*. Veterinary and Comparative Oncology. 9(4). 275–282. 12 indexed citations

Barry, Elizabeth L., John A. Baron, Maria V. Grau, et al.. (2006). Ornithine Decarboxylase Polymorphism Modification of Response to Aspirin Treatment for Colorectal Adenoma Prevention. JNCI Journal of the National Cancer Institute. 98(20). 1494–1500. 31 indexed citations

George, Kenneth, et al.. (2005). Identification of an X-linked locus modifying mouse skin tumor susceptibility. Molecular Carcinogenesis. 44(3). 212–218. 10 indexed citations

Chen, Yan, et al.. (2004). Therapy of murine squamous cell carcinomas with 2-difluoromethylornithine.. Journal of Carcinogenesis. 3(1). 10–10. 8 indexed citations

Megosh, Louis C., et al.. (2002). Genetic Control of Polyamine-Dependent Susceptibility to Skin Tumorigenesis. Genomics. 79(4). 505–512. 14 indexed citations

Ahmad, Nihal, Anita C. Gilliam, Santosh K. Katiyar, Thomas G. O’Brien, & Hasan Mukhtar. (2001). A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis. American Journal Of Pathology. 159(3). 885–892. 58 indexed citations

Rosson, Dan & Thomas G. O’Brien. (1998). AP-1 Activity Affects the Levels of Induced Erythroid and Megakaryocytic Differentiation of K562 Cells. Archives of Biochemistry and Biophysics. 352(2). 298–305. 13 indexed citations

Rosson, Dan, Thomas G. O’Brien, Zoltán Szállási, et al.. (1997). Protein Kinase C-α Activity Modulates Transepithelial Permeability and Cell Junctions in the LLC-PK1 Epithelial Cell Line. Journal of Biological Chemistry. 272(23). 14950–14953. 83 indexed citations

Soler, Alejandro Peralta, et al.. (1996). Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity. Journal of Investigative Dermatology. 106(5). 1108–1113. 57 indexed citations

10.

Rosson, Dan & Thomas G. O’Brien. (1995). Expression and Modulation of Protein Kinase C Isoforms in Differentiation-Competent and Differentiation-Resistant Erythroleukemic Cells. Biochemical and Biophysical Research Communications. 210(1). 90–97. 13 indexed citations

11.

Gilmour, Susan K., Fredika M. Robertson, Louis C. Megosh, et al.. (1992). Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate. Carcinogenesis. 13(1). 51–56. 22 indexed citations

12.

Smyth, Miriam J., Thomas G. O’Brien, & Walker Wharton. (1990). Complex mitogenic requirements of Na⁺ ‐K⁺ ‐Cl⁻ ‐cotransport‐deficient BALB/c‐3T3 cells. Journal of Cellular Physiology. 145(3). 531–535. 5 indexed citations

13.

Robertson, Fredika M., Susan K. Gilmour, Andrew J. Beavis, et al.. (1990). Flow cytometric detection of ornithine decarboxylase activity in epidermal cell subpopulations. Cytometry. 11(7). 832–836. 4 indexed citations

14.

Gilmour, Susan K. & Thomas G. O’Brien. (1989). Regulation of ornithine decarboxylase gene expression in normal and transformed hamster embryo fibroblasts following stimulation by 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis. 10(1). 157–162. 7 indexed citations

15.

O’Brien, Thomas G., et al.. (1988). A phorbol ester‐nonproliferative variant of Swiss 3T3 cells is deficient in Na⁺ K⁺ Cl⁻ cotransport activity. Journal of Cellular Physiology. 134(2). 302–306. 11 indexed citations

16.

Mullin, James M. & Thomas G. O’Brien. (1987). Spontaneous reversal of polarity of the voltage across LLC‐PK₁ renal epithelial cell sheets. Journal of Cellular Physiology. 133(3). 515–522. 6 indexed citations

17.

O’Brien, Thomas G. & Leila Diamond. (1978). A cell culture bioassay to analyze metabolism of phorbol diester tumor promoters.. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich). 38(8). 2567–72. 12 indexed citations

18.

O’Brien, Thomas G. & Leila Diamond. (1977). Ornithine decarboxylase induction and DNA synthesis in hamster embryo cell cultures treated with tumor-promoting phorbol diesters.. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich). 37(11). 3895–900. 81 indexed citations

19.

O’Brien, Thomas G., R. C. Simsiman, & R. K. Boutwell. (1975). Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents.. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich). 35(7). 1662–70. 442 indexed citations breakdown →

20.

O’Brien, Thomas G. & Elton Watkins. (1960). GAS-EXCHANGE DYNAMICS OF GLYCEROLIZED FROZEN BLOOD. Journal of Thoracic and Cardiovascular Surgery. 40(5). 611–624. 19 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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