Henk Granzier

16.7k total citations · 3 hit papers
212 papers, 11.7k citations indexed

About

Henk Granzier is a scholar working on Cardiology and Cardiovascular Medicine, Molecular Biology and Cell Biology. According to data from OpenAlex, Henk Granzier has authored 212 papers receiving a total of 11.7k indexed citations (citations by other indexed papers that have themselves been cited), including 185 papers in Cardiology and Cardiovascular Medicine, 131 papers in Molecular Biology and 49 papers in Cell Biology. Recurrent topics in Henk Granzier's work include Cardiomyopathy and Myosin Studies (175 papers), Muscle Physiology and Disorders (96 papers) and Cellular Mechanics and Interactions (43 papers). Henk Granzier is often cited by papers focused on Cardiomyopathy and Myosin Studies (175 papers), Muscle Physiology and Disorders (96 papers) and Cellular Mechanics and Interactions (43 papers). Henk Granzier collaborates with scholars based in United States, Germany and Netherlands. Henk Granzier's co-authors include Siegfried Labeit, Christian Witt, Martin M. LeWinter, Yiming Wu, Coen A. C. Ottenheijm, Carlos Hidalgo, Michael Gotthardt, D. Labeit, Carol C. Gregorio and Mark McNabb and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Circulation.

In The Last Decade

Henk Granzier

210 papers receiving 11.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System

2001 523 citations Christian Witt, Carol C. Gregorio et al. Circulation Research profile →
Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction

2015 499 citations Rebecca Slater, Henk Granzier et al. Circulation profile →
Research Priorities for Heart Failure With Preserved Ejection Fraction

2020 273 citations Henk Granzier et al. Circulation profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Henk Granzier United States	64	8.5k	6.5k	1.9k	1.0k	945	212	11.7k
Wolfgang A. Linke Germany	64	8.7k 1.0×	6.0k 0.9×	2.1k 1.1×	2.3k 2.2×	1.3k 1.4×	180	12.6k
Ger J.M. Stienen Netherlands	53	7.0k 0.8×	4.0k 0.6×	605 0.3×	382 0.4×	1.0k 1.1×	183	9.7k
Elisabeth Ehler United Kingdom	52	3.2k 0.4×	4.9k 0.8×	1.4k 0.8×	219 0.2×	498 0.5×	137	7.7k
Dieter O. Fürst Germany	49	4.1k 0.5×	5.4k 0.8×	2.1k 1.1×	412 0.4×	212 0.2×	125	7.5k
Henk Granzier United States	36	4.5k 0.5×	3.2k 0.5×	1.1k 0.6×	1.3k 1.2×	646 0.7×	43	5.8k
Jian‐Ping Jin United States	49	3.8k 0.4×	4.4k 0.7×	1.1k 0.6×	300 0.3×	274 0.3×	241	7.1k
Edna C. Hardeman Australia	45	2.2k 0.3×	5.3k 0.8×	2.0k 1.1×	134 0.1×	335 0.4×	144	8.4k
Benoit G. Bruneau United States	62	2.5k 0.3×	14.1k 2.2×	768 0.4×	110 0.1×	505 0.5×	133	17.0k
Gerald A. Meininger United States	44	1.6k 0.2×	2.0k 0.3×	1.2k 0.6×	359 0.4×	582 0.6×	123	5.7k
Thomas K. Borg United States	48	4.1k 0.5×	3.6k 0.6×	1.4k 0.8×	94 0.1×	1.4k 1.5×	165	9.0k

Countries citing papers authored by Henk Granzier

Since Specialization

Citations

This map shows the geographic impact of Henk Granzier's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Henk Granzier with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Henk Granzier more than expected).

Fields of papers citing papers by Henk Granzier

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Henk Granzier. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Henk Granzier. The network helps show where Henk Granzier may publish in the future.

Co-authorship network of co-authors of Henk Granzier

This figure shows the co-authorship network connecting the top 25 collaborators of Henk Granzier. A scholar is included among the top collaborators of Henk Granzier based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Henk Granzier. Henk Granzier is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Methawasin, Mei, Yanghai Zhang, Zachery R. Gregorich, et al.. (2025). Reducing Granules Without Splicing Restoration Alleviates RBM20 Cardiomyopathy. Circulation Research. 136(10). 1134–1146. 1 indexed citations

Methawasin, Mei, Joshua Strom, Jochen Gohlke, et al.. (2025). An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency. American Journal of Physiology-Heart and Circulatory Physiology. 328(4). H719–H733. 3 indexed citations

Pijl, Robbert van der, Joshua Strom, Rebecca Slater, et al.. (2025). Importance of N2BA Titin in Maintaining Cardiac Homeostasis and Its Role in Dilated Cardiomyopathy. Circulation Heart Failure. 18(3). e012083–e012083. 1 indexed citations

Granzier, Henk & Siegfried Labeit. (2025). Discovery of Titin and Its Role in Heart Function and Disease. Circulation Research. 136(1). 135–157. 10 indexed citations

Ko, Christopher Y., et al.. (2024). Differential sex-dependent susceptibility to diastolic dysfunction and arrhythmia in cardiomyocytes from obese diabetic heart failure with preserved ejection fraction model. Cardiovascular Research. 121(2). 254–266. 19 indexed citations

Barefield, David Y., Paola Tonino, Kathleen C. Woulfe, et al.. (2023). Myosin-binding protein H-like regulates myosin-binding protein distribution and function in atrial cardiomyocytes. Proceedings of the National Academy of Sciences. 120(51). e2314920120–e2314920120. 4 indexed citations

Pijl, Robbert van der, Marloes van den Berg, Sylvia J. P. Bogaards, et al.. (2021). Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator. The Journal of General Physiology. 153(7). 22 indexed citations

Gohlke, Jochen, Paola Tonino, Johan Lindqvist, John E. Smith, & Henk Granzier. (2020). The number of Z-repeats and super-repeats in nebulin greatly varies across vertebrates and scales with animal size. The Journal of General Physiology. 153(3). 6 indexed citations

Cho, Woo Jung, et al.. (2020). MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling. Cardiovascular Research. 117(1). 188–200. 76 indexed citations

10.

Methawasin, Mei, Joshua Strom, Tomasz Borkowski, et al.. (2020). Phosphodiesterase 9a Inhibition in Mouse Models of Diastolic Dysfunction. Circulation Heart Failure. 13(5). e006609–e006609. 33 indexed citations

11.

Lee, Eun‐Jeong, Justin Kolb, Darren T. Hwee, Fady I. Malik, & Henk Granzier. (2019). Functional Characterization of the Intact Diaphragm in a Nebulin-Based Nemaline Myopathy (NM) Model-Effects of the Fast Skeletal Muscle Troponin Activator tirasemtiv. International Journal of Molecular Sciences. 20(20). 5008–5008. 5 indexed citations

12.

Methawasin, Mei, et al.. (2018). Sarcomere length–dependent effects on Ca2+-troponin regulation in myocardium expressing compliant titin. The Journal of General Physiology. 151(1). 30–41. 15 indexed citations

13.

Granzier, Henk, Paola Tonino, Balázs Kiss, et al.. (2018). The Giant Protein Titin Regulates the Length of the Striated Muscle Thick Filament-Titin Rules. Biophysical Journal. 114(3). 496a–496a. 1 indexed citations

14.

Slater, Rebecca, Giorgia Del Favero, Brian Anderson, et al.. (2015). Phosphorylating Titin’s Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force. Biophysical Journal. 109(12). 2592–2601. 35 indexed citations

15.

Granzier, Henk, Kirk R. Hutchinson, Paola Tonino, et al.. (2014). Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function. Proceedings of the National Academy of Sciences. 111(40). 14589–14594. 68 indexed citations

16.

Buck, Danielle, et al.. (2011). Thin Filament Length in Mouse Skeletal Muscle and its Relationship to Differential Splicing of Nebulin. Biophysical Journal. 100(3). 587a–587a. 1 indexed citations

17.

Ali, Mohammad, Woo Jung Cho, Bryan D. Hudson, et al.. (2010). Titin is a Target of Matrix Metalloproteinase-2. Circulation. 122(20). 2039–2047. 153 indexed citations

18.

Moriscot, Anselmo Sigari, Igor L. Baptista, Julius Bogomolovas, et al.. (2010). MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. Journal of Structural Biology. 170(2). 344–353. 72 indexed citations

19.

Granzier, Henk & Siegfried Labeit. (2007). Structure–function relations of the giant elastic protein titin in striated and smooth muscle cells. Muscle & Nerve. 36(6). 740–755. 107 indexed citations

20.

Fukuda, Norio, Yiming Wu, Preetha Nair, & Henk Granzier. (2005). Phosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner. The Journal of General Physiology. 125(3). 257–271. 157 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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