Stefan Tholen

1.7k total citations · 1 hit paper
32 papers, 1.2k citations indexed

About

Stefan Tholen is a scholar working on Molecular Biology, Cancer Research and Oncology. According to data from OpenAlex, Stefan Tholen has authored 32 papers receiving a total of 1.2k indexed citations (citations by other indexed papers that have themselves been cited), including 22 papers in Molecular Biology, 13 papers in Cancer Research and 10 papers in Oncology. Recurrent topics in Stefan Tholen's work include Protease and Inhibitor Mechanisms (10 papers), Peptidase Inhibition and Analysis (8 papers) and Cardiac Structural Anomalies and Repair (3 papers). Stefan Tholen is often cited by papers focused on Protease and Inhibitor Mechanisms (10 papers), Peptidase Inhibition and Analysis (8 papers) and Cardiac Structural Anomalies and Repair (3 papers). Stefan Tholen collaborates with scholars based in Germany, United States and Canada. Stefan Tholen's co-authors include Oliver Schilling, Elizabeth Hamson, Fiona M. Keane, Mark D. Gorrell, Martin L. Biniossek, Jayachandran N. Kizhakkedathu, Ângela Castoldi, Marco Prinz, Charlotte Mezö and Omar Mossad and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Nature Communications and Cell Metabolism.

In The Last Decade

Stefan Tholen

30 papers receiving 1.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

2021 319 citations Daniel Erny, Nikolaos Dokalis et al. Cell Metabolism profile →

Peers

Stefan Tholen

ONCOL

SURGE

PHYSI

Shinji Oki Japan

Yang Mao‐Draayer United States

Yun‐Yan Xiang Canada

Kim Ohl Germany

Enrico Velardi Italy

Anil Shanker United States

Jin Ren United States

Steven J. Mullett United States

Jyoti Misra Sen United States

Taisuke Kondo Japan

Shinji Oki Japan

Stefan Tholen

601 ×1.1

235 ×0.5

ONCOL

133 ×0.4

99 ×0.5

SURGE

161 ×1.0

PHYSI

Citations per year, relative to Stefan Tholen Stefan Tholen (= 1×) peers Shinji Oki

Countries citing papers authored by Stefan Tholen

Since Specialization

Citations

This map shows the geographic impact of Stefan Tholen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stefan Tholen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stefan Tholen more than expected).

Fields of papers citing papers by Stefan Tholen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stefan Tholen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stefan Tholen. The network helps show where Stefan Tholen may publish in the future.

Co-authorship network of co-authors of Stefan Tholen

This figure shows the co-authorship network connecting the top 25 collaborators of Stefan Tholen. A scholar is included among the top collaborators of Stefan Tholen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Stefan Tholen. Stefan Tholen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Tholen, Stefan, Viktoria Reimann, Oliver Schilling, et al.. (2025). The RRM domain–containing protein Rbp3 interacts with ribosomes and the 3’ ends of mRNAs encoding photosynthesis proteins. Proceedings of the National Academy of Sciences. 122(26). e2506275122–e2506275122.

Lindner, Diana, Dennis Wolf, Stefan Tholen, et al.. (2025). Experimental evidence on colchicine's mode of action in human carotid artery plaques. Atherosclerosis. 406. 119239–119239. 2 indexed citations

Neubauer, Björn, Stefan Tholen, Alexis Hofherr, et al.. (2024). The role of the co‐chaperone DNAJB11 in polycystic kidney disease: Molecular mechanisms and cellular origin of cyst formation. The FASEB Journal. 38(21). e70162–e70162.

Martin, Gottfried, Stefan Tholen, Oliver Schilling, et al.. (2024). Enrichment, Characterization, and Proteomic Profiling of Small Extracellular Vesicles Derived from Human Limbal Mesenchymal Stromal Cells and Melanocytes. Cells. 13(7). 623–623. 7 indexed citations

Ziegler‐Waldkirch, Stephanie, Stefan Tholen, Marius Schwabenland, et al.. (2023). Tpr Misregulation in Hippocampal Neural Stem Cells in Mouse Models of Alzheimer’s Disease. Cells. 12(23). 2757–2757. 5 indexed citations

Tholen, Stefan, Roma Patel, Kyle M. Kovary, et al.. (2022). Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy. Cell Reports. 39(13). 111018–111018. 12 indexed citations

Tholen, Stefan, et al.. (2022). Isolation of intact and active FoF1 ATP synthase using a FLAG-tagged subunit from the cyanobacterium Synechocystis sp. PCC 6803. STAR Protocols. 3(3). 101623–101623. 1 indexed citations

Ferrarese, Roberto, Annalisa Izzo, Geoffroy Andrieux, et al.. (2022). ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma. Life Science Alliance. 6(1). e202201400–e202201400. 9 indexed citations

Tholen, Stefan, et al.. (2022). Early enforcement of cell identity by a functional component of the terminally differentiated state. PLoS Biology. 20(12). e3001900–e3001900. 4 indexed citations

10.

Erny, Daniel, Nikolaos Dokalis, Charlotte Mezö, et al.. (2021). Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease. Cell Metabolism. 33(11). 2260–2276.e7. 319 indexed citations breakdown →

11.

Tholen, Stefan, Martin L. Biniossek, Bettina Mayer, et al.. (2017). The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1865(4). 444–452. 22 indexed citations

12.

Tholen, Stefan, Justin Mastroianni, Bettina Mayer, et al.. (2016). Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival. Journal of Cancer. 7(14). 2018–2027. 5 indexed citations

13.

Tholen, Stefan, Daniel Maresch, Martin L. Biniossek, et al.. (2016). The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity. Archives of Biochemistry and Biophysics. 603. 110–117. 22 indexed citations

14.

Tholen, Stefan, et al.. (2015). The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1853(10). 2515–2525. 22 indexed citations

15.

Koczorowska, Maria Magdalena, Stefan Tholen, Felicitas Bucher, et al.. (2015). Fibroblast activation protein‐α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations. Molecular Oncology. 10(1). 40–58. 87 indexed citations

16.

Tholen, Martina, et al.. (2014). Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo. Nature Communications. 5(1). 4931–4931. 17 indexed citations

17.

Tholen, Stefan, et al.. (2013). Proteomic identification of protease cleavage sites: cell-biological and biomedical applications. Expert Review of Proteomics. 10(5). 421–433. 26 indexed citations

18.

Tholen, Stefan, Martin L. Biniossek, Alejandro Gomez‐Auli, et al.. (2012). Deletion of Cysteine Cathepsins B or L Yields Differential Impacts on Murine Skin Proteome and Degradome. Molecular & Cellular Proteomics. 12(3). 611–625. 34 indexed citations

19.

Gunka, Katrin, et al.. (2011). SPABBATS: A pathway-discovery method based on Boolean satisfiability that facilitates the characterization of suppressor mutants. BMC Systems Biology. 5(1). 5–5. 17 indexed citations

20.

Tholen, Stefan, Martin L. Biniossek, S. Müller, et al.. (2011). Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts. Biological Chemistry. 392(11). 961–971. 27 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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