Simon J. Teague

4.3k citations

51 papers · 3.2k indexed · 3 hit papers · h-index 23

Impact in

Computational Theory and Mathematics top 0.5%
- Computational Drug Discovery Methods
Organic Chemistry top 2%
- Synthesis and biological activity
- Click Chemistry and Applications

Papers in

Organic Chemistry 24
- Synthetic Organic Chemistry Methods 8
Biochemistry 5

Co-authors: A. M. Davis Tudor I. Oprea Paul D. Leeson Gerard J. Kleywegt Gerald Pattenden Robert Andrews A. I. MEYERS Michael J. Stocks
Journals: Bioorganic & Medicinal Chemistry Letters (11 papers)Tetrahedron Letters (10 papers)Angewandte Chemie International Edition (4 papers)The Journal of Organic Chemistry (3 papers)Tetrahedron (2 papers)
Partner nations: United Kingdom Sweden Singapore

In The Last Decade

Simon J. Teague

50 papers receiving 3.0k citations

Hit Papers

align trajectories log scale

Implications of protein flexibility for drug discovery 2003 · 548 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2003 Nature Reviews Drug Discovery
2001 Journal of Chemical Information and Computer Sciences
1999 Angewandte Chemie International Edition

Peers

Countries citing papers authored by Simon J. Teague

Since Specialization

Citations

This map shows the geographic impact of Simon J. Teague's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Simon J. Teague with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Simon J. Teague more than expected).

Fields of papers citing papers by Simon J. Teague

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Simon J. Teague. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Simon J. Teague. The network helps show where Simon J. Teague may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Simon J. Teague, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Simon J. Teague Line = papers co-authored together Simon J. Teague links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	How to identify and eliminate compounds with a risk of high clinical dose during the early phase of lead optimisation in drug discovery European Journal of Pharmaceutical Sciences ·Simon J. Teague, Klára Valkó	2017	15
2	Acylglycinamides as inhibitors of glycine transporter type 1 Bioorganic & Medicinal Chemistry Letters ·Geraldine Iwanski, Roderick A. Porter, Amanda Johns, D. Nash, 有紀子小島, Paul Wyman, Hugh J. Herdon, Simon J. Teague, Kristine U. Hernandez, Stefano Fontana, Laurie Gordon	2011	1
3	Learning lessons from drugs that have recently entered the market Drug Discovery Today ·Simon J. Teague	2011	29
4	Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists—discovery of AZD1981 Bioorganic & Medicinal Chemistry Letters ·Tim Luker, Roger V. Bonnert, RM Fauzih, Anthony R. Cook, Mark Dickinson, Iain G. Dougall, 陈永顶, S A Pedhnekar, Stuart W. Paine, Hitesh J. Sanganee, Carol A. Sargent, 登三上, Simon J. Teague, Stephen Thom	2011	32
5	Identification of novel α7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods Bioorganic & Medicinal Chemistry Letters ·Anna Maria Capelli, Laura Castelletti, J. Kim, Beatrice Oliosi, Jara Minaya Gustavo Javier Jara Minaya Gustavo Javier, Caterina Virginio, Andrew P. Lightfoot, James N.C. Kew, Simon J. Teague	2010	9
6	Synthesis of 6-substituted 5-cyano-7-hydroxy-2-carboxybenzofurans Tetrahedron Letters ·Simon J. Teague, Andrew Schiro	2010	3
7	In vitro and in vivo characterization of PheTQS, a novel α7 nAChR positive allosteric modulator Biochemical Pharmacology ·James N.C. Kew, Rengstedt Malin, Orasa Patarapiboolchai, Caterina Virginio, Laura Castelletti, Eric Southam, Carol A. Jennings, Lee A. Dawson, Laurent Lacroix, Liu Sheng Yu, Simon J. Teague, Zeenat Atcha, Darrel J. Pemberton, Charlie Reavill, Hoddesdon, Jackie Cilia, Kevin S. Choo, Karen Stevens, Andrew P. Lightfoot	2009	1
8	Structure-driven HtL: Design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity Bioorganic & Medicinal Chemistry Letters ·Michael J. Stocks, Andrew Schiro, Jéssica J. S. Lima, Frédéric R. Leroux, Stephen A. St-Gallay, Simon J. Teague, Yafeng Xue	2005	37
9	Implications of protein flexibility for drug discovery Nature Reviews Drug Discovery ·Simon J. Teague Hit paper breakdown →	2003	548
10	Application and Limitations of X‐ray Crystallographic Data in Structure‐Based Ligand and Drug Design Angewandte Chemie International Edition ·A. M. Davis, Simon J. Teague, Gerard J. Kleywegt	2003	282
11	Functional Properties of the High-Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist (4-Hydroxy-5-iodo-3-methoxyphenylacetate ester) Iodo-Resiniferatoxin Journal of Pharmacology and Experimental Therapeutics ·Guy R. Seabrook, Kathy Sutton, Wolfgang Jarolimek, Gregory J. Hollingworth, Simon J. Teague, J.K. Webb, Natalie Clark, Susan Boyce, Julie Kerby, Zahid Ali, J. Medvecká, Richard E. Middleton, Gregory J. Kaczorowski, A. Brian Jones	2002	108
12	Hydrogen Bonding, Hydrophobic Interactions, and Failure of the Rigid Receptor Hypothesis Angewandte Chemie International Edition ·A. M. Davis, Simon J. Teague	1999	265
13	Solid-Phase Synthesis of Tyrosine Peptide Aldehydes. Analogues of (S)-MAPI The Journal of Organic Chemistry ·Patrick Page, Mark Bradley, Iain A. S. Walters, Simon J. Teague	1999	27
14	Design kombinatorischer Leitstruktur-Bibliotheken Angewandte Chemie ·Simon J. Teague, A. M. Davis, Paul D. Leeson, Tudor I. Oprea	1999	23
15	ChemInform Abstract: Hydrogen Bonding, Hydrophobic Interactions, and Failure of the Rigid Receptor Hypothesis ChemInform ·A. M. Davis, Simon J. Teague	1999	0
16	The Design of Leadlike Combinatorial Libraries Angewandte Chemie International Edition ·Simon J. Teague, A. M. Davis, Paul D. Leeson, Tudor I. Oprea Hit paper breakdown →	1999	604
17	Solid-Phase Total Synthesis of Oscillamide Y and Analogues The Journal of Organic Chemistry ·Ian R. Marsh, Mark Bradley, Simon J. Teague	1997	24
18	Synthetic FKBP12 ligands. Design and synthesis of pyranose replacements. Bioorganic & Medicinal Chemistry Letters ·Heather Darden, Larissa Hetterich, A C Nolasco, Martin Cooper, David K. Donald, Mark Furber, Mehran Sardareh, Richard P. Harrison, K. Harrou. A. Aboulfalah, Matthew W. D. Perry, Michael J. Stocks, Simon J. Teague, Bertha González Forte	1994	5
19	Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogs: the first examples of a new class of calcium channel activator Journal of Medicinal Chemistry ·Andrew Baxter, Jack Dixon, Rena Sugarbaker, Carol N. Manners, Simon J. Teague	1993	30
20	A new synthesis of FPL 64176 and analogues: The discovery of benzoylpyrrole calcium channel activators with low nanomolar potency Tetrahedron ·Andrew Baxter, Simon J. Teague	1993	8

About Simon J. Teague

Simon J. Teague is a scholar working on Organic Chemistry, Biochemistry, Toxicology, Biotechnology and Computational Theory and Mathematics, having authored 51 papers that have together received 3.2k indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (10 papers), Computational Drug Discovery Methods (9 papers), Synthetic Organic Chemistry Methods (8 papers), Signaling Pathways in Disease (6 papers), Marine Sponges and Natural Products (5 papers), Receptor Mechanisms and Signaling (5 papers), Protein Structure and Dynamics (4 papers) and Peptidase Inhibition and Analysis (4 papers). The work is most often cited by research in Computational Theory and Mathematics (1.1k citations), Organic Chemistry (1.1k citations), Molecular Biology (1.9k citations), Pharmacology (210 citations) and Toxicology (68 citations). Simon J. Teague has collaborated with scholars based in United Kingdom, Sweden and Singapore. Frequent co-authors include A. M. Davis, Tudor I. Oprea, Paul D. Leeson, Gerard J. Kleywegt, Gerald Pattenden, Robert Andrews, A. I. MEYERS, Michael J. Stocks, Mark Bradley and Andrew Baxter. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, Angewandte Chemie International Edition, The Journal of Organic Chemistry and Tetrahedron.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact