Simon A. Hirota

6.3k total citations · 2 hit papers
84 papers, 4.9k citations indexed

About

Simon A. Hirota is a scholar working on Molecular Biology, Immunology and Infectious Diseases. According to data from OpenAlex, Simon A. Hirota has authored 84 papers receiving a total of 4.9k indexed citations (citations by other indexed papers that have themselves been cited), including 37 papers in Molecular Biology, 19 papers in Immunology and 18 papers in Infectious Diseases. Recurrent topics in Simon A. Hirota's work include Gut microbiota and health (20 papers), Clostridium difficile and Clostridium perfringens research (17 papers) and Inflammatory Bowel Disease (11 papers). Simon A. Hirota is often cited by papers focused on Gut microbiota and health (20 papers), Clostridium difficile and Clostridium perfringens research (17 papers) and Inflammatory Bowel Disease (11 papers). Simon A. Hirota collaborates with scholars based in Canada, United States and Australia. Simon A. Hirota's co-authors include Paul L. Beck, Daniel A. Muruve, Justin A. MacDonald, Gustavo Batista Menezes, Christopher C. M. Waterhouse, Keir Pittman, Ingrid Slaba, Braedon McDonald, Paul Kubes and Keith A. Sharkey and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Nature Medicine.

In The Last Decade

Simon A. Hirota

80 papers receiving 4.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

2010 930 citations Braedon McDonald, Keir Pittman et al. Science profile →
Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia

2021 220 citations Fernando Vicentini, Simon A. Hirota et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Simon A. Hirota Canada	33	2.4k	1.3k	739	590	583	84	4.9k
Eric L. Campbell United States	31	2.9k 1.2×	1.5k 1.1×	701 0.9×	977 1.7×	477 0.8×	57	6.0k
Hua Xu United States	36	2.1k 0.9×	419 0.3×	1.1k 1.5×	334 0.6×	605 1.0×	152	4.5k
Jia Sun China	36	2.1k 0.9×	617 0.5×	922 1.2×	597 1.0×	230 0.4×	119	4.3k
Ye Chen China	41	2.7k 1.1×	569 0.4×	1.5k 2.0×	559 0.9×	638 1.1×	237	5.6k
Louise Glover United States	33	2.6k 1.1×	1.2k 0.9×	533 0.7×	856 1.5×	391 0.7×	81	5.0k
Flávio A. Amaral Brazil	34	1.6k 0.7×	1.3k 1.0×	325 0.4×	431 0.7×	409 0.7×	102	4.0k
Douglas J. Kominsky United States	29	2.8k 1.2×	873 0.7×	485 0.7×	950 1.6×	579 1.0×	52	5.1k
Ryota Hokari Japan	35	1.2k 0.5×	1.1k 0.8×	909 1.2×	511 0.9×	173 0.3×	175	4.0k
Robert D. Specian United States	40	1.5k 0.6×	1.0k 0.8×	1.2k 1.6×	803 1.4×	343 0.6×	107	5.3k

Countries citing papers authored by Simon A. Hirota

Since Specialization

Citations

This map shows the geographic impact of Simon A. Hirota's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Simon A. Hirota with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Simon A. Hirota more than expected).

Fields of papers citing papers by Simon A. Hirota

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Simon A. Hirota. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Simon A. Hirota. The network helps show where Simon A. Hirota may publish in the future.

Co-authorship network of co-authors of Simon A. Hirota

This figure shows the co-authorship network connecting the top 25 collaborators of Simon A. Hirota. A scholar is included among the top collaborators of Simon A. Hirota based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Simon A. Hirota. Simon A. Hirota is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Gutierrez, Mackenzie W., Erik van Tilburg Bernardes, Sunita Sharma, et al.. (2025). Early-life gut mycobiome core species modulate metabolic health in mice. Nature Communications. 16(1). 1467–1467. 2 indexed citations

Flannigan, Kyle L., Elizabeth M. Hughes, Matthew Stephens, et al.. (2025). Indole-3-propionic acid protects medium-diversity colitic mice via barrier enhancement preferentially over anti-inflammatory effects. American Journal of Physiology-Gastrointestinal and Liver Physiology. 328(6). G696–G715. 2 indexed citations

Kollath, Vinayaraj Ozhukil, Vivek Krishna Pulakazhi Venu, Mahmoud Saifeddine, et al.. (2024). Polynorepinephrine nanoparticles activate vascular smooth muscle alpha-1 adrenergic receptors. Nanoscale Advances. 7(3). 830–839.

Hirota, Simon A., et al.. (2024). Dietary Phytic Acid, Dephytinization, and Phytase Supplementation Alter Trace Element Bioavailability—A Narrative Review of Human Interventions. Nutrients. 16(23). 4069–4069. 3 indexed citations

Allain, Thibault, et al.. (2022). Protoporphyrin IX derived from dual-species anaerobic biofilms of Fusobacterium necrophorum and Porphyromonas levii attenuates bovine neutrophil function. Biofilm. 4. 100095–100095.

Flannigan, Kyle L., et al.. (2022). The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis. Cellular and Molecular Gastroenterology and Hepatology. 15(3). 765–795. 60 indexed citations

Cluny, Nina L., et al.. (2022). Recruitment of α4β7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior. Journal of Neuroinflammation. 19(1). 73–73. 15 indexed citations

Venu, Vivek Krishna Pulakazhi, Laurie Alston, Mircea Iftinca, et al.. (2021). Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts. American Journal of Physiology-Gastrointestinal and Liver Physiology. 321(3). G280–G297. 37 indexed citations

Matisz, Chelsea E., Fernando Vicentini, Simon A. Hirota, Keith A. Sharkey, & Aaron J. Gruber. (2020). Behavioral adaptations in a relapsing mouse model of colitis. Physiology & Behavior. 216. 112802–112802. 13 indexed citations

10.

Flannigan, Kyle L., et al.. (2019). Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity. Science Advances. 5(8). eaax2358–eaax2358. 90 indexed citations

11.

Venu, Vivek Krishna Pulakazhi, Mahmoud El‐Daly, Mahmoud Saifeddine, et al.. (2019). Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes. Canadian Journal of Diabetes. 43(7). 510–514. 21 indexed citations

12.

Flannigan, Kyle L., Vivek Krishna Pulakazhi Venu, Laurie Alston, et al.. (2019). Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation. Journal of Pharmacology and Experimental Therapeutics. 370(1). 44–53. 26 indexed citations

13.

Ma, Christopher, Vipul Jairath, Benjamin Click, et al.. (2019). Targeting anti-fibrotic pathways in Crohn’s disease – The final frontier?. Best Practice & Research Clinical Gastroenterology. 38-39. 101603–101603. 13 indexed citations

14.

Dicay, Michael, Martin Ståhl, Marilyn Gordon, et al.. (2017). A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function. American Journal of Physiology-Gastrointestinal and Liver Physiology. 313(5). G467–G475. 39 indexed citations

15.

Hirota, Simon A., Aito Ueno, Helen M. Becker, et al.. (2016). Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice. Mediators of Inflammation. 2016. 1–12. 3 indexed citations

16.

Gulbransen, Brian D., Mohammad Bashashati, Simon A. Hirota, et al.. (2012). Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis. Nature Medicine. 18(4). 600–604. 352 indexed citations

17.

Fichna, Jakub, Michael Dicay, Simon A. Hirota, et al.. (2011). Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum. Neurogastroenterology & Motility. 23(6). 583–e212. 12 indexed citations

18.

McDonald, Braedon, Keir Pittman, Gustavo Batista Menezes, et al.. (2010). Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation. Science. 330(6002). 362–366. 930 indexed citations breakdown →

19.

Hirota, Simon A., Eikichi Ihara, Yan Li, et al.. (2010). Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury. Gastroenterology. 139(1). 259–269.e3. 79 indexed citations

20.

Hirota, Christina L., et al.. (2007). E-Ring Isoprostanes Stimulate a Cl− Conductance in Airway Epithelium via Prostaglandin E2-Selective Prostanoid Receptors. American Journal of Respiratory Cell and Molecular Biology. 38(1). 88–94. 14 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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