Simon A. Hirota

6.3k citations

84 papers · 4.9k indexed · 2 hit papers · h-index 33

Gastroenterology top 1%
- Gastrointestinal motility and disorders 7
Biological Psychiatry top 2%
- Tryptophan and brain disorders 7
Immunology top 2%
- IL-33, ST2, and ILC Pathways 7
Physiology top 1%
Nephrology top 2%
Molecular Biology
- Gut microbiota and health 20
Infectious Diseases
- Clostridium difficile and Clostridium perfringens research 17
Genetics
- Inflammatory Bowel Disease 11
Epidemiology
- Microscopic Colitis 6
Surgery
- Helicobacter pylori-related gastroenterology studies 6

Co-authors: Paul L. Beck Daniel A. Muruve Justin A. MacDonald Ingrid Slaba Paul Kubes Braedon McDonald Keir Pittman Gustavo Batista Menezes
Cited by: Gastroenterology Biological Psychiatry Immunology
Journals: American Journal of Physiology-Gastrointestinal and Liver Physiology (6 papers)British Journal of Pharmacology (4 papers)The FASEB Journal (4 papers)
Partner nations: Canada United States Australia

In The Last Decade

Simon A. Hirota

80 papers receiving 4.8k citations

Hit Papers

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Peers

Countries citing papers authored by Simon A. Hirota

Since Specialization

Citations

This map shows the geographic impact of Simon A. Hirota's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Simon A. Hirota with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Simon A. Hirota more than expected).

Fields of papers citing papers by Simon A. Hirota

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Simon A. Hirota. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Simon A. Hirota. The network helps show where Simon A. Hirota may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Simon A. Hirota, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Simon A. Hirota Line = papers co-authored together Simon A. Hirota links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Early-life gut mycobiome core species modulate metabolic health in mice Nature Communications ·Mackenzie W. Gutierrez,Erik van Tilburg Bernardes,M. Holzwarth,憲司泉,WM. Ewart,Michael Stolberg,Hans-Martin Herz,Anuario de Historia del Derecho Español,Sunita Sharma,Petr Ivanovich Lapin,Ferrol Ann Accola,Faye Chleilat,Simon A. Hirota,Raylene A. Reimer,Marie‐Claire Arrieta	2025	2
2	Mycobacterium avium subspecies paratuberculosis targets M cells in enteroid-derived monolayers through interactions with β1 integrins American Journal of Physiology-Gastrointestinal and Liver Physiology ·Yunfeng Li,Kyle L. Flannigan,Laurie Alston,Zhao Sirui,Hong Zhang,Jeroen De Buck,Pina Colarusso,Simon A. Hirota	2025	0
3	Dietary Phytic Acid, Dephytinization, and Phytase Supplementation Alter Trace Element Bioavailability—A Narrative Review of Human Interventions Nutrients ·L. Atmore,雅康綿井,Damir LELAS,Simon A. Hirota,Odysseas Androutsos,Vaios Svolos	2024	3
4	Polynorepinephrine nanoparticles activate vascular smooth muscle alpha-1 adrenergic receptors Nanoscale Advances ·Vinayaraj Ozhukil Kollath,Vivek Krishna Pulakazhi Venu,Mahmoud Saifeddine,Koichiro Mihara,Simon A. Hirota,Jānis Poikāns,Kunal Karan	2024	0
5	Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts American Journal of Physiology-Gastrointestinal and Liver Physiology ·Vivek Krishna Pulakazhi Venu,Laurie Alston,Mircea Iftinca,Behnaz A. Mirzai,Matthew Stephens,Timothy N. Ash,Sonia Rehal,Marcela Lima,Lauren Goff,Pierre‐Yves von der Weid,Christophe Altier,Simon A. Hirota	2021	37
6	Intestinal microbiota shapes gut physiology and regulates enteric neurons and gliabreakdown → Microbiome ·Fernando Vicentini,Catherine M. Keenan,Laurie E. Wallace,Crystal Woods,Jean‐Baptiste Cavin,Amanda Flockton,Wendy B. Macklin,Jaime Belkind‐Gerson,Simon A. Hirota,Keith A. Sharkey	2021	220
7	Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity Science Advances ·Leontine Turgeon,Kyle L. Flannigan,Hannah Rahim,雄作小林,Ian A. Lewis,Simon A. Hirota,Steven C. Greenway	2019	90
8	Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes Canadian Journal of Diabetes ·Vivek Krishna Pulakazhi Venu,Mahmoud El‐Daly,Mahmoud Saifeddine,Simon A. Hirota,Hong Ding,Chris R. Triggle,Morley D. Hollenberg	2019	21
9	Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice Mediators of Inflammation ·Simon A. Hirota,Aito Ueno,Khairani Alawiyah Matondang,Helen M. Becker,L. Patrick Schenck,Wing Sum Pang,Yan Li,Subrata Ghosh,Daniel A. Muruve,Justin A. MacDonald,Paul L. Beck	2016	3
10	IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria Mucosal Immunology ·Kyle L. Flannigan,Vu L. Ngo,Duke Geem,Akihito Harusato,Simon A. Hirota,Charles A. Parkos,Nicholas W. Lukacs,Asma Nusrat,Valérie Gaboriau‐Routhiau,Nadine Cerf–Bensussan,Andrew T. Gewirtz,Timothy L. Denning	2016	102
11	Inflammatory Bowel Disease Cause-specific Mortality Inflammatory Bowel Diseases ·Zain Kassam,Sara Belga,Idan Roifman,Simon A. Hirota,Humberto Jijon,Gilaad G. Kaplan,Subrata Ghosh,Paul L. Beck	2014	43
12	Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis Nature Medicine ·Brian D. Gulbransen,Mohammad Bashashati,Simon A. Hirota,Xianyong Gui,Jane Roberts,Justin A. MacDonald,Daniel A. Muruve,Derek M. McKay,Paul L. Beck,Gary M. Mawe,Roger Thompson,Keith A. Sharkey	2012	352
13	Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum Neurogastroenterology & Motility ·Jakub Fichna,Michael Dicay,Simon A. Hirota,Ante Franić,Justin A. MacDonald,Anna Janecka,Paul L. Beck,Jordan K. Zjawiony,Wallace K. MacNaughton,Martin Storr	2011	12
14	Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammationbreakdown → Science ·Braedon McDonald,Keir Pittman,Gustavo Batista Menezes,Simon A. Hirota,Ingrid Slaba,Christopher C. M. Waterhouse,Paul L. Beck,Daniel A. Muruve,Paul Kubes	2010	930
15	Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury Gastroenterology ·Simon A. Hirota,Μαρία Λινού,Diana M. Baran,Nawang Lukita Wardani Putri,Вараева Елена Александровна,Eikichi Ihara,Yan Li,William G. Willmore,Daniel C. Chung,Melanie Scully,Thomas Louie,Shaun Medlicott,Manigandan Lejeune,Kris Chadee,Glen D. Armstrong,Sean P. Colgan,Daniel A. Muruve,Justin A. MacDonald,Paul L. Beck	2010	79
16	The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD Journal of the American Society of Nephrology ·Akosua Vilaysane,Justin Chun,Mark E. Seamone,Wenjie Wang,Rick Chin,Simon A. Hirota,Yan Li,Sharon A. Clark,Jürg Tschopp,Kiril Trpkov,Brenda R. Hemmelgarn,Paul L. Beck,Daniel A. Muruve	2010	480
17	NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis Inflammatory Bowel Diseases ·Simon A. Hirota,Diana M. Baran,Xu-Yuan Du,Maitham A. Khajah,Ken Kuljit S. Parhar,Yan Li,Victor L. Lam,Wing Sum Pang,Kelvin S. Ng,moohamad amrolahi,Donna‐Marie McCafferty,Kevin P. Rioux,Subrata Ghosh,Ramnik J. Xavier,Sean P. Colgan,Jürg Tschopp,Daniel A. Muruve,Justin A. MacDonald,Paul L. Beck	2010	366
18	The reverse mode of the Na⁺/Ca²⁺ exchanger provides a source of Ca²⁺ for store refilling following agonist-induced Ca²⁺ mobilization American Journal of Physiology-Lung Cellular and Molecular Physiology ·Simon A. Hirota,Evi Pertens,Luke J. Janssen	2006	53
19	Airway smooth muscle excitation-contraction coupling and airway hyperresponsiveness Canadian Journal of Physiology and Pharmacology ·Simon A. Hirota,Steudler Susanne,Adriana Catalli,Iman M. El saeidy,Luke J. Janssen	2005	23
20	Vascular relaxation response to hydrogen peroxide is impaired in hypertension British Journal of Pharmacology ·Yujing Gao,Yongde Zhang,Simon A. Hirota,Luke J. Janssen,Robert M.K.W. Lee	2004	18

About Simon A. Hirota

Simon A. Hirota is a scholar working on Biological Psychiatry, Gastroenterology and Transplantation, having authored 84 papers that have together received 4.9k indexed citations. Recurring topics across this work include Gut microbiota and health (20 papers), Clostridium difficile and Clostridium perfringens research (17 papers), Inflammatory Bowel Disease (11 papers), Gastrointestinal motility and disorders (7 papers), IL-33, ST2, and ILC Pathways (7 papers), Tryptophan and brain disorders (7 papers), Microscopic Colitis (6 papers) and Helicobacter pylori-related gastroenterology studies (6 papers). The work is most often cited by research in Gastroenterology (394 citations), Biological Psychiatry (172 citations) and Immunology (1.3k citations). Simon A. Hirota has collaborated with scholars based in Canada, United States and Australia. Frequent co-authors include Paul L. Beck, Daniel A. Muruve, Justin A. MacDonald, Ingrid Slaba, Paul Kubes, Braedon McDonald, Keir Pittman, Gustavo Batista Menezes, Christopher C. M. Waterhouse and Keith A. Sharkey. Their work appears in journals such as American Journal of Physiology-Gastrointestinal and Liver Physiology, British Journal of Pharmacology, The FASEB Journal, Gastroenterology and Inflammatory Bowel Diseases.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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