Shaoyong Lu

7.6k citations

143 papers · 5.7k indexed · 1 hit paper · h-index 46

Impact in

Computational Theory and Mathematics top 0.2%
- Computational Drug Discovery Methods
Molecular Biology top 1%
- Protein Structure and Dynamics
- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- RNA and protein synthesis mechanisms
- Chemical Synthesis and Analysis

Papers in

Computational Theory and Mathematics 36
- Computational Drug Discovery Methods 36
Molecular Biology 125
- Receptor Mechanisms and Signaling 38
- Protein Structure and Dynamics 31
- Protein Kinase Regulation and GTPase Signaling 29
- PI3K/AKT/mTOR signaling in cancer 16
- Chemical Synthesis and Analysis 12

Co-authors: Jian Zhang Duan Ni Ruth Nussinov Hyunbum Jang Qiancheng Shen Xinheng He Wenkang Huang Jun Pu
Journals: Drug Discovery Today (9 papers)Nucleic Acids Research (6 papers)Journal of Chemical Information and Modeling (6 papers)Computational and Structural Biotechnology Journal (5 papers)International Journal of Biological Macromolecules (5 papers)
Partner nations: China United States Australia

In The Last Decade

Shaoyong Lu

140 papers receiving 5.6k citations

Hit Papers

align trajectories log scale

G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery 2024 · 171 citations

Peers

Countries citing papers authored by Shaoyong Lu

Since Specialization

Citations

This map shows the geographic impact of Shaoyong Lu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Shaoyong Lu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Shaoyong Lu more than expected).

Fields of papers citing papers by Shaoyong Lu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Shaoyong Lu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Shaoyong Lu. The network helps show where Shaoyong Lu may publish in the future.

Co-authors

The 25 scholars most cited alongside Shaoyong Lu, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Shaoyong Lu Line = papers co-authored together Shaoyong Lu links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	In silico identification and experimental validation of long-range allosteric inhibition of Staphylococcus aureus Cas9 catalytic activity by an anti-CRISPR protein AcrIIA14 International Journal of Biological Macromolecules ·Jiacheng Wei, Barbara Stroheeker, Xun Lu, Santopuoli N, Stefan Emminger, Jianxiang Huang, Ning Liu, Jian Zhang, Zong‐Tao Chai, Shaoyong Lu	2025	6
2	Decoding allosteric landscapes: computational methodologies for enzyme modulation and drug discovery RSC Chemical Biology ·Subuh Tugiono, Chengwei Wu, S. Kohani, Shaoyong Lu, Jian Zhang	2025	4
3	Mechanistic Insights into the Mechanism of Allosteric Inhibition of Ubiquitin-Specific Protease 7 (USP7) Biomolecules ·Silvana Escalier, Ning Liu, Nur hotimah Hotimah, Shaoyong Lu, A. Montanari	2025	1
4	Designed dualsteric modulators: A novel route for drug discovery Drug Discovery Today ·Nur hotimah Hotimah, Guodong Zheng, Lili Fu, Ning Liu, Ting Chen, Shaoyong Lu	2024	3
5	Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5 Nature Communications ·Raymond N. Westra, Xiaobing Lan, I. Fronval, Romo Arango, Xun Lu, Jun Pu, Shaoyong Lu, Jian Zhang	2024	14
6	Progressive computational approaches to facilitate decryption of allosteric mechanism and drug discovery Current Opinion in Structural Biology ·Xun Lu, Xiaobing Lan, Shaoyong Lu, Jian Zhang	2023	3
7	Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors Nature Communications ·Jie Zhong, Yuegui Guo, Shaoyong Lu, Kun Song, Ying Wang, Li Feng, Zhen Zheng, Qiufen Zhang, Jiacheng Wei, Peng Sang, Yan Shi, Jianfeng Cai, Guoqiang Chen, Chen‐Ying Liu, LCM Costa, Jian Zhang	2022	10
8	Harnessing Reversed Allosteric Communication: A Novel Strategy for Allosteric Drug Discovery Journal of Medicinal Chemistry ·Santopuoli N, Yaqin Liu, Ren Kong, Duan Ni, Zhengtian Yu, Shaoyong Lu, Jian Zhang	2021	33
9	Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design Nature Communications ·Shaoyong Lu, Xinheng He, Zhao Yang, Zong‐Tao Chai, Shuhua Zhou, Junyan Wang, Ashfaq Ur Rehman, Duan Ni, Jun Pu, Jin‐Peng Sun, Jian Zhang	2021	160
10	Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells Acta Pharmaceutica Sinica B ·Qiufen Zhang, Yingyi Chen, Duan Ni, Zhimin Huang, Jiacheng Wei, Feng Li, Jun‐Cheng Su, R. de la Vega, Shaobo Ning, Elizabeth Bruce, Mingzhu Zhao, Yuran Qiu, Kun Song, Zhengtian Yu, Jianrong Xu, Xinyi Li, Hou‐Wen Lin, Shaoyong Lu, Jian Zhang	2021	52
11	Mechanism of zinc ejection by disulfiram in nonstructural protein 5A Physical Chemistry Chemical Physics ·Ashfaq Ur Rehman, N Y Kharkhuta, Karla Ribeiro Cruz Santos, Duan Ni, Jiayi Li, Abdul Nasır, Moustafa T. Gabr, Joan Mary Jamison, Abdul Wadood, Shaoyong Lu, Jian Zhang, Haifeng Chen	2021	29
12	Pentabromoethylbenzene Exposure Induces Transcriptome Aberration and Thyroid Dysfunction: In Vitro, in Silico, and in Vivo Investigations Environmental Science & Technology ·Liping Lu, Hao Wu, Shixuan Cui, Tingjie Zhan, Chunlong Zhang, Shaoyong Lu, Weiping Liu, Shulin Zhuang	2020	49
13	Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy Chemical Science ·Duan Ni, Jiacheng Wei, Xinheng He, Ashfaq Ur Rehman, Xinyi Li, Yuran Qiu, Jun Pu, Shaoyong Lu, Jian Zhang	2020	108
14	Unraveling allosteric landscapes of allosterome with ASD Nucleic Acids Research ·Xinyi Liu, Shaoyong Lu, Tao Lei, Qiancheng Shen, Duan Ni, Qian Li, Xinheng He, Hao Zhang, Qi Wang, Yingyi Chen, Xinyi Li, Jing Wu, Chunquan Sheng, Guoqiang Chen, Yaqin Liu, Xuefeng Lu, Jian Zhang	2019	55
15	AlloDriver: a method for the identification and analysis of cancer driver targets Nucleic Acids Research ·Kun Song, Qian Li, Wei Gao, Shaoyong Lu, Qiancheng Shen, Xinyi Liu, Yongyan Wu, Binquan Wang, Hou‐Wen Lin, Guoqiang Chen, Jian Zhang	2019	34
16	Allosteric Methods and Their Applications: Facilitating the Discovery of Allosteric Drugs and the Investigation of Allosteric Mechanisms Accounts of Chemical Research ·Shaoyong Lu, Qiancheng Shen, Jian Zhang	2019	137
17	Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit Biochemistry ·Mahya Elahi, Mingzhen Zhang, Hyunbum Jang, Shaoyong Lu, Donn Brazier, Guoqiang Chen, Ruth Nussinov, Jian Zhang, Vadim Gaponenko	2018	10
18	AlloFinder: a strategy for allosteric modulator discovery and allosterome analyses Nucleic Acids Research ·Min Huang, Kun Song, Xinyi Liu, Shaoyong Lu, Qiancheng Shen, Renxiao Wang, 大介長江, Jiya Bhandari, Qian Li, Duan Ni, Jianrong Xu, Guoqiang Chen, Jian Zhang	2018	78
19	Are the Apo Proteins Suitable for the Rational Discovery of Allosteric Drugs? Journal of Chemical Information and Modeling ·Xiaoli An, Shaoyong Lu, Kun Song, Qiancheng Shen, Meilan Huang, Xiaojun Yao, Huanxiang Liu, Jian Zhang	2018	20
20	Improved Method for the Identification and Validation of Allosteric Sites Journal of Chemical Information and Modeling ·Kun Song, Liisa L. Bergmann, Wenkang Huang, Shaoyong Lu, Qiancheng Shen, Lu Zhang, Jian Zhang	2017	98

About Shaoyong Lu

Shaoyong Lu is a scholar working on Computational Theory and Mathematics, Molecular Biology, Geriatrics and Gerontology, Physiology and Toxicology, having authored 143 papers that have together received 5.7k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (38 papers), Computational Drug Discovery Methods (36 papers), Protein Structure and Dynamics (31 papers), Protein Kinase Regulation and GTPase Signaling (29 papers), PI3K/AKT/mTOR signaling in cancer (16 papers), Neuropeptides and Animal Physiology (14 papers), Enzyme Structure and Function (12 papers) and Chemical Synthesis and Analysis (12 papers). The work is most often cited by research in Computational Theory and Mathematics (1.4k citations), Molecular Biology (4.7k citations), Toxicology (103 citations), Cellular and Molecular Neuroscience (408 citations) and Physiology (101 citations). Shaoyong Lu has collaborated with scholars based in China, United States and Australia. Frequent co-authors include Jian Zhang, Duan Ni, Ruth Nussinov, Hyunbum Jang, Qiancheng Shen, Xinheng He, Wenkang Huang, Jun Pu, Yuran Qiu and Shuai Li. Their work appears in journals such as Drug Discovery Today, Nucleic Acids Research, Journal of Chemical Information and Modeling, Computational and Structural Biotechnology Journal and International Journal of Biological Macromolecules.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact