Ruth Brenk

3.5k citations

61 papers · 2.3k indexed · 1 hit paper · h-index 27

Molecular Biology top 5%
Organic Chemistry top 2%
Computational Theory and Mathematics top 0.5%
Epidemiology top 10%
Materials Chemistry

Co-authors: Paul G. Wyatt Julie A. Frearson Ian H. Gilbert Alessandro Schipani Brian K. Shoichet G. Klebe Torsten Luksch David A. Robinson
Topics: Computational Drug Discovery Methods (19 papers)RNA and protein synthesis mechanisms (18 papers)Biochemical and Molecular Research (10 papers)
Cited by: Computational Theory and Mathematics Organic Chemistry Molecular Biology
Journals: PLoS ONE Journal of Molecular Biology Nature Chemistry
Partner nations: United Kingdom Germany Norway

In The Last Decade

Ruth Brenk

60 papers receiving 2.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

2007 482 citations Ruth Brenk, Ian H. Gilbert et al. ChemMedChem profile →

Peers

Countries citing papers authored by Ruth Brenk

Since Specialization

Citations

This map shows the geographic impact of Ruth Brenk's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ruth Brenk with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ruth Brenk more than expected).

Fields of papers citing papers by Ruth Brenk

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ruth Brenk. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ruth Brenk. The network helps show where Ruth Brenk may publish in the future.

Co-authorship network of co-authors of Ruth Brenk

This figure shows the co-authorship network connecting the top 25 collaborators of Ruth Brenk. A scholar is included among the top collaborators of Ruth Brenk based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ruth Brenk. Ruth Brenk is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Assessing small molecule conformational sampling methods in molecular docking 2024 ·Journal of Computational Chemistry ·Qing Xia,(unknown),(unknown),Ruth Brenk,Niu Huang	3
2	Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection 2024 ·RSC Medicinal Chemistry ·(unknown),(unknown),(unknown),Sridhar Sreeramulu,(unknown),Christian Richter,(unknown),(unknown),Edgar Specker,Kristaps Jaudzems,(unknown),Robert K. Harmel,Philip Gribbon,Harald Schwalbe,Ruth Brenk,Aigars Jirgensons,Andrea Zaliani,Jordi Mestres	7
3	Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97 2022 ·Communications Chemistry ·(unknown),Petra Hänzelmann,(unknown),(unknown),(unknown),Christoph Wiedemann,Ute A. Hellmich,Ruth Brenk,Hermann Schindelin,Christoph Sotriffer	5
4	Fragment‐Based Drug Discovery for RNA Targets 2021 ·ChemMedChem ·(unknown),(unknown),Charlotte H. Gotfredsen,Ruth Brenk,Mads H. Clausen	24
5	Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design 2019 ·PLoS ONE ·(unknown),(unknown),(unknown),Werner Kiefer,Ruth Brenk,Maria Elena Ortiz‐Soto,Jürgen Seibel,Tanja Schirmeister	6
6	A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N -Myristoyltransferase Inhibitors 2018 ·Journal of Medicinal Chemistry ·Justin R. Harrison,Stephen Brand,Victoria Smith,David A. Robinson,Stephen Thompson,(unknown),Kenneth Davies,N. Yi Mok,Leah S. Torrie,Iain T. Collie,Irene Hallyburton,Suzanne Norval,Frederick R. C. Simeons,Laste Stojanovski,Julie A. Frearson,Ruth Brenk,Paul G. Wyatt,Ian H. Gilbert,Kevin D. Read	46
7	In silico identification and experimental validation of hits active against KPC-2 β-lactamase 2018 ·PLoS ONE ·(unknown),Pasquale Linciano,Giuseppe Celenza,Pierangelo Bellio,(unknown),Jesús Blázquez,Laura Cendron,Ruth Brenk,Donatella Tondi	9
8	Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors 2017 ·Journal of Medicinal Chemistry ·Tracy Bayliss,David A. Robinson,Victoria Smith,Stephen Brand,Stuart P. McElroy,Leah S. Torrie,Chido Mpamhanga,Suzanne Norval,Laste Stojanovski,Ruth Brenk,Julie A. Frearson,Kevin D. Read,Ian H. Gilbert,Paul G. Wyatt	16
9	To Hit or Not to Hit, That Is the Question – Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa Proteins 2015 ·PLoS ONE ·Aurijit Sarkar,Ruth Brenk	8
10	From On‐Target to Off‐Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti‐Trypanosoma brucei Drug Discovery Lead Molecules 2013 ·ChemMedChem ·Andrew Woodland,Raffaella Grimaldi,Torsten Luksch,Laura A. T. Cleghorn,Kayode K. Ojo,Wesley C. Van Voorhis,Ruth Brenk,Julie A. Frearson,Ian H. Gilbert,Paul G. Wyatt	22
11	Structure-Based Virtual Screening for the Identification of RNA-Binding Ligands 2013 ·Methods in molecular biology ·Peter Daldrop,Ruth Brenk	6
12	Change or be changed 2012 ·Bioorganic & Medicinal Chemistry ·Ruth Brenk,Daniel Rauh	1
13	Optimisation of the Anti‐Trypanosoma brucei Activity of the Opioid Agonist U50488 2011 ·ChemMedChem ·Victoria Smith,Laura A. T. Cleghorn,Andrew Woodland,Daniel Spinks,Irene Hallyburton,Iain T. Collie,N. Yi Mok,Suzanne Norval,Ruth Brenk,Alan H. Fairlamb,Julie A. Frearson,Kevin D. Read,Ian H. Gilbert,Paul G. Wyatt	6
14	Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 2010 ·ChemMedChem ·Daniel Spinks,Han B. Ong,Chidochangu P. Mpamhanga,Emma Shanks,David A. Robinson,Iain T. Collie,Kevin D. Read,Julie A. Frearson,Paul G. Wyatt,Ruth Brenk,Alan H. Fairlamb,Ian H. Gilbert	32
15	Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase 2010 ·Bioorganic & Medicinal Chemistry ·G.F. Ruda,Gordon Campbell,Vincent Pius Alibu,Michael P. Barrett,Ruth Brenk,Ian H. Gilbert	19
16	Nucleosomes can invade DNA territories occupied by their neighbors 2009 ·Nature Structural & Molecular Biology ·Maik Engeholm,Martijn de Jager,Andrew Flaus,Ruth Brenk,John van Noort,Tom Owen‐Hughes	89
17	Crystal Structures of tRNA-guanine Transglycosylase (TGT) in Complex with Novel and Potent Inhibitors Unravel Pronounced Induced-fit Adaptations and Suggest Dimer Formation Upon Substrate Binding 2007 ·Journal of Molecular Biology ·(unknown),Emmanuel A. Meyer,A. Heine,Ruth Brenk,François Diederich,G. Klebe	48
18	Probing Molecular Docking in a Charged Model Binding Site 2006 ·Journal of Molecular Biology ·Ruth Brenk,Stefan W. Vetter,S.E. Boyce,David B. Goodin,Brian K. Shoichet	55
19	Here Be Dragons: Docking and Screening in an Uncharted Region of Chemical Space 2005 ·SLAS DISCOVERY ·Ruth Brenk,John J. Irwin,Brian K. Shoichet	34
20	De Novo Design, Synthesis, and In Vitro Evaluation of Inhibitors for Prokaryotic tRNA-Guanine Transglycosylase: A Dramatic Sulfur Effect on Binding Affinity 2002 ·ChemBioChem ·Emmanuel A. Meyer,Ruth Brenk,Ronald K. Castellano,(unknown),G. Klebe,François Diederich	30

About Ruth Brenk

Ruth Brenk is a scholar working on Computational Theory and Mathematics, Molecular Medicine and Molecular Biology, having authored 61 papers that have together received 2.3k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (19 papers), RNA and protein synthesis mechanisms (18 papers) and Biochemical and Molecular Research (10 papers). The work is most often cited by research in Computational Theory and Mathematics (659 citations), Organic Chemistry (754 citations) and Molecular Biology (1.5k citations). Ruth Brenk has collaborated with scholars based in United Kingdom, Germany and Norway. Frequent co-authors include Paul G. Wyatt, Julie A. Frearson, Ian H. Gilbert, Alessandro Schipani, Brian K. Shoichet, G. Klebe, Torsten Luksch, David A. Robinson, N. Yi Mok and Alan P. Graves. Their work appears in journals such as PLoS ONE, Journal of Molecular Biology and Nature Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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