Robin E. Pearce

3.0k citations

58 papers · 2.4k indexed · h-index 29

Impact in

Pharmacology top 0.1%
- Pharmacogenetics and Drug Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Drug-Induced Hepatotoxicity and Protection
Pediatrics, Perinatology and Child Health top 2%
- Pharmaceutical studies and practices
- Pharmacological Effects and Toxicity Studies

Papers in ⓘ

Pharmacology 39
- Pharmacogenetics and Drug Metabolism 39
Clinical Biochemistry 8
- Metabolism and Genetic Disorders 8

Co-authors: J. Steven Leeder (38 shared papers)Andrea Gaedigk (25 shared papers)Andrew Parkinson (5 shared papers)Roger Gaedigk (10 shared papers)Gregory L. Kearns (12 shared papers)Bhagwat Prasad (8 shared papers)Deepak Bhatt (6 shared papers)Jorge Goldstein (1 shared paper)
Journals: Drug Metabolism and Disposition (18 papers)Clinical Pharmacology & Therapeutics (7 papers)Journal of Pharmacology and Experimental Therapeutics (4 papers)Clinical and Translational Science (3 papers)Chemical Research in Toxicology (2 papers)
Partner nations: United States Canada Sweden

In The Last Decade

Robin E. Pearce

58 papers receiving 2.3k citations

Peers

Countries citing papers authored by Robin E. Pearce

Since Specialization

Citations

This map shows the geographic impact of Robin E. Pearce's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Robin E. Pearce with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Robin E. Pearce more than expected).

Fields of papers citing papers by Robin E. Pearce

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Robin E. Pearce. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Robin E. Pearce. The network helps show where Robin E. Pearce may publish in the future.

Co-authors

The 25 scholars most cited alongside Robin E. Pearce, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Robin E. Pearce Line = papers co-authored together Robin E. Pearce links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	Effects of Freezing, Thawing, and Storing Human Liver Microsomes on Cytochrome P450 Activity Archives of Biochemistry and Biophysics ·Robin E. Pearce, Christin J. McIntyre, Ajay Madan, U.Y. Sanzgiri, Alison J. Draper, Peter L. Bullock, Dorn C. Cook, L. Alayne Burton, Jason Latham, Cheryl Nevins, Andrew Parkinson	1996	207
2	Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: Effects on coumarin, dicumarol, and testosterone oxidation Archives of Biochemistry and Biophysics ·Robin E. Pearce, Denise Greenway, Andrew Parkinson	1992	165
3	Human carboxylesterases HCE1 and HCE2: Ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin Biochemical Pharmacology ·Dongfang Yang, Robin E. Pearce, Xiliang Wang, Roger Gaedigk, Yu‐Jui Yvonne Wan, Bingfang Yan	2008	136
4	Identification of the human P450 enzymes involved in lansoprazole metabolism. Journal of Pharmacology and Experimental Therapeutics ·Robin E. Pearce, A. David Rodrigues, Jorge Goldstein, A. Parkinson	1996	129
5	Ontogeny of Dextromethorphan O- and N-demethylation in the First Year of Life Clinical Pharmacology & Therapeutics ·Michael Blake, Andrea Gaedigk, Robin E. Pearce, Lisa Bomgaars, Michael L. Christensen, Cindy D. Stowe, Laura P. James, John T. Wilson, Gregory L. Kearns, J. Steven Leeder	2007	128
6	Pathways of Carbamazepine Bioactivation in Vitro I. Characterization of Human Cytochromes P450 Responsible for the Formation of 2- and 3-Hydroxylated Metabolites Drug Metabolism and Disposition ·Robin E. Pearce, Gangadhara R. Vakkalagadda, J. Steven Leeder	2002	114
7	Variability of CYP3A7 Expression in Human Fetal Liver Journal of Pharmacology and Experimental Therapeutics ·J. Steven Leeder, Roger Gaedigk, Kenda Marcucci, Andrea Gaedigk, Carrie A. Vyhlidal, Bradley P. Schindel, Robin E. Pearce	2005	111
8	Age‐ and Genotype‐Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate‐Glucuronosyltransferases in Human Liver Clinical Pharmacology & Therapeutics ·Deepak Bhatt, Aanchal Mehrotra, Andrea Gaedigk, Revathi Chapa, Abdul Basit, Haeyoung Zhang, Prachi Choudhari, Mikael Boberg, Robin E. Pearce, Roger Gaedigk, Ulrich Broeckel, J. Steven Leeder, Bhagwat Prasad	2018	90
9	Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants Drug Metabolism and Disposition ·Mikael Boberg, Marc Vrana, Aanchal Mehrotra, Robin E. Pearce, Andrea Gaedigk, Deepak Bhatt, J. Steven Leeder, Bhagwat Prasad	2016	86
10	Pathways of Carbamazepine Bioactivation in Vitro. III. The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine Drug Metabolism and Disposition ·Robin E. Pearce, Wei Lü, Yongqiang Wang, Jack Uetrecht, Maria Almira Correia, J. Steven Leeder	2008	79
11	Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans The Pharmacogenomics Journal ·Andrea Gaedigk, Anahita Bhathena, Liliane Ndjountché, Robin E. Pearce, S. M. Abdel‐Rahman, S W Alander, L. DiAnne Bradford, J. Steven Leeder	2005	65
12	Effect of Diet on the Development of Drug Metabolism by Cytochrome P-450 Enzymes in Healthy Infants Pediatric Research ·Michael Blake, Susan M. Abdel‐Rahman, Robin E. Pearce, J. Steven Leeder, Gregory L. Kearns	2006	61
13	PATHWAYS OF CARBAMAZEPINE BIOACTIVATION IN VITRO: II. THE ROLE OF HUMAN CYTOCHROME P450 ENZYMES IN THE FORMATION OF 2-HYDROXYIMINOSTILBENE Drug Metabolism and Disposition ·Robin E. Pearce, (unknown), (unknown)	2005	59
14	Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes Carcinogenesis ·Chitra Mani, Robin E. Pearce, Andrew Parkinson, David Kupfer	1994	55
15	Characterization of Cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 Activities toward Model CYP2D6 Substrates Dextromethorphan, Bufuralol, and Debrisoquine Drug Metabolism and Disposition ·Kenda Marcucci, Robin E. Pearce, Charles L. Crespi, Dorothy T. Steimel, J. Steven Leeder, Andrea Gaedigk	2002	53
16	Reference Intervals for Urinary Renal Injury Biomarkers KIM-1 and NGAL in Healthy Children Biomarkers in Medicine ·Stephen J McWilliam, Daniel J. Antoine, Venkata Sabbisetti, Robin E. Pearce, Andrea Jorgensen, Yvonne S. Lin, J. Steven Leeder, Joseph V. Bonventre, Rosalind L. Smyth, Munir Pirmohamed	2014	53
17	CYP3A4-Mediated Carbamazepine (CBZ) Metabolism: Formation of a Covalent CBZ-CYP3A4 Adduct and Alteration of the Enzyme Kinetic Profile Drug Metabolism and Disposition ·Ping Kang, Mingxiang Liao, Michael R. Wester, J. Steven Leeder, Robin E. Pearce, Maria Almira Correia	2007	50
18	Studies on the Conversion of Haloperidol and Its Tetrahydropyridine Dehydration Product to Potentially Neurotoxic Pyridinium Metabolites by Human Liver Microsomes Chemical Research in Toxicology ·Etsuko Usuki, Robin E. Pearce, Andrew Parkinson, Neal Castagnoli	1996	50
19	Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex Drug Metabolism and Disposition ·Deepak Bhatt, Abdul Basit, Haeyoung Zhang, Andrea Gaedigk, Seung‐been Lee, Katrina G. Claw, Aanchal Mehrotra, Amarjit S. Chaudhry, Robin E. Pearce, Roger Gaedigk, Ulrich Broeckel, Timothy A. Thornton, Deborah A. Nickerson, Erin G. Schuetz, John K. Amory, J. Steven Leeder, Bhagwat Prasad	2018	46
20	Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism Drug Metabolism and Disposition ·Mayur K. Ladumor, Deepak Bhatt, Andrea Gaedigk, S.C. Sharma, Aarzoo Thakur, Robin E. Pearce, J. Steven Leeder, Michael B. Bolger, Saranjit Singh, Bhagwat Prasad	2019	46

About Robin E. Pearce

Robin E. Pearce is a scholar working on Pharmacology, Clinical Biochemistry, Pediatrics, Perinatology and Child Health, Gastroenterology and Oncology, having authored 58 papers that have together received 2.4k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (39 papers), Drug Transport and Resistance Mechanisms (16 papers), Pharmaceutical studies and practices (10 papers), Metabolism and Genetic Disorders (8 papers), Pharmacological Effects and Toxicity Studies (5 papers), Receptor Mechanisms and Signaling (4 papers), Diet and metabolism studies (4 papers) and Chemical Reactions and Isotopes (4 papers). The work is most often cited by research in Pharmacology (1.3k citations), Pediatrics, Perinatology and Child Health (631 citations), Pharmacology (447 citations), Clinical Biochemistry (157 citations) and Oncology (621 citations). Robin E. Pearce has collaborated with scholars based in United States, Canada and Sweden. Frequent co-authors include J. Steven Leeder, Andrea Gaedigk, Andrew Parkinson, Roger Gaedigk, Gregory L. Kearns, Bhagwat Prasad, Deepak Bhatt, Jorge Goldstein, A. David Rodrigues and A. Parkinson. Their work appears in journals such as Drug Metabolism and Disposition, Clinical Pharmacology & Therapeutics, Journal of Pharmacology and Experimental Therapeutics, Clinical and Translational Science and Chemical Research in Toxicology.

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