Richard W. Tsien

61.4k citations

243 papers · 49.1k indexed · 27 hit papers · h-index 119

Molecular Biology top 0.02%
Cellular and Molecular Neuroscience top 0.01%
Cardiology and Cardiovascular Medicine top 0.05%
Cognitive Neuroscience top 0.2%
Cell Biology top 0.1%

Co-authors: Martha C. Nowycky Karl Deisseroth A P Fox J B Lansman Roberto Malinow Peter Hess Aaron P. Fox Denis Noble
Topics: Neuroscience and Neuropharmacology Research (128 papers)Ion channel regulation and function (120 papers)Cardiac electrophysiology and arrhythmias (64 papers)
Cited by: Cellular and Molecular Neuroscience Molecular Biology Cardiology and Cardiovascular Medicine
Journals: Nature Science Cell
Partner nations: United States Germany China

In The Last Decade

Richard W. Tsien

242 papers receiving 47.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 1.8k citations Richard W. Tsien et al. Nature profile →
Multiple types of neuronal calcium channels and their selective modulation

1988 1.2k citations Richard W. Tsien et al. profile →
Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones.

1987 1.1k citations Richard W. Tsien et al. The Journal of Physiology profile →
Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 1.1k citations Howard Schulman, Richard W. Tsien et al. Science profile →
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

1984 1.1k citations Richard W. Tsien et al. Nature profile →
Calcium Channels, Stores, and Oscillations

1990 1.0k citations Richard W. Tsien et al. PubMed profile →
CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 956 citations Richard W. Tsien et al. profile →
Roles of N-Type and Q-Type Ca ²⁺ Channels in Supporting Hippocampal Synaptic Transmission

1994 834 citations David B. Wheeler, Andrew D. Randall et al. Science profile →
MicroRNA-mediated conversion of human fibroblasts to neurons

2011 778 citations Andrew S. Yoo, Alfred Xuyang Sun et al. Nature profile →
Dominant Role of N-Type Ca ²⁺ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons

1988 761 citations Richard W. Tsien et al. Science profile →
Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

1983 725 citations Richard W. Tsien et al. Nature profile →
Mechanism of ion permeation through calcium channels

1984 709 citations Richard W. Tsien et al. Nature profile →
Calmodulin supports both inactivation and facilitation of L-type calcium channels

1999 697 citations Geoffrey S. Pitt, Karl Deisseroth et al. Nature profile →
A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle

1987 686 citations Richard W. Tsien et al. Nature profile →
Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle.

1987 671 citations Richard W. Tsien et al. Proceedings of the National Academy of Sciences profile →
Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices

1990 668 citations Richard W. Tsien et al. Nature profile →
Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity

1996 612 citations Karl Deisseroth, Richard W. Tsien et al. Neuron profile →
A novel type of cardiac calcium channel in ventricular cells

1985 596 citations Richard W. Tsien et al. Nature profile →
Calcium Channels in Excitable Cell Membranes

1983 595 citations Richard W. Tsien profile →
Lidocaine block of cardiac sodium channels.

1983 572 citations Richard W. Tsien et al. profile →
Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons

1993 561 citations Andrew D. Randall, William A. Sather et al. profile →
Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons

1998 544 citations Karl Deisseroth, Richard W. Tsien et al. Nature profile →
Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres.

1978 518 citations Richard W. Tsien et al. The Journal of Physiology profile →
Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

1993 506 citations William A. Sather, Richard W. Tsien et al. Nature profile →
Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells.

1986 505 citations Richard W. Tsien et al. profile →
Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore.

1986 490 citations Richard W. Tsien et al. profile →
Free calcium in heart muscle at rest and during contraction measured with Ca2+-sensitive microelectrodes

1980 225 citations Eduardo Marbán, Richard W. Tsien et al. Nature profile →

Peers

Countries citing papers authored by Richard W. Tsien

Since Specialization

Citations

This map shows the geographic impact of Richard W. Tsien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard W. Tsien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard W. Tsien more than expected).

Fields of papers citing papers by Richard W. Tsien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard W. Tsien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard W. Tsien. The network helps show where Richard W. Tsien may publish in the future.

Co-authorship network of co-authors of Richard W. Tsien

This figure shows the co-authorship network connecting the top 25 collaborators of Richard W. Tsien. A scholar is included among the top collaborators of Richard W. Tsien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard W. Tsien. Richard W. Tsien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Functional specialization of hippocampal somatostatin-expressing interneurons 2024 ·Proceedings of the National Academy of Sciences ·Simon Chamberland,(unknown),Robert Machold,(unknown),Guoling Tian,(unknown),(unknown),Klas Kullander,Richard W. Tsien	18
2	A role of GPR55 in the antiepileptic properties of cannabidiol (CBD) (P2.277) 2018 ·Neurology ·Benjamin J. Whalley,Michaël Bazelot,Evan C. Rosenberg,Richard W. Tsien	4
3	Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression 2016 ·Science ·Boxing Li,Michael R. Tadross,Richard W. Tsien	86
4	Cannabinoids and Epilepsy 2015 ·Neurotherapeutics ·Evan C. Rosenberg,Richard W. Tsien,Benjamin J. Whalley,Orrin Devinsky	167
5	Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus 2015 ·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Huan Ma,Boxing Li,Richard W. Tsien	29
6	Influence of Synaptic Vesicle Position on Release Probability and Exocytotic Fusion Mode 2012 ·Science ·Hyokeun Park,Yulong Li,Richard W. Tsien	96
7	MicroRNA-mediated conversion of human fibroblasts to neuronsbreakdown → 2011 ·Nature ·Andrew S. Yoo,Alfred Xuyang Sun,Li Li,Aleksandr Shcheglovitov,Thomas Portmann,Yulong Li,(unknown),Ricardo E. Dolmetsch,Richard W. Tsien,Robert H. Crabtree	778
8	The Dynamic Control of Kiss-And-Run and Vesicular Reuse Probed with Single Nanoparticles 2009 ·Science ·Qi Zhang,Yulong Li,Richard W. Tsien	280
9	The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of Ca _V 1.2 L-type calcium channels 2008 ·Proceedings of the National Academy of Sciences ·Curtis F. Barrett,Richard W. Tsien	136
10	Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant Ca _V 2.1 channels 2008 ·Proceedings of the National Academy of Sciences ·Kei Watase,Curtis F. Barrett,Taisuke Miyazaki,Taro Ishiguro,Kinya Ishikawa,Yuanxin Hu,Toshinori Unno,Yaling Sun,(unknown),Masahiko Watanabe,Christopher M. Gómez,Hidehiro Mizusawa,Richard W. Tsien,Huda Y. Zoghbi	122
11	Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca ²⁺ channel activity and inhibitory synaptic transmission 2005 ·Proceedings of the National Academy of Sciences ·Yuqing Cao,Richard W. Tsien	61
12	CaMKII tethers to L-type Ca2 + channels, establishing a local and dedicated integrator of Ca2 + signals for facilitation 2005 ·The Journal of Cell Biology ·Andy Hudmon,Howard Schulman,James Kim,(unknown),Richard W. Tsien,Geoffrey S. Pitt	266
13	α- and βCaMKII 2002 ·Neuron ·Tara C. Thiagarajan,Erika S. Piedras-Renterı́a,Richard W. Tsien	240
14	Dynamic Multiphosphorylation Passwords for Activity-Dependent Gene Expression 2002 ·Neuron ·Karl Deisseroth,Richard W. Tsien	99
15	Calmodulin priming: Nuclear translocation of a calmodulin complex and the memory of prior neuronal activity 2001 ·Proceedings of the National Academy of Sciences ·P. Mermelstein,Karl Deisseroth,(unknown),(unknown),Richard W. Tsien	74
16	Increased expression of alpha 1A Ca2+ channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6. 2001 ·PubMed ·Erika S. Piedras-Renterı́a,Kei Watase,Nobutoshi Harata,Olga Zhuchenko,Huda Y. Zoghbi,Cheng Chi Lee,Richard W. Tsien	74
17	Chapter 6 Neuronal calcium channels encoded by the α1A subunit and their contribution to excitatory synaptic transmission in the CNS 1995 ·Progress in brain research ·David B. Wheeler,Andrew D. Randall,William A. Sather,Richard W. Tsien	46
18	Glutamate-induced increases in intracellular Ca2+ in cultured frog tectal cells mediated by direct activation of NMDA receptor channels 1991 ·Neuron ·(unknown),Richard W. Tsien	45
19	Is the slow inward calcium current of heart muscle inactivated by calcium 1981 ·Biophysical Journal ·Eduardo Marbán,Richard W. Tsien	24
20	Ouabain increases the slow inward calcium current in ventricular muscle of the ferret 1979 ·The Journal of Physiology ·Eduardo Marbán,Richard W. Tsien	2

About Richard W. Tsien

Richard W. Tsien is a scholar working on Cellular and Molecular Neuroscience, Cardiology and Cardiovascular Medicine and Molecular Biology, having authored 243 papers that have together received 49.1k indexed citations. Recurring topics across this work include Neuroscience and Neuropharmacology Research (128 papers), Ion channel regulation and function (120 papers) and Cardiac electrophysiology and arrhythmias (64 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (32.2k citations), Molecular Biology (36.8k citations) and Cardiology and Cardiovascular Medicine (11.2k citations). Richard W. Tsien has collaborated with scholars based in United States, Germany and China. Frequent co-authors include Martha C. Nowycky, Karl Deisseroth, A P Fox, J B Lansman, Roberto Malinow, Peter Hess, Aaron P. Fox, Denis Noble, Haruhiko Bito and Robert S. Kass. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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