Richard A. Koup

69.3k citations

309 papers · 42.6k indexed · 18 hit papers · h-index 102

Immunology top 0.01%
Virology top 0.01%
Infectious Diseases top 0.01%
Epidemiology top 0.05%
Molecular Biology top 0.5%

Co-authors: Daniel C. Douek Mario Roederer Michael R. Betts William A. Paxton Jason M. Brenchley David D. Ho David A. Price Joseph P. Casazza
Topics: HIV Research and Treatment (177 papers)Immune Cell Function and Interaction (136 papers)T-cell and B-cell Immunology (94 papers)
Cited by: Virology Immunology Infectious Diseases
Journals: Nature Science New England Journal of Medicine
Partner nations: United States United Kingdom Sweden

In The Last Decade

Richard A. Koup

308 papers receiving 41.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 2.6k citations Richard A. Koup, William A. Paxton et al. profile →
Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 2.4k citations William A. Paxton, Richard A. Koup et al. profile →
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 2.0k citations Richard A. Koup, Jeffrey T. Safrit et al. Journal of Virology profile →
Changes in thymic function with age and during the treatment of HIV infection

1998 1.5k citations Daniel C. Douek, Philip Keiser et al. profile →
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

2003 1.3k citations Michael R. Betts, Jason M. Brenchley et al. profile →
The role of a mutant CCR5 allele in HIV–1 transmission and disease progression

1996 1.1k citations William A. Paxton, Richard A. Koup et al. profile →
Genotypic and Phenotypic Characterization of HIV-1 Patients with Primary Infection

1993 1.0k citations Richard A. Koup et al. profile →
HIV preferentially infects HIV-specific CD4+ T cells

2002 982 citations Daniel C. Douek, Jason M. Brenchley et al. profile →
Antiretroviral-Drug Resistance among Patients Recently Infected with HIV

2002 878 citations Susan J. Little, Richard A. Koup et al. profile →
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

2003 812 citations Jason M. Brenchley, Michael R. Betts et al. profile →
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 725 citations Constantinos Petrovas, Joseph P. Casazza et al. The Journal of Experimental Medicine profile →
Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

1990 653 citations Richard A. Koup, John L. Sullivan et al. profile →
CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

1997 631 citations William A. Paxton, Richard A. Koup et al. The Journal of Experimental Medicine profile →
HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

1999 629 citations Richard A. Koup, Louis J. Picker et al. profile →
Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 ⁺ and CD8 ⁺ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection

2001 574 citations Michael R. Betts, David R. Ambrozak et al. Journal of Virology profile →
Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques.

1996 556 citations Richard A. Koup et al. The Journal of Experimental Medicine profile →
Relative resistance to HIV–1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high–risk sexual exposures

1996 518 citations William A. Paxton, Richard A. Koup et al. profile →
A Covid-19 Milestone Attained — A Correlate of Protection for Vaccines

2022 109 citations Richard A. Koup et al. profile →

Peers

Countries citing papers authored by Richard A. Koup

Since Specialization

Citations

This map shows the geographic impact of Richard A. Koup's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard A. Koup with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard A. Koup more than expected).

Fields of papers citing papers by Richard A. Koup

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard A. Koup. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard A. Koup. The network helps show where Richard A. Koup may publish in the future.

Co-authorship network of co-authors of Richard A. Koup

This figure shows the co-authorship network connecting the top 25 collaborators of Richard A. Koup. A scholar is included among the top collaborators of Richard A. Koup based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard A. Koup. Richard A. Koup is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates 2023 ·Nature Communications ·Chaim A. Schramm,(unknown),(unknown),Noemia S. Lima,(unknown),Kristin L. Boswell,Amy R. Henry,Farida Laboune,David R. Ambrozak,Samuel Darko,I‐Ting Teng,Kathryn E. Foulds,Andrea Carfı́,Darin K. Edwards,Peter D. Kwong,Richard A. Koup,Robert A. Seder,Daniel C. Douek	5
2	Immortalization and functional screening of natively paired human T cell receptor repertoires 2021 ·Protein Engineering Design and Selection ·Ahmed S. Fahad,(unknown),Sheila N. López Acevedo,(unknown),Bharat Madan,Matías Gutiérrez-González,Rodrigo Matus‐Nicodemos,(unknown),(unknown),(unknown),(unknown),Sian Llewellyn‐Lacey,Richard A. Koup,Daniel C. Douek,Henry H. Balfour,David A. Price,Brandon J. DeKosky	5
3	Concordance of immunological events between intrarectal and intravenous SHIVAD8-EO infection when assessed by Fiebig-equivalent staging 2021 ·Journal of Clinical Investigation ·Joana Dias,Giulia Fabozzi,(unknown),Mangaiarkarasi Asokan,(unknown),Jonathan Fintzi,(unknown),Yoshiaki Nishimura,John-Paul Todd,Jeffrey D. Lifson,Malcolm A. Martin,Lúcio Gama,Constantinos Petrovas,Amarendra Pegu,John R. Mascola,Richard A. Koup	4
4	Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures 2021 ·Proceedings of the National Academy of Sciences ·Kartika Padhan,Eirini Moysi,Alessandra Noto,(unknown),Khader Ghneim,(unknown),(unknown),(unknown),Giulia Fabozzi,David R. Ambrozak,Antigoni Poultsidi,Μαρία Ιωάννου,Craig Fenwick,Samuel Darko,Daniel C. Douek,Rafick‐Pierre Sékaly,Giuseppe Pantaleo,Richard A. Koup,Constantinos Petrovas	14
5	Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia 2020 ·The Journal of Experimental Medicine ·Yoshiaki Nishimura,Olivia K. Donau,Joana Dias,Sara Ferrando‐Martínez,(unknown),Reza Sadjadpour,Rajeev Gautam,Alicia Buckler‐White,Romas Geleziunas,Richard A. Koup,Michel C. Nussenzweig,Malcolm A. Martin	37
6	Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial 2019 ·PLoS ONE ·Cristina Carter,Katherine V. Houser,Galina V. Yamshchikov,Abbie R. Bellamy,Jeanine May,Mary E. Enama,Uzma Sarwar,Brenda Larkin,Robert T. Bailer,Richard A. Koup,Grace Chen,Shital M. Patel,Patricia Winokur,Robert B. Belshe,Cornelia L. Dekker,Barney S. Graham,Julie E. Ledgerwood,(unknown)	16
7	Lower Baseline Germinal Center Activity and Preserved Th1 Immunity are Associated with Hepatitis B Vaccine Response in Treated HIV Infection 2017 ·SHILAP Revista de lepidopterología ·Robert Paris,Lucimar G. Milagres,Eirini Moysi,Jason F. Okulicz,Brian K. Agan,(unknown),Constantinos Petrovas,Richard A. Koup	10
8	HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation 2015 ·PLoS ONE ·(unknown),Angéline Rouers,Takuya Yamamoto,Yin Xu,Alejandra Urrutia,Hang‐Phuong Pham,Sylvain Cardinaud,Assia Samri,Karim Dorgham,Pierre‐Grégoire Coulon,Rémi Cheynier,Anne Hosmalin,Éric Oksenhendler,Adrien Six,Anthony D. Kelleher,John Zaunders,Richard A. Koup,Brigitte Autran,Arnaud Moris,Stéphanie Graff‐Dubois	50
9	The Phenotype of the Cryptococcus-Specific CD4+ Memory T-Cell Response Is Associated With Disease Severity and Outcome in HIV-Associated Cryptococcal Meningitis 2013 ·The Journal of Infectious Diseases ·Joseph N Jarvis,Joseph P. Casazza,(unknown),Graeme Meintjes,Stephen D Lawn,Stuart M. Levitz,Thomas S. Harrison,Richard A. Koup	105
10	Adenovirus type-35 vectors block human CD4 ⁺ T-cell activation via CD46 ligation 2011 ·Proceedings of the National Academy of Sciences ·William C. Adams,Cornelia Gujer,Gerald M. McInerney,Jason G. Gall,Constantinos Petrovas,Gunilla B. Karlsson Hedestam,Richard A. Koup,Karin Loré	32
11	Preferential infection and depletion of Mycobacterium tuberculosis –specific CD4 T cells after HIV-1 infection 2010 ·The Journal of Experimental Medicine ·Christof Geldmacher,Njabulo Ngwenyama,Alexandra Schuetz,Constantinos Petrovas,Klaus Reither,Edwin J. Heeregrave,Joseph P. Casazza,David R. Ambrozak,Mark K. Louder,William Ampofo,Georgios Pollakis,Brenna J. Hill,Erica Sanga,Elmar Saathoff,Leonard Maboko,Mario Roederer,William A. Paxton,Michael Höelscher,Richard A. Koup	179
12	Systemic and Mucosal T-Lymphocyte Activation Induced by Recombinant Adenovirus Vaccines in Rhesus Monkeys 2009 ·Journal of Virology ·Yue Sun,Robert T. Bailer,Srinivas S. Rao,John R. Mascola,Gary J. Nabel,Richard A. Koup,Norman L. Letvin	14
13	Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes 2009 ·Proceedings of the National Academy of Sciences ·Jung S. Byun,Madeline Wong,Wenwu Cui,Gila Idelman,(unknown),Adriana De Siervi,Sven Bilke,Cynthia M. Haggerty,Audrey Player,Yong Hong Wang,Michael J. Thirman,Joseph J. Kaberlein,Constantinos Petrovas,Richard A. Koup,Dan L. Longo,Keiko Ozato,Kevin Gardner	52
14	Immediate Cytotoxicity But Not Degranulation Distinguishes Effector and Memory Subsets of CD8+ T Cells 2004 ·The Journal of Experimental Medicine ·Petra Wolint,Michael R. Betts,Richard A. Koup,Annette Oxenius	217
15	Absence of Immunodominant Anti-Gag p17 (SL9) Responses among Gag CTL-Positive, HIV-Uninfected Vaccine Recipients Expressing the HLA-A0201 Allele 2004 ·The Journal of Immunology* ·Guido Ferrari,(unknown),Janet Ottinger,(unknown),Bradley H. Edwards,Paul A. Goepfert,Michael R. Betts,Richard A. Koup,Susan Buchbinder,M. Juliana McElrath,Jim Tartaglia,Kent J. Weinhold	24
16	HIV-Infected Langerhans Cells Preferentially Transmit Virus to Proliferating Autologous CD4+ Memory T Cells Located within Langerhans Cell-T Cell Clusters 2004 ·The Journal of Immunology ·Makoto Sugaya,Karin Loré,Richard A. Koup,Daniel C. Douek,Andrew Blauvelt	53
17	Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 ⁺ and CD8 ⁺ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infectionbreakdown → 2001 ·Journal of Virology ·Michael R. Betts,David R. Ambrozak,Daniel C. Douek,Sebastian Bonhoeffer,Jason M. Brenchley,Joseph P. Casazza,Richard A. Koup,Louis J. Picker	574
18	Evidence for Increased T Cell Turnover and Decreased Thymic Output in HIV Infection 2001 ·The Journal of Immunology ·Daniel C. Douek,Michael R. Betts,Brenna J. Hill,Susan J. Little,Richard A. Lempicki,Julia A. Metcalf,Joseph P. Casazza,Christian Yoder,Joseph W. Adelsberger,Randy Stevens,Michael Baseler,Philip Keiser,Douglas D. Richman,Richard T. Davey,Richard A. Koup	192
19	Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design (vol 57, pg 105, 1997) 1997 ·Immunology Letters ·(unknown),(unknown),Richard A. Koup,Pascal Poignard,Quentin J. Sattentau,Paola Fisicaro,Burton	2
20	Quantitative Assessment of Human Immunodeficiency Virus Type 1 Replication in Human Xenografts of Acutely Infected Hu-PBL-SCID Mice 1994 ·AIDS Research and Human Retroviruses ·Richard A. Koup,R M Hesselton,Jeffrey T. Safrit,Mohan Somasundaran,John L. Sullivan	16

About Richard A. Koup

Richard A. Koup is a scholar working on Virology, Immunology and Infectious Diseases, having authored 309 papers that have together received 42.6k indexed citations. Recurring topics across this work include HIV Research and Treatment (177 papers), Immune Cell Function and Interaction (136 papers) and T-cell and B-cell Immunology (94 papers). The work is most often cited by research in Virology (22.9k citations), Immunology (24.4k citations) and Infectious Diseases (13.9k citations). Richard A. Koup has collaborated with scholars based in United States, United Kingdom and Sweden. Frequent co-authors include Daniel C. Douek, Mario Roederer, Michael R. Betts, William A. Paxton, Jason M. Brenchley, David D. Ho, David A. Price, Joseph P. Casazza, Louis J. Picker and David R. Ambrozak. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact