Daniel C. Douek

74.6k total citations · 22 hit papers
338 papers, 44.9k citations indexed

About

Daniel C. Douek is a scholar working on Immunology, Virology and Infectious Diseases. According to data from OpenAlex, Daniel C. Douek has authored 338 papers receiving a total of 44.9k indexed citations (citations by other indexed papers that have themselves been cited), including 251 papers in Immunology, 145 papers in Virology and 76 papers in Infectious Diseases. Recurrent topics in Daniel C. Douek's work include Immune Cell Function and Interaction (180 papers), T-cell and B-cell Immunology (147 papers) and HIV Research and Treatment (143 papers). Daniel C. Douek is often cited by papers focused on Immune Cell Function and Interaction (180 papers), T-cell and B-cell Immunology (147 papers) and HIV Research and Treatment (143 papers). Daniel C. Douek collaborates with scholars based in United States, United Kingdom and Australia. Daniel C. Douek's co-authors include Jason M. Brenchley, Richard A. Koup, David A. Price, Mario Roederer, Brenna J. Hill, Michael R. Betts, Steven G. Deeks, Louis J. Picker, Timothy W. Schacker and Joseph P. Casazza and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Daniel C. Douek

332 papers receiving 44.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

2006 2.7k citations Jason M. Brenchley, David A. Price et al. profile →
Changes in thymic function with age and during the treatment of HIV infection

1998 1.5k citations Daniel C. Douek, Ashley T. Haase et al. profile →
A human memory T cell subset with stem cell–like properties

2011 1.4k citations Máire F. Quigley, Jorge R. Almeida et al. profile →
CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract

2004 1.4k citations Jason M. Brenchley, Timothy W. Schacker et al. The Journal of Experimental Medicine profile →
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

2009 1.3k citations Nicolas Chomont, Jason M. Brenchley et al. profile →
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

2003 1.3k citations Michael R. Betts, Jason M. Brenchley et al. profile →
Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

2005 989 citations Daniel C. Douek, Mario Roederer et al. profile →
HIV preferentially infects HIV-specific CD4+ T cells

2002 982 citations Daniel C. Douek, Jason M. Brenchley et al. profile →
Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

2011 856 citations Netanya G. Sandler, Handan Wand et al. The Journal of Infectious Diseases profile →
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

2008 848 citations Jason M. Brenchley, Daniel C. Douek et al. profile →
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

2003 812 citations Jason M. Brenchley, Michael R. Betts et al. Blood profile →
PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

2014 772 citations Alena Gros, Paul F. Robbins et al. Journal of Clinical Investigation profile →
Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

2012 766 citations Daniel C. Douek et al. profile →
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 725 citations Joseph P. Casazza, Jason M. Brenchley et al. The Journal of Experimental Medicine profile →
Systemic Effects of Inflammation on Health during Chronic HIV Infection

2013 588 citations Steven G. Deeks, Daniel C. Douek et al. profile →
Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 ⁺ and CD8 ⁺ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection

2001 574 citations Michael R. Betts, David R. Ambrozak et al. Journal of Virology profile →
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

2007 542 citations Jorge R. Almeida, David A. Price et al. The Journal of Experimental Medicine profile →
Relationship between T Cell Activation and CD4 ⁺ T Cell Count in HIV‐Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy

2007 506 citations Peter W. Hunt, Jason M. Brenchley et al. The Journal of Infectious Diseases profile →
Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

2014 503 citations Gregory J. Beilman, Alexander Khoruts et al. Proceedings of the National Academy of Sciences profile →
Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection

2009 463 citations Peter W. Hunt, Jeffrey N. Martin et al. The Journal of Infectious Diseases profile →
Microbial translocation in HIV infection: causes, consequences and treatment opportunities

2012 352 citations Netanya G. Sandler, Daniel C. Douek profile →
SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

2021 230 citations Robert A. Seder, Daniel C. Douek et al. Nature Microbiology profile →

Peers

Countries citing papers authored by Daniel C. Douek

Since Specialization

Citations

This map shows the geographic impact of Daniel C. Douek's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Daniel C. Douek with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Daniel C. Douek more than expected).

Fields of papers citing papers by Daniel C. Douek

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Daniel C. Douek. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Daniel C. Douek. The network helps show where Daniel C. Douek may publish in the future.

Co-authorship network of co-authors of Daniel C. Douek

This figure shows the co-authorship network connecting the top 25 collaborators of Daniel C. Douek. A scholar is included among the top collaborators of Daniel C. Douek based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Daniel C. Douek. Daniel C. Douek is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	NK cell activation and CD4+ T cell α4β7 expression are associated with susceptibility to HIV-1 2025 ·Journal of Clinical Investigation ·Kawthar Machmach, (unknown), Rohit Farmer, Sucheta Godbole, Dohoon Kim, Lauren McCormick, Noemia S. Lima, Amy R. Henry, Farida Laboune, Isabella Swafford, (unknown), Bonnie M. Slike, Jeffrey R. Currier, Leigh Anne Eller, Julie A. Ake, Sandhya Vasan, Merlin L. Robb, Shelly J. Krebs, Daniel C. Douek, Dominic Paquin‐Proulx	0
2	A family of olfactory receptors uniquely expanded in marsupial and monotreme genomes are expressed by a T cell subset also unique to marsupials and monotremes 2024 ·Developmental & Comparative Immunology ·(unknown), (unknown), Daniel C. Douek, Robert D. Miller	0
3	Recruitment and retention of pediatric participants for pandemic preparedness research: Experience from the PREMISE EV-D68 Pilot Study 2024 ·Contemporary Clinical Trials Communications ·(unknown), Alicen B. Spaulding, Kevin Messacar, Matthew R. Vogt, Perdita Permaul, Daniel C. Douek, (unknown), C. A. Thompson, (unknown), (unknown), (unknown)	0
4	A non-human primate model for human norovirus infection 2024 ·Nature Microbiology ·(unknown), Natthawan Chaimongkol, (unknown), Bianca M. Nagata, Samuel Darko, (unknown), Amy R. Henry, Stanislav V. Sosnovtsev, Adam S. Olia, Raffaello Verardi, Karin Bok, John-Paul Todd, Ruth Woodward, Peter D. Kwong, Daniel C. Douek, Derron A. Alves, Kim Y. Green, Mario Roederer	7
5	Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates 2023 ·Nature Communications ·Chaim A. Schramm, (unknown), (unknown), Noemia S. Lima, (unknown), Kristin L. Boswell, Amy R. Henry, Farida Laboune, David R. Ambrozak, Samuel Darko, I‐Ting Teng, Kathryn E. Foulds, Andrea Carfı́, Darin K. Edwards, Peter D. Kwong, Richard A. Koup, Robert A. Seder, Daniel C. Douek	5
6	Human CCR6+ Th Cells Show Both an Extended Stable Gradient of Th17 Activity and Imprinted Plasticity 2023 ·The Journal of Immunology ·Satya P. Singh, (unknown), (unknown), Hongwei H. Zhang, Jinguo Chen, Francisco Otaizo‐Carrasquero, (unknown), (unknown), Amy Ransier, (unknown), Amirhossein Shamsaddini, Paul J. Gardina, Samuel Darko, Tej Pratap Singh, Daniel C. Douek, Timothy G. Myers, Joshua Μ. Farber	5
7	Immortalization and functional screening of natively paired human T cell receptor repertoires 2021 ·Protein Engineering Design and Selection ·Ahmed S. Fahad, (unknown), Sheila N. López Acevedo, (unknown), Bharat Madan, Matías Gutiérrez-González, Rodrigo Matus‐Nicodemos, (unknown), (unknown), (unknown), (unknown), Sian Llewellyn‐Lacey, Richard A. Koup, Daniel C. Douek, Henry H. Balfour, David A. Price, Brandon J. DeKosky	5
8	Unified platform for genetic and serological detection of COVID-19 with single-molecule technology 2021 ·PLoS ONE ·Noa Furth, (unknown), (unknown), (unknown), (unknown), (unknown), Adina Weinberger, Amiel A. Dror, Asaf Zigron, Mona Shehadeh, Eyal Sela, Samer Srouji, Sharon Amit, Itzchak Levy, Eran Segal, Rony Dahan, Daniel Jones, Daniel C. Douek, Efrat Shema	2
9	The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage 2021 ·Science ·(unknown), Marcin Wegrecki, T. Praveena, (unknown), Lijing Bu, (unknown), Samuel Darko, Daniel C. Douek, Jamie Rossjohn, Robert D. Miller, Jérôme Le Nours	16
10	High levels of genetically intact HIV in HLA-DR+ memory T cells indicates their value for reservoir studies 2020 ·AIDS ·Bethany A. Horsburgh, Eunok Lee, Bonnie Hiener, John‐Sebastian Eden, Timothy E. Schlub, Susanne von Stockenström, (unknown), Jeffrey M. Milush, Teri Liegler, Elizabeth Sinclair, Rebecca Hoh, Eli Boritz, Daniel C. Douek, Rémi Fromentin, Nicolas Chomont, Steven G. Deeks, Frederick Hecht, Sarah Palmer	30
11	Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis 2019 ·Journal of Clinical Investigation ·Ting Wen, Bruce J. Aronow, Yrina Rochman, Mark Rochman, Kiran KC, Phillip J. Dexheimer, Philip E. Putnam, Vincent A. Mukkada, Heather Foote, K. Rehn, Samuel Darko, Daniel C. Douek, Marc E. Rothenberg	140
12	Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor 2016 ·Cancer Immunology Research ·Anna Pasetto, Alena Gros, Paul F. Robbins, (unknown), Todd D. Prickett, Rodrigo Matus‐Nicodemos, Daniel C. Douek, Bryan Howie, Harlan Robins, Maria R. Parkhurst, Jared J. Gartner, Katarzyna Trebska-McGowan, Jessica S. Crystal, Steven A. Rosenberg	148
13	Loss of a Tyrosine-Dependent Trafficking Motif in the Simian Immunodeficiency Virus Envelope Cytoplasmic Tail Spares Mucosal CD4 Cells but Does Not Prevent Disease Progression 2012 ·Journal of Virology ·Matthew W. Breed, Andrea P. O. Jordan, Pyone P. Aye, (unknown), Cecily C. Midkiff, Faith Schiro, Beth Haggarty, Chie Sugimoto, Xavier Álvarez, Netanya G. Sandler, Daniel C. Douek, Marcelo J. Kuroda, Bapi Pahar, Michael Piatak, Jeffrey D. Lifson, Brandon F. Keele, James A. Hoxie, Andrew A. Lackner	27
14	HLA B5701-Positive Long-Term Nonprogressors/Elite Controllers Are Not Distinguished from Progressors by the Clonal Composition of HIV-Specific CD8 ⁺ T Cells 2012 ·Journal of Virology* ·Daniel Mendoza, (unknown), Laura E. Ruff, David R. Ambrozak, Máire F. Quigley, Thurston H. Y. Dang, Vanessa Venturi, David A. Price, Daniel C. Douek, Stephen A. Migueles, Mark Connors	20
15	Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection breakdown → 2011 ·The Journal of Infectious Diseases ·Netanya G. Sandler, Handan Wand, Annelys Roque, Matthew Law, Martha Nason, Daniel E. Nixon, Court Pedersen, Kiat Ruxrungtham, Sharon R. Lewin, Sean Emery, James D. Neaton, Jason M. Brenchley, Steven G. Deeks, Irini Sereti, Daniel C. Douek	856
16	Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of T _H 17 to Regulatory T Cells in HIV Disease 2010 ·Science Translational Medicine ·David Favre, Jeff E. Mold, Peter W. Hunt, Bittoo Kanwar, P’ng Loke, Lillian Seu, Jason D. Barbour, Margaret M. Lowe, (unknown), Francesca Aweeka, Yong Huang, Daniel C. Douek, Jason M. Brenchley, Jeffrey N. Martin, Frederick Hecht, Steven G. Deeks, Joseph M. McCune	423
17	Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity 2009 ·Blood ·Jorge R. Almeida, Delphine Sauce, David A. Price, Laura Papagno, So Youn Shin, Arnaud Moris, Martin Larsen, Gianfranco Pancino, Daniel C. Douek, Brigitte Autran, Asier Sáez‐Cirión, Victor Appay	160
18	Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination 2006 ·Proceedings of the National Academy of Sciences ·Vanessa Venturi, Katherine Kedzierska, David A. Price, Peter C. Doherty, Daniel C. Douek, Stephen T. Turner, Miles P. Davenport	129
19	CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract breakdown → 2004 ·The Journal of Experimental Medicine ·Jason M. Brenchley, Timothy W. Schacker, Laura E. Ruff, David A. Price, Jodie H. Taylor, Gregory J. Beilman, Phuong L. Nguyen, Alexander Khoruts, Matthew Larson, Ashley T. Haase, Daniel C. Douek	1353
20	Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 ⁺ and CD8 ⁺ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection breakdown → 2001 ·Journal of Virology ·Michael R. Betts, David R. Ambrozak, Daniel C. Douek, Sebastian Bonhoeffer, Jason M. Brenchley, Joseph P. Casazza, Richard A. Koup, Louis J. Picker	574

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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