R. Keith Humphries

30.7k total citations · 5 hit papers
314 papers, 21.5k citations indexed

About

R. Keith Humphries is a scholar working on Molecular Biology, Hematology and Genetics. According to data from OpenAlex, R. Keith Humphries has authored 314 papers receiving a total of 21.5k indexed citations (citations by other indexed papers that have themselves been cited), including 198 papers in Molecular Biology, 145 papers in Hematology and 65 papers in Genetics. Recurrent topics in R. Keith Humphries's work include Hematopoietic Stem Cell Transplantation (67 papers), Acute Myeloid Leukemia Research (64 papers) and Virus-based gene therapy research (54 papers). R. Keith Humphries is often cited by papers focused on Hematopoietic Stem Cell Transplantation (67 papers), Acute Myeloid Leukemia Research (64 papers) and Virus-based gene therapy research (54 papers). R. Keith Humphries collaborates with scholars based in Canada, United States and Germany. R. Keith Humphries's co-authors include Guy Sauvageau, Connie J. Eaves, Gerald Krystal, Cheryl D. Helgason, H. Jeffrey Lawrence, Corey Largman, Donna E. Hogge, Peter M. Lansdorp, Bob Argiropoulos and Jennifer Antonchuk and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

R. Keith Humphries

308 papers receiving 20.9k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 535 citations Patricia M. Rosten, R. Keith Humphries et al. profile →
HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo

2002 518 citations Guy Sauvageau, R. Keith Humphries et al. profile →
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

2009 507 citations Daniel T. Starczynowski, Florian Kuchenbauer et al. profile →
Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.

1983 494 citations R. Keith Humphries, Connie J. Eaves et al. profile →
5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

1982 424 citations R. Keith Humphries, Neal S. Young et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
R. Keith Humphries Canada	85	13.0k	7.5k	4.7k	3.5k	3.2k	314	21.5k
Hiromitsu Nakauchi Japan	87	15.2k 1.2×	8.1k 1.1×	8.2k 1.7×	3.9k 1.1×	3.0k 0.9×	496	30.3k
David A. Williams United States	74	11.0k 0.8×	3.6k 0.5×	5.5k 1.2×	3.0k 0.9×	4.7k 1.5×	338	21.2k
Gerard C. Grosveld United States	65	10.8k 0.8×	6.8k 0.9×	4.7k 1.0×	3.8k 1.1×	2.0k 0.6×	158	21.9k
Michael L. Cleary United States	84	15.3k 1.2×	5.6k 0.8×	3.0k 0.6×	2.9k 0.8×	2.2k 0.7×	206	23.2k
Margaret A. Goodell United States	74	14.5k 1.1×	6.5k 0.9×	4.3k 0.9×	5.8k 1.6×	1.9k 0.6×	217	24.7k
Thalia Papayannopoulou United States	62	6.9k 0.5×	5.8k 0.8×	3.0k 0.6×	4.0k 1.1×	2.7k 0.9×	224	14.9k
Connie J. Eaves Canada	85	14.1k 1.1×	11.5k 1.5×	6.0k 1.3×	5.9k 1.7×	3.4k 1.1×	395	29.2k
Seishi Ogawa Japan	69	8.3k 0.6×	5.1k 0.7×	3.0k 0.6×	2.0k 0.6×	1.7k 0.5×	474	16.1k
Terence H. Rabbitts United Kingdom	80	11.5k 0.9×	3.5k 0.5×	5.8k 1.2×	2.2k 0.6×	2.3k 0.7×	280	19.6k
Tsvee Lapidot Israel	65	8.4k 0.6×	8.2k 1.1×	7.3k 1.6×	4.0k 1.1×	1.4k 0.4×	152	21.6k

Countries citing papers authored by R. Keith Humphries

Since Specialization

Citations

This map shows the geographic impact of R. Keith Humphries's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by R. Keith Humphries with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites R. Keith Humphries more than expected).

Fields of papers citing papers by R. Keith Humphries

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by R. Keith Humphries. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by R. Keith Humphries. The network helps show where R. Keith Humphries may publish in the future.

Co-authorship network of co-authors of R. Keith Humphries

This figure shows the co-authorship network connecting the top 25 collaborators of R. Keith Humphries. A scholar is included among the top collaborators of R. Keith Humphries based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with R. Keith Humphries. R. Keith Humphries is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Cole, Grace, Jeremy Parker, Eric Yung, et al.. (2023). Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression. Nature Communications. 14(1). 4537–4537. 10 indexed citations

Xiang, Ping, Edith Schneider, Wei Wei, et al.. (2022). Elucidating the importance and regulation of key enhancers for human MEIS1 expression. Leukemia. 36(8). 1980–1989. 6 indexed citations

Kloos, Arnold, Razif Gabdoulline, Nidhi Jyotsana, et al.. (2020). Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia. Leukemia. 34(11). 2951–2963. 9 indexed citations

Humphries, R. Keith, E Giamarellos-Bourboulis, David W. Wright, et al.. (2020). A 29 messenger RNA host response signature identifies bacterial and viral infections among emergency department patients. 27.

Pabst, Caroline, Anne Bergeron, Vincent‐Philippe Lavallée, et al.. (2016). GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo. Blood. 127(16). 2018–2027. 115 indexed citations

Lin, Hanyang, Katharina Rothe, Jens Rüschmann, et al.. (2014). Identification of New microRNA Biomarkers and Candidate Target Genes in Primitive CML Cells Using Global Comparative RNA analyses. Blood. 124(21). 3133–3133. 2 indexed citations

Jenkins, Catherine E., Olena O Shevchuk, Vincenzo Giambra, et al.. (2012). IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein. Experimental Hematology. 40(9). 715–723.e6. 17 indexed citations

Starczynowski, Daniel T., Ryan D. Morin, Andrew McPherson, et al.. (2010). Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood. 117(2). 595–607. 94 indexed citations

Reindl, Carola, Hilmar Quentmeier, Konstantin Petropoulos, et al.. (2009). CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes. Clinical Cancer Research. 15(7). 2238–2247. 89 indexed citations

10.

Pineault, Nicolas, Carolina Abramovich, & R. Keith Humphries. (2005). Transplantable cell lines generated with NUP98–Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA. Leukemia. 19(4). 636–643. 30 indexed citations

11.

Aplan, Peter D., et al.. (2004). NUP98-Topoisomerase 1 acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation. Blood. 104(4). 1127–1136. 1 indexed citations

12.

Imren, Suzan, Mary E. Fabry, Karen A. Westerman, et al.. (2004). High-level β-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells. Journal of Clinical Investigation. 114(7). 953–962. 94 indexed citations

13.

Krošl, Jana, Nathalie Beslu, Nadine Mayotte, R. Keith Humphries, & Guy Sauvageau. (2003). The Competitive Nature of HOXB4-Transduced HSC Is Limited by PBX1. Immunity. 18(4). 561–571. 62 indexed citations

14.

Pawliuk, Robert, Karen A. Westerman, Mary E. Fabry, et al.. (2001). Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy. Science. 294(5550). 2368–2371. 428 indexed citations

15.

Abramovich, Carolina, Weifeng Shen, Nicolas Pineault, et al.. (2000). Functional Cloning and Characterization of a Novel Nonhomeodomain Protein That Inhibits the Binding of PBX1-HOX Complexes to DNA. Journal of Biological Chemistry. 275(34). 26172–26177. 54 indexed citations

16.

Brauweiler, Anne, Idan Tamir, Joseph Dal Porto, et al.. (2000). Differential Regulation of B Cell Development, Activation, and Death by the Src Homology 2 Domain–Containing 5′ Inositol Phosphatase (Ship). The Journal of Experimental Medicine. 191(9). 1545–1554. 108 indexed citations

17.

Hogge, Donna E., Heather J. Sutherland, Johanne D. Cashman, et al.. (1994). 3 Cytokines acting early in human haematopoiesis. Baillière s Clinical Haematology. 7(1). 49–63. 9 indexed citations

18.

Fraser, Christopher, R. Keith Humphries, & Dixie L. Mager. (1988). Chromosomal distribution of the RTVL-H family of human endogenous retrovirus-like sequences. Genomics. 2(4). 280–287. 24 indexed citations

19.

Young, Neal S., et al.. (1984). Aplastic anemia : stem cell biology and advances in treatment : proceedings of the Third International Conference on Aplastic Anemia, held in Airlie, Virginia, June 26-28, 1983. 1 indexed citations

20.

Cj, Eaves, R. Keith Humphries, & Eaves Ac. (1979). Marrow flask cultures -- a system for examining early erythropoietic differentiation events.. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich). 5(3). 377–87. 5 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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