Paul Hales

3.0k citations

22 papers · 2.2k indexed · 1 hit paper · h-index 15

Impact in

Cardiology and Cardiovascular Medicine top 2%
- Renin-Angiotensin System Studies
Endocrinology, Diabetes and Metabolism top 2%
- Hormonal Regulation and Hypertension

Papers in

Clinical Biochemistry 2
- Metabolism and Genetic Disorders 2
Oncology 7
- Peptidase Inhibition and Analysis 7

Co-authors: Lawrence R. Dick Chad Vickers Peter J. Tummino James M. Gavin Michael A. Patane Virendar K. Kaushik F. Hsieh Thomas F. Parsons
Journals: Biochemical Journal (5 papers)Journal of the American Chemical Society (2 papers)PLoS ONE (2 papers)Blood (2 papers)FEBS Letters (1 paper)
Partner nations: United States Canada United Kingdom

In The Last Decade

Paul Hales

22 papers receiving 2.2k citations

Hit Papers

align trajectories log scale

Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase 2002 · 1.1k citations

Peers

Countries citing papers authored by Paul Hales

Since Specialization

Citations

This map shows the geographic impact of Paul Hales's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul Hales with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul Hales more than expected).

Fields of papers citing papers by Paul Hales

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul Hales. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul Hales. The network helps show where Paul Hales may publish in the future.

Co-authors

The 25 scholars most cited alongside Paul Hales, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Paul Hales Line = papers co-authored together Paul Hales links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Spontaneous Extracellular Matrix Accumulation in a Human in vitro Model of Renal Fibrosis Is Mediated by αV Integrins The Nephron journals/Nephron journals ·Hélène Bon, Paul Hales, Simon Lumb, Gill Holdsworth, Timothy S. Johnson, Omar Qureshi, Breda M. Twomey	2019	29
2	Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma PLoS ONE ·Akul Singhania, Hitasha Rupani, Nivenka Jayasekera, Simon Lumb, Paul Hales, Neil Gozzard, Donna E. Davies, Christopher H. Woelk, Peter Howarth	2017	43
3	Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi Toxicology Research ·Vilmos Csizmadia, Paul Hales, Christopher Tsu, Jingya Ma, Jiejin Chen, Pooja Shah, Paul Fleming, Joseph J. Senn, Vivek J. Kadambi, Lawrence R. Dick, Francis S. Wolenski	2016	10
4	KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism PLoS ONE ·Nibedita Chattopadhyay, Allison Berger, Erik Koenig, Bret Bannerman, James Garnsey, Hugues Bernard, Paul Hales, Angel Maldonado Lopez, Yang Yu, Jill Donelan, Kristen G. Jordan, Stephen Tirrell, Bradley Stringer, Cindy Q. Xia, Greg Hather, Katherine Galvin, Mark Manfredi, Nelson Rhodes, Ben Amidon	2015	14
5	Identification of Potent and Selective Non-covalent Inhibitors of the Plasmodium falciparum Proteasome Journal of the American Chemical Society ·Hao Li, Christopher Tsu, Christopher Blackburn, Gang Li, Paul Hales, Lawrence R. Dick, Matthew Bogyo	2014	46
6	Optimization of a series of dipeptides with a P3 β-neopentyl asparagine residue as non-covalent inhibitors of the chymotrypsin-like activity of human 20S proteasome MedChemComm ·Christopher Blackburn, Cynthia Barrett, Jonathan L. Blank, Frank J. Bruzzese, Nancy J. Bump, Lawrence R. Dick, Paul Fleming, Khristofer Garcia, Paul Hales, Matthew D. Jones, Jane X. Liu, Masayuki Nagayoshi, Darshan S. Sappal, Michael D. Sintchak, Christopher Tsu, Cindy Q. Xia, Xiansi Zhou, Kenneth M. Gigstad	2012	9
7	Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea Cancer Chemotherapy and Pharmacology ·Bret Bannerman, Ling Xu, Matthew D. Jones, Christopher Tsu, Jie Yu, Paul Hales, Johan Monbaliu, Paul Fleming, Lawrence R. Dick, Mark Manfredi, Christopher F. Claiborne, Joseph B. Bolen, Erik Kupperman, Allison Berger	2011	32
8	Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer Cancer Research ·Erik Kupperman, Edmund C. Lee, Yueying Cao, Bret Bannerman, Michael Fitzgerald, Allison Berger, Jie Yu, Yang Yu, Paul Hales, Frank J. Bruzzese, Jane Liu, Jonathan L. Blank, Khristofer Garcia, Christopher Tsu, Lawrence R. Dick, Paul Fleming, Li Yu, Mark Manfredi, Mark Rolfe, Joe Bolen	2010	409
9	Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome Bioorganic & Medicinal Chemistry Letters ·Christopher Blackburn, Cynthia Barrett, Jonathan L. Blank, Frank J. Bruzzese, Nancy J. Bump, Lawrence R. Dick, Paul Fleming, Khristofer Garcia, Paul Hales, Zhigen Hu, Matthew D. Jones, Jane X. Liu, Darshan S. Sappal, Michael D. Sintchak, Christopher Tsu, Kenneth M. Gigstad	2010	39
10	Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit Biochemical Journal ·Christopher Blackburn, Kenneth M. Gigstad, Paul Hales, Khristofer Garcia, Matthew D. Jones, Frank J. Bruzzese, Cynthia Barrett, Jane X. Liu, Teresa A. Soucy, Darshan S. Sappal, Nancy J. Bump, Edward J. Olhava, Paul Fleming, Lawrence R. Dick, Christopher Tsu, Michael D. Sintchak, Jonathan L. Blank	2010	129
11	Antitumor Activity of MLN9708, a Second-Generation Proteasome Inhibitor, in Preclinical Models of Lymphoma. Blood ·Jill Donelan, Bret Bannerman, Kristen Bano, Trisha Babcock, Paul Hales, Bradley Stringer, Kristine Burke, Hadi Danaee, Laura Faron-Yowe, Erik Koenig, David I. Lichter, Erik Kupperman	2009	1
12	Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase Journal of Biological Chemistry ·Chad Vickers, Paul Hales, Virendar K. Kaushik, Lawrence R. Dick, James M. Gavin, Jin Tang, Kevin Godbout, Thomas F. Parsons, Elizabeth Baronas, F. Hsieh, Susan Acton, Michael A. Patane, Andrew J. Nichols, Peter J. Tummino Hit paper breakdown →	2002	1139
13	Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors Journal of the American Chemical Society ·Natalie A. Dales, Alexandra E. Gould, James A. Brown, Emily F. Calderwood, Bing Guan, Charles A. Minor, James M. Gavin, Paul Hales, Virendar K. Kaushik, Michael Stewart, Peter J. Tummino, Chad Vickers, Timothy D. Ocain, Michael A. Patane	2002	145
14	Sustained decreases in weight and serum insulin, glucose, triacylglycerol and cholesterol in JCR: LA‐corpulent rats treated with d‐fenfluramine British Journal of Pharmacology ·David N. Brindley, Paul Hales, Abdulbasit I. Al‐Sieni, James C. Russell	1992	14
15	Phosphatidate phosphohydrolases in liver, heart and adipose tissue of the JCR:LA corpulent rat and the lean genotypes: implications for glycerolipid synthesis and signal transduction. PubMed ·Zahirali Jamal, Annie Martin, Antonio Gómez‐Muñoz, Paul Hales, Eun‐Ju Chang, J C Russell, David N. Brindley	1992	26
16	Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism ·David N. Brindley, Paul Hales, Abdulbasit I. Al‐Sieni, James C. Russell	1991	22
17	Effects of the lipase inhibitors, Triton WR‐1339 and tetrahydrolipstatin on the synthesis and secretion of lipids by rat hepatocytes FEBS Letters ·Dominique Hermier, Paul Hales, David N. Brindley	1991	17
18	Unsaturated fatty acids activate glycogen phosphorylase in cultured rat hepatocytes Biochemical Journal ·Antonio Gómez‐Muñoz, Paul Hales, David N. Brindley	1991	7
19	Rapid activation of glycogen phosphorylase by steroid hormones in cultured rat hepatocytes Biochemical Journal ·Antonio Gómez‐Muñoz, Paul Hales, David N. Brindley, M. J. Sancho	1989	27
20	A rapid assay for measuring the activity and the Mg2+ and Ca2+ requirements of phosphatidate phosphohydrolase in cytosolic and microsomal fractions of rat liver Biochemical Journal ·A Martin, Paul Hales, David N. Brindley	1987	44

About Paul Hales

Paul Hales is a scholar working on Clinical Biochemistry, Oncology, Molecular Biology, Genetics and Hematology, having authored 22 papers that have together received 2.2k indexed citations. Recurring topics across this work include Ubiquitin and proteasome pathways (9 papers), Peptidase Inhibition and Analysis (7 papers), Pancreatic function and diabetes (4 papers), Metabolism and Genetic Disorders (2 papers), Renin-Angiotensin System Studies (2 papers), Protein Hydrolysis and Bioactive Peptides (2 papers), Liver Disease Diagnosis and Treatment (2 papers) and Pharmacology and Obesity Treatment (2 papers). The work is most often cited by research in Cardiology and Cardiovascular Medicine (756 citations), Endocrinology, Diabetes and Metabolism (539 citations), Pharmacology (425 citations), Hematology (216 citations) and Infectious Diseases (333 citations). Paul Hales has collaborated with scholars based in United States, Canada and United Kingdom. Frequent co-authors include Lawrence R. Dick, Chad Vickers, Peter J. Tummino, James M. Gavin, Michael A. Patane, Virendar K. Kaushik, F. Hsieh, Thomas F. Parsons, Kevin Godbout and Susan Acton. Their work appears in journals such as Biochemical Journal, Journal of the American Chemical Society, PLoS ONE, Blood and FEBS Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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