Nobuo Machinaga

532 citations

27 papers · 428 indexed · h-index 15

Organic Chemistry top 10%
- Chemical synthesis and alkaloids 7
- Synthetic Organic Chemistry Methods 4
Immunology and Allergy top 10%
- Cell Adhesion Molecules Research 7
Pharmaceutical Science
Biochemistry
Biotechnology
Oncology
- Peptidase Inhibition and Analysis 6
Cellular and Molecular Neuroscience
- Neuropeptides and Animal Physiology 4
Molecular Biology
- Chemical Synthesis and Analysis 3
- Phenothiazines and Benzothiazines Synthesis and Activities 3
Physiology
- Erythrocyte Function and Pathophysiology 3

Co-authors: Chihiro Kibayashi Jun Chiba Gensuke Takayama Mika Yokoyama Atsushi Nakayama Tohru Takashi Shin Iimura Toshiyuki Watanabe
Cited by: Organic Chemistry Immunology and Allergy Pharmaceutical Science
Journals: Journal of Medicinal Chemistry (1 paper)The Journal of Organic Chemistry (2 papers)Tetrahedron Letters (5 papers)
Partner nations: Japan Germany United States

In The Last Decade

Nobuo Machinaga

26 papers receiving 404 citations

Peers

Countries citing papers authored by Nobuo Machinaga

Since Specialization

Citations

This map shows the geographic impact of Nobuo Machinaga's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nobuo Machinaga with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nobuo Machinaga more than expected).

Fields of papers citing papers by Nobuo Machinaga

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nobuo Machinaga. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nobuo Machinaga. The network helps show where Nobuo Machinaga may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Nobuo Machinaga, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Nobuo Machinaga Line = papers co-authored together Nobuo Machinaga links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Discovery of DS34942424: An orally potent analgesic without mu opioid receptor agonist activity Bioorganic & Medicinal Chemistry ·Tsuyoshi Arita,Masayoshi Asano,Kazufumi Kubota,Yuki Domon,Nobuo Machinaga,Kousei Shimada	2020	5
2	Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity Bioorganic & Medicinal Chemistry Letters ·Tsuyoshi Arita,Masayoshi Asano,Kazufumi Kubota,Yuki Domon,Nobuo Machinaga,Kousei Shimada	2019	2
3	Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity Bioorganic & Medicinal Chemistry Letters ·Tsuyoshi Arita,Masayoshi Asano,Kazufumi Kubota,Yuki Domon,Nobuo Machinaga,Kousei Shimada	2019	5
4	Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate Cell chemical biology ·Mamoru Ohtoyo,Nobuo Machinaga,Ryotaku Inoue,Katsunobu Hagihara,Hiroshi Yuita,Masakazu Tamura,Ryuji Hashimoto,Jun Chiba,Fumihito Muro,Jun Watanabe,Yoshimasa Kobayashi,Koji Abe,Yasuo Kita,Miyuki Nagasaki,Takaichi Shimozato	2016	15
5	Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1‐Phosphate Levels Lipids ·Mamoru Ohtoyo,Masakazu Tamura,Nobuo Machinaga,Fumihito Muro,Ryuji Hashimoto	2016	3
6	Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency Molecular and Cellular Biochemistry ·Mamoru Ohtoyo,Masakazu Tamura,Nobuo Machinaga,Fumihito Muro,Ryuji Hashimoto	2014	17
7	A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid Bioorganic & Medicinal Chemistry ·Masaki Setoguchi,Shin Iimura,Yuuichi Sugimoto,Yoshiyuki Yoneda,Jun Chiba,Toshiyuki Watanabe,Fumihito Muro,Yutaka Iigo,Gensuke Takayama,Mika Yokoyama,Tomoe Taira,Misato Aonuma,Tohru Takashi,Atsushi Nakayama,Nobuo Machinaga	2012	19
8	A Concise Synthesis of a Very Late Antigen-4 Antagonist <i>trans</i>-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxyamide)phenyl]acetyl]-(4<i>S</i>)-methoxy-(2<i>S</i>)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid <i>via</i> Reductive Etherification Chemical and Pharmaceutical Bulletin ·Jun Chiba,Fumihito Muro,Masaki Setoguchi,Nobuo Machinaga	2012	0
9	Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist Bioorganic & Medicinal Chemistry ·Masaki Setoguchi,Shin Iimura,Yuuichi Sugimoto,Yoshiyuki Yoneda,Jun Chiba,Toshiyuki Watanabe,Fumihito Muro,Yutaka Iigo,Gensuke Takayama,Mika Yokoyama,Tomoe Taira,Misato Aonuma,Tohru Takashi,Atsushi Nakayama,Nobuo Machinaga	2011	10
10	A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid Bioorganic & Medicinal Chemistry ·Fumihito Muro,Shin Iimura,Yoshiyuki Yoneda,Jun Chiba,Toshiyuki Watanabe,Masaki Setoguchi,Gensuke Takayama,Mika Yokoyama,Tohru Takashi,Atsushi Nakayama,Nobuo Machinaga	2008	15
11	Identification of 4-[1-[3-chloro-4-[N’-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist Bioorganic & Medicinal Chemistry ·Fumihito Muro,Shin Iimura,Yoshiyuki Yoneda,Jun Chiba,Toshiyuki Watanabe,Masaki Setoguchi,Yutaka Iigou,Gensuke Takayama,Mika Yokoyama,Tohru Takashi,Atsushi Nakayama,Nobuo Machinaga	2008	9
12	Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists Bioorganic & Medicinal Chemistry ·Jun Chiba,Shin Iimura,Yoshiyuki Yoneda,Toshiyuki Watanabe,Fumito Muro,Masao Tsubokawa,Yutaka Iigou,Atsushi Satoh,Gensuke Takayama,Mika Yokoyama,Tohru Takashi,Atsushi Nakayama,Nobuo Machinaga	2006	15
13	4-(Pyrrolidinyl)methoxybenzoic Acid Derivatives as a Potent, Orally Active VLA-4 Antagonist Chemical and Pharmaceutical Bulletin ·Jun Chiba,Shin Iimura,Yoshiyuki Yoneda,Yuichi Sugimoto,Takao Horiuchi,Fumito Muro,Yuichi Ochiai,Tomomi Ogasawara,Masao Tsubokawa,Yutaka Iigou,Gensuke Takayama,Tomoe Taira,Yoshimi Takata,Mika Yokoyama,Tohru Takashi,Atsushi Nakayama,Nobuo Machinaga	2006	15
14	Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists Bioorganic & Medicinal Chemistry ·Jun Chiba,Gensuke Takayama,Tohru Takashi,Mika Yokoyama,Atsushi Nakayama,John J. Baldwin,Edward McDonald,K.J.M. Moriarty,Christopher R. Sarko,Kurt W. Saionz,R. N. Swanson,Zahid Hussain,Angela Wong,Nobuo Machinaga	2005	31
15	Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist Bioorganic & Medicinal Chemistry Letters ·Jun Chiba,Nobuo Machinaga,Tohru Takashi,Akio Ejima,Gensuke Takayama,Mika Yokoyama,Atsushi Nakayama,John J. Baldwin,Edward McDonald,Kurt W. Saionz,R. N. Swanson,Zahid Hussain,Angela Wong	2004	20
16	General entry to the 3,5-disubstituted indolizidine class of dendrobatid alkaloids. Total syntheses of both enantiomers of indolizidines 195B, 223AB, 239AB, and 239CD from a common chiral synthon The Journal of Organic Chemistry ·Nobuo Machinaga,Chihiro Kibayashi	1992	46
17	Enantioselective total synthesis of (+)- and (-)-pyrrolidine 197B, a new class of alkaloid from the dendrobatid poison frog: assignment of the absolute configuration The Journal of Organic Chemistry ·Nobuo Machinaga,Chihiro Kibayashi	1991	44
18	Total synthesis of (–)-indolizidine 239CD Journal of the Chemical Society Chemical Communications ·Nobuo Machinaga,Chihiro Kibayashi	1991	6
19	Enantiodivergent total synthesis of naturally occurring trans-2-butyl-5-pentylpyrrolidine Tetrahedron Letters ·Nobuo Machinaga,C. KIBAYASHI	1990	18
20	1,5-dihydro-3H-2,4-benzodioxepine as a novel carbonyl protecting group Tetrahedron Letters ·Nobuo Machinaga,Chihiro Kibayashi	1989	14

About Nobuo Machinaga

Nobuo Machinaga is a scholar working on Immunology and Allergy, Organic Chemistry and Oncology, having authored 27 papers that have together received 428 indexed citations. Recurring topics across this work include Cell Adhesion Molecules Research (7 papers), Chemical synthesis and alkaloids (7 papers), Peptidase Inhibition and Analysis (6 papers), Synthetic Organic Chemistry Methods (4 papers), Neuropeptides and Animal Physiology (4 papers), Chemical Synthesis and Analysis (3 papers), Erythrocyte Function and Pathophysiology (3 papers) and Phenothiazines and Benzothiazines Synthesis and Activities (3 papers). The work is most often cited by research in Organic Chemistry (271 citations), Immunology and Allergy (47 citations) and Pharmaceutical Science (24 citations). Nobuo Machinaga has collaborated with scholars based in Japan, Germany and United States. Frequent co-authors include Chihiro Kibayashi, Jun Chiba, Gensuke Takayama, Mika Yokoyama, Atsushi Nakayama, Tohru Takashi, Shin Iimura, Toshiyuki Watanabe, Masakazu Tamura and John J. Baldwin. Their work appears in journals such as Journal of Medicinal Chemistry, The Journal of Organic Chemistry and Tetrahedron Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact