Nigel J. Pyne

11.6k citations

190 papers · 9.1k indexed · 2 hit papers · h-index 53

Impact in

Cell Biology top 0.2%
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
Molecular Biology top 0.5%
- Sphingolipid Metabolism and Signaling
- Lipid Membrane Structure and Behavior
- Protein Kinase Regulation and GTPase Signaling
- Receptor Mechanisms and Signaling
- Phosphodiesterase function and regulation

Papers in

Cell Biology 67
- Endoplasmic Reticulum Stress and Disease 37
- Cellular transport and secretion 27
Molecular Biology 177
- Sphingolipid Metabolism and Signaling 100
- Protein Kinase Regulation and GTPase Signaling 71
- Phosphodiesterase function and regulation 33
- Receptor Mechanisms and Signaling 31
- Lipid Membrane Structure and Behavior 27

Co-authors: Susan Pyne Jaclyn S. Long Robert Bittman Soma Rakhit Miles D. Houslay David R. Adams Catherine Waters Ann-Marie Conway
Journals: Biochemical Journal (24 papers)Cellular Signalling (21 papers)Biochemical Society Transactions (18 papers)British Journal of Pharmacology (15 papers)Journal of Biological Chemistry (14 papers)
Partner nations: United Kingdom United States Australia

In The Last Decade

Nigel J. Pyne

189 papers receiving 8.9k citations

Hit Papers

align trajectories log scale

Sphingosine 1-phosphate and cancer 2010 · 705 citations

Peers

Countries citing papers authored by Nigel J. Pyne

Since Specialization

Citations

This map shows the geographic impact of Nigel J. Pyne's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nigel J. Pyne with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nigel J. Pyne more than expected).

Fields of papers citing papers by Nigel J. Pyne

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nigel J. Pyne. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nigel J. Pyne. The network helps show where Nigel J. Pyne may publish in the future.

Co-authors

The 25 scholars most cited alongside Nigel J. Pyne, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Nigel J. Pyne Line = papers co-authored together Nigel J. Pyne links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1 Cells ·Ling‐Wei Hii, Felicia Fei‐Lei Chung, Chun‐Wai Mai, Bernadett BajnÃ czi, Hong Hao Chan, Vijay J. Raja, Noah Dephoure, Nigel J. Pyne, Susan Pyne, Chee‐Onn Leong	2020	32
2	Short Periods of Hypoxia Upregulate Sphingosine Kinase 1 and Increase Vasodilation of Arteries to Sphingosine 1-Phosphate (S1P) via S1P3 Journal of Pharmacology and Experimental Therapeutics ·William S. Peavy, Tarek Almabrouk, Jean-Bruno Eymery, C.J. Daly, Susan Pyne, Nigel J. Pyne, Simon Kennedy	2019	7
3	Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors Trends in Pharmacological Sciences ·Nigel J. Pyne, David R. Adams, Susan Pyne	2017	38
4	Synthesis of selective inhibitors of sphingosine kinase 1 Chemical Communications ·Dong Jae Baek, Neil MacRitchie, Nigel J. Pyne, Susan Pyne, Robert Bittman	2013	48
5	Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1 Cell Death and Disease ·Claire Rutherford, 川口哲, 崔瑛曹灿, Liane M. McGlynn, Ramasamy Thangaraj, Scott R. Macfarlane, 道映天野, Susan Pyne, Nigel J. Pyne, Joanne Edwards, Timothy M. Palmer	2013	76
6	Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: Functional differences between sphingosine kinase 1a and 1b The International Journal of Biochemistry & Cell Biology ·Keng Gat Lim, Francesca Tonelli, Evgeny Berdyshev, И. А. Горшкова, Tamara Leclercq, Stuart M. Pitson, Robert Bittman, Susan Pyne, Nigel J. Pyne	2012	34
7	Receptor tyrosine kinase–G-protein-coupled receptor signalling platforms: out of the shadow? Trends in Pharmacological Sciences ·Nigel J. Pyne, Susan Pyne	2011	87
8	Sphingosine 1-Phosphate Regulation of Extracellular Signal-Regulated Kinase-1/2 in Embryonic Stem Cells Stem Cells and Development ·Kati Anne Ayers, Kelsey Wiltse, Jaclyn S. Long, Antonio Delgado, Nigel J. Pyne, Susan Pyne	2009	35
9	New aspects of sphingosine 1-phosphate signaling in mammalian cells Advances in Enzyme Regulation ·Nigel J. Pyne, Jaclyn S. Long, Sue Çhin Lee, Carolyn J. Loveridge, Laura A. Gillies, Susan Pyne	2009	14
10	Targeting sphingosine-1-phosphate signalling for cardioprotection Current Opinion in Pharmacology ·Simon Kennedy, Kathleen A. Kane, Nigel J. Pyne, Susan Pyne	2008	38
11	The Inhibitory γ Subunit of the Type 6 Retinal cGMP Phosphodiesterase Functions to Link c-Src and G-protein-coupled Receptor Kinase 2 in a Signaling Unit That Regulates p42/p44 Mitogen-activated Protein Kinase by Epidermal Growth Factor Journal of Biological Chemistry ·Kah Fei Wan, Balwinder Sambi, Rothwelle J. Tate, Catherine Waters, Nigel J. Pyne	2003	24
12	Interaction of caspase‐3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1) European Journal of Biochemistry ·Mhairi J. Frame, Rothwelle J. Tate, David R. Adams, Keith M. Morgan, Miles D. Houslay, Peter Vandenabeele, Nigel J. Pyne	2003	9
13	Cyclic nucleotide phosphodiesterases in pancreatic islets Diabetologia ·Nigel J. Pyne, B L Furman	2003	64
14	The γ subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3 Cellular Signalling ·Mhairi J. Frame, Kah Fei Wan, Rothwelle J. Tate, Peter Vandenabeele, Nigel J. Pyne	2001	8
15	Assessment of agonism at G‐protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells British Journal of Pharmacology ·Forbes Alderton, Balwinder Sambi, Rothwelle J. Tate, Nigel J. Pyne, Susan Pyne	2001	29
16	Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors Pharmacology & Therapeutics ·Susan Pyne, Nigel J. Pyne	2000	150
17	The identification of apparently novel cyclic AMP and cyclic GMP phosphodiesterase activities in guinea‐pig tracheal smooth muscle British Journal of Pharmacology ·Fiona Burns, Patricia A. Stevens, Nigel J. Pyne	1994	9
18	Bradykinin-stimulated phosphatidate and 1, 2-diacylglycerol accumulation in guinea-pig airway smooth muscle: Evidence for regulation ‘down-stream’ of phospholipases Cellular Signalling ·Susan Pyne, Nigel J. Pyne	1994	7
19	Cellular signal pathways in tracheal smooth muscle Cellular Signalling ·Nigel J. Pyne, Susan Pyne	1993	2
20	Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein G_i FEBS Letters ·Nigel J. Pyne, Gregory Murphy, Julieta Yegros, Miles D. Houslay	1989	75

About Nigel J. Pyne

Nigel J. Pyne is a scholar working on Cell Biology, Molecular Biology, Physiology, Endocrinology, Diabetes and Metabolism and Genetics, having authored 190 papers that have together received 9.1k indexed citations. Recurring topics across this work include Sphingolipid Metabolism and Signaling (100 papers), Protein Kinase Regulation and GTPase Signaling (71 papers), Endoplasmic Reticulum Stress and Disease (37 papers), Phosphodiesterase function and regulation (33 papers), Receptor Mechanisms and Signaling (31 papers), Cellular transport and secretion (27 papers), Lipid Membrane Structure and Behavior (27 papers) and Diabetes Treatment and Management (15 papers). The work is most often cited by research in Cell Biology (2.7k citations), Molecular Biology (7.8k citations), Physiology (291 citations), Physiology (1.2k citations) and Biochemistry (304 citations). Nigel J. Pyne has collaborated with scholars based in United Kingdom, United States and Australia. Frequent co-authors include Susan Pyne, Jaclyn S. Long, Robert Bittman, Soma Rakhit, Miles D. Houslay, David R. Adams, Catherine Waters, Ann-Marie Conway, Balwinder Sambi and Joanne Edwards. Their work appears in journals such as Biochemical Journal, Cellular Signalling, Biochemical Society Transactions, British Journal of Pharmacology and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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