Michael J. Comb

16.4k citations

76 papers · 11.3k indexed · 5 hit papers · h-index 47

Impact in

Molecular Biology top 0.5%
- Ubiquitin and proteasome pathways
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related gene regulation
Cellular and Molecular Neuroscience top 0.5%
- Neuropeptides and Animal Physiology

Papers in ⓘ

Molecular Biology 62
- Receptor Mechanisms and Signaling 18
- Protein Kinase Regulation and GTPase Signaling 10
- Ubiquitin and proteasome pathways 9
- Signaling Pathways in Disease 7
- PI3K/AKT/mTOR signaling in cancer 6
- Chemical Synthesis and Analysis 5
Cellular and Molecular Neuroscience 24
- Neuropeptides and Animal Physiology 16

Co-authors: Howard M. Goodman (5 shared papers)Ailan Guo (11 shared papers)A. John Rush (11 shared papers)Roberto D. Polakiewicz (14 shared papers)Edward Herbert (5 shared papers)Steven E. Hyman (13 shared papers)Steven P. Gygi (4 shared papers)Kimberly A. Lee (5 shared papers)
Journals: Journal of Biological Chemistry (10 papers)Molecular and Cellular Biology (7 papers)Molecular Endocrinology (5 papers)Proceedings of the National Academy of Sciences (5 papers)Molecular & Cellular Proteomics (3 papers)
Partner nations: United States Germany Canada

In The Last Decade

Michael J. Comb

75 papers receiving 11.0k citations

Hit Papers

5 papers align trajectories log scale

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome 2011 · 1.3k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2011 Molecular Cell
2004 Nature Biotechnology
1996 The EMBO Journal
1986 Nature
1982 Nature

Peers

Countries citing papers authored by Michael J. Comb

Since Specialization

Citations

This map shows the geographic impact of Michael J. Comb's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael J. Comb with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael J. Comb more than expected).

Fields of papers citing papers by Michael J. Comb

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael J. Comb. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael J. Comb. The network helps show where Michael J. Comb may publish in the future.

Co-authors

The 25 scholars most cited alongside Michael J. Comb, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Michael J. Comb Line = papers co-authored together Michael J. Comb links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 76 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome Molecular Cell ·Woong Kim, Eric J. Bennett, Edward L. Huttlin, Ailan Guo, Jing Li, Anthony Possemato, Mathew E. Sowa, Ramin Rad, A. John Rush, Michael J. Comb, J. Wade Harper, Steven P. Gygi Hit paper breakdown →	2011	1287
2	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells Nature Biotechnology ·A. John Rush, Albrecht Moritz, Kimberly A. Lee, Ailan Guo, Valerie L. Goss, Erik J. Spek, Hui Zhang, Xiang‐ming Zha, Roberto D. Polakiewicz, Michael J. Comb Hit paper breakdown →	2004	913
3	A cyclic AMP- and phorbol ester-inducible DNA element Nature ·Michael J. Comb, Neal C. Birnberg, Audrey F. Seasholtz, Edward Herbert, Howard M. Goodman Hit paper breakdown →	1986	678
4	FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. The EMBO Journal ·Yejun Tan, John Rouse, A. Zhang, S. Cariati, Philip Cohen, Michael J. Comb Hit paper breakdown →	1996	575
5	Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA Nature ·Michael J. Comb, Peter H. Seeburg, John P. Adelman, Lee E. Eiden, Edward Herbert Hit paper breakdown →	1982	560
6	Signaling networks assembled by oncogenic EGFR and c-Met Proceedings of the National Academy of Sciences ·Ailan Guo, Judit Villén, Jon M. Kornhauser, Kimberly A. Lee, Matthew P. Stokes, Klarisa Rikova, Anthony Possemato, Julie Nardone, Gregory Innocenti, Randall K. Wetzel, Yi Wang, Joan MacNeill, Jeffrey T. Mitchell, Steven P. Gygi, A. John Rush, Roberto D. Polakiewicz, Michael J. Comb	2008	424
7	Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation Molecular & Cellular Proteomics ·Ailan Guo, Hongbo Gu, Jing Zhou, Daniel Mulhern, Yi Wang, Kimberly A. Lee, Vicky K. Yang, Mike Aguiar, Jon M. Kornhauser, Xiaoying Jia, Jianmin Ren, Sean A. Beausoleil, Jeffrey C. Silva, Vidyasiri Vemulapalli, Mark T. Bedford, Michael J. Comb	2013	371
8	CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2 Nucleic Acids Research ·Michael J. Comb, Howard M. Goodman	1990	351
9	Regulation of the p70 S6 Kinase by Phosphorylation in Vivo Journal of Biological Chemistry ·Qing-Ping Weng, Mark T. Kozlowski, Christopher Belham, Aihua Zhang, Michael J. Comb, Joseph Avruch	1998	330
10	Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. The EMBO Journal ·Michael J. Comb, Nicolas Mermod, Steven E. Hyman, Joseph Pearlberg, M. Elizabeth Ross, H. M. Goodman	1988	317
11	FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions Journal of Biological Chemistry ·Randall T. Peterson, Peter A. Beal, Michael J. Comb, Stuart L. Schreiber	2000	282
12	BAD Ser-155 Phosphorylation Regulates BAD/Bcl-XL Interaction and Cell Survival Journal of Biological Chemistry ·Yi Tan, Matthew R. Demeter, Hong Ruan, Michael J. Comb	2000	265
13	Profiling of UV-induced ATM/ATR signaling pathways Proceedings of the National Academy of Sciences ·Matthew P. Stokes, A. John Rush, Joan MacNeill, Jian Ren, Kam Sprott, Julie Nardone, Vicky K. Yang, Sean A. Beausoleil, Steven P. Gygi, Mark Livingstone, Hui Zhang, Roberto D. Polakiewicz, Michael J. Comb	2007	247
14	Akt–RSK–S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases Science Signaling ·Albrecht Moritz, Li Yu, Ailan Guo, Judit Villén, Yi Wang, Joan MacNeill, Jon M. Kornhauser, Kam Sprott, Jing Zhou, Anthony Possemato, Jian Ren, Peter Hornbeck, Lewis C. Cantley, Steven P. Gygi, A. John Rush, Michael J. Comb	2010	247
15	Phosphoprotein Analysis Using Antibodies Broadly Reactive against Phosphorylated Motifs Journal of Biological Chemistry ·Hui Zhang, Xiang‐ming Zha, Yi Tan, Peter Hornbeck, Allison J. Mastrangelo, Dario R. Alessi, Roberto D. Polakiewicz, Michael J. Comb	2002	223
16	p90RSK Blocks Bad-mediated Cell Death via a Protein Kinase C-dependent Pathway Journal of Biological Chemistry ·Yi Tan, Hong Ruan, Matthew R. Demeter, Michael J. Comb	1999	221
17	Survival- and Death-Promoting Events after Transient Cerebral Ischemia: Phosphorylation of Akt, Release of Cytochrome C, and Activation of Caspase-Like Proteases Journal of Cerebral Blood Flow & Metabolism ·Yi‐Bing Ouyang, Ying Tan, Michael J. Comb, Chunli Liu, Maryann E. Martone, Bo K. Siesjö, Bingren Hu	1999	220
18	Calorie restriction alters mitochondrial protein acetylation Aging Cell ·Bjoern Schwer, Mark Eckersdorff, Yu Li, Jeffrey C. Silva, Damian Fermin, Martin V. Kurtev, Cosmas Giallourakis, Michael J. Comb, Frederick W. Alt, David B. Lombard	2009	208
19	μ-Opioid Receptor Activates Signaling Pathways Implicated in Cell Survival and Translational Control Journal of Biological Chemistry ·Roberto D. Polakiewicz, Sandra M. Schieferl, Anne‐Claude Gingras, Nahum Sonenberg, Michael J. Comb	1998	160
20	Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs Scientific Reports ·Surbhi Dhar, Vidyasiri Vemulapalli, Alexander N. Patananan, Grace L. Huang, Alessandra Di Lorenzo, Stéphane Richard, Michael J. Comb, Ailan Guo, Steven Clarke, Mark T. Bedford	2013	156

About Michael J. Comb

Michael J. Comb is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience, Genetics, Oncology and Behavioral Neuroscience, having authored 76 papers that have together received 11.3k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (18 papers), Neuropeptides and Animal Physiology (16 papers), Protein Kinase Regulation and GTPase Signaling (10 papers), Ubiquitin and proteasome pathways (9 papers), Signaling Pathways in Disease (7 papers), PI3K/AKT/mTOR signaling in cancer (6 papers), Genetics and Neurodevelopmental Disorders (6 papers) and Chemical Synthesis and Analysis (5 papers). The work is most often cited by research in Molecular Biology (8.6k citations), Cellular and Molecular Neuroscience (2.1k citations), Cell Biology (1.2k citations), Spectroscopy (1.0k citations) and Behavioral Neuroscience (221 citations). Michael J. Comb has collaborated with scholars based in United States, Germany and Canada. Frequent co-authors include Howard M. Goodman, Ailan Guo, A. John Rush, Roberto D. Polakiewicz, Edward Herbert, Steven E. Hyman, Steven P. Gygi, Kimberly A. Lee, Yi Tan and Anthony Possemato. Their work appears in journals such as Journal of Biological Chemistry, Molecular and Cellular Biology, Molecular Endocrinology, Proceedings of the National Academy of Sciences and Molecular & Cellular Proteomics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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