Ludger Klein

17.4k total citations · 5 hit papers
60 papers, 9.8k citations indexed

About

Ludger Klein is a scholar working on Immunology, Genetics and Epidemiology. According to data from OpenAlex, Ludger Klein has authored 60 papers receiving a total of 9.8k indexed citations (citations by other indexed papers that have themselves been cited), including 51 papers in Immunology, 8 papers in Genetics and 7 papers in Epidemiology. Recurrent topics in Ludger Klein's work include Immune Cell Function and Interaction (45 papers), T-cell and B-cell Immunology (43 papers) and Immunotherapy and Immune Responses (28 papers). Ludger Klein is often cited by papers focused on Immune Cell Function and Interaction (45 papers), T-cell and B-cell Immunology (43 papers) and Immunotherapy and Immune Responses (28 papers). Ludger Klein collaborates with scholars based in Germany, United States and Austria. Ludger Klein's co-authors include Bruno Kyewski, Harald von Boehmer, Jens Derbinski, Louise M. D’Cruz, Paul M. Allen, Kristin A. Hogquist, Maria Hinterberger, Antje Schulte, Irina Apostolou and Martin Aichinger and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Ludger Klein

60 papers receiving 9.7k citations

Hit Papers

Projection of an Immunological Self Shadow Within the Thy... 2001 2026 2009 2017 2002 2014 2001 2002 2006 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
    2002 1.7k citations Mark S. Anderson, Emily S. Venanzi et al. Science profile →
  2. Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
    2014 928 citations Ludger Klein, Bruno Kyewski et al. Nature reviews. Immunology profile →
  3. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    2001 835 citations Jens Derbinski, Antje Schulte et al. Nature Immunology profile →
  4. Origin of regulatory T cells with known specificity for antigen
    2002 697 citations Ludger Klein, Harald von Boehmer et al. Nature Immunology profile →
  5. A CENTRAL ROLE FOR CENTRAL TOLERANCE
    2006 522 citations Bruno Kyewski, Ludger Klein profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Ludger Klein Germany 38 7.3k 1.7k 1.6k 1.6k 1.1k 60 9.8k
Bruno Kyewski Germany 49 6.7k 0.9× 1.5k 0.9× 1.9k 1.2× 1.7k 1.1× 1.4k 1.3× 110 9.6k
Benoı̂t L. Salomon France 45 8.7k 1.2× 1.9k 1.1× 1.1k 0.7× 386 0.2× 1.5k 1.4× 87 10.9k
Yousuke Takahama Japan 55 6.4k 0.9× 980 0.6× 3.9k 2.5× 1.2k 0.8× 2.2k 2.1× 188 10.8k
Stuart P. Berzins Australia 33 5.0k 0.7× 890 0.5× 766 0.5× 862 0.6× 1.2k 1.1× 64 6.4k
Eric J. Jenkinson United Kingdom 56 6.6k 0.9× 904 0.5× 2.8k 1.8× 983 0.6× 1.7k 1.6× 170 10.2k
Brian T. Fife United States 34 4.6k 0.6× 979 0.6× 974 0.6× 392 0.3× 2.3k 2.1× 73 6.7k
Mary E. Brunkow United States 19 5.7k 0.8× 2.0k 1.2× 2.3k 1.5× 374 0.2× 1.2k 1.2× 28 8.6k
Achim Leutz Germany 51 2.5k 0.3× 1.4k 0.8× 6.5k 4.1× 698 0.4× 1.5k 1.4× 116 10.0k
Willem van Ewijk Netherlands 44 4.9k 0.7× 663 0.4× 2.0k 1.3× 379 0.2× 1.3k 1.2× 110 7.7k
Hitoshi Kikutani Japan 65 9.2k 1.3× 1.7k 1.0× 4.4k 2.8× 486 0.3× 3.9k 3.7× 186 17.0k

Countries citing papers authored by Ludger Klein

Since Specialization
Citations

This map shows the geographic impact of Ludger Klein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ludger Klein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ludger Klein more than expected).

Fields of papers citing papers by Ludger Klein

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ludger Klein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ludger Klein. The network helps show where Ludger Klein may publish in the future.

Co-authorship network of co-authors of Ludger Klein

This figure shows the co-authorship network connecting the top 25 collaborators of Ludger Klein. A scholar is included among the top collaborators of Ludger Klein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ludger Klein. Ludger Klein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Federle, Christine, Jelena Nedjic, Sarina Ravens, et al.. (2025). Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells. Nature Immunology. 26(7). 1127–1138. 1 indexed citations
2.
Kazerani, Maryam, Filippo M. Cernilogar, Maria Hinterberger, et al.. (2024). Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers. Proceedings of the National Academy of Sciences. 121(52). e2409656121–e2409656121. 1 indexed citations
3.
Brabec, Tomáš, Jan Dobeš, Jan Kubovčiak, et al.. (2020). Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation. Nature Communications. 11(1). 2361–2361. 38 indexed citations
4.
Federle, Christine, Thamotharampillai Dileepan, Kilian Schober, et al.. (2019). Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors. Proceedings of the National Academy of Sciences. 116(37). 18537–18543. 20 indexed citations
5.
Yamano, Tomoyoshi, Jan Dobeš, Tomáš Brabec, et al.. (2019). Aire-expressing ILC3-like cells in the lymph node display potent APC features. The Journal of Experimental Medicine. 216(5). 1027–1037. 47 indexed citations
6.
Derbinski, Jens, Antje Schulte, Bruno Kyewski, & Ludger Klein. (2016). Pillars Article: Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Mirrors the Peripheral Self. Nat. Immunol. 2001. 2: 1032–1039. The Journal of Immunology. 196(7). 2915–2922. 7 indexed citations
7.
Nedjic, Jelena, Christine Federle, Hidde L. Ploegh, et al.. (2016). Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83. The Journal of Experimental Medicine. 213(9). 1685–1694. 65 indexed citations
8.
Yamano, Tomoyoshi, et al.. (2015). Thymic B Cells and Central T Cell Tolerance. Frontiers in Immunology. 6. 376–376. 17 indexed citations
9.
Aichinger, Martin, Chunyan Wu, Jelena Nedjic, & Ludger Klein. (2013). Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance. The Journal of Experimental Medicine. 210(2). 287–300. 117 indexed citations
10.
Klein, Ludger, et al.. (2011). Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance. Trends in Immunology. 32(5). 188–193. 45 indexed citations
11.
Wirnsberger, Gerald, Florian Mair, & Ludger Klein. (2009). Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control. Proceedings of the National Academy of Sciences. 106(25). 10278–10283. 81 indexed citations
12.
Klein, Ludger, Maria Hinterberger, Gerald Wirnsberger, & Bruno Kyewski. (2009). Antigen presentation in the thymus for positive selection and central tolerance induction. Nature reviews. Immunology. 9(12). 833–844. 386 indexed citations
13.
Havari, Evis, Ludger Klein, Jacqueline Taylor, et al.. (2004). Expression of the B7.1 Costimulatory Molecule on Pancreatic β Cells Abrogates the Requirement for CD4 T Cells in the Development of Type 1 Diabetes. The Journal of Immunology. 173(2). 787–796. 13 indexed citations
14.
Klein, Ludger, Khashayarsha Khazaie, & Harald von Boehmer. (2003). In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proceedings of the National Academy of Sciences. 100(15). 8886–8891. 326 indexed citations
15.
Jaeckel, Elmar, Ludger Klein, Natalia Martín‐Orozco, & Harald von Boehmer. (2003). Normal Incidence of Diabetes in NOD Mice Tolerant to Glutamic Acid Decarboxylase. The Journal of Experimental Medicine. 197(12). 1635–1644. 73 indexed citations
16.
Anderson, Mark S., Emily S. Venanzi, Ludger Klein, et al.. (2002). Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein. Science. 298(5597). 1395–1401. 1744 indexed citations breakdown →
17.
Kyewski, Bruno, et al.. (2002). Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends in Immunology. 23(7). 364–371. 161 indexed citations
18.
Gounari, Fotini, Sabina Signoretti, Roderick T. Bronson, et al.. (2002). Stabilization of β-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia. Oncogene. 21(26). 4099–4107. 87 indexed citations
19.
Kyewski, Bruno, et al.. (2000). Making Central T-Cell Tolerance Efficient: Thymic Stromal Cells Sample Distinct Self-Antigen Pools. Current topics in microbiology and immunology. 251. 139–145. 13 indexed citations
20.
Klein, Ludger & Bruno Kyewski. (2000). Promiscuous expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity?. Journal of Molecular Medicine. 78(9). 483–494. 85 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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