Lianyi Han

14.0k citations

85 papers · 10.6k · 4 hit papers · h-index 31

Impact in

Computational Theory and Mathematics top 0.1%
- Computational Drug Discovery Methods
Pharmacology top 0.5%

Papers in

Computational Theory and Mathematics 39
- Computational Drug Discovery Methods 39
Molecular Biology 49
- Machine Learning in Bioinformatics 19
- Protein Structure and Dynamics 13
- RNA and protein synthesis mechanisms 11
- Bioinformatics and Genomic Networks 7
- Metabolomics and Mass Spectrometry Studies 5
- Biomedical Text Mining and Ontologies 4

Co-authors: Stephen H. Bryant (8 shared papers)Siqian He (3 shared papers)Jane He (2 shared papers)Yu Zong Chen (45 shared papers)Evan Bolton (4 shared papers)Jian Jeff Zhang (3 shared papers)Asta Gindulytė (2 shared papers)Benjamin A. Shoemaker (2 shared papers)
Journals: Nucleic Acids Research (14 papers)Drug Discovery Today (5 papers)BMC Bioinformatics (3 papers)Journal of Cheminformatics (3 papers)Bioinformatics (2 papers)
Partner nations: China Singapore United States

In The Last Decade

Lianyi Han

81 papers receiving 10.4k citations

Lianyi Han's Hit Papers

align trajectories log scale

CDD/SPARCLE: functional classification of proteins via subfamily domain architectures 2016 · 2.1k citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2016 Nucleic Acids Research
2015 Nucleic Acids Research
2011 Nucleic Acids Research
2009 Nucleic Acids Research

Peers

Countries citing papers authored by Lianyi Han

Since Specialization

Citations

This map shows the geographic impact of Lianyi Han's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lianyi Han with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lianyi Han more than expected).

Fields of papers citing papers by Lianyi Han

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lianyi Han. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lianyi Han. The network helps show where Lianyi Han may publish in the future.

Co-authors

The 25 scholars most cited alongside Lianyi Han, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Lianyi Han Line = papers co-authored together Lianyi Han links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 85 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	PubChem Substance and Compound databases Nucleic Acids Research ·Sunghwan Kim, Paul A. Thiessen, Evan Bolton, Jie Chen, Gang Fu, Asta Gindulytė, Lianyi Han, Jane He Hit paper breakdown →	2015	4215
2	CDD/SPARCLE: functional classification of proteins via subfamily domain architectures Nucleic Acids Research ·Aron Marchler‐Bauer, Bo Yu, Lianyi Han, Jane He, Christopher J. Lanczycki, Shennan Lu, Farideh Chitsaz, Myra K. Derbyshire Hit paper breakdown →	2016	2125
3	The NCBI BioSystems database Nucleic Acids Research ·Lewis Y. Geer, Aron Marchler‐Bauer, Renata C. Geer, Lianyi Han, Jane He, Siqian He, Chunlei Liu, Wenyao Shi Hit paper breakdown →	2009	684
4	PubChem's BioAssay Database Nucleic Acids Research ·Y. Wang, J. Xiao, Tuğba Önal-Süzek, Jian Jeff Zhang, Jiguang Wang, Zhigang Zhou, Lianyi Han, K. V. Karapetyan Hit paper breakdown →	2011	520
5	PROFEAT: a web server for computing structural and physicochemical features of proteins and peptides from amino acid sequence Nucleic Acids Research ·Zhong-Xiao Li, Honghuang Lin, Lianyi Han, Lu-Wei Jiang, Xinzhang Chen, Yu Zong Chen	2006	258
6	Update of TTD: Therapeutic Target Database Nucleic Acids Research ·Feng Zhu, Bucong Han, Pankaj Kumar, Xianghui Liu, Xiaohua Ma, Xiaona Wei, Lu Huang, Yangfan Guo	2009	227
7	Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation British Journal of Pharmacology ·Xi Chen, Hufeng Zhou, Y B Liu, Jinxiang Wang, H Li, Choong Yong Ung, Lianyi Han, Zhiwei Cao	2006	182
8	Enzyme family classification by support vector machines Proteins Structure Function and Bioinformatics ·Cong Cai, Lianyi Han, Ji Zhang, Yu Zong Chen	2004	153
9	PubChem3D: a new resource for scientists Journal of Cheminformatics ·Evan Bolton, Jie Chen, Sunghwan Kim, Lianyi Han, Siqian He, Wenyao Shi, Vahan V. Simonyan, Yan Lindsay Sun	2011	148
10	Therapeutic Targets: Progress of Their Exploration and Investigation of Their Characteristics Pharmacological Reviews ·Chaofei Zheng, Lianyi Han, Chun Wei Yap, Zhang Ji, Zhi Wei Cao, Yu Zong Chen	2006	144
11	Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives Drug Discovery Today ·Xiaojie Ma, Chaofei Zheng, Lianyi Han, Bo Xie, Jing Jia, Zhi Wei Cao, Y.X. Li, Yu Zong Chen	2009	134
12	Prediction of RNA-binding proteins from primary sequence by a support vector machine approach RNA ·Lianyi Han, Cong Cai, Siaw Ling Lo, Maxey C. M. Chung, Yu Zong Chen	2004	110
13	Developing and validating predictive decision tree models from mining chemical structural fingerprints and high–throughput screening data in PubChem BMC Bioinformatics ·Lianyi Han, Yanli Wang, Stephen H. Bryant	2008	85
14	Predicting functional family of novel enzymes irrespective of sequence similarity: a statistical learning approach Nucleic Acids Research ·Lianyi Han, Cong Cai, Zhang Ji, Zhiwei Cao, Juan Cui, Yu Zong Chen	2004	81
15	A support vector machines approach for virtual screening of active compounds of single and multiple mechanisms from large libraries at an improved hit-rate and enrichment factor Journal of Molecular Graphics and Modelling ·Lianyi Han, Xiangyang Ma, Honghuang Lin, Jing Jia, Feng Zhu, Ying Wen Xue, Zirui Li, Zhixing Cao	2008	78
16	Prediction of the functional class of metal-binding proteins from sequence derived physicochemical properties by support vector machine approach BMC Bioinformatics ·Honghuang Lin, Lianyi Han, H. L. Zhang, CJ Zheng, Bo Xie, Z F Cao, Yu Zong Chen	2006	71
17	Computer prediction of allergen proteins from sequence-derived protein structural and physicochemical properties Molecular Immunology ·Juan Cui, Lianyi Han, Hu Li, Choong Yong Ung, Zhi Qun Tang, Chuxin Zheng, Zhi Wei Cao, Yu Zong Chen	2006	66
18	Support vector machines approach for predicting druggable proteins: recent progress in its exploration and investigation of its usefulness Drug Discovery Today ·Lianyi Han, Chuxin Zheng, Bin Xie, Jia Jia, Hua Xiao, Feng Zhu, Honghuang Lin, Xin Chen	2007	66
19	Traditional Chinese medicine information database Clinical Pharmacology & Therapeutics ·Jing Wang, Hufeng Zhou, Lianyi Han, X. Chen, Yu Zong Chen, Zhiwei Cao	2005	59
20	Recent progresses in the application of machine learning approach for predicting protein functional class independent of sequence similarity PROTEOMICS ·Lianyi Han, Juan Cui, Honghuang Lin, Zhi‐Liang Ji, Zhiwei Cao, Yixue Li +1 other	2006	57

About Lianyi Han

Lianyi Han is a scholar working on Computational Theory and Mathematics, Molecular Biology, Pharmacology, Spectroscopy and Biophysics, having authored 85 papers that have together received 10.6k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (39 papers), Machine Learning in Bioinformatics (19 papers), Protein Structure and Dynamics (13 papers), RNA and protein synthesis mechanisms (11 papers), Pharmacogenetics and Drug Metabolism (7 papers), Bioinformatics and Genomic Networks (7 papers), Metabolomics and Mass Spectrometry Studies (5 papers) and Biomedical Text Mining and Ontologies (4 papers). The work is most often cited by research in Computational Theory and Mathematics (3.0k citations), Pharmacology (686 citations), Molecular Biology (5.5k citations), Pharmacology (800 citations) and Complementary and alternative medicine (297 citations). Lianyi Han has collaborated with scholars based in China, Singapore and United States. Frequent co-authors include Stephen H. Bryant, Siqian He, Jane He, Yu Zong Chen, Evan Bolton, Jian Jeff Zhang, Asta Gindulytė, Benjamin A. Shoemaker, Bo Yu and Sunghwan Kim. Their work appears in journals such as Nucleic Acids Research, Drug Discovery Today, BMC Bioinformatics, Journal of Cheminformatics and Bioinformatics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Lianyi Han's Hit Papers

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All Works

About Lianyi Han

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