Keith A. Houck

23.1k citations

111 papers · 17.0k indexed · 11 hit papers · h-index 58

Impact in

Health, Toxicology and Mutagenesis top 0.1%
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Environmental Toxicology and Ecotoxicology
Small Animals top 0.1%
- Animal testing and alternatives

Papers in

Health, Toxicology and Mutagenesis 45
- Effects and risks of endocrine disrupting chemicals 38
- Toxic Organic Pollutants Impact 9
Small Animals 21
- Animal testing and alternatives 21

Co-authors: Napoleone Ferrara David W. M. Leung Jane Winer David J. Dix Matthew T. Martin Richard Judson Robert J. Kavlock Lyn B. Jakeman
Journals: Toxicological Sciences (10 papers)Environmental Health Perspectives (9 papers)Environmental Science & Technology (8 papers)Chemical Research in Toxicology (7 papers)Journal of Biological Chemistry (5 papers)
Partner nations: United States Canada France

In The Last Decade

Keith A. Houck

110 papers receiving 16.5k citations

Hit Papers

11 papers align trajectories log scale

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology 2016 · 480 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2016 Chemical Research in Toxicology
2015 Nature Nanotechnology
2012 Chemical Research in Toxicology
2009 Environmental Health Perspectives
2006 Toxicological Sciences
1994 Journal of Biological Chemistry
1992 Science
1992 Journal of Biological Chemistry
1992 Endocrine Reviews
1991 Molecular Endocrinology
1991 Journal of Cellular Biochemistry

Peers

Countries citing papers authored by Keith A. Houck

Since Specialization

Citations

This map shows the geographic impact of Keith A. Houck's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keith A. Houck with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keith A. Houck more than expected).

Fields of papers citing papers by Keith A. Houck

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keith A. Houck. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keith A. Houck. The network helps show where Keith A. Houck may publish in the future.

Co-authors

The 25 scholars most cited alongside Keith A. Houck, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Keith A. Houck Line = papers co-authored together Keith A. Houck links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Verification of In Vivo Estrogenic Activity for Four Per- and Polyfluoroalkyl Substances (PFAS) Identified as Estrogen Receptor Agonists via New Approach Methodologies Environmental Science & Technology ·Daniel L. Villeneuve, Brett R. Blackwell, Jenna E. Cavallin, Jacob Collins, John X. Hoang, Rachel N. Hofer, Keith A. Houck, Kathleen Jensen, Michael D. Kahl, Robin N. Kutsi, Anne S. Opseth, Kelvin Santana Rodriguez, Christopher M. Schaupp, Emma Stacy, Gerald T. Ankley	2023	36
2	High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures npj Systems Biology and Applications ·Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen Ferguson, Keith A. Houck, John F. Wambaugh	2021	27
3	A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish ( Danio rerio ) Environmental Health Perspectives ·Jiajun Han, Wen Gu, Holly Barrett, Diwen Yang, Song Tang, Jianxian Sun, Jia‐Bao Liu, Henry M. Krause, Keith A. Houck, Hui Peng	2021	38
4	Exploration of xenobiotic metabolism within cell lines used for Tox21 chemical screening Toxicology in Vitro ·Wei Qu, David M. Crizer, Michael J. DeVito, Suramya Waidyanatha, Menghang Xia, Keith A. Houck, Stephen Ferguson	2021	15
5	Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity Toxicological Sciences ·Todd J. Zurlinden, Katerine S. Saili, Nathaniel Rush, Parth Kothiya, Richard Judson, Keith A. Houck, E. Sidney Hunter, Nancy Baker, Jessica Palmer, Russell S. Thomas, Thomas B. Knudsen	2020	38
6	Evaluation of a multiplexed, multispecies nuclear receptor assay for chemical hazard assessment Toxicology in Vitro ·Keith A. Houck, Anita Simha, Audrey J. Bone, Jon A. Doering, Sara M.F. Vliet, Carlie A. LaLone, Alexander V. Medvedev, Sergei S. Makarov	2020	10
7	Potential Toxicity of Complex Mixtures in Surface Waters from a Nationwide Survey of United States Streams: Identifying in Vitro Bioactivities and Causative Chemicals Environmental Science & Technology ·Brett R. Blackwell, Gerald T. Ankley, Paul M. Bradley, Keith A. Houck, Sergei S. Makarov, Alexander V. Medvedev, Joe Swintek, Daniel L. Villeneuve	2018	89
8	Evaluating biological activity of compounds by transcription factor activity profiling Science Advances ·Alexander V. Medvedev, Matt Moeser, Liubov Medvedeva, E. S. Martsen, Alexander Granick, Lydia Raines, Ming Zeng, Sergei Makarov, (unknown), Keith A. Houck, Sergei S. Makarov	2018	23
9	Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system Toxicology in Vitro ·Barbara A. Wetmore, Rebecca A. Clewell, Brian Cholewa, Bethany Parks, Salil N. Pendse, Michael B. Black, Kamel Mansouri, Saad Haider, Ellen L. Berg, Richard Judson, Keith A. Houck, Matthew T. Martin, Harvey J. Clewell, Melvin E. Andersen, Russell S. Thomas, Patrick D. McMullen	2018	10
10	An “EAR” on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure–Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters Environmental Science & Technology ·Brett R. Blackwell, Gerald T. Ankley, Steven R. Corsi, Laura DeCicco, Keith A. Houck, Richard Judson, Shibin Li, Matthew T. Martin, Elizabeth W. Murphy, Anthony Schroeder, Edwin Smith, Joe Swintek, Daniel L. Villeneuve	2017	90
11	Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates Archives of Toxicology ·Jenna D. Strickland, Matthew T. Martin, Ann M. Richard, Keith A. Houck, Timothy J. Shafer	2017	58
12	Use of Neural Models of Proliferation and Neurite Outgrowth to Screen Environmental Chemicals in the ToxCast Phase I Library Nicholas M. Radio, Joseph M. Breier, David M. Reif, Richard Judson, Matthew T. Martin, Keith A. Houck, William R. Mundy, Timothy J. Shafer	2015	9
13	Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure Environmental Health Perspectives ·Imran Shah, R. Woodrow Setzer, John Jack, Keith A. Houck, Richard Judson, Thomas B. Knudsen, Jie Liu, Matthew T. Martin, David M. Reif, Ann M. Richard, Russell S. Thomas, Kevin M. Crofton, David J. Dix, Robert J. Kavlock	2015	58
14	Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate Toxicological Sciences ·John F. Wambaugh, R. Woodrow Setzer, Ann M. Pitruzzello, Jie Liu, David M. Reif, Nicole Kleinstreuer, Nina Ching Y. Wang, Nisha S. Sipes, Matthew T. Martin, Kaberi Das, Jamie C. DeWitt, Mark J. Strynar, Richard Judson, Keith A. Houck, Christopher Lau	2013	39
15	Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors Environmental Health Perspectives ·Ruili Huang, Menghang Xia, Ming-Hsuang Cho, Srilatha Sakamuru, Paul Shinn, Keith A. Houck, David J. Dix, Richard Judson, Kristine L. Witt, Robert J. Kavlock, Raymond R. Tice, Christopher P. Austin	2011	166
16	Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data Environmental Health Perspectives ·David M. Reif, Matthew T. Martin, Shirlee Tan, Keith A. Houck, Richard Judson, Ann M. Richard, Thomas B. Knudsen, David J. Dix, Robert J. Kavlock	2010	301
17	Understanding mechanisms of toxicity: Insights from drug discovery research Toxicology and Applied Pharmacology ·Keith A. Houck, Robert J. Kavlock	2007	67
18	High-Content Screening Assay for Activators of the Wnt/Fzd Pathway in Primary Human Cells Assay and Drug Development Technologies ·Kristen M. Borchert, Rachelle J. Sells Galvin, Charles A. Frolik, Laura V. Hale, David L. Halladay, Robin J. Gonyier, O. Joseph Trask, Debra Nickischer, Keith A. Houck	2005	35
19	Increased AKT Activity Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and Diminishing p27Kip1 Expression Journal of Biological Chemistry ·Jeremy R. Graff, Bruce W. Konicek, Ann M. McNulty, Zejing Wang, Keith A. Houck, Sheryl Allen, Jonathan Paul, Ahed Hbaiu, Robin G. Goode, George E. Sandusky, Robert L. Vessella, Blake Lee Neubauer	2000	320
20	Potential uses of microbiological testing in cheese plant HACCP and quality assurance systems Steven C. Ingham, A.M. Larson, Marianne Smukowski, Keith A. Houck, E. T. Johnson, Melissa H. Johnson, R J Bishop	1997	7

About Keith A. Houck

Keith A. Houck is a scholar working on Health, Toxicology and Mutagenesis, Small Animals, Computational Theory and Mathematics, Pharmacology and Immunology and Allergy, having authored 111 papers that have together received 17.0k indexed citations. Recurring topics across this work include Effects and risks of endocrine disrupting chemicals (38 papers), Computational Drug Discovery Methods (34 papers), Animal testing and alternatives (21 papers), Estrogen and related hormone effects (15 papers), Pharmacogenetics and Drug Metabolism (11 papers), Liver physiology and pathology (9 papers), Toxic Organic Pollutants Impact (9 papers) and Carcinogens and Genotoxicity Assessment (9 papers). The work is most often cited by research in Health, Toxicology and Mutagenesis (3.9k citations), Small Animals (1.5k citations), Cancer Research (3.0k citations), Chemical Health and Safety (129 citations) and Computational Theory and Mathematics (2.3k citations). Keith A. Houck has collaborated with scholars based in United States, Canada and France. Frequent co-authors include Napoleone Ferrara, David W. M. Leung, Jane Winer, David J. Dix, Matthew T. Martin, Richard Judson, Robert J. Kavlock, Lyn B. Jakeman, Ann M. Richard and Jaime A. Escobedo. Their work appears in journals such as Toxicological Sciences, Environmental Health Perspectives, Environmental Science & Technology, Chemical Research in Toxicology and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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