Ke‐He Ruan

1.7k total citations
79 papers, 1.4k citations indexed

About

Ke‐He Ruan is a scholar working on Molecular Biology, Pharmacology and Radiology, Nuclear Medicine and Imaging. According to data from OpenAlex, Ke‐He Ruan has authored 79 papers receiving a total of 1.4k indexed citations (citations by other indexed papers that have themselves been cited), including 52 papers in Molecular Biology, 35 papers in Pharmacology and 13 papers in Radiology, Nuclear Medicine and Imaging. Recurrent topics in Ke‐He Ruan's work include Inflammatory mediators and NSAID effects (31 papers), Receptor Mechanisms and Signaling (26 papers) and Eicosanoids and Hypertension Pharmacology (13 papers). Ke‐He Ruan is often cited by papers focused on Inflammatory mediators and NSAID effects (31 papers), Receptor Mechanisms and Signaling (26 papers) and Eicosanoids and Hypertension Pharmacology (13 papers). Ke‐He Ruan collaborates with scholars based in United States, Japan and China. Ke‐He Ruan's co-authors include Shui‐Ping So, Eiji Ishikawa, Kenneth K. Wu, Shuhei Inoue, Jiaxin Wu, Hui Deng, Jiaxin Wu, Vanessa Cervantes, Aimin Huang and Richard J. Kulmacz and has published in prestigious journals such as Journal of Biological Chemistry, Circulation and Journal of Clinical Investigation.

In The Last Decade

Ke‐He Ruan

79 papers receiving 1.4k citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Ke‐He Ruan United States 23 733 377 165 146 146 79 1.4k
Réjean Ruel Canada 19 1.4k 1.9× 345 0.9× 131 0.8× 133 0.9× 64 0.4× 32 2.4k
Akinori Arimura Japan 24 456 0.6× 322 0.9× 166 1.0× 57 0.4× 60 0.4× 67 2.2k
Carina L. Bos Netherlands 14 473 0.6× 267 0.7× 37 0.2× 87 0.6× 50 0.3× 17 1.4k
Julius Leyton United States 30 765 1.0× 178 0.5× 351 2.1× 190 1.3× 369 2.5× 47 2.1k
Seymour Mong United States 27 974 1.3× 247 0.7× 140 0.8× 119 0.8× 32 0.2× 71 2.0k
James B. Summers United States 25 568 0.8× 330 0.9× 60 0.4× 72 0.5× 101 0.7× 46 1.7k
Dilip Amin United States 14 529 0.7× 102 0.3× 69 0.4× 132 0.9× 94 0.6× 26 1.6k
Gary V. Richieri United States 22 1.5k 2.0× 134 0.4× 83 0.5× 257 1.8× 71 0.5× 30 2.1k
Daisuke Kamei Japan 20 720 1.0× 829 2.2× 54 0.3× 214 1.5× 37 0.3× 33 1.7k
Thomas J. Carty United States 21 561 0.8× 609 1.6× 52 0.3× 201 1.4× 27 0.2× 41 1.5k

Countries citing papers authored by Ke‐He Ruan

Since Specialization
Citations

This map shows the geographic impact of Ke‐He Ruan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ke‐He Ruan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ke‐He Ruan more than expected).

Fields of papers citing papers by Ke‐He Ruan

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ke‐He Ruan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ke‐He Ruan. The network helps show where Ke‐He Ruan may publish in the future.

Co-authorship network of co-authors of Ke‐He Ruan

This figure shows the co-authorship network connecting the top 25 collaborators of Ke‐He Ruan. A scholar is included among the top collaborators of Ke‐He Ruan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ke‐He Ruan. Ke‐He Ruan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
2.
Ruan, Ke‐He, et al.. (2016). A TRANSGENIC MOUSE MODEL EXPRESSING A NOVEL SINGLE-CHAIN ENZYME COMPLEX OF CYCLOOXYGENASE AND PROSTACYCLIN SYNTHASE EXHIBITS ROBUST RESISTANCE TO HEART DISEASE AND VASCULAR ASSAULT. Journal of the American College of Cardiology. 67(13). 2288–2288. 1 indexed citations
3.
Ruan, Ke‐He, et al.. (2016). Identification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1. Archives of Biochemistry and Biophysics. 603. 29–37. 18 indexed citations
4.
5.
Lin, Haocheng, Jiuhong Yuan, Ke‐He Ruan, et al.. (2013). COX-2-10aa-PGIS Gene Therapy Improves Erectile Function in Rats After Cavernous Nerve Injury. The Journal of Sexual Medicine. 10(6). 1476–1487. 23 indexed citations
6.
Xi, Yutao, Shui‐Ping So, Jia Zhang, et al.. (2011). Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells. Journal of Cellular Physiology. 227(7). 2907–2916. 15 indexed citations
7.
8.
Ruan, Ke‐He, Vanessa Cervantes, & Shui‐Ping So. (2009). Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2. Protein Engineering Design and Selection. 22(12). 733–740. 21 indexed citations
9.
Zhang, Lihai, Murat Bastepe, Harald Jüppner, & Ke‐He Ruan. (2006). Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Gαs protein in human coronary artery smooth muscle cells. Archives of Biochemistry and Biophysics. 454(1). 80–88. 11 indexed citations
10.
Ruan, Ke‐He & Jean‐Michel Dogné. (2006). Implications of the Molecular Basis of Prostacyclin Biosynthesis and Signaling in Pharmaceutical Designs. Current Pharmaceutical Design. 12(8). 925–941. 11 indexed citations
11.
Ruan, Ke‐He, Jiaxin Wu, & Lee‐Ho Wang. (2005). Solution structure of a common substrate mimetic of cyclooxygenase-downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique. Archives of Biochemistry and Biophysics. 444(2). 165–173. 3 indexed citations
12.
Ruan, Ke‐He, Hui Deng, Jiaxin Wu, & Shui‐Ping So. (2005). The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase. Archives of Biochemistry and Biophysics. 435(2). 372–381. 12 indexed citations
13.
Dogné, Jean‐Michel, Xavier de Leval, Julien Hanson, et al.. (2004). New Developments on Thromboxane and Prostacyclin Modulators Part I: Thromboxane Modulators. Current Medicinal Chemistry. 11(10). 1223–1241. 68 indexed citations
14.
Geng, Linda N., Jiaxin Wu, Shui‐Ping So, Gangxiong Huang, & Ke‐He Ruan. (2004). Structural and functional characterization of the first intracellular loop of human thromboxane A2 receptor. Archives of Biochemistry and Biophysics. 423(2). 253–265. 27 indexed citations
15.
Ruan, Ke‐He, et al.. (2004). NMR structure of the thromboxane A2 receptor ligand recognition pocket. European Journal of Biochemistry. 271(14). 3006–3016. 27 indexed citations
16.
Wu, Jiaxin, Shui‐Ping So, & Ke‐He Ruan. (2003). Determination of the membrane contact residues and solution structure of the helix F/G loop of prostaglandin I2 synthase. Archives of Biochemistry and Biophysics. 411(1). 27–35. 7 indexed citations
17.
So, Shui‐Ping, Jiaxin Wu, Gangxiong Huang, et al.. (2003). Identification of Residues Important for Ligand Binding of Thromboxane A2 Receptor in the Second Extracellular Loop Using the NMR Experiment-guided Mutagenesis Approach. Journal of Biological Chemistry. 278(13). 10922–10927. 35 indexed citations
18.
Deng, Hui, et al.. (2000). Topology of Catalytic Portion of Prostaglandin I2 Synthase: Identification by Molecular Modeling-Guided Site-Specific Antibodies. Archives of Biochemistry and Biophysics. 379(2). 188–197. 15 indexed citations
19.
Xu, Xiaoming, et al.. (1993). Enhanced prostacyclin synthesis in endothelial cells by retrovirus-mediated transfer of prostaglandin H synthase cDNA.. Journal of Clinical Investigation. 91(4). 1843–1849. 27 indexed citations
20.
Jiang, Jing, et al.. (1992). Highly Sensitive Sandwich Enzyme Immunoassay for Alpha-Fetoprotein in Human Saliva. Annals of Clinical Biochemistry International Journal of Laboratory Medicine. 29(5). 519–522. 5 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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