Kees Smid

3.7k citations

90 papers · 3.1k indexed · h-index 29

Impact in

Oncology top 1%
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
Cancer Research top 5%
- Cancer, Hypoxia, and Metabolism

Papers in ⓘ

Oncology 66
- Colorectal Cancer Treatments and Studies 45
- Pancreatic and Hepatic Oncology Research 12
- Cancer-related Molecular Pathways 10
Molecular Biology 49
- Biochemical and Molecular Research 23
- DNA Repair Mechanisms 9

Co-authors: Godefridus J. Peters (86 shared papers)Herbert M. Pinedo (35 shared papers)C.L. van der Wilt (26 shared papers)Paul Noordhuis (20 shared papers)Sybren L. Meijer (7 shared papers)C.J. van Groeningen (6 shared papers)Gerrit Jansen (7 shared papers)Baukelien van Triest (3 shared papers)
Journals: Nucleosides Nucleotides & Nucleic Acids (11 papers)Advances in experimental medicine and biology (8 papers)European Journal of Cancer (5 papers)Cancer Research (5 papers)British Journal of Cancer (4 papers)
Partner nations: Netherlands United States Italy

In The Last Decade

Kees Smid

89 papers receiving 3.0k citations

Peers

Countries citing papers authored by Kees Smid

Since Specialization

Citations

This map shows the geographic impact of Kees Smid's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kees Smid with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kees Smid more than expected).

Fields of papers citing papers by Kees Smid

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kees Smid. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kees Smid. The network helps show where Kees Smid may publish in the future.

Co-authors

The 25 scholars most cited alongside Kees Smid, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Kees Smid Line = papers co-authored together Kees Smid links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 90 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·Godefridus J. Peters, Harold H.J. Backus, SJ Freemantle, Baukelien van Triest, Giovanni Codacci-Pisanelli, C.L. van der Wilt, Kees Smid, John Lunec, A. Hilary Calvert, Sharon Marsh, Howard L. McLeod, Elisabeth Bloemena, Sybren L. Meijer, Gerrit Jansen, C.J. van Groeningen, Herbert M. Pinedo	2002	328
2	5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers Annals of Oncology ·Paul Noordhuis, U. Holwerda, C.L. van der Wilt, C.J. van Groeningen, Kees Smid, Sybren L. Meijer, Herbert M. Pinedo, Godefridus J. Peters	2004	210
3	Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. Journal of Clinical Oncology ·Godefridus J. Peters, C.L. van der Wilt, C.J. van Groeningen, Kees Smid, Sybren L. Meijer, Herbert M. Pinedo	1994	165
4	In vivo Induction of Resistance to Gemcitabine Results in Increased Expression of Ribonucleotide Reductase Subunit M1 as the Major Determinant Cancer Research ·Andries M. Bergman, Paul P. Eijk, Veronique W.T. Ruiz van Haperen, Kees Smid, Gijsbert Veerman, Isabelle Hubeek, Paul van den IJssel, Bauke Ylstra, Godefridus J. Peters	2005	159
5	Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia British Journal of Cancer ·Mina Maftouh, Abolfazl Avan, Rocco Sciarrillo, Carlotta Granchi, Lg Leon, Reshma Rani, Niccola Funel, Kees Smid, Richard J. Honeywell, Ugo Boggi, Filippo Minutolo, Godefridus J. Peters, Elisa Giovannetti	2013	142
6	Molecular Mechanisms Underlying the Synergistic Interaction of Erlotinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, with the Multitargeted Antifolate Pemetrexed in Non-Small-Cell Lung Cancer Cells Molecular Pharmacology ·Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José Antonio Rodríguez, S Ricciardi, Romano Danesi, Giuseppe Giaccone, Godefridus J. Peters	2008	130
7	Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines. PubMed ·Baukelien van Triest, Herbert M. Pinedo, Yvette van Hensbergen, Kees Smid, F. Telleman, Pascale S. Schoenmakers, C.L. van der Wilt, Jan van Laar, Paul Noordhuis, Gerrit Jansen, Godefridus J. Peters	1999	125
8	Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer. PubMed ·Baukelien van Triest, Herbert M. Pinedo, J. L. G. Blaauwgeers, P. J. van Diest, Pascale S. Schoenmakers, Daphne Voorn, Kees Smid, Klaas Hoekman, H. F. W. Hoitsma, Godefridus J. Peters	2000	112
9	Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. PubMed ·C.L. van der Wilt, Herbert M. Pinedo, Kees Smid, Godefridus J. Peters	1992	103
10	Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside Cell Death and Differentiation ·Michael Grusch, Doris Polgar, S Gfatter, Katharina Leuhuber, S Huettenbrenner, C. Leisser, Gabriel Fuhrmann, Fekadu Kassie, Herta Steinkellner, Kees Smid, Godefridus J. Peters, Hiremagalur N. Jayaram, Waltraud Klepal, Thomas Szekeres, Siegfried Knasmüller, Georg Krupitza	2002	68
11	Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. Data Archiving and Networked Services (DANS) ·C.L. van der Wilt, Harold H.J. Backus, Kees Smid, L Comijn, G. Veerman, D. Wouters, Daphne Voorn, David G. Priest, Marlene A. Bunni, F. Mitchell, Ann L. Jackman, Gerrit Jansen, Godefridus J. Peters	2001	56
12	5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients Annals of Oncology ·Harold H.J. Backus, Danny F. Dukers, C.J. van Groeningen, W Vos, Elisabeth Bloemena, D. Wouters, J.M.G.H. van Riel, Kees Smid, Giuseppe Giaccone, Herbert M. Pinedo, Godefridus J. Peters	2001	56
13	A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function Chemical Communications ·Johannes Broichhagen, James A. Frank, Natalie R. Johnston, Ryan K. Mitchell, Kees Smid, Piero Marchetti, Marco Bugliani, Guy A. Rutter, Dirk Trauner, David J. Hodson	2015	50
14	End-joining deficiency and radiosensitization induced by gemcitabine. PubMed ·van Putten JWG, Groen HJM, Kees Smid, Godefridus J. Peters, Harm H. Kampinga	2001	44
15	Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase Annals of Oncology ·Carolien H. Smorenburg, Godefridus J. Peters, C.J. van Groeningen, Paul Noordhuis, Kees Smid, A.M.G.H. van Riel, W. Dercksen, Herbert M. Pinedo, Giuseppe Giaccone	2005	44
16	Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126 Investigational New Drugs ·Auke D. Adema, Kees Smid, Nienke Losekoot, Richard J. Honeywell, Henk M.W. Verheul, Finn Myhren, Marit Liland Sandvold, Godefridus J. Peters	2011	42
17	Transformation of mouse fibroblasts with the oncogenes H‐ras or trk is associated with pronounced changes in drug sensitivity and metabolism International Journal of Cancer ·Godefridus J. Peters, M. Wets, Y. P. A. M. Keepers, R. Oskam, J van Ark-Otte, Paul Noordhuis, Kees Smid, Herbert M. Pinedo	1993	42
18	Inhibition of thymidylate synthase by 2′,2′-difluoro-2′-deoxycytidine (Gemcitabine) and its metabolite 2′,2′-difluoro-2′-deoxyuridine The International Journal of Biochemistry & Cell Biology ·Richard J. Honeywell, Veronique W.T. Ruiz van Haperen, Gijsbert Veerman, Kees Smid, Godefridus J. Peters	2015	41
19	Molecular pathways involved in the synergistic interaction of the PKCβ inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells British Journal of Cancer ·Christina Tekle, Elisa Giovannetti, J. Sigmond, Jeremy R. Graff, Kees Smid, Godefridus J. Peters	2008	41
20	The effect of allopurinol and low-dose thiopurine combination therapy on the activity of three pivotal thiopurine metabolizing enzymes: Results from a prospective pharmacological study Journal of Crohn s and Colitis ·Margien L. Seinen, Dirk P. van Asseldonk, Nanne K.H. de Boer, Nienke Losekoot, Kees Smid, Chris J. Mulder, (unknown), Godefridus J. Peters, Ad A. van Bodegraven	2013	41

About Kees Smid

Kees Smid is a scholar working on Oncology, Molecular Biology, Pulmonary and Respiratory Medicine, Cancer Research and Pathology and Forensic Medicine, having authored 90 papers that have together received 3.1k indexed citations. Recurring topics across this work include Colorectal Cancer Treatments and Studies (45 papers), Biochemical and Molecular Research (23 papers), Gastric Cancer Management and Outcomes (15 papers), Pancreatic and Hepatic Oncology Research (12 papers), Cancer-related Molecular Pathways (10 papers), Cancer, Hypoxia, and Metabolism (10 papers), Genetic factors in colorectal cancer (9 papers) and DNA Repair Mechanisms (9 papers). The work is most often cited by research in Oncology (1.7k citations), Cancer Research (506 citations), Molecular Biology (1.5k citations), Pathology and Forensic Medicine (350 citations) and Pulmonary and Respiratory Medicine (606 citations). Kees Smid has collaborated with scholars based in Netherlands, United States and Italy. Frequent co-authors include Godefridus J. Peters, Herbert M. Pinedo, C.L. van der Wilt, Paul Noordhuis, Sybren L. Meijer, C.J. van Groeningen, Gerrit Jansen, Baukelien van Triest, Daphne Voorn and Elisa Giovannetti. Their work appears in journals such as Nucleosides Nucleotides & Nucleic Acids, Advances in experimental medicine and biology, European Journal of Cancer, Cancer Research and British Journal of Cancer.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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