Kees Smid

3.7k total citations
90 papers, 3.1k citations indexed

About

Kees Smid is a scholar working on Oncology, Molecular Biology and Pulmonary and Respiratory Medicine. According to data from OpenAlex, Kees Smid has authored 90 papers receiving a total of 3.1k indexed citations (citations by other indexed papers that have themselves been cited), including 66 papers in Oncology, 49 papers in Molecular Biology and 20 papers in Pulmonary and Respiratory Medicine. Recurrent topics in Kees Smid's work include Colorectal Cancer Treatments and Studies (45 papers), Biochemical and Molecular Research (23 papers) and Gastric Cancer Management and Outcomes (15 papers). Kees Smid is often cited by papers focused on Colorectal Cancer Treatments and Studies (45 papers), Biochemical and Molecular Research (23 papers) and Gastric Cancer Management and Outcomes (15 papers). Kees Smid collaborates with scholars based in Netherlands, United States and Italy. Kees Smid's co-authors include Godefridus J. Peters, Herbert M. Pinedo, C.L. van der Wilt, Paul Noordhuis, Sybren L. Meijer, C.J. van Groeningen, Gerrit Jansen, Baukelien van Triest, Daphne Voorn and Elisa Giovannetti and has published in prestigious journals such as Journal of Clinical Oncology, PLoS ONE and Cancer Research.

In The Last Decade

Kees Smid

89 papers receiving 3.0k citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Kees Smid Netherlands	29	1.7k	1.5k	606	506	350	90	3.1k
C.L. van der Wilt Netherlands	25	1.6k 0.9×	1.2k 0.8×	508 0.8×	342 0.7×	325 0.9×	60	2.7k
Robert D. Ladner United States	32	1.6k 0.9×	1.9k 1.3×	375 0.6×	376 0.7×	339 1.0×	51	3.3k
C.J. van Groeningen Netherlands	28	1.4k 0.8×	983 0.7×	483 0.8×	288 0.6×	290 0.8×	51	2.4k
Paul Noordhuis Netherlands	32	1.7k 1.0×	1.4k 0.9×	506 0.8×	412 0.8×	237 0.7×	82	3.4k
Harry K. Slocum United States	27	1.1k 0.6×	1.0k 0.7×	471 0.8×	479 0.9×	185 0.5×	71	2.4k
Susan L. Kelley United States	17	888 0.5×	1.3k 0.9×	281 0.5×	315 0.6×	361 1.0×	26	3.4k
Herman Burger Netherlands	28	1.3k 0.7×	1.2k 0.8×	330 0.5×	246 0.5×	128 0.4×	45	2.6k
Raymond Taetle United States	38	1.2k 0.7×	2.2k 1.5×	267 0.4×	518 1.0×	428 1.2×	129	4.4k
Stephan Ruetz Switzerland	23	2.0k 1.2×	1.7k 1.2×	340 0.6×	272 0.5×	119 0.3×	36	3.5k
Henk J. Broxterman Netherlands	26	1.3k 0.7×	1.4k 1.0×	379 0.6×	470 0.9×	97 0.3×	51	2.8k

Countries citing papers authored by Kees Smid

Since Specialization

Citations

This map shows the geographic impact of Kees Smid's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kees Smid with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kees Smid more than expected).

Fields of papers citing papers by Kees Smid

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kees Smid. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kees Smid. The network helps show where Kees Smid may publish in the future.

Co-authorship network of co-authors of Kees Smid

This figure shows the co-authorship network connecting the top 25 collaborators of Kees Smid. A scholar is included among the top collaborators of Kees Smid based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kees Smid. Kees Smid is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Peters, Godefridus J., Ietje Kathmann, Elisa Giovannetti, et al.. (2024). The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity. Frontiers in Pharmacology. 15. 1450418–1450418. 1 indexed citations

Honeywell, Richard J., Veronique W.T. Ruiz van Haperen, Gijsbert Veerman, Kees Smid, & Godefridus J. Peters. (2015). Inhibition of thymidylate synthase by 2′,2′-difluoro-2′-deoxycytidine (Gemcitabine) and its metabolite 2′,2′-difluoro-2′-deoxyuridine. The International Journal of Biochemistry & Cell Biology. 60. 73–81. 41 indexed citations

Floor, Karijn, Kees Smid, Richard J. Honeywell, et al.. (2014). Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine. SpringerPlus. 3(1). 732–732. 25 indexed citations

Maftouh, Mina, Abolfazl Avan, Rocco Sciarrillo, et al.. (2013). Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia. British Journal of Cancer. 110(1). 172–182. 142 indexed citations

Smid, Kees, Nienke Losekoot, Richard J. Honeywell, et al.. (2011). Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126. Investigational New Drugs. 30(5). 1908–1916. 42 indexed citations

Temmink, Olaf H., Irene V. Bijnsdorp, Henk‐Jan Prins, et al.. (2010). Trifluorothymidine Resistance Is Associated with Decreased Thymidine Kinase and Equilibrative Nucleoside Transporter Expression or Increased Secretory Phospholipase A2. Molecular Cancer Therapeutics. 9(4). 1047–1057. 25 indexed citations

Asseldonk, Dirk P. van, Nanne K.H. de Boer, Kees Smid, et al.. (2010). Limited Intra-Individual Variability in Hypoxanthine-Guanine Phosphoribosyl Transferase, Thiopurine S-Methyl Transferase, and Xanthine Oxidase Activity in Inflammatory Bowel Disease Patients During 6-Thioguanine Therapy. Nucleosides Nucleotides & Nucleic Acids. 29(4-6). 284–290. 5 indexed citations

Giovannetti, Elisa, et al.. (2009). Polymorphisms in the Enhancer Region of the Thymidylate Synthase Gene Are Associated with Thymidylate Synthase Levels in Normal Tissues but Not in Malignant Tissues of Patients with Colorectal Cancer. Clinical Colorectal Cancer. 8(3). 146–154. 19 indexed citations

Giovannetti, Elisa, Clara Lemos, Christina Tekle, et al.. (2008). Molecular Mechanisms Underlying the Synergistic Interaction of Erlotinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, with the Multitargeted Antifolate Pemetrexed in Non-Small-Cell Lung Cancer Cells. Molecular Pharmacology. 73(4). 1290–1300. 130 indexed citations

10.

Groeningen, Cees J. van, et al.. (2007). Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5‐fluorouracil to patients with colorectal cancer. International Journal of Cancer. 120(12). 2609–2612. 13 indexed citations

11.

Wiel, Mark A. van de, José Luís Costa, Kees Smid, et al.. (2005). Expression Microarray Analysis and Oligo Array Comparative Genomic Hybridization of Acquired Gemcitabine Resistance in Mouse Colon Reveals Selection for Chromosomal Aberrations. Cancer Research. 65(22). 10208–10213. 24 indexed citations

12.

Bruin, Michiel de, Kees Smid, Kasper van der Born, et al.. (2004). Role of Platelet Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase in Fluoropyrimidine Sensitivity and Potential Role of Deoxyribose‐1‐Phosphate. Nucleosides Nucleotides & Nucleic Acids. 23(8-9). 1485–1490. 12 indexed citations

13.

Noordhuis, Paul, U. Holwerda, C.L. van der Wilt, et al.. (2004). 5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers. Annals of Oncology. 15(7). 1025–1032. 210 indexed citations

14.

Peters, Godefridus J., Paul Noordhuis, André B. P. Kuilenburg, et al.. (2003). Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors. Cancer Chemotherapy and Pharmacology. 52(1). 1–12. 39 indexed citations

15.

Grusch, Michael, Doris Polgar, C. Leisser, et al.. (2002). Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside. Cell Death and Differentiation. 9(2). 169–178. 68 indexed citations

16.

Peters, Godefridus J., Harold H.J. Backus, Baukelien van Triest, et al.. (2002). Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1587(2-3). 194–205. 328 indexed citations

17.

Wilt, C.L. van der, Harold H.J. Backus, Kees Smid, et al.. (2001). Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.. Data Archiving and Networked Services (DANS). 61(9). 3675–81. 56 indexed citations

18.

Grusch, Michael, Monika Fritzer‐Szekeres, Georg Rosenberger, et al.. (2001). Activation of caspases and induction of apoptosis by novel ribonucleotide reductase inhibitors amidox and didox. Experimental Hematology. 29(5). 623–632. 36 indexed citations

19.

Kuilenburg, André B. P., Godefridus J. Peters, A. H. van Gennip, et al.. (1998). No Circadian Variation of Dihydropyrimidine Dehydrogenase, Uridine Phosphorylase, β-Alanine, and 5-Fluorouracil During Continuous Infusion of 5-Fluorouracil. Advances in experimental medicine and biology. 431. 811–816. 12 indexed citations

20.

Wilt, C.L. van der, et al.. (1993). In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis. British Journal of Cancer. 68(4). 702–707. 8 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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