Karena Last

3.5k citations

34 papers · 2.8k indexed · 1 hit paper · h-index 25

Impact in

Immunology and Allergy top 0.5%
- Cell Adhesion Molecules Research
Rheumatology top 0.5%
- Osteoarthritis Treatment and Mechanisms

Papers in

Immunology and Allergy 14
- Cell Adhesion Molecules Research 14
Cancer Research 27
- Protease and Inhibitor Mechanisms 25

Co-authors: Amanda Fosang Gillian Murphy Peter J. Neame Vera Knäuper Suzanne B. Golub Tim Hardingham Heather Stanton John A. Hamilton
Journals: Journal of Biological Chemistry (7 papers)FEBS Letters (4 papers)Biochemical Journal (3 papers)Blood (2 papers)British Journal of Cancer (1 paper)
Partner nations: Australia United States United Kingdom

In The Last Decade

Karena Last

33 papers receiving 2.8k citations

Hit Papers

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro 2005 · 726 citations

Peers

Countries citing papers authored by Karena Last

Since Specialization

Citations

This map shows the geographic impact of Karena Last's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karena Last with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karena Last more than expected).

Fields of papers citing papers by Karena Last

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karena Last. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karena Last. The network helps show where Karena Last may publish in the future.

Co-authors

The 25 scholars most cited alongside Karena Last, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Karena Last Line = papers co-authored together Karena Last links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Complex II assembly drives metabolic adaptation to OXPHOS dysfunction Science Advances ·Quang Van Vo, Séverin Jobert, Joanna Sacharz, Ann E. Frazier, Lishenga Lisiolo Josephat, Latu Lal Mahata, Shuai Nie, Michael G. Leeming, Linden Muellner-Wong, Karena Last, Tegan Stait, David P. De Souza, David R. Thorburn, Malcolm J. McConville, David A. Stroud	2025	0
2	An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2 JCI Insight ·Rachel E. Miller, Shingo Ishihara, Phuong Bich Tran, Suzanne B. Golub, Karena Last, Richard J. Miller, Amanda Fosang, Anne‐Marie Malfait	2018	86
3	Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C‐terminus Arthritis & Rheumatism ·André Struglics, Stefan Lohmander, Karena Last, Jonathan Akikusa, Roger C. Allen, Amanda Fosang	2012	14
4	Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo Biology Open ·Edward Bastow, Karena Last, Afia Frimpomaa Asare Marfo, Jennifer L. Stow, Amanda C. Stanley, Amanda Fosang	2012	13
5	Cytokine‐induced increases in ADAMTS‐4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS‐5–deficient mice Arthritis & Rheumatism ·Fraser M. Rogerson, Md Ilias Mahmud, ちあき岩崎, Karena Last, Amanda Fosang	2010	40
6	Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved Aggrecan Methods in molecular biology ·Amanda Fosang, Karena Last, Heather Stanton, Suzanne B. Golub, Christopher B. Little, Lorena E. Brown, David C. Jackson	2009	27
7	Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan Matrix Biology ·Amanda Fosang, Karena Last, Christopher Poon, Anna Plaas	2008	12
8	The activity of methylated and non-methylated selenium species in lymphoma cell lines and primary tumours Annals of Oncology ·Karena Last, T. T. Chen, Erik Wengström, Sandra J. Strauss, Jude Fitzgibbon, Tim Lister, Rodney A. McTaggart	2006	30
9	Mortality within 30 days of chemotherapy: a clinical governance benchmarking issue for oncology patients British Journal of Cancer ·Mary O’Brien, Yulia A. Pogodina, Anne Rigg, Alexandra Léary, L. Assersohn, Karena Last, Sylvia Tan, S Milan, Diana Tait, Ian E. Smith	2006	96
10	ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro Nature ·Heather Stanton, Fraser M. Rogerson, Bartosz Syzdek, Suzanne B. Golub, Kate E. Lawlor, Med Schlegel, Christopher B. Little, Karena Last, Pamela J. Farmer, Ian K. Campbell, Anne M. Fourie, Amanda Fosang Hit paper breakdown →	2005	726
11	Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan FEBS Letters ·Sarah M. Knox, Amanda Fosang, Karena Last, James Melrose, John M. Whitelock	2005	49
12	ADAMTS4 Cleaves at the Aggrecanase Site (Glu373-Ala374) and Secondarily at the Matrix Metalloproteinase Site (Asn341-Phe342) in the Aggrecan Interglobular Domain Journal of Biological Chemistry ·Jennifer Westling, Amanda Fosang, Karena Last, Vivian P. Thompson, Liang Xiao-yun, N. Ye. Latysheva, Thomas McDonagh, Lisa A. Collins‐Racie, Edward R. LaVallie, Elizabeth A. Morris, John D. Sandy	2002	72
13	Generation and Novel Distribution of Matrix Metalloproteinase-derived Aggrecan Fragments in Porcine Cartilage Explants Journal of Biological Chemistry ·Amanda Fosang, Karena Last, Heather Stanton, David E. Weeks, Ian K. Campbell, Tim Hardingham, M Bassuoni	2000	67
14	Mutations in the Interglobular Domain of Aggrecan Alter Matrix Metalloproteinase and Aggrecanase Cleavage Patterns Journal of Biological Chemistry ·Francesca Mercuri, Rose A. Maciewicz, Jonathan Tart, Karena Last, Amanda Fosang	2000	44
15	Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP) FEBS Letters ·Jan Olaf Stracke, Amanda Fosang, Karena Last, Francesca Mercuri, Alberto M. Pendás, Elena Llano, Roberto Perris, Paul E. Di Cesare, Gillian Murphy, Vera Knäuper	2000	100
16	Recombinant Human Aggrecan G1-G2 Exhibits Native Binding Properties and Substrate Specificity for Matrix Metalloproteinases and Aggrecanase Journal of Biological Chemistry ·Francesca Mercuri, Kurt Doege, Elizabeth C. Arner, Michael A. Pratta, Karena Last, Amanda Fosang	1999	37
17	Degradation of cartilage aggrecan by collagenase‐3 (MMP‐13) FEBS Letters ·Amanda Fosang, Karena Last, Vera Knäuper, Gillian Murphy, Peter J. Neame	1996	319
18	Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent. Journal of Clinical Investigation ·Amanda Fosang, Karena Last, Rose A. Maciewicz	1996	170
19	Independent regulation of plasminogen activator inhibitor 2 and plasminogen activator inhibitor 1 in human synovial fibroblasts Arthritis & Rheumatism ·John A. Hamilton, Jitendra Thakur, Enrico L Filonzi, Diana S. Piccoli, Johann Wojta, Ken Macdonald, Katherine McGrath, Karena Last	1992	26
20	Recombinant human inteleukin-1 inhibits plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes Biochemical and Biophysical Research Communications ·Ian K. Campbell, Karena Last, Ulrike Novak, Leif R. Lund, John A. Hamilton	1991	30

About Karena Last

Karena Last is a scholar working on Immunology and Allergy, Cancer Research, Hematology, Rheumatology and Cell Biology, having authored 34 papers that have together received 2.8k indexed citations. Recurring topics across this work include Protease and Inhibitor Mechanisms (25 papers), Cell Adhesion Molecules Research (14 papers), Osteoarthritis Treatment and Mechanisms (12 papers), Blood Coagulation and Thrombosis Mechanisms (9 papers), Peptidase Inhibition and Analysis (7 papers), Proteoglycans and glycosaminoglycans research (6 papers), Inflammatory mediators and NSAID effects (3 papers) and Glycosylation and Glycoproteins Research (2 papers). The work is most often cited by research in Immunology and Allergy (718 citations), Rheumatology (1.5k citations), Cancer Research (1.3k citations), Hematology (360 citations) and Cell Biology (439 citations). Karena Last has collaborated with scholars based in Australia, United States and United Kingdom. Frequent co-authors include Amanda Fosang, Gillian Murphy, Peter J. Neame, Vera Knäuper, Suzanne B. Golub, Tim Hardingham, Heather Stanton, John A. Hamilton, Fraser M. Rogerson and Christopher B. Little. Their work appears in journals such as Journal of Biological Chemistry, FEBS Letters, Biochemical Journal, Blood and British Journal of Cancer.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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