John T. Isaacs

29.9k total citations · 5 hit papers
311 papers, 21.3k citations indexed

About

John T. Isaacs is a scholar working on Pulmonary and Respiratory Medicine, Molecular Biology and Oncology. According to data from OpenAlex, John T. Isaacs has authored 311 papers receiving a total of 21.3k indexed citations (citations by other indexed papers that have themselves been cited), including 156 papers in Pulmonary and Respiratory Medicine, 151 papers in Molecular Biology and 65 papers in Oncology. Recurrent topics in John T. Isaacs's work include Prostate Cancer Treatment and Research (149 papers), Hormonal and reproductive studies (60 papers) and Prostate Cancer Diagnosis and Treatment (35 papers). John T. Isaacs is often cited by papers focused on Prostate Cancer Treatment and Research (149 papers), Hormonal and reproductive studies (60 papers) and Prostate Cancer Diagnosis and Treatment (35 papers). John T. Isaacs collaborates with scholars based in United States, Japan and Netherlands. John T. Isaacs's co-authors include Samuel R. Denmeade, Natasha Kyprianou, Donald S. Coffey, Hugh F. English, Natasha Kyprianou, W. Nathaniel Brennen, Jin‐Tang Dong, Jasminka Vukanovic, Yuzo Furuya and Susan L. Dalrymple and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

John T. Isaacs

308 papers receiving 20.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

2004 783 citations G. Steven Bova, John T. Isaacs et al. profile →
KAI1 , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2

1995 645 citations John T. Isaacs et al. profile →
Activation of Programmed Cell Death in the Rat Ventral Prostate after Castration*

1988 604 citations John T. Isaacs et al. profile →
Etiology and disease process of benign prostatic hyperplasia

1989 408 citations John T. Isaacs, Donald S. Coffey The Prostate profile →
Establishment and characterization of seven dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers

1986 362 citations John T. Isaacs, William B. Isaacs et al. The Prostate profile →

Peers

Countries citing papers authored by John T. Isaacs

Since Specialization

Citations

This map shows the geographic impact of John T. Isaacs's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John T. Isaacs with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John T. Isaacs more than expected).

Fields of papers citing papers by John T. Isaacs

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John T. Isaacs. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John T. Isaacs. The network helps show where John T. Isaacs may publish in the future.

Co-authorship network of co-authors of John T. Isaacs

This figure shows the co-authorship network connecting the top 25 collaborators of John T. Isaacs. A scholar is included among the top collaborators of John T. Isaacs based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John T. Isaacs. John T. Isaacs is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer 2024 ·Molecular Cancer Therapeutics ·Mannan Nouri, Andreas Varkaris, Maya Ridinger, Susan L. Dalrymple, (unknown), John T. Isaacs, David J. Einstein, W. Nathaniel Brennen, Steven P. Balk	3
2	Targeting the fibroblast growth factor pathway in molecular subtypes of castration‐resistant prostate cancer 2023 ·The Prostate ·Mark P. Labrecque, Lisha G. Brown, Ilsa M. Coleman, Holly M. Nguyen, Susan L. Dalrymple, W. Nathaniel Brennen, John T. Isaacs, Dapei Li, Bryce Lakely, (unknown), John K. Lee, Michael T. Schweizer, Daniel W. Lin, Eva Corey, Peter S. Nelson, Colm Morrissey	4
3	Third generation quinoline‐3‐carboxamide transcriptional disrupter of HDAC4, HIF‐1α, and MEF‐2 signaling for metastatic castration‐resistant prostate cancer 2023 ·The Prostate ·John T. Isaacs, Susan L. Dalrymple, Lizamma Antony, (unknown), Ilsa M. Coleman, Peter S. Nelson, Maya Kostova, Iain A. Murray, Gary H. Perdew, Samuel R. Denmeade, (unknown), W. Nathaniel Brennen	3
4	Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling 2022 ·Cancer Research ·Jesse C. Patterson, Andreas Varkaris, Peter J.P. Croucher, Maya Ridinger, Susan L. Dalrymple, Mannan Nouri, Fang Xie, Shohreh Varmeh, Oliver Jonas, Matthew A. Whitman, (unknown), (unknown), (unknown), Jun Luo, John T. Isaacs, Mark G. Erlander, David J. Einstein, Steven P. Balk, Michael B. Yaffe	12
5	Microparticle Encapsulation of a Prostate-targeted Biologic for the Treatment of Liver Metastases in a Preclinical Model of Castration-resistant Prostate Cancer 2020 ·Molecular Cancer Therapeutics ·(unknown), Lizamma Antony, Oren Levy, Nitin Joshi, Brian W. Simons, Susan L. Dalrymple, Dina Rosen, (unknown), (unknown), (unknown), Sudhir H. Ranganath, Lei Zheng, Jeffrey M. Karp, S. Peter Howard, Samuel R. Denmeade, John T. Isaacs, W. Nathaniel Brennen	3
6	Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression 2019 ·Cancer Research ·Robert M. Hughes, Brian W. Simons, (unknown), Rebecca L. Miller, (unknown), (unknown), Debebe Theodros, Michael C. Haffner, Tamara L. Lotan, Jessie Huang, Elai Davicioni, Steven S. An, Ryan C. Riddle, Daniel L.J. Thorek, Isla P. Garraway, Elana J. Fertig, John T. Isaacs, W. Nathaniel Brennen, Ben Ho Park, Paula J. Hurley	52
7	Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer 2016 ·Clinical Cancer Research ·Liana B. Guedes, Carlos L. Morais, Fawaz Almutairi, Michael C. Haffner, Qizhi Zheng, John T. Isaacs, Emmanuel S. Antonarakis, Changxue Lu, Harrison Tsai, Jun Luo, Angelo M. De Marzo, Tamara L. Lotan	25
8	Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation 2016 ·Clinical Cancer Research ·(unknown), Michael C. Haffner, Jonathan B. Coulter, Raju R. Raval, Yonggang Zhang, Haoming Zhou, Omar Y. Mian, Emma Knight, (unknown), Susan L. Dalrymple, John T. Isaacs, (unknown), Russell K. Hales, William G. Nelson, Srinivasan Yegnasubramanian, Theodore L. DeWeese	33
9	Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment 2012 ·Cancer Research ·John T. Isaacs, Lizamma Antony, Susan L. Dalrymple, W. Nathaniel Brennen, (unknown), Hans J. Hammers, Michel D. Wissing, Sushant K. Kachhap, Jun Luo, Li Xing, Per Björk, Anders Olsson, (unknown), Tomas Leanderson	89
10	Loss of Androgen Receptor-Dependent Growth Suppression by Prostate Cancer Cells Can Occur Independently from Acquiring Oncogenic Addiction to Androgen Receptor Signaling 2010 ·PLoS ONE ·Jason M. D’Antonio, (unknown), Lizamma Antony, (unknown), Susan L. Dalrymple, Shahriar Koochekpour, John T. Isaacs	29
11	DNA licensing as a novel androgen receptor mediated therapeutic target for prostate cancer 2009 ·Endocrine Related Cancer ·Jason M. D’Antonio, Donald J. Vander Griend, John T. Isaacs	41
12	Low-Calcium Serum-Free Defined Medium Selects for Growth of Normal Prostatic Epithelial Stem Cells 2006 ·Cancer Research ·Ivan V. Litvinov, Donald J. Vander Griend, Yi Xu, Lizamma Antony, Susan L. Dalrymple, John T. Isaacs	115
13	Cyclin-Dependent Kinase 5 Activity Controls Cell Motility and Metastatic Potential of Prostate Cancer Cells 2006 ·Cancer Research ·Christopher J. Strock, Jong‐In Park, Eric K. Nakakura, G. Steven Bova, John T. Isaacs, Douglas W. Ball, Barry D. Nelkin	128
14	Prostate-Specific Membrane Antigen (PSMA) targeted prodrug “smartbombs” as therapy for prostate cancer 2006 ·Cancer Research ·(unknown), Pratap Singh, Marc Rosen, Craig A. Dionne, S. Brøgger Christensen, John T. Isaacs, Samuel R. Denmeade	1
15	Prostate cancer : principles and practice 2002 ·Lippincott Williams & Wilkins eBooks ·Philip W. Kantoff, Peter R. Carroll, Anthony V. D’Amico, Ronald K. Ross, John T. Isaacs, Howard I. Scher	52
16	Recent advances in the development of animal and cell culture models for prostate cancer research A minireview 1996 ·Urologic Oncology Seminars and Original Investigations ·Maarten C. Bosland, Leland W.K. Chung, Norman M. Greenberg, Shuk‐Mei Ho, John T. Isaacs, (unknown), Donna M. Peehl, Timothy C. Thompson, G.J. van Steenbrugge, Wytske M. van Weerden	26
17	Programming events in the regulation of cell proliferation and death. 1993 ·PubMed ·R. Berges, John T. Isaacs	16
18	Models for development of nonreceptor methods for distinguishing androgen-sensitive and -insensitive prostatic tumors. 1979 ·Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) ·John T. Isaacs, William B. Isaacs, Donald S. Coffey	25
19	Animal models in the study of prostatic cancer 1979 ·Cancer Detection and Prevention ·John T. Isaacs, (unknown)	7
20	Animal models of the hormone-sensitive and -insensitive prostatic adenocarcinomas, Dunning R-3327-H, R-3327-HI, and R-3327-AT. 1978 ·Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) ·John T. Isaacs, Warren D.W. Heston, Robert M. Weissman, Donald S. Coffey	144

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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