John S. O’Brien

12.2k citations

165 papers · 9.8k indexed · 3 hit papers · h-index 56

Impact in

Physiology top 0.2%
- Lysosomal Storage Disorders Research
Cell Biology top 0.5%
- Cellular transport and secretion

Papers in

Physiology 72
- Lysosomal Storage Disorders Research 64
Cell Biology 32
- Cellular transport and secretion 19

Co-authors: Shintaro Okada Elizabeth L Sampson Mae Wan Ho Yasuo Kishimoto George Rouser Dorothy L. Fillerup Masao Hiraiwa W. Marie Campana
Journals: Clinical Genetics (14 papers)Science (9 papers)Journal of Behavior Therapy and Experimental Psychiatry (9 papers)Journal of Lipid Research (9 papers)Analytical Biochemistry (6 papers)
Partner nations: United States Belgium Japan

In The Last Decade

John S. O’Brien

161 papers receiving 8.9k citations

Hit Papers

align trajectories log scale

Tay-Sachs Disease: Generalized Absence of a Beta-D- N -Acetylhexosaminidase Component 1969 · 544 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1969 Science
1965 Journal of Lipid Research
1965 Journal of Lipid Research

Peers

Replace Lars Svennerholm with:

Lars Svennerholm Sweden

Glyn Dawson United States

Yoshio Hirabayashi Japan

Wilhelm Stoffel Germany

Koji Takio Japan

Roscoe O. Brady United States

Jean E. Vance Canada

Robert H. Michell United Kingdom

Barry I. Posner Canada

John S. O’Brien relative to Lars Svennerholm Sweden Lars Svennerholm's profile →

Citations per field

00.5×2×2.9×

Lars Svennerholm · 1×

×0.8 4k/6k

PHYSI

×0.5 2k/3k

CB

×0.6 607/1k

CB

×0.6 618/1k

BIOCH

×0.4 5k/13k

MB

Citations per year

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Countries citing papers authored by John S. O’Brien

Since Specialization

Citations

This map shows the geographic impact of John S. O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John S. O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John S. O’Brien more than expected).

Fields of papers citing papers by John S. O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John S. O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John S. O’Brien. The network helps show where John S. O’Brien may publish in the future.

Co-authorship network

The 25 scholars most cited alongside John S. O’Brien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John S. O’Brien Line = papers co-authored together John S. O’Brien links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	A retro-inverso Prosaptide™ D5 promotes a myelination process in developing rats Developmental Brain Research ·Masao Hiraiwa, W. Marie Campana, Chhabi Seth -, Deborah A. C. Otero, John S. O’Brien	2001	9
2	Neuroprotective effect of retro-inverso Prosaptide D5 on focal cerebral ischemia in rat Neuroreport ·Andrew Zalesak, Deborah A. C. Otero, Masao Hiraiwa, John S. O’Brien	2000	21
3	Retro-Inverso Prosaptide Peptides Retain Bioactivity, Are Stable In Vivo, and Are Blood-Brain Barrier Permeable Journal of Pharmacology and Experimental Therapeutics ·Eve M. Taylor, Deborah A. C. Otero, William A. Banks, John S. O’Brien	2000	51
4	Spectrum of mutations in fucosidosis European Journal of Human Genetics ·Patrick J. Willems, Hee‐Chan Seo, Paul Coucke, Rossana Tonlorenzi, John S. O’Brien	1999	70
5	Prosaposin Receptor: Evidence for a G-Protein-Associated Receptor Biochemical and Biophysical Research Communications ·Masao Hiraiwa, W. Marie Campana, Brian M. Martin, John S. O’Brien	1997	65
6	Model SV40-transformed fibroblast lines for metabolic studies of human prosaposin and acid ceramidase deficiencies Clinica Chimica Acta ·A. Gomez, K. Harzer, Helen Christomanou, Jean Feunteun, Marie‐Thérèse Pieraggi, Barbara C. Paton, Yasuo Kishimoto, John S. O’Brien, D. Lopes Pegna, Jean‐Claude Thiers, Robert Salvayre, Thierry Levade	1997	28
7	Comparison of the canine and human acid β-galactosidase gene American Journal of Medical Genetics ·栄史大鶴, Keith A. Kretz, John S. O’Brien	1996	6
8	A 66-Basepair insertion in Exon 6 of the α-L-fucosidase gene of a fucosidosis patient; Human Mutation ·Ekaterina Gennadievna Vodopyanova, Meiheng Yang, H. Soek, John S. O’Brien, Richard A. DiCioccio, B. A. Gordon	1996	2
9	Structural study of the oligosaccharide moieties of sphingolipid activator proteins, saposins A, C and D obtained from the spleen of a Gaucher patient European Journal of Biochemistry ·Keita Ito, Noriko Takahashi, Akira Takahashi, Ichio Shimada, Yoji Arata, John S. O’Brien, Yasuo Kishimoto	1993	16
10	Distribution of Saposins (Sphingolipid Activator Proteins) in Tissues of Lysosomal Storage Disease Patients Journal of Molecular Neuroscience ·Masanobu Tayama, John S. O’Brien, Yasuo Kishimoto	1992	8
11	Fucosidosis revisited: A review of 77 patients American Journal of Medical Genetics ·Patrick J. Willems, Rosanna Gatti, John Darby, Rada Cossutta, Paolo Durand, Jan E. Dumon, John S. O’Brien	1991	115
12	Determination of saposin proteins (sphingolipid activator proteins) in human tissues Analytical Biochemistry ·Satoshi Morimoto, Yoshimi Yamamoto, John S. O’Brien, Yasuo Kishimoto	1990	15
13	Isolation, Characterization, and Mapping of a Human Acid β-Galactosidase cDNA DNA and Cell Biology ·Kh. Dj Asli, Rafael Carralero, Brian M. Martin, Keith A. Kretz, 栄史大鶴, Susan L. Naylor, Michal Mudd, John S. O’Brien	1990	50
14	Characterization of EcoRI mutation in fucosidosis patients: A stop codon in the open reading frame Journal of Molecular Neuroscience ·Keith A. Kretz, John Darby, Patrick J. Willems, John S. O’Brien	1989	17
15	Chromogenic Immuno detection of Human Serum Albumin and α- l -Fucosidase Clones in a Human Hepatoma cDNA Expression Library DNA ·Jeffrey R. de Wet, Kerstin Knopf, Nazneen N. Dewji, Edward R. Wilcox, John S. O’Brien, Donald R. Helinski	1984	68
16	Molecular genetics of GM1 beta-galactosidase. PubMed ·John S. O’Brien	1975	62
17	FUCOSIDOSIS: DEFICIENCY OF ALPHA-L-FUCOSIDASE IN CULTURED SKIN FIBROBLASTS The Journal of Experimental Medicine ·K Zielke, M. Lois Veath, John S. O’Brien	1972	36
18	Ozone and Unsaturated Fatty Acids Archives of Environmental Health An International Journal ·Oscar J. Balchum, John S. O’Brien, Bernard D. Goldstein	1971	33
19	Generalized gangliosidosis The Journal of Pediatrics ·John S. O’Brien	1969	79
20	TAY-SACHS' DISEASE. California medicine ·John S. O’Brien	1965	2

About John S. O’Brien

John S. O’Brien is a scholar working on Physiology, Cell Biology, Clinical Biochemistry, Molecular Biology and Nutrition and Dietetics, having authored 165 papers that have together received 9.8k indexed citations. Recurring topics across this work include Lysosomal Storage Disorders Research (64 papers), Glycosylation and Glycoproteins Research (49 papers), Carbohydrate Chemistry and Synthesis (29 papers), Cellular transport and secretion (19 papers), Sphingolipid Metabolism and Signaling (11 papers), Metabolism and Genetic Disorders (9 papers), Infant Nutrition and Health (9 papers) and Trypanosoma species research and implications (9 papers). The work is most often cited by research in Physiology (4.5k citations), Cell Biology (1.7k citations), Clinical Biochemistry (607 citations), Biochemistry (618 citations) and Molecular Biology (5.4k citations). John S. O’Brien has collaborated with scholars based in United States, Belgium and Japan. Frequent co-authors include Shintaro Okada, Elizabeth L Sampson, Mae Wan Ho, Yasuo Kishimoto, George Rouser, Dorothy L. Fillerup, Masao Hiraiwa, W. Marie Campana, Anthony G.W. Norden and Thomas G. Warner. Their work appears in journals such as Clinical Genetics, Science, Journal of Behavior Therapy and Experimental Psychiatry, Journal of Lipid Research and Analytical Biochemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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